Horacio Bach, University of British Columbia

Research

Animal Models Phage Display Recombinant Antibodies Single-Chain Antibodies Antibody Engineering Avian Influenza Diagnostic Environmental Surveillance

Latest papers

Advancements in single-chain antibody functionalized nanoparticles for the treatment of advanced solid tumors.
Nanomedicine (London, England) · 2026 · senior author
Diagnostic value of antibody responses to Mycobacterium avium subsp. paratuberculosis-derived proteins PtpA and PtpB in rheumatoid arthritis.
PloS one · 2026
Nanocarriers for potential treatment of sensorineural hearing loss and retinitis in congenital cytomegalovirus.
Nanomedicine (London, England) · 2026 · senior author

All 107 publications

Latest funding

Development of single-chain antibodies against avian influenza H5N1 for environmental and diagnostic applications
CIHR · 2024 · Nominated PI
$112,500
COVID-19 Variant Supplement - Neutralizing human-derived single-chain antibodies against SARS-CoV-2
CIHR · 2021 · Nominated PI
$50,000
Sex as a Biological Variable Supplement - Neutralizing human-derived single-chain antibodies against SARS-CoV-2
CIHR · 2020 · Nominated PI
$50,000

All 7 grants and awards

107 publications.

01

Advancements in single-chain antibody functionalized nanoparticles for the treatment of advanced solid tumors.

Wieben T, Bach H

Nanomedicine (London, England)2026Senior author

DOI: 10.1080/17435889.2026.2689414 PMID: 42307620

02

Diagnostic value of antibody responses to Mycobacterium avium subsp. paratuberculosis-derived proteins PtpA and PtpB in rheumatoid arthritis.

Hernández-Bello J, Cerpa-Cruz S, Sánchez-Zuno GA, Nicoletti F, Bach H, Muñoz-Valle JF

PloS one2026

DOI: 10.1371/journal.pone.0341403 PMID: 42149931

03

Nanocarriers for potential treatment of sensorineural hearing loss and retinitis in congenital cytomegalovirus.

Daniel M, Bach H

Nanomedicine (London, England)2026Senior author

DOI: 10.1080/17435889.2026.2648661 PMID: 41866766

04

Precision nanomedicine against pulmonary tuberculosis: the role of lipid-based drug delivery systems.

He N, Dong K, Lee W, Bach H

Nanomedicine (London, England)2026Senior author

DOI: 10.1080/17435889.2026.2624741 PMID: 41612129

05

Advancements in nanotrap technology for the prevention, diagnosis and treatment of infectious diseases.

Keefer S, Lorenzo-Leal AC, Bach H

Nanomedicine (London, England)2026Senior author

DOI: 10.1080/17435889.2026.2614545 PMID: 41521058

06

Nanomedicine in the development of vaccines against Herpesviridae: a narrative review.

Lee DH, Lee W, Bach H

Nanomedicine (London, England)2026Senior author

DOI: 10.1080/17435889.2025.2587714 PMID: 41217254

07

Antiviral effect of 222 nm far-UVC light against human coronavirus and rhinovirus, and murine norovirus using dried inocula.

Lorenzo-Leal AC, Tam D, Bach H

Infection prevention in practice2025Senior author

DOI: 10.1016/j.infpip.2025.100473 PMID: 40678586

08

Current treatments and the future of nanomedicine in hepatitis C.

Julien D, Bach H

Nanomedicine (London, England)2025Senior author

DOI: 10.1080/17435889.2025.2518912 PMID: 40568840

09

CEST MRI in the Management/Diagnosis of Neuroinfectious Diseases.

Kortje ZA, Bach H

International journal of molecular sciences2025Senior author

DOI: 10.3390/ijms26125650 PMID: 40565114

10

Expression of nisin in Scenedesmus acutus and evaluation of its antimicrobial activity.

