Faculty profile
Joerg Gsponer
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Research
Latest papers
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Cell reports · 2023
Protein feature analysis of heat shock induced ubiquitination sites reveals preferential modification site localization.
Journal of proteomics · 2021
Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae.
Journal of cell science · 2020
Latest funding
- $250,000
Out of time: Combining AI, Statistical Physics and Biochemistry to Develop In-silico techniques for molecular scale simulation of nucleation events
SSHRC · 2023 · Principal investigator
- $150,000
High throughput flow cytometer for the Michael Smith Laboratories
NSERC · 2020 · Co-investigator
- $240,000
Designing interactions mediated by disordered protein regions
NSERC · 2020 · Principal investigator
12 publications.
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Sun C, Seranova E, Cohen MA, Chipara M, Roberts J, Astuti D, Palhegyi AM, Acharjee A, Sedlackova L, Kataura T, Otten EG, Panda PK, Lara-Reyna S, Korsgen ME, Kauffman KJ, Huerta-Uribe A, Zatyka M, Silva LFSE, Torresi J, Zhang S, Hughes GW, Ward C, Kuechler ER, Cartwright D, Trushin S, Trushina E, Sahay G, Buganim Y, Lavery GG, Gsponer J, Anderson DG, Frickel EM, Rosenstock TR, Barrett T, Maddocks ODK, Tennant DA, Wang H, Jaenisch R, Korolchuk VI, Sarkar S
Protein feature analysis of heat shock induced ubiquitination sites reveals preferential modification site localization.
Kuechler ER, Rose A, Bolten M, Madero A, Kammoonah S, Colborne S, Gsponer J, Morin GB, Mayor T
Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae.
Zhu M, Kuechler ER, Zhang J, Matalon O, Dubreuil B, Hofmann A, Loewen C, Levy ED, Gsponer J, Mayor T
Computational Disorder Analysis in Ethylene Response Factors Uncovers Binding Motifs Critical to Their Diverse Functions.
Sun X, Malhis N, Zhao B, Xue B, Gsponer J, Rikkerink EHA
Topological Dissection of the Membrane Transport Protein Mhp1 Derived from Cysteine Accessibility and Mass Spectrometry.
Calabrese AN, Jackson SM, Jones LN, Beckstein O, Heinkel F, Gsponer J, Sharples D, Sans M, Kokkinidou M, Pearson AR, Radford SE, Ashcroft AE, Henderson PJF
The [PSI +] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI +] cells can promote aneuploidy.
Chan PHW, Lee L, Kim E, Hui T, Stoynov N, Nassar R, Moksa M, Cameron DM, Hirst M, Gsponer J, Mayor T
Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.
Fang NN, Chan GT, Zhu M, Comyn SA, Persaud A, Deshaies RJ, Rotin D, Gsponer J, Mayor T
Mechanically tightening a protein slipknot into a trefoil knot.
He C, Lamour G, Xiao A, Gsponer J, Li H
Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease.
Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP, Cohen MA, Chakraborty S, Wang H, Spooner E, Ploegh H, Gsponer J, Korolchuk VI, Jaenisch R
Protein synthesis rate is the predominant regulator of protein expression during differentiation.
Kristensen AR, Gsponer J, Foster LJ
Out of time: Combining AI, Statistical Physics and Biochemistry to Develop In-silico techniques for molecular scale simulation of nucleation events
Principal investigators: Gsponer, Joerg
High throughput flow cytometer for the Michael Smith Laboratories
Principal investigators: Mayor, Thibault
Designing interactions mediated by disordered protein regions
Principal investigators: Gsponer, Joerg
Keywords: intrinsically disordered proteins; protein-protein interactions; allostery; phase separation; molecular modeling; molecular dynamics simulations; machine learning
Redesigning SARS CoV-2 spike protein to improve immunization - COVID-19_x000d_ _x000d_
Principal investigators: Gsponer, Joerg
Training Program in High-Dimensional Bioinformatics (HDB)
Principal investigators: Pavlidis, Paul
Prediction of interactions involving intrinsically disordered proteins
Principal investigators: Gsponer, Joerg
Protein interaction networks structurally integrated
Principal investigators: Gsponer, Joerg
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Thibault Mayor and Joerg Gsponer: 4 shared papers
- Martin Hirst and Thibault Mayor: 1 shared paper
- Martin Hirst and Joerg Gsponer: 1 shared paper
- Thibault Mayor and Daniela Rotin: 1 shared paper
- Thibault Mayor and Hongbin Li: 1 shared paper
- Daniela Rotin and Joerg Gsponer: 1 shared paper
- Hongbin Li and Joerg Gsponer: 1 shared paper
- Department of Biochemistry and Molecular Biology
- Department of Biochemistry
- Department of Chemistry
- Department of Microbiology and Immunology
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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