Sanjiv Dhingra, University of Manitoba

Research

Hypoxia Heart Disease Immunoprivilege Stem Cells Cell Signaling Cell Survival Heart Function Ischemia

Latest papers

MXene Chemistries for Biomedicine: On-Body, In-Body, and Beyond.
ACS nano · 2026
Effect of polypropylene mesh with MXene-containing hydrogel on adhesions in a rat hernia model.
Current problems in surgery · 2026 · senior author
Generation of a patient-derived iPSC line from a clinically diagnosed MELAS case carrying the mtDNA m.3243A > G variant.
Stem cell research · 2026 · senior author

All 80 publications

Latest funding

MXene nanomaterials for maturation of induced pluripotent stem cells derived cardiomyocytes
CIHR · 2026 · Supervisor
$6,000
Role of immunoproteasome in the loss of immunoprivilege of mesenchymal stem cells in the ischemic heart
CIHR · 2024 · Nominated PI
$1,067,176
Determinants of immunogenicity of allogeneic mesenchymal stem cells in the ischemic heart
CIHR · 2023 · Nominated PI
$1,027,780

All 9 grants and awards

80 publications.

01

MXene Chemistries for Biomedicine: On-Body, In-Body, and Beyond.

Alkaya D, Cagliani R, Summak GY, Giro L, Besbinar O, Alhosani M, Pogorielov M, Gupta M, Dhingra S, Orecchioni M, Vitale F, Chessa G, Palmieri V, Chacon B, Gogotsi Y, Pappa AM, Fusco L, Yilmazer A, Delogu LG

ACS nano2026

DOI: 10.1021/acsnano.6c05051 PMID: 42708906

02

Effect of polypropylene mesh with MXene-containing hydrogel on adhesions in a rat hernia model.

Ayata O, Er S, Alkaya D, Unal MA, Yilmazer A, Aydin AH, Dhingra S

Current problems in surgery2026Senior author

DOI: 10.1016/j.cpsurg.2026.102093 PMID: 42700996

03

Generation of a patient-derived iPSC line from a clinically diagnosed MELAS case carrying the mtDNA m.3243A > G variant.

Sharma G, Srivastava A, Rockman-Greenberg C, Dhingra S

Stem cell research2026Senior author

DOI: 10.1016/j.scr.2026.104038 PMID: 42320428

04

iPSC generation from PBMCs of a MELAS patient for mitochondrial dysfunction studies.

Sharma G, Srivastava A, Rockman-Greenberg C, Dhingra S

Stem cell research2026Senior author

DOI: 10.1016/j.scr.2026.103992 PMID: 42024990

05

Association of Fontan Circulation With Gut Microbiome Derived Straight and Branched Short Chain Fatty Acids.

Shah AH, Liu Y, Armstrong HK, Han J, Goodlett DR, Ravandi A, Dhingra S

Journal of gastroenterology and hepatology2026Senior author

DOI: 10.1111/jgh.70405 PMID: 42067956

06

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo.

Srivastava A, Rafieerad A, Yan W, Alagarsamy KN, Guan Q, Saleth LR, Aliani M, Dhingra S

Advanced functional materials2026Senior author

DOI: 10.1002/adfm.202521057 PMID: 42630643

07

TCA cycle intermediates as an adjunct strategy for human iPSC-derived cardiomyocyte maturation.

Alagarsamy KN, Bueckert E, Gupta M, Aliani M, Dhingra S

BBA advances2026Senior author

DOI: 10.1016/j.bbadva.2026.100183 PMID: 41743073

08

Rosuvastatin-loaded injectable immunomodulatory hydrogel mitigates local immune response against transplanted stem cells and promotes heart repair in vivo.

Yan W, Alagarsamy KN, Srivastava A, Rafieerad A, Arora RC, Dhingra S

Biomaterials advances2026Senior author

DOI: 10.1016/j.bioadv.2025.214481 PMID: 40902371

09

IMpact of therapY using coleSevelam treatment reducing bile acids in patients with fonTan cIrCulation (MYSTIC): Rationale and study design.

Shah AH, Armstrong HK, Mittal I, Reimer A, Kunutsor SK, Ducas RA, Alizadeh K, Tam JW, Ravandi A, Dhingra S

American heart journal2026Senior author

DOI: 10.1016/j.ahj.2025.08.011 PMID: 40840821

10

Interplay between Elevated Bile Acids and Reduced Vitamin D Levels in Fontan Circulation: A Double-Edged Sword.

Shah AH, Ravandi A, Dhingra S, Aliani M, Sivakumar K, Krasuski RA, Ramakrishnan S

Current cardiology reports2025

DOI: 10.1007/s11886-025-02304-w PMID: 41128958

MXene nanomaterials for maturation of induced pluripotent stem cells derived cardiomyocytes

SupervisorCIHR2026Undergraduate Student Research Awards (USRA)

Principal investigators: Uzonna, Jason

Keywords: Cellular Developmen; In Vitro Organ-On-Chip Models; Pluripotent Stem Cell-Derived Cardiomyocytes

$6,000

Role of immunoproteasome in the loss of immunoprivilege of mesenchymal stem cells in the ischemic heart

Nominated PICIHR2024Project Grant

Principal investigators: Dhingra, Sanjiv

Keywords: Cell Biology; Cell Signaling; Cell Survival; Heart Disease; Heart Function; Hypoxia; Immunoprivilege; Ischemia; Proteasome; Stem Cells

