Faculty profile

Daniela Rotin

ResearcherCell BiologyUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Daniela Rotin

Researcher

Cell Biology

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
8 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (6 CIHR, 3 NSERC), most recently in 2017.
Supervised 2 trainees who won CIHR awards, most recently in 2018.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

225

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Signal Transduction Ubiquitin Endocytosis Lysosome Mtorc1 Membrane Phosphorylation Biochemistry

Latest papers

Negative regulation of the NF-κB pathway by the ubiquitin ligase Nedd4-1(NE).
Communications biology · 2026 · senior author
The ubiquitin ligase Nedd4-2 promotes localization of DNMBP/Tuba to P-bodies under hyperosmotic stress.
The Journal of biological chemistry · 2025 · senior author
The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation.
Cell reports · 2024

All 61 publications

Latest funding

Investigating the molecular basis of the Nedd4-FGFR1 interaction and its role in cancer
CIHR · 2018 · Supervisor
$105,000
Role of the ubiquitin system in Drosophila muscle synaptogenesis and function
NSERC · 2017 · Principal investigator
$192,000
Ubiquitin-mediated regulation of membrane proteins
CIHR · 2017 · Nominated PI
$2,240,289

All 12 grants and awards

61 publications.

Negative regulation of the NF-κB pathway by the ubiquitin ligase Nedd4-1(NE).

Persaud A, Kefalas G, Shteiman A, Priya A, Liang H, Melnyk RA, Astori A, Raught B, Rotin D

Communications biology2026Senior author

DOI: 10.1038/s42003-026-09634-7 PMID: 41654613

The ubiquitin ligase Nedd4-2 promotes localization of DNMBP/Tuba to P-bodies under hyperosmotic stress.

Liu Z, Jiang C, Yeung F, Raught B, Rotin D

The Journal of biological chemistry2025Senior author

DOI: 10.1016/j.jbc.2025.110738 PMID: 40975170

The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation.

Xiao YX, Lee SY, Aguilera-Uribe M, Samson R, Au A, Khanna Y, Liu Z, Cheng R, Aulakh K, Wei J, Farias AG, Reilly T, Birkadze S, Habsid A, Brown KR, Chan K, Mero P, Huang JQ, Billmann M, Rahman M, Myers C, Andrews BJ, Youn JY, Yip CM, Rotin D, Derry WB, Forman-Kay JD, Moses AM, Pritišanac I, Gingras AC, Moffat J

Cell reports2024

DOI: 10.1016/j.celrep.2024.114417 PMID: 38980795

Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.

Altas B, Rhee HJ, Ju A, Solís HC, Karaca S, Winchenbach J, Kaplan-Arabaci O, Schwark M, Ambrozkiewicz MC, Lee C, Spieth L, Wieser GL, Chaugule VK, Majoul I, Hassan MA, Goel R, Wojcik SM, Koganezawa N, Hanamura K, Rotin D, Pichler A, Mitkovski M, de Hoz L, Poulopoulos A, Urlaub H, Jahn O, Saher G, Brose N, Rhee J, Kawabe H

The Journal of cell biology2024

DOI: 10.1083/jcb.201902050 PMID: 38032389

Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.

Rotin D, Prag G

Physiology (Bethesda, Md.)2024First author

DOI: 10.1152/physiol.00023.2023 PMID: 37962894

Primate-specific isoform of Nedd4-1 regulates substrate binding via Ser/Thr phosphorylation and 14-3-3 binding.

Kefalas G, Rotin D

Scientific reports2023Senior author

DOI: 10.1038/s41598-023-44761-9 PMID: 37863970

Regulation of the p38-MAPK pathway by hyperosmolarity and by WNK kinases.

Liu Z, Demian W, Persaud A, Jiang C, Subramanaya AR, Rotin D

Scientific reports2022Senior author

DOI: 10.1038/s41598-022-18630-w PMID: 36008477

Elevated intracellular Na+ and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2.

Persaud A, Jiang C, Liu Z, Kefalas G, Demian WL, Rotin D

Proceedings of the National Academy of Sciences of the United States of America2022Senior author

DOI: 10.1073/pnas.2122495119 PMID: 35858421

High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids.

Xia S, Bozóky Z, Di Paola M, Laselva O, Ahmadi S, Jiang JX, Pitstick AL, Jiang C, Rotin D, Mayhew CN, Jones NL, Bear CE

Cells2021

DOI: 10.3390/cells10123419 PMID: 34943927

Split Chloramphenicol Acetyl-Transferase Assay Reveals Self-Ubiquitylation-Dependent Regulation of UBE3B.

Levin-Kravets O, Kordonsky A, Shusterman A, Biswas S, Persaud A, Elias S, Langut Y, Florentin A, Simpson-Lavy KJ, Yariv E, Avishid R, Sror M, Almog O, Marshanski T, Kadosh S, Ben David N, Manori B, Fischer Z, Lilly J, Borisova E, Ambrozkiewicz MC, Tarabykin V, Kupiec M, Thaker M, Rotin D, Prag G

Journal of molecular biology2021

DOI: 10.1016/j.jmb.2021.167276 PMID: 34599943

Investigating the molecular basis of the Nedd4-FGFR1 interaction and its role in cancer

SupervisorCIHR2018Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Kefalas, George

Keywords: Cancer Mutations; Cell Biology; Fgf Receptor 1; Nedd4; Nuclear Magnetic Resonance; Ubiquitin

$105,000