Faculty profile
Paul Rennie
Back to facultyThis profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
Androgen receptor plasticity and its implications for prostate cancer therapy.
Cancer treatment reviews · 2019
UV Light-inactivated HSV-1 Stimulates Natural Killer Cell-induced Killing of Prostate Cancer Cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) · 2019
Divergent androgen regulation of unfolded protein response pathways drives prostate cancer.
EMBO molecular medicine · 2015
Latest funding
- $351,900
Preclinical development of a novel androgen receptor antagonist to treat castration-resistant prostate cancer
CIHR · 2017 · Co-investigator
- $459,000
Design and evaluation of small molecules that target the dimerization interface of full-length and splice-variant forms of the androgen receptor as a potential treatment for advanced prostate cancer
CIHR · 2017 · Co-investigator
- $401,364
Development of targeted therapeutics for ERG-expressing prostate cancers
CIHR · 2016 · Co-investigator
7 publications.
Androgen receptor plasticity and its implications for prostate cancer therapy.
Snow O, Lallous N, Singh K, Lack N, Rennie P, Cherkasov A
UV Light-inactivated HSV-1 Stimulates Natural Killer Cell-induced Killing of Prostate Cancer Cells.
Samudio I, Hofs E, Cho B, Li M, Bolduc K, Bu L, Liu G, Lam V, Rennie P, Jia W, Elisia I, Krystal G
Divergent androgen regulation of unfolded protein response pathways drives prostate cancer.
Sheng X, Arnoldussen YJ, Storm M, Tesikova M, Nenseth HZ, Zhao S, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen H, Mills IG, Jin Y, Hotamisligil G, Saatcioglu F
STAMP2 increases oxidative stress and is critical for prostate cancer.
Jin Y, Wang L, Qu S, Sheng X, Kristian A, Mælandsmo GM, Pällmann N, Yuca E, Tekedereli I, Gorgulu K, Alpay N, Sood A, Lopez-Berestein G, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen HE, Ozpolat B, Saatcioglu F
The expression of glucocorticoid receptor is negatively regulated by active androgen receptor signaling in prostate tumors.
Xie N, Cheng H, Lin D, Liu L, Yang O, Jia L, Fazli L, Gleave ME, Wang Y, Rennie P, Dong X
Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.
Liu L, Xie N, Rennie P, Challis JR, Gleave M, Lye SJ, Dong X
Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity
Zoubeidi A, Zardan A, Beraldi E, Fazli L, Sowery R, Rennie P, Nelson C, Gleave M
Preclinical development of a novel androgen receptor antagonist to treat castration-resistant prostate cancer
Principal investigators: Gleave, Martin E; Lack, Nathan A
Keywords: Androgen Receptor; Binding Function-3; Prostate Cancer; Small Molecule Inhibitors
Design and evaluation of small molecules that target the dimerization interface of full-length and splice-variant forms of the androgen receptor as a potential treatment for advanced prostate cancer
Principal investigators: Cherkasov, Artem
Keywords: Androgen Receptor; Drug-Design; Prostate Cancer; Small Molecule Inhibitors; Transciption Factor Dimerization
Development of targeted therapeutics for ERG-expressing prostate cancers
Principal investigators: Cox, Michael E; Gleave, Martin E
Keywords: Animal Models; Biochemistry; Cell Biology; Computer-Aided Design; Drug Chemistry; E26 Transformation-Specific Gene Family; Gene Expression; Metastasis; Prostatic Adenocarcinoma; Therapeutic Development
The effect of ERG inhibitors on the formation of tumor micro-environment and metastatic niche.
