Jiming Kong, University of Manitoba

Research

Bnip3 Delayed Neuronal Death Ischemic Stroke Mitochondria Vdac

Latest papers

A multi-scale framework to advance experimental models of skin aging.
Experimental gerontology · 2026 · senior author
Posttranslational oxidation of SOD1 and skin aging: Evidence, gaps, and future directions.
Ageing research reviews · 2026
Introducing Borsantrazole: A Trifunctional Boron-Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026

All 81 publications

Latest funding

Development of a biomarker-driven 'best-in-class' treatment for amyotrophic lateral sclerosis: Discovery and proof-of-concept
CIHR · 2024 · Co-investigator
$730,576
Development of novel agents for the treatment of amyotrophic lateral sclerosis: Discovery and proof-of-concept
CIHR · 2022 · Co-investigator
$100,000
Protecting delayed neuronal death in ischemic stroke by targeting the BNIP3 pathway
CIHR · 2013 · Nominated PI
$225,000

All 8 grants and awards

81 publications.

01

A multi-scale framework to advance experimental models of skin aging.

Li C, Guan T, Qi X, Kong J

Experimental gerontology2026Senior author

DOI: 10.1016/j.exger.2026.113300 PMID: 42648505

02

Posttranslational oxidation of SOD1 and skin aging: Evidence, gaps, and future directions.

Li C, Qi X, Kong J, Guan T

Ageing research reviews2026

DOI: 10.1016/j.arr.2026.103351 PMID: 42697334

03

Introducing Borsantrazole: A Trifunctional Boron-Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice.

Sanghai N, Kelley R, Lao Y, Madlangsakay MIR, Paul P, Llanes-Cuesta MA, Wang JF, Zahedi RP, Kong J, Tranmer GK

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026

DOI: 10.1002/advs.76432 PMID: 42503607

04

Targeting mitophagy for neuroprotection: mechanisms and therapeutic opportunities.

Yang J, Li J, Hou X, Zheng Y, Zhao Z, Zhou T, Jing T, Kong J, Zhang G, Guo Y

npj aging2026

DOI: 10.1038/s41514-026-00424-3 PMID: 42236747

05

Insights gained from single-cell sequencing analysis of ischemic stroke.

Mei Y, Guan T, Fu L, Kong J, Lv Y

Frontiers in cell and developmental biology2026

DOI: 10.3389/fcell.2026.1784660 PMID: 42093724

06

Metabolic Symbiosis and Vulnerability in the CNS Axon-Myelin Unit.

Miao K, Meng M, Liu L, Li M, Bai Y, Guo Y, Zhang G, Kong J, Mu J

Cellular and molecular neurobiology2026

DOI: 10.1007/s10571-026-01729-3 PMID: 41964710

07

Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration.

Zheng Y, Yang J, Li X, Qi L, Zheng Z, Kong J, Zhang G, Guo Y

Neurobiology of disease2025

DOI: 10.1016/j.nbd.2025.106862 PMID: 40049539

08

Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration.

Na D, Zhang Z, Meng M, Li M, Gao J, Kong J, Zhang G, Guo Y

Cellular and molecular neurobiology2025

DOI: 10.1007/s10571-025-01555-z PMID: 40259102

09

Volumetric Changes in Cerebellar Transverse Zones: Age and Sex Effects in Health and Neurological Disorders.

Ghiyamihoor F, Peymani P, Perron J, Asemi-Rad A, Marzban M, Mohite A, Ardila K, Aljada B, Marzban A, Toback M, Eltonsy S, Ko JH, Siddiqui TJ, Steele CJ, Kong J, Manto M, MacDonald ME, Gill JS, Sillitoe RV, Balcı F, Beheshti I, Marzban H

Human brain mapping2025

DOI: 10.1002/hbm.70214 PMID: 40241499

10

Oxidized SOD1 accelerates cellular senescence in neural stem cells.

