Faculty profile

Shyh-Dar Li

ResearcherUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.

Shyh-Dar Li

Researcher

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
27 publications in the last five years, latest in 2026.
Senior (last) author on 22 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (6 CIHR, 2 NSERC), most recently in 2019.
Supervised 5 trainees who won CIHR awards, most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Analgesic Chronic Pain Drug Validation And Commercialization Opioid Crisis Anticancer Drug Delivery Lipid Nanoparticles Oral Pediatric Formulation Oro-Dispersible Formulation

Latest papers

Next-generation colon-targeted oral delivery for immune modulation in inflammatory bowel diseases.
Journal of controlled release : official journal of the Controlled Release Society · 2026 · senior author
Extrahepatic RNA delivery is a vascular access problem.
Journal of controlled release : official journal of the Controlled Release Society · 2026 · senior author
Temporal Immune and Metabolic Shifts Drive the Anti-Tumor Efficacy of Resiquimod-Loaded Nanoparticles in Peritoneal Carcinomatosis.
Advanced healthcare materials · 2026 · senior author

All 57 publications

Latest funding

Development of polymer-lipid hybrid nanoparticles for enhanced gene delivery
CIHR · 2024 · Supervisor
$210,000
Investigating the Mechanism Behind Lipid Nanoparticle Delivered Resiquimod in Tuning the Metastatic Colorectal Cancer Immune Microenvironment
CIHR · 2024 · Supervisor
$120,000
Development and evaluation of novel nanoparticle formulations for therapeutic genome editing
CIHR · 2023 · Co-investigator
$975,376

All 17 grants and awards

57 publications.

Next-generation colon-targeted oral delivery for immune modulation in inflammatory bowel diseases.

Lin SW, Wang L, Chao PH, Chou PY, Li SD

Journal of controlled release : official journal of the Controlled Release Society2026Senior author

DOI: 10.1016/j.jconrel.2026.115218 PMID: 42532146

Extrahepatic RNA delivery is a vascular access problem.

Hung HY, Kannan R, Li SD

Journal of controlled release : official journal of the Controlled Release Society2026Senior author

DOI: 10.1016/j.jconrel.2026.115391 PMID: 42767376

Temporal Immune and Metabolic Shifts Drive the Anti-Tumor Efficacy of Resiquimod-Loaded Nanoparticles in Peritoneal Carcinomatosis.

Chan V, Chao PH, Sun X, Han J, MacPherson S, Andrew LJ, Brittain NY, Do T, Bally MB, Lum JJ, Li SD

Advanced healthcare materials2026Senior author

DOI: 10.1002/adhm.71424 PMID: 42421168

Formulation and administration timing of lipid derivatized JAK-inhibitor and corticosteroid modulate saRNA-LNP inflammation and expression.

Bathula NV, Casmil IC, Friesen JJ, Yuan E, Liao S, Maiti B, Liou JP, Lai MJ, Li SD, Chen S, Tam YYC, Blakney AK

Journal of controlled release : official journal of the Controlled Release Society2026

DOI: 10.1016/j.jconrel.2026.114736 PMID: 41722617

Biodegradable polymers with tertiary amines enhance mRNA delivery of lipid nanoparticles via improved endosomal escape.

Zhao F, Luppi B, Chao PH, Yang J, Zhang Y, Feng R, Chan V, Kannan R, Dong S, Gogoulis A, Wang L, Lee A, Hudson Z, Li SD

Biomaterials2026Senior author

DOI: 10.1016/j.biomaterials.2025.123541 PMID: 40644791

Incorporation of a polyamine into lipid nanoparticles increases the endosomal release and transfection of nucleic acids without toxicity.

Kannan R, Tran B, Le Q, Hohenwarter L, Chao PH, Brar V, Roesger S, Chen S, Zhao F, Wu J, Lee A, Liou JP, Li SD

Journal of controlled release : official journal of the Controlled Release Society2025Senior author

DOI: 10.1016/j.jconrel.2025.114366 PMID: 41167339

Emerging vesicular nanosystems capable of effectively targeting hepatocytes.

Chan V, St Pierre A, Do T, Li SD

Nanomedicine (London, England)2025Senior author

DOI: 10.1080/17435889.2025.2534326 PMID: 40685853

Imiquimod-Loaded Phospholipid-Free Small Unilamellar Vesicles Activate the Tumor Immune Microenvironment to Treat Liver Cancer and Liver Metastases.

Chan V, Lee HM, Takata H, Cheng SL, Yen YT, Pfeifer L, Rushton L, Chao PH, Zhao F, Ong CY, Al-Fayez N, Ishida T, Chen Y, Li SD

Advanced healthcare materials2025Senior author

DOI: 10.1002/adhm.202501691 PMID: 40525653

Nanomedicines modulate the tumor immune microenvironment for cancer therapy.

Chao PH, Chan V, Li SD

Expert opinion on drug delivery2024Senior author

DOI: 10.1080/17425247.2024.2412245 PMID: 39354745

Liposome biodistribution mapping with in vivo X-ray fluorescence imaging.

