Faculty profile

Sarah Hedtrich

ResearcherUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.

Sarah Hedtrich

Researcher

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
28 publications in the last five years, latest in 2026.
Senior (last) author on 13 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 CIHR, 2 NSERC), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Gene Therapy Skin Crc Atopic Diseases Drug Discovery And Development Inflammatory Skin Diseases New Anti-Inflammatory Drugs Topical Drug Delivery

Latest papers

Lipid@polymer hybrid nanoparticles for efficient siRNA transport across the lung barriers: Mechanistic insights into the role of Ionizable lipids.
Journal of colloid and interface science · 2026
Polyglycerol-b-polyoxazoline: A next-generation biocompatible agent for diabetic wound treatment.
Biomaterials · 2026
Advantages and limitations of in vitro models for atopic dermatitis: A consensus expert opinion.
The Journal of investigative dermatology · 2026

All 45 publications

Latest funding

Biofilm-Mimetic Nanofibrous Microgels to Encapsulate Bacterial Live Biotherapeutic Products and Overcome Oral Delivery Challenges for the Treatment of Ulcerative Colitis
CIHR · 2026 · Co-investigator
$879,750
In Situ Gene Editing to Rescue Genetic Skin Diseases
CIHR · 2025 · Nominated PI
$887,400
Canada Research Chair - Tier 1
CIHR · 2024 · Nominated PI
$1,400,000

All 11 grants and awards

45 publications.

Lipid@polymer hybrid nanoparticles for efficient siRNA transport across the lung barriers: Mechanistic insights into the role of Ionizable lipids.

Brusco S, Villano E, Silvestri T, Azad AJ, Molbay M, d'Angelo I, Miro A, Brocca P, Merkel OM, Hedtrich S, Costabile G, Ungaro F

Journal of colloid and interface science2026

DOI: 10.1016/j.jcis.2026.140683 PMID: 42150356

Polyglycerol-b-polyoxazoline: A next-generation biocompatible agent for diabetic wound treatment.

Zabihi F, Beyranvand S, Mohammadi Z, Zeinivand M, Dezfoulian O, Farjanikish G, Achazi K, Chong C, Rancan F, Vogt A, Hedtrich S, Mohammadi HR, Haag R, Adeli M

Biomaterials2026

DOI: 10.1016/j.biomaterials.2025.123974 PMID: 41690123

Advantages and limitations of in vitro models for atopic dermatitis: A consensus expert opinion.

Peters RHW, Smits JPH, van den Bogaard EH, Kelemen E, Krohn IK, De Vriese S, Gutowska-Owsiak D, Sevilla LM, Pérez P, Furundžić D, Hedtrich S, Zalewska-Janowska A, Simon M, Dubrac S

The Journal of investigative dermatology2026

DOI: 10.1016/j.jid.2026.04.032 PMID: 42246919

Advancing regenerative medicine with RNA nanotechnology for chronic and end organ diseases.

Bakrania A, Nguyen Lefebvre AT, de Vries R, Laflamme MA, Jaeckel E, Hansen He H, Radvanyi L, Hedtrich S, Sahay G, Blakney A, Sefton M, Li B, Zheng G, Bhat M

Communications medicine2026

DOI: 10.1038/s43856-026-01476-y PMID: 41965828

A Human-Based Skin-Lymphoreticular Model-on-Chip to Emulate Inflammatory Skin Conditions.

Tan Z, Adhikary PP, Wörz D, Hedtrich S

Advanced healthcare materials2026Senior author

DOI: 10.1002/adhm.202503170 PMID: 41495975

Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models.

Apaydin DC, Sadhnani G, Carlaw T, Renziehausen J, Lizunova E, Filor V, Hiller A, Brumhard S, Halim V, Brüning U, Bischof J, Marodin RH, Kurek DZ, Rhiel M, Ammann S, Cornu TI, Cathomen T, Sander LE, Obermayer B, Coscia F, Kirwan J, Koller U, Gruber AD, Bäumer W, Hedtrich S

Cell stem cell2026Senior author

DOI: 10.1016/j.stem.2026.01.001 PMID: 41605220

A hair-follicle reconstructed in vitro immunocompetent skin model for prediction of the sensitizing potential of chemicals.

Tripetchr T, Dubau M, Hedtrich S, Kleuser B

Archives of toxicology2025

DOI: 10.1007/s00204-025-04130-z PMID: 40681688

Lung tissue-optimized gene editing in human cystic fibrosis models following topical application of lipid nanoparticles.

Tafech B, Carlaw T, Sadhnani G, Schmidt K, Morin T, Leung J, Weiner J, An K, Balázs A, Ross C, Beule D, Mall MA, Fuchs H, Kulkarni J, Cullis PR, Hedtrich S

Journal of controlled release : official journal of the Controlled Release Society2025Senior author

DOI: 10.1016/j.jconrel.2025.114053 PMID: 40684992

Spatially Defined Post-manufacturing Loading of Nanoparticles into Hydrogel-Forming Microneedles.

Arguello A, Sadhnani G, Leung J, Moawad F, Cullis PR, Hedtrich S, Brambilla D

Molecular pharmaceutics2025

DOI: 10.1021/acs.molpharmaceut.5c00403 PMID: 40642971

Unveiling tissue-specific transcriptional adaptations in iPSC-derived fibroblasts via co-culture systems.