Guan T, Guo Y, Zhou T, Yu Q, Sun J, Sun B, Zhang G, Kong J

Stem cell research & therapy2024Senior author

DOI: 10.1186/s13287-024-03669-5 PMID: 38414053

Development of a biomarker-driven 'best-in-class' treatment for amyotrophic lateral sclerosis: Discovery and proof-of-concept

Co-investigatorCIHR2024Project Grant

Principal investigators: Tranmer, Geoffrey

Keywords: Amyotrophic Lateral Sclerosis; Antioxidants; Biomarker-Driven; Boron Medicinal Chemistry; Edaravone; Nsc-34 Cell Lines; Primary Cortical Neuron Culture; Sod1; Sod1-G37r Mouse Model

$730,576

Development of novel agents for the treatment of amyotrophic lateral sclerosis: Discovery and proof-of-concept

Co-investigatorCIHR2022Project Grant

Principal investigators: Tranmer, Geoffrey

Keywords: Amyotrophic Lateral Sclerosis; Antioxidants; Boron Medicinal Chemistry; Edaravone; Nsc-34 Cell Lines; Primary Cortical Neuron Culture; Sod1; Sod1-G37r Mouse Model

$100,000

Protecting delayed neuronal death in ischemic stroke by targeting the BNIP3 pathway

Nominated PICIHR2013China-Canada Joint Health Research Initiative

Principal investigators: Kong, Jiming; Xu, Xingshun

Keywords: Bnip3; Delayed Neuronal Death; Ischemic Stroke; Mitochondria; Vdac

$225,000

Oligodendrocyte dysfunction in schizophrenia: mechanism and target of treatment

Co-investigatorCIHR2012Operating Grant - PA: Regional Partnership Program : Manitoba

Principal investigators: Li, Xin-Min

Keywords: Antipsychotics; Myelin; Neuroprotection; Oligodendrocyte Dysfunction; Schizophrenia; Stress

$100,000

A mechanistic study of major depressive disorder: Role of oligodendrocytes

Co-investigatorCIHR2010China-Canada Joint Health Research Initiative

Principal investigators: Li, Xin-Min; Zhang, Zhijun

Keywords: Depression; Genetics; Major Depressive Disorder; Mri; Myelin; Oligodendrocytes; Stress

$150,000

Posttranslational oxidative modification of SOD1 as a mechanism of motor neuron death in amytrophic lateral sclerosis

Nominated PICIHR2009China-Canada Joint Health Research Initiative

Principal investigators: Kong, Jiming; Wang, Han

Keywords: Amyotrophic Lateral Sclerosis; Cell Death; Motor Neuron; Oxidative Modification; Sod1

$150,000

CIHR Team in Schizophrenia. Are oligodendrocytes the missing piece of the puzzle? A systematic study of the role of oligodendrocytes in schizophrenia from bench-to-bedside

Principal investigatorCIHR2009Team Grant: China-Canada Collaborative Teams in Health Research

Principal investigators: Li, Xin-Min; He, Jue; Kong, Jiming; Martin, Melanie

Keywords: Antipsychotics; Demyelination/Remyelination; Genetic Susceptibility; Neuroimaging; Oligodendrocytes; Schizophrenia

$500,000

Protecting neurons from hypoxia-induced cell death by targeting the BNIP3 death gene family

SupervisorCIHR2009Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Weng, JIEQUN

Keywords: Bnip3; Mitochondria; Necrostatin-1; Rnai; Stroke

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Human Anatomy & Cell Science
Psychiatry
Pharmacology and Therapeutics
Physiology and Pathophysiology
College of Pharmacy

Co-authors at University of Manitoba, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Xin-Min Li

Psychiatry

12 shared papers, latest 2014

Jun-Feng Wang

Pharmacology and Therapeutics

4 shared papers, latest 2026

Xingshun Xu

Human Anatomy & Cell Science

1 shared papers, latest 2011

Sanjiv Dhingra

Physiology and Pathophysiology

1 shared papers, latest 2021

Sherif Eltonsy

College of Pharmacy

1 shared papers, latest 2025

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Paper to mention

Subject: Prospective PhD student: Bnip3 Dear Professor Kong, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A multi-scale framework to advance experimental models of skin aging." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]