This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
Longitudinal single-cell analysis reveals RUNX1T1 as an early driver in treatment-induced neuroendocrine transdifferentiation.
bioRxiv : the preprint server for biology · 2025
Androgen receptor plasticity and its implications for prostate cancer therapy.
Cancer treatment reviews · 2019
Small molecule-induced degradation of the full length and V7 truncated variant forms of human androgen receptor.
European journal of medicinal chemistry · 2018
Latest funding
- $921,826
Molecular drivers of androgen receptor activity in castrate resistant prostate cancer
CIHR · 2025 · Nominated PI
- $956,250
Understanding epigenetic regulation and modulation of cell stress responses by the cholesterol transporter, scavenger receptor-B1 as a novel target for treating advanced prostate cancer
CIHR · 2022 · Co-investigator
- $413,100
Identification of HOXB13 inhibitors to treat castrate-resistant prostate cancer
CIHR · 2020 · Principal investigator
4 publications.
Longitudinal single-cell analysis reveals RUNX1T1 as an early driver in treatment-induced neuroendocrine transdifferentiation.
Ni Y, Lin D, Shi M, Lin YY, Xue H, Dong X, Liu L, Sar F, Wu R, Morova T, Haegert A, Bell R, Pang X, Classen A, Wang Y, Chen J, Volik S, Bihan SL, Lack N, Ong C, Wang G, Zeng H, Collins C, Wang Y
Androgen receptor plasticity and its implications for prostate cancer therapy.
Snow O, Lallous N, Singh K, Lack N, Rennie P, Cherkasov A
Small molecule-induced degradation of the full length and V7 truncated variant forms of human androgen receptor.
Dalal K, Morin H, Ban F, Shepherd A, Fernandez M, Tam KJ, Li H, LeBlanc E, Lack N, Prinz H, Rennie PS, Cherkasov A
A CD74-dependent MHC class I endolysosomal cross-presentation pathway.
Basha G, Omilusik K, Chavez-Steenbock A, Reinicke AT, Lack N, Choi KB, Jefferies WA
Molecular drivers of androgen receptor activity in castrate resistant prostate cancer
Principal investigators: Lack, Nathan A
Keywords: Androgen Receptor; Enhancers; Functional Genomics; Prostate Cancer; Single Cell Method Development
Understanding epigenetic regulation and modulation of cell stress responses by the cholesterol transporter, scavenger receptor-B1 as a novel target for treating advanced prostate cancer
Principal investigators: Cox, Michael E; Wasan, Kishor M
Keywords: Cell Stress Pathways; Cholesterol; Epigenetics; Pharmacologic Inhibitors; Prostate Cancer; Scavenger Receptor-B1; Synthetic Lethal Screen; Therapy Resistance
Identification of HOXB13 inhibitors to treat castrate-resistant prostate cancer
Principal investigators: Gleave, Martin E; Lack, Nathan A
Keywords: Hoxb13; Prostate Cancer; Small Molecule Inhibitors; Transcriptional Regulation
Interference with Gli to Control Castration Resistant Prostate Cancer
Principal investigators: Buttyan, Ralph
Keywords: Androgen Receptors; Cancer Cell Growth; Cancer Cell Transcriptome; Computerized Small Molecule Docking; Gli Transcription Factors; Hedgehog Signalling; Prostate Cancer; Therapy Resistance; Three-Dimensional Protein Structure; Tumour Growth
Preclinical development of a novel androgen receptor antagonist to treat castration-resistant prostate cancer
Principal investigators: Gleave, Martin E; Lack, Nathan A
Keywords: Androgen Receptor; Binding Function-3; Prostate Cancer; Small Molecule Inhibitors
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Urologic Sciences
- Pathology and Laboratory Medicine
- Medicine/Neurology
- Other
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Artem Cherkasov
Urologic Sciences
2 shared papers, latest 2019
Gang Wang
Pathology and Laboratory Medicine
1 shared papers, latest 2025
Christopher Ong
Urologic Sciences
1 shared papers, latest 2025
Paul Rennie
Urologic Sciences
1 shared papers, latest 2019
Yuzhuo Wang
Urologic Sciences
1 shared papers, latest 2025
Colin Collins
Urologic Sciences
1 shared papers, latest 2025
Yu Wang
Medicine/Neurology
1 shared papers, latest 2025
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