Ponce-Alonso J, Martínez-González L, Alpuche-Solís ÁG, Martinez-Gutierrez F, Lorenzo-Leal AC, Bach H, Soria-Guerra RE

Biotechnology letters2025

DOI: 10.1007/s10529-025-03603-6 PMID: 40504289

Development of single-chain antibodies against avian influenza H5N1 for environmental and diagnostic applications

Nominated PICIHR2024Catalyst Grant: Avian Influenza OneHealth Research

Principal investigators: Bach, Horacio

Keywords: Antibody Engineering; Avian Influenza; Diagnostic; Environmental Surveillance

$112,500

COVID-19 Variant Supplement - Neutralizing human-derived single-chain antibodies against SARS-CoV-2

Nominated PICIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: Bach, Horacio

Keywords: Animal Models; Phage Display; Recombinant Antibodies; Single-Chain Antibodies

$50,000

Sex as a Biological Variable Supplement - Neutralizing human-derived single-chain antibodies against SARS-CoV-2

Nominated PICIHR2020Op Grant: Sex as a Biological Variable Supplement: COVID-19 Rapid Research FO

Principal investigators: Bach, Horacio

Keywords: Animal Models; Phage Display; Recombinant Antibodies; Single-Chain Antibodies

$50,000

Neutralizing human-derived single-chain antibodies against SARS-CoV-2

Nominated PICIHR2020Operating Grant: COVID-19 - Therapeutics

Principal investigators: Bach, Horacio

Keywords: Animal Models; Phage Display; Recombinant Antibodies; Single-Chain Antibodies

$395,600

Flow Cytometer for Radioactive Samples

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Hafeli, Urs

$150,000

Investigating the Mechanism of Eradication of Multi Drug Resistant Bacteria by Inorganic (mixed metal oxides), Organic (antibiotic), and Protein-based Nanoparticles

Nominated PICIHR2014Operating Grant:Joint Programming Initiative on Antimicrobial Resistance(JPIAMR)

Principal investigators: Bach, Horacio; Hafeli, Urs O

Keywords: Microbial

$297,723

A study of Mycobacterium avium subsp. paratuberculosis shedding patterns in feces, milk and colostrum and development of methods to detect the bacteria in colostrum

Co-investigatorNSERC2009Collaborative Research and Development Grants

Principal investigators: Keefe, Greg

$71,351

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Infectious Diseases
Pathology and Laboratory Medicine
Biochemistry and Molecular Biology
Other

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Dirk Lange

Pathology and Laboratory Medicine

1 shared papers, latest 2013

Thibault Mayor

Biochemistry and Molecular Biology

1 shared papers, latest 2019

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Animal Models Dear Professor Bach, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Advancements in single-chain antibody functionalized nanoparticles for the treatment of advanced solid tumors." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Development of single-chain antibodies against avian influenza H5N1 for environmental and diagnostic applications" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Horacio Bach

Research

Latest papers

Latest funding

Advancements in single-chain antibody functionalized nanoparticles for the treatment of advanced solid tumors.

Diagnostic value of antibody responses to Mycobacterium avium subsp. paratuberculosis-derived proteins PtpA and PtpB in rheumatoid arthritis.

Nanocarriers for potential treatment of sensorineural hearing loss and retinitis in congenital cytomegalovirus.

Precision nanomedicine against pulmonary tuberculosis: the role of lipid-based drug delivery systems.

Advancements in nanotrap technology for the prevention, diagnosis and treatment of infectious diseases.

Nanomedicine in the development of vaccines against Herpesviridae: a narrative review.

Antiviral effect of 222 nm far-UVC light against human coronavirus and rhinovirus, and murine norovirus using dried inocula.

Current treatments and the future of nanomedicine in hepatitis C.

CEST MRI in the Management/Diagnosis of Neuroinfectious Diseases.

Expression of nisin in Scenedesmus acutus and evaluation of its antimicrobial activity.

Development of single-chain antibodies against avian influenza H5N1 for environmental and diagnostic applications

COVID-19 Variant Supplement - Neutralizing human-derived single-chain antibodies against SARS-CoV-2

Sex as a Biological Variable Supplement - Neutralizing human-derived single-chain antibodies against SARS-CoV-2

Neutralizing human-derived single-chain antibodies against SARS-CoV-2

Flow Cytometer for Radioactive Samples

Investigating the Mechanism of Eradication of Multi Drug Resistant Bacteria by Inorganic (mixed metal oxides), Organic (antibiotic), and Protein-based Nanoparticles

A study of Mycobacterium avium subsp. paratuberculosis shedding patterns in feces, milk and colostrum and development of methods to detect the bacteria in colostrum

Frequent collaborators

Yossef Av-Gay

Dirk Lange

Shyh-Dar Li

Philippe Joubert

Neil Reiner

Thibault Mayor