Principal investigators: Roshan Moniri, Mani
Keywords: Dormancy Of Cancer Cells; Erg Inhibitors; Formation Of Tumor Micro-Environment; Metastatic Niche; Pre And Post-Treatment
Lipid nanomedicines for health and disease
Principal investigators: Cullis, Pieter R
Keywords: Anticancer; Drug Delivery System; Gene Therapy; Immunosuppressant; Lipid Nanoparticles; Mrna; Nanomedicine; Sirna; Small Molecule Drugs; Trigger Release
First-in-Class Small-molecule Inhibitors Selectively Targeting the DNA-binding Domain of Human Androgen Receptor and Its Splice Variants for the Treatment of Resistant Prostate Cancer
Principal investigators: Cherkasov, Artem; Rennie, Paul S
Keywords: Androgen Receptor (Ar); Anti-Androgens; Ar Splice Variants; Computer-Aided Drug Design; Drug Resistance; Prostate Cancer; Small Molecule Inhibitors
Targeting ETS Factor ERG as a Novel Therapeutic for the Treatment of Prostate Cancer
Principal investigators: Roshan Moniri, Mani
Keywords: Cancer Biology & Therapeutics; Molecular & Cellular Biology Of Cancer; Prostate Cancer; Therapeutic
Targeting Androgen Receptor dimerization as a potential therapy for Prostate Cancer
Principal investigators: Dalal, Kush
Keywords: Prostate Cancer
Identification of miRNAs and their Specific Gene Targets that are Critical for Prostate Cancer Metastases
Principal investigators: Wang, Yuzhuo; Collins, Colin C; Jia, William W; Rennie, Paul S
Keywords: Metastasis; Mirna; Oncolytic Virus; Prostate Cancer; Therapy; Xenograft
Next generation anti-androgens for the treatment of castration-resistant prostate cancers
Principal investigators: Cherkasov, Artem; Rennie, Paul S
Keywords: Androgen Receptor; Chemical Genomics; Computer-Aided Drug Design; Drug Resistance; Hormone Resistance; Prostate Cancer; Small Molecule Drugs
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Yuzhuo Wang and Martin Gleave: 24 shared papers
- Martin Gleave and Amina Zoubeidi: 22 shared papers
- Yuzhuo Wang and Amina Zoubeidi: 17 shared papers
- Xuesen Dong and Martin Gleave: 15 shared papers
- Yuzhuo Wang and Xuesen Dong: 11 shared papers
- Artem Cherkasov and Yuzhuo Wang: 6 shared papers
- Artem Cherkasov and Xuesen Dong: 6 shared papers
- Artem Cherkasov and Martin Gleave: 6 shared papers
- Richard Sowery and Amina Zoubeidi: 3 shared papers
- Richard Sowery and Martin Gleave: 2 shared papers
- Artem Cherkasov and Nathan Lack: 2 shared papers
- Paul Rennie and Xuesen Dong: 2 shared papers
- Paul Rennie and Martin Gleave: 2 shared papers
- Richard Sowery and Paul Rennie: 1 shared paper
- Artem Cherkasov and Paul Rennie: 1 shared paper
- Artem Cherkasov and William Jia: 1 shared paper
- Paul Rennie and Yuzhuo Wang: 1 shared paper
- Paul Rennie and William Jia: 1 shared paper
- Paul Rennie and Nathan Lack: 1 shared paper
- Paul Rennie and Amina Zoubeidi: 1 shared paper
- Yuzhuo Wang and Nathan Lack: 1 shared paper
- William Jia and Martin Gleave: 1 shared paper
- Department of Urologic Sciences
- Department of Surgery
- Experimental Therapeutics
- Other
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Martin Gleave
Department of Urologic Sciences
2 shared papers, latest 2011
Xuesen Dong
Department of Urologic Sciences
2 shared papers, latest 2015
William Jia
Experimental Therapeutics
1 shared papers, latest 2019
Amina Zoubeidi
Department of Urologic Sciences
1 shared papers, latest 2007
Nathan Lack
Faculty
1 shared papers, latest 2019
Yuzhuo Wang
Department of Urologic Sciences
1 shared papers, latest 2015
Richard Sowery
Department of Surgery
1 shared papers, latest 2007
Artem Cherkasov
Department of Urologic Sciences
1 shared papers, latest 2019
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