Azad AJ, Bentivogli A, Germar H, Wörz D, Lizunova E, Cumberland MJ, Weiner J, Hedtrich S

Stem cell research & therapy2025Senior author

DOI: 10.1186/s13287-025-04537-6 PMID: 40739279

Biofilm-Mimetic Nanofibrous Microgels to Encapsulate Bacterial Live Biotherapeutic Products and Overcome Oral Delivery Challenges for the Treatment of Ulcerative Colitis

Co-investigatorCIHR2026Project Grant

Principal investigators: Finbloom, Joel A

Keywords: Bacteria; Biomaterials; Drug Delivery; Inflammation; Live Biotherapeutic Products; Nanomedicine; Oral Delivery; Peptides; Probiotics; Ulcerative Colitis

$879,750

In Situ Gene Editing to Rescue Genetic Skin Diseases

Nominated PICIHR2025Project Grant

Principal investigators: Hedtrich, Sarah

Keywords: Gene Therapy; Skin

$887,400

Canada Research Chair - Tier 1

Nominated PICIHR2024Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Hedtrich, Sarah

Keywords: Crc

$1,400,000

Development and evaluation of novel nanoparticle formulations for therapeutic genome editing

Co-investigatorCIHR2023Project Grant

Principal investigators: Ross, Colin J; Blakney, Anna

Keywords: Animal Models; Base Editor; Gene Editing; Genetic Disease; Lipid Nanoparticle; Nanoparticle; Prime Editor

$975,376

Development and evaluation of novel nanoparticle formulations for therapeutic genome editing

Co-investigatorCIHR2022Project Grant

Principal investigators: Ross, Colin J; Blakney, Anna

Keywords: Animal Models; Base Editor; Gene Editing; Genetic Disease; Lipid Nanoparticle; Nanoparticle; Prime Editor

$100,000

Biomolecular Imaging System for Nanomedicine and Chemical Biology Applications in Pharmaceutical Sciences

Co-investigatorNSERC2021Research Tools and Instruments

Principal investigators: Frankel, Adam

$144,803

Cutaneous adjuvant conditioning to enhance vaccine responses

Co-investigatorCIHR2021Project Grant - PA: Pandemic and Health Emergencies Research

Principal investigators: Dutz, Jan P

Keywords: Skin Immune System; Tissue Resident Memory T Cells; Tlr9; Vaccine Adjuvant

$450,000

Targeting TSLP - Novel anti-inflammatory compounds for the treatment and prevention of atopic diseases

Nominated PICIHR2020Project Grant

Principal investigators: Hedtrich, Sarah

Keywords: Atopic Diseases; Drug Discovery And Development; Inflammatory Skin Diseases; New Anti-Inflammatory Drugs; Topical Drug Delivery; Tslp Inhibitors

$803,250

Development of complex-human-based organ models

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Hedtrich, Sarah

$114,000

Development of complex-human-based organ models

Principal investigatorNSERC2020Discovery Launch Supplement

Principal investigators: Hedtrich, Sarah

$12,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Sarah Hedtrich

Research

Latest papers

Latest funding

Lipid@polymer hybrid nanoparticles for efficient siRNA transport across the lung barriers: Mechanistic insights into the role of Ionizable lipids.

Polyglycerol-b-polyoxazoline: A next-generation biocompatible agent for diabetic wound treatment.

Advantages and limitations of in vitro models for atopic dermatitis: A consensus expert opinion.

Advancing regenerative medicine with RNA nanotechnology for chronic and end organ diseases.

A Human-Based Skin-Lymphoreticular Model-on-Chip to Emulate Inflammatory Skin Conditions.

Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models.

A hair-follicle reconstructed in vitro immunocompetent skin model for prediction of the sensitizing potential of chemicals.

Lung tissue-optimized gene editing in human cystic fibrosis models following topical application of lipid nanoparticles.

Spatially Defined Post-manufacturing Loading of Nanoparticles into Hydrogel-Forming Microneedles.

Unveiling tissue-specific transcriptional adaptations in iPSC-derived fibroblasts via co-culture systems.

Biofilm-Mimetic Nanofibrous Microgels to Encapsulate Bacterial Live Biotherapeutic Products and Overcome Oral Delivery Challenges for the Treatment of Ulcerative Colitis

In Situ Gene Editing to Rescue Genetic Skin Diseases

Canada Research Chair - Tier 1

Development and evaluation of novel nanoparticle formulations for therapeutic genome editing

Development and evaluation of novel nanoparticle formulations for therapeutic genome editing

Biomolecular Imaging System for Nanomedicine and Chemical Biology Applications in Pharmaceutical Sciences

Cutaneous adjuvant conditioning to enhance vaccine responses

Targeting TSLP - Novel anti-inflammatory compounds for the treatment and prevention of atopic diseases

Development of complex-human-based organ models

Development of complex-human-based organ models

Frequent collaborators

Shyh-Dar Li

Anna Blakney

Bowen Li

Davide Brambilla

Colin Ross

Gang Zheng

Pieter Cullis

Eric Jan

Mamatha Bhat

Michael Sefton