$1,067,176

Determinants of immunogenicity of allogeneic mesenchymal stem cells in the ischemic heart

Nominated PICIHR2023Project Grant

Principal investigators: Dhingra, Sanjiv

Keywords: Cell Signaling; Cell Survival; Heart Disease; Heart Function; Hypoxia; Immunoprivilege; Ischemia; Molecular Biology; Stem Cells

$1,027,780

Development of iPSC-based clinical trial selection platform for patients with ultrarare inborn mitochondrial disorders

SupervisorCIHR2021CIHR Fellowship

Principal investigators: Srivastava, Abhay D

Keywords: Disease Modelling; Drug Screening Platform; Inborn Mitochondrial Disorders; Induced Pluripotent Stem Cells; Metabolic Correction

$135,000

Role of COP 9 signalosome subunit 5 in preserving immunoprivilege of allogeneic mesenchymal stem cells in the ischemic heart

Nominated PICIHR2021Project Grant

Principal investigators: Dhingra, Sanjiv

Keywords: Cell Biology; Cell Signaling; Cell Survival; Heart Disease; Heart Function; Hypoxia; Immunoprivilege; Ischemia; Molecular Biology; Stem Cells

$960,076

Rational design, synthesis and immunocharacterization of next-generation biomaterials

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Dhingra, Sanjiv

$132,000

Novel MXene Quantum Dots for Immunomodulation and Prevention of Cardiac Allograft Vasculopathy

SupervisorCIHR2019CIHR Fellowship

Principal investigators: Yan, Weiang

Keywords: Allograft Vasculopathy; Animal Surgery; Biomaterials; Endothelial Cells; Inflammation; Mxene Quantum Dots

$119,166

Role of HSP90-alpha in preserving immunoprivilege of allogenic mesenchymal stem cells in the ischemic heart

Nominated PICIHR2017Project Grant

Principal investigators: Dhingra, Sanjiv

Keywords: Angiogenesis; Cardiovascular Disease; Cardiovascular Function; Endothelial Cells; Hypoxia; Immunogenicity; Immunoprivilege; Mhc-Ii; Myocardial Infarction; Stem Cells

$749,700

Preserving the immunoprivilege of transplanted allogeneic mesenchymal stem cells in the ischemic heart

Nominated PICIHR2015Operating Grant

Principal investigators: Dhingra, Sanjiv

Keywords: Allogeneic Stem Cells; Cardiac Repair; Heart Disease; Hypoxia; Mhc-Ii; Molecular Biology; Stem Cell Signaling; Stem Cell Therapy

$521,185

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology and Pathophysiology
Human Anatomy & Cell Science
Physiology
Human Nutritional Sciences
Pharmacology and Therapeutics
Cardiovascular Surgery
Mechanical Engineering

Co-authors at University of Manitoba, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Michel Aliani

Human Nutritional Sciences

5 shared papers, latest 2026

Paul Fernyhough

Pharmacology and Therapeutics

3 shared papers, latest 2025

Ren-Ke Li

Cardiovascular Surgery

2 shared papers, latest 2016

Mohsen Akbari

Mechanical Engineering

1 shared papers, latest 2018

Inna Rabinovich-Nikitin

Physiology and Pathophysiology

1 shared papers, latest 2022

Filio Billia

Physiology

1 shared papers, latest 2022

Michael Czubryt

Physiology and Pathophysiology

1 shared papers, latest 2019

Jiming Kong

Human Anatomy & Cell Science

1 shared papers, latest 2021

Pawan Singal

Physiology

1 shared papers, latest 2018

Elissavet Kardami

Human Anatomy & Cell Science

1 shared papers, latest 2019

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Hypoxia Dear Professor Dhingra, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "MXene Chemistries for Biomedicine: On-Body, In-Body, and Beyond." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Role of immunoproteasome in the loss of immunoprivilege of mesenchymal stem cells in the ischemic heart" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Sanjiv Dhingra

Research

Latest papers

Latest funding

MXene Chemistries for Biomedicine: On-Body, In-Body, and Beyond.

Effect of polypropylene mesh with MXene-containing hydrogel on adhesions in a rat hernia model.

Generation of a patient-derived iPSC line from a clinically diagnosed MELAS case carrying the mtDNA m.3243A&#xa0;>&#xa0;G variant.

iPSC generation from PBMCs of a MELAS patient for mitochondrial dysfunction studies.

Association of Fontan Circulation With Gut Microbiome Derived Straight and Branched Short Chain Fatty Acids.

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo.

TCA cycle intermediates as an adjunct strategy for human iPSC-derived cardiomyocyte maturation.

Rosuvastatin-loaded injectable immunomodulatory hydrogel mitigates local immune response against transplanted stem cells and promotes heart repair in vivo.

IMpact of therapY using coleSevelam treatment reducing bile acids in patients with fonTan cIrCulation (MYSTIC): Rationale and study design.

Interplay between Elevated Bile Acids and Reduced Vitamin D Levels in Fontan Circulation: A Double-Edged Sword.

Rational design, synthesis and immunocharacterization of next-generation biomaterials

Frequent collaborators

Michel Aliani

Paul Fernyhough

Ren-Ke Li

Mohsen Akbari

Inna Rabinovich-Nikitin

Filio Billia

Michael Czubryt

Jiming Kong

Pawan Singal

Elissavet Kardami

Generation of a patient-derived iPSC line from a clinically diagnosed MELAS case carrying the mtDNA m.3243A > G variant.