Faculty profile

Sriram Subramaniam

ResearcherUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.

Sriram Subramaniam

Researcher

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
27 publications in the last five years, latest in 2026.
Senior (last) author on 9 recent papers, a sign of leading a research group.
Principal investigator on 1 research grant (1 CIHR), most recently in 2018.
Supervised 1 trainee who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Cerc

Latest papers

VCP variants cause Adams-Oliver syndrome with or without pulmonary hypertension.
Genetics in medicine : official journal of the American College of Medical Genetics · 2026
Cryo-EM analysis of cooperative conformational changes in the SARS-CoV-2 spike protein trimer.
IUCrJ · 2026
Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor.
IUCrJ · 2026 · senior author

All 47 publications

Latest funding

Investigating Ryanodine Receptor Modulation to Inform Structure Guided Drug Design
CIHR · 2023 · Supervisor
$105,000
Redesigning SARS CoV-2 spike protein to improve immunization - COVID-19_x000d_ _x000d_
NSERC · 2020 · Co-investigator
$50,000
Canada Excellence Research Chair in Precision Cancer Drug Design
CIHR · 2018 · Nominated PI
$10,000,000

All 3 grants and awards

47 publications.

VCP variants cause Adams-Oliver syndrome with or without pulmonary hypertension.

Lehman A, Ahmed S, Mohajeri A, Berezuk AM, Mannar D, Cholak S, Tuttle KS, Bennett JT, Magno JA, Hannibal M, Kovacevic G, Kuburović V, Lewis MES, Moldovan O, Nelson Z, Raskin S, Vandersteen AM, Roach JC, Subramaniam S, Patel MS

Genetics in medicine : official journal of the American College of Medical Genetics2026

DOI: 10.1016/j.gim.2026.102579 PMID: 41979051

Cryo-EM analysis of cooperative conformational changes in the SARS-CoV-2 spike protein trimer.

Wang Q, Cholak S, Woollard G, Subramaniam S, Dao Duc K

IUCrJ2026

DOI: 10.1107/s2052252526004513 PMID: 42345087

Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor.

Crawford J, Munuganti R, Leung C, Singh K, Gates E, Zhu X, Bally M, Santos ND, Sharifiaghdam M, Nosrati Z, Axerio-Cilies P, Berezuk AM, Cholak S, Merk A, Cameron DR, Subramaniam S

IUCrJ2026Senior author

DOI: 10.1107/s2052252526004604 PMID: 42329166

Cryo-EM: the revolution continues.

Subramaniam S, Kühlbrandt W, Henderson R

IUCrJ2026First author

DOI: 10.1107/s2052252526003842 PMID: 42258316

Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.

Hu L, Lin J, Sun L, Berezuk AM, Tuttle KS, Zhu X, Seo HS, Dhe-Paganon S, Li P, Sun Y, Ni L, Zhang J, Tan D, Wakimoto H, Cahill DP, Bai X, Luo X, Asara JM, Subramaniam S, Shan Y, Wu X

Nature chemical biology2026

DOI: 10.1038/s41589-025-02131-8 PMID: 41530531

Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future.

Subramaniam S, Saville JW, Feng F, Freiburger L

Biochemistry2025First author

DOI: 10.1021/acs.biochem.5c00192 PMID: 40773381

SARS-CoV-2 Variants Omicron BA.4/5 and XBB.1.5 Significantly Escape T Cell Recognition in Solid-organ Transplant Recipients Vaccinated Against the Ancestral Strain.

Halvorson T, Ivison S, Huang Q, Ladua G, Yotis DM, Mannar D, Subramaniam S, Ferreira VH, Kumar D, Belga S, Levings MK, PREVenT Study Group

Transplantation2024

DOI: 10.1097/tp.0000000000004873 PMID: 38012843

Community recommendations on cryoEM data archiving and validation.

Kleywegt GJ, Adams PD, Butcher SJ, Lawson CL, Rohou A, Rosenthal PB, Subramaniam S, Topf M, Abbott S, Baldwin PR, Berrisford JM, Bricogne G, Choudhary P, Croll TI, Danev R, Ganesan SJ, Grant T, Gutmanas A, Henderson R, Heymann JB, Huiskonen JT, Istrate A, Kato T, Lander GC, Lok SM, Ludtke SJ, Murshudov GN, Pye R, Pintilie GD, Richardson JS, Sachse C, Salih O, Scheres SHW, Schroeder GF, Sorzano COS, Stagg SM, Wang Z, Warshamanage R, Westbrook JD, Winn MD, Young JY, Burley SK, Hoch JC, Kurisu G, Morris K, Patwardhan A, Velankar S

IUCrJ2024

DOI: 10.1107/s2052252524001246 PMID: 38358351

Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM.

Marcus K, Huang Y, Subramanian S, Gee CL, Gorday K, Ghaffari-Kashani S, Luo XR, Zheng L, O'Donnell M, Subramaniam S, Kuriyan J

Nature structural & molecular biology2024

DOI: 10.1038/s41594-023-01177-3 PMID: 38177685

Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.

Mannar D, Saville JW, Poloni C, Zhu X, Bezeruk A, Tidey K, Ahmed S, Tuttle KS, Vahdatihassani F, Cholak S, Cook L, Steiner TS, Subramaniam S

Nature communications2024Senior author

DOI: 10.1038/s41467-024-46104-2 PMID: 38424106

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Sriram Subramaniam

Research

Latest papers

Latest funding

VCP variants cause Adams-Oliver syndrome with or without pulmonary hypertension.

Cryo-EM analysis of cooperative conformational changes in the SARS-CoV-2 spike protein trimer.

Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor.

Cryo-EM: the revolution continues.

Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.

Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future.

SARS-CoV-2 Variants Omicron BA.4/5 and XBB.1.5 Significantly Escape T Cell Recognition in Solid-organ Transplant Recipients Vaccinated Against the Ancestral Strain.

Community recommendations on cryoEM data archiving and validation.

Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM.

Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.

Investigating Ryanodine Receptor Modulation to Inform Structure Guided Drug Design

Redesigning SARS CoV-2 spike protein to improve immunization - COVID-19_x000d_ _x000d_

Canada Excellence Research Chair in Precision Cancer Drug Design

Frequent collaborators

Inna Sekirov

Deepali Kumar

Filip Van Petegem

Marcel Bally

Darryl Falzarano