Faculty profile

Filip Van Petegem

ResearcherDepartment of Biochemistry and Molecular BiologyUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses may be missing. Find their university profile.

Filip Van Petegem

Researcher

Department of Biochemistry and Molecular Biology

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
44 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (9 CIHR), most recently in 2025.
Supervisor on 8 trainee awards (8 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

120

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

X-Ray Crystallography Structural Biology Cryo-Electron Microscopy Cardiac Arrhythmia Calcium Signaling Ion Channel Electrophysiology Protein Biochemistry

Latest papers

A Seven Amino Acid Long Region in the Cardiac Cav1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and "Fight or Flight" Responses.
Cells · 2026
Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV.
The Journal of general physiology · 2026
A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis.
Science advances · 2026

All 120 publications

Latest funding

Molecular Mechanisms of Malignant Hyperthermia and Myopathies
CIHR · 2025 · Nominated PI
$1,082,476
AI-supported mapping and probing of the regulation of cardiac voltage-gated calcium channels.
CIHR · 2025 · Co-investigator
$895,050
A Structural and Electrophysiological Investigation of NaV1.9: A Sodium Channel Involved in Pain.
CIHR · 2025 · Supervisor
$120,000

All 23 grants and awards

120 publications.

A Seven Amino Acid Long Region in the Cardiac Cav1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and "Fight or Flight" Responses.

Jenkins C, Cserne Szappanos H, Dyrda A, Er TS, van Petegem F, Hool LC

Cells2026

DOI: 10.3390/cells15181655 PMID: 42782755

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV.

Lammens M, De Waele J, Labro AJ, Van Petegem F, Bosmans F

The Journal of general physiology2026

DOI: 10.1085/jgp.202614018 PMID: 42370886

A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis.

Yamauchi S, Vander Cruyssen J, Cervellera M, Wohler E, De Waele J, Lammens M, Boehm C, Sobreira NL, Blevins C, Ecoff K, Mei Y, Theys M, Shoyombo I, Shishikura M, Yi H, Rodgers K, Lee B, Khan H, Gurau A, Nizam W, Shirodkar S, Kim C, Choi J, Coleman D, Dorman B, Iwasawa T, Kang JU, Heremans Y, Orita H, Fukunaga T, Van Petegem F, Baylin SB, Barth AS, Chung TH, Rowe PC, Treisman G, Ha J, Dmitriev RI, Valle D, Bosmans F, Brock MV

Science advances2026

DOI: 10.1126/sciadv.aed3221 PMID: 42467787

Structural enzymology of a Fusarium graminearum aldehyde oxidase reveals a distinct active-site and reactivity versus its paralog galactose oxidase.

Fong JK, Mazo L, Nairn AK, Lorizolla Cordeiro R, Mathieu Y, Chen YS, Rovira C, Walton PH, Van Petegem F, Brumer H

The Biochemical journal2026

DOI: 10.1042/bcj20260010 PMID: 41883256

Structural insights into insect-selective sodium channel toxins drive AI-enhanced biopesticide design.

Jiang H, Gao R, Xu H, Wang C, Ma S, Gong Y, Lin L, Yang L, Li X, Liu Y, Lu R, Ma JA, Xu J, Dong K, Van Petegem F, Liu Z, Wu S, Yuchi Z

Nature communications2026

DOI: 10.1038/s41467-026-70190-z PMID: 41786748

An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel.

Costa F, Ng LCT, Chow SS, Van Petegem F, Accili EA

Communications biology2026

DOI: 10.1038/s42003-026-09626-7 PMID: 41639298

Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel.

Ng L, Xia J, Van Petegem F, Accili E

Biochemistry and cell biology = Biochimie et biologie cellulaire2026

DOI: 10.1139/bcb-2026-0147 PMID: 42241720

Identification of novel potentially causative RYR1 variants in individuals with malignant hyperthermia susceptibility.

Rossi D, Pranzo C, Roccabianca S, Galli L, Orrico A, Sorbello G, Tegazzin V, D'Onofrio P, Fucci A, Quarta S, Perni S, Rubino EM, Serano M, Berti G, Lopergolo D, Malandrini A, Van Petegem F, Sorrentino V

Neuromuscular disorders : NMD2026

DOI: 10.1016/j.nmd.2025.106296 PMID: 41418732

The kinase homology and dimerization domains in retinal membrane guanylyl cyclase 1 form the binding interface for the calcium sensor GCAP1.

Peshenko IV, Tan L, Mahto J, Van Petegem F, Molday RS, Dizhoor AM

The Journal of biological chemistry2026

DOI: 10.1016/j.jbc.2026.113606 PMID: 42785436

Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets.

Molinarolo S, Valdivia CR, Valdivia HH, Van Petegem F

Nature communications2025Senior author

DOI: 10.1038/s41467-025-66522-0 PMID: 41266329

Molecular Mechanisms of Malignant Hyperthermia and Myopathies

Nominated PICIHR2025Project Grant

Principal investigators: Van Petegem, Filip

Keywords: Calcium Imaging; Electrophysiology; Ion Channel Structure-Function; Malignant Hyperthermia; Protein Biochemistry; Structure

$1,082,476

AI-supported mapping and probing of the regulation of cardiac voltage-gated calcium channels.

Co-investigatorCIHR2025Project Grant

Principal investigators: Gsponer, Jörg

Keywords: Calcium Channels; Electrophysiology; Heart Cells; Machine Learning; Protein Engineering; Structural Biology; Structure Prediction; X-Ray Crystallography

$895,050

A Structural and Electrophysiological Investigation of NaV1.9: A Sodium Channel Involved in Pain.