Saladino GM, Chao PH, Brodin B, Li SD, Hertz HM

Nanoscale2024

DOI: 10.1039/d4nr02793k PMID: 39212620

Development of polymer-lipid hybrid nanoparticles for enhanced gene delivery

SupervisorCIHR2024CIHR Fellowship

Principal investigators: Wu, Jiamin

Keywords: Drug Delivery; Gene Therapy; Lipid Nanoparticles; Polymer

$210,000

Investigating the Mechanism Behind Lipid Nanoparticle Delivered Resiquimod in Tuning the Metastatic Colorectal Cancer Immune Microenvironment

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Chan, Vanessa

Keywords: Cancer; Colorectal Cancer; Drug Delivery; Immunotherapy; Lipid Nanoparticles; Resiquimod; Tlr Agonists

$120,000

Development and evaluation of novel nanoparticle formulations for therapeutic genome editing

Co-investigatorCIHR2023Project Grant

Principal investigators: Ross, Colin J; Blakney, Anna

Keywords: Animal Models; Base Editor; Gene Editing; Genetic Disease; Lipid Nanoparticle; Nanoparticle; Prime Editor

$975,376

Development and evaluation of novel nanoparticle formulations for therapeutic genome editing

Co-investigatorCIHR2022Project Grant

Principal investigators: Ross, Colin J; Blakney, Anna

Keywords: Animal Models; Base Editor; Gene Editing; Genetic Disease; Lipid Nanoparticle; Nanoparticle; Prime Editor

$100,000

Biomolecular Imaging System for Nanomedicine and Chemical Biology Applications in Pharmaceutical Sciences

Co-investigatorNSERC2021Research Tools and Instruments

Principal investigators: Frankel, Adam

$144,803

Fine-tuning drug-polymer conjugate chemistry for enhanced drug delivery to breast cancer

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Nguyen, Anne

Keywords: Breast Cancer; Cancer; Chemistry; Click Chemistry; In Vivo Efficacy; Nanomedicine; Platform Technology; Polymer-Drug Conjugates; Solubility; Structure-Activity Relationships

$105,000

Correcting monogenic skin diseases in situ: Assessing the potential of topically applicable gene therapy.

Co-investigatorCIHR2019Project Grant

Principal investigators: Hedtrich, Sarah

Keywords: 3d Skin Disease Models; Autosomal Recessive Congenital Ichthyosis; Crispr-Cas9; Gene Editing; Monogenic Skin Disease; Nanocarriers For Topical Drug Delivery; Novel Treatment Options For Orphan Disease; Topical Delivery Of Biomacromolecules

$472,770

Validation and commercialization of an innovative analgesic for chronic pain

Nominated PICIHR2019Project Grant

Principal investigators: Li, Shyh-Dar; Cairns, Brian E; Malone, Amanda

Keywords: Analgesic; Chronic Pain; Drug Validation And Commercialization; Opioid Crisis

$524,026

Development of the liposomal formulation of 6-Mercaptopurine (6-MP) for improved oral absorption and enhanced therapeutic outcome against cancer

SupervisorCIHR2017Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Tang, Wei-Lun

Keywords: 6-Mercaptopurine; Child-Friendly Oral Formulation; Liposomal Formulation; Medication Adherence; Oral Bioavailability; Therapy Of Childhood Leukemia

$6,000

Development of active loading technologies for encapsulating highly charged molecules into liposomes

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Li, ShyhDar

$168,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Shyh-Dar Li

Research

Latest papers

Latest funding

Next-generation colon-targeted oral delivery for immune modulation in inflammatory bowel diseases.

Extrahepatic RNA delivery is a vascular access problem.

Temporal Immune and Metabolic Shifts Drive the Anti-Tumor Efficacy of Resiquimod-Loaded Nanoparticles in Peritoneal Carcinomatosis.

Formulation and administration timing of lipid derivatized JAK-inhibitor and corticosteroid modulate saRNA-LNP inflammation and expression.

Biodegradable polymers with tertiary amines enhance mRNA delivery of lipid nanoparticles via improved endosomal escape.

Incorporation of a polyamine into lipid nanoparticles increases the endosomal release and transfection of nucleic acids without toxicity.

Emerging vesicular nanosystems capable of effectively targeting hepatocytes.

Imiquimod-Loaded Phospholipid-Free Small Unilamellar Vesicles Activate the Tumor Immune Microenvironment to Treat Liver Cancer and Liver Metastases.

Nanomedicines modulate the tumor immune microenvironment for cancer therapy.

Liposome biodistribution mapping with in vivo X-ray fluorescence imaging.

Development of polymer-lipid hybrid nanoparticles for enhanced gene delivery

Investigating the Mechanism Behind Lipid Nanoparticle Delivered Resiquimod in Tuning the Metastatic Colorectal Cancer Immune Microenvironment

Development and evaluation of novel nanoparticle formulations for therapeutic genome editing

Development and evaluation of novel nanoparticle formulations for therapeutic genome editing

Biomolecular Imaging System for Nanomedicine and Chemical Biology Applications in Pharmaceutical Sciences

Fine-tuning drug-polymer conjugate chemistry for enhanced drug delivery to breast cancer

Correcting monogenic skin diseases in situ: Assessing the potential of topically applicable gene therapy.

Validation and commercialization of an innovative analgesic for chronic pain

Development of the liposomal formulation of 6-Mercaptopurine (6-MP) for improved oral absorption and enhanced therapeutic outcome against cancer

Development of active loading technologies for encapsulating highly charged molecules into liposomes

Frequent collaborators

Sarah Hedtrich

Brent Page

Eno Hysi

Pieter Cullis

Alasdair Barr

David Hedley

Horacio Bach