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Snir Shaool, Sol

Keywords: Cryogenic Electron Microscopy; Electrophysiology; Pain Sensation; Protein Expression And Purification; Structural Biology; Structure-Function Relationships; Voltage Gated Ion Channels

$120,000

Structural and functional investigation of Junctophilins in health and disease

Nominated PICIHR2022Project Grant

Principal investigators: Van Petegem, Filip

Keywords: Calcium Signaling; Cryo-Electron Microscopy; Excitation-Contraction Coupling; Ion Channels; Muscle Physiology; Structural Biology; X-Ray Crystallography

$852,976

Regulatory mechanisms of voltage-gated calcium channels

Nominated PICIHR2022Project Grant

Principal investigators: Van Petegem, Filip

Keywords: Calcium Signaling; Cardiac Arrhythmia; Cryo-Electron Microscopy; Electrical Signals; Ion Channel; Structural Biology; X-Ray Crystallography

$864,450

Structural characterization of interactions between STAC3 and calcium-release channels

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Rufenach, Britany

Keywords: Cryo-Electron Microscopy; Ion Channels; Protein-Protein Interactions; Structural Biology

$105,000

Catecholaminergic polymorphic ventricular tachycardia (CPVT): arrhythmogenic mechanisms and personalized intervention

Co-investigatorCIHR2020Project Grant

Principal investigators: Tibbits, Glen F

Keywords: Arrhythmogenesis; Inherited Arrhythmias; Ryanodine Receptor; Sr Calcium Release; Sudden Cardiac Death

$924,120

High Resolution Structure of Human ABCA4, an ATP-binding Cassette (ABC) Lipid Importer Associated with Inherited Retinal Degenerative Diseases

Co-investigatorCIHR2020Project Grant

Principal investigators: Molday, Robert S

Keywords: Abc Transporter; Atpase Assays; Conformational States; Cryo-Electron Microscopy; Lipid Transport; Macular Degeneration; Photoreceptor Cells; Protein Expression And Purification; Protein Structure; Site-Directed Mutagenesis

$918,000

Ion channel modulators to treat itch

Nominated PICIHR2020Team Grant: NEURON

Principal investigators: Van Petegem, Filip

Keywords: 3d Structure; Cryo-Electron Microscopy; Drug Design; Ion Channel; Itch; Pain; Protein Biochemistry; X-Ray Crystallography

$225,000

Identification of HOXB13 inhibitors to treat castrate-resistant prostate cancer

Co-investigatorCIHR2020Project Grant

Principal investigators: Gleave, Martin E; Lack, Nathan A

Keywords: Hoxb13; Prostate Cancer; Small Molecule Inhibitors; Transcriptional Regulation

$413,100

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Filip Van Petegem

Research

Latest papers

Latest funding

A Seven Amino Acid Long Region in the Cardiac Cav1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and "Fight or Flight" Responses.

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV.

A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis.

Structural enzymology of a Fusarium graminearum aldehyde oxidase reveals a distinct active-site and reactivity versus its paralog galactose oxidase.

Structural insights into insect-selective sodium channel toxins drive AI-enhanced biopesticide design.

An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel.

Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel.

Identification of novel potentially causative RYR1 variants in individuals with malignant hyperthermia susceptibility.

The kinase homology and dimerization domains in retinal membrane guanylyl cyclase 1 form the binding interface for the calcium sensor GCAP1.

Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets.

Molecular Mechanisms of Malignant Hyperthermia and Myopathies

AI-supported mapping and probing of the regulation of cardiac voltage-gated calcium channels.

A Structural and Electrophysiological Investigation of NaV1.9: A Sodium Channel Involved in Pain.

Structural and functional investigation of Junctophilins in health and disease

Regulatory mechanisms of voltage-gated calcium channels

Structural characterization of interactions between STAC3 and calcium-release channels

Catecholaminergic polymorphic ventricular tachycardia (CPVT): arrhythmogenic mechanisms and personalized intervention

High Resolution Structure of Human ABCA4, an ATP-binding Cassette (ABC) Lipid Importer Associated with Inherited Retinal Degenerative Diseases

Ion channel modulators to treat itch

Identification of HOXB13 inhibitors to treat castrate-resistant prostate cancer

Frequent collaborators

Harry Brumer

Shubhayan Sanatani

Zachary Laksman

Guy Tanentzapf

David Fedida

Omid Haji-Ghassemi

Xiaoyan Jiang

Kirsten Bartels

Francis Lynn

Sriram Subramaniam

Laura Arbour

Sheila Riazi

Jason Roberts

Artem Cherkasov

Filip Van Petegem

Research

Latest papers

Latest funding

A Seven Amino Acid Long Region in the Cardiac Cav1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and "Fight or Flight" Responses.

Differential regulation of &#x3b2;1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV.

A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis.

Structural enzymology of a Fusarium graminearum aldehyde oxidase reveals a distinct active-site and reactivity versus its paralog galactose oxidase.

Structural insights into insect-selective sodium channel toxins drive AI-enhanced biopesticide design.

An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel.

Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel.

Identification of novel potentially causative RYR1 variants in individuals with malignant hyperthermia susceptibility.

The kinase homology and dimerization domains in retinal membrane guanylyl cyclase 1 form the binding interface for the calcium sensor GCAP1.

Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets.

Frequent collaborators

Harry Brumer

Shubhayan Sanatani

Zachary Laksman

Guy Tanentzapf

David Fedida

Omid Haji-Ghassemi

Xiaoyan Jiang

Kirsten Bartels

Francis Lynn

Sriram Subramaniam

Laura Arbour

Sheila Riazi

Jason Roberts

Artem Cherkasov

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV.