Faculty profile

Paul Fernyhough

ResearcherPharmacology and TherapeuticsUniversity of Manitoba

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Manitoba directory, so their courses and email address may be missing. Find their university profile.

Paul Fernyhough

Researcher

Pharmacology and Therapeutics

Health Sciences

University of Manitoba

Winnipeg, Manitoba, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
14 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (6 CIHR, 3 NSERC), most recently in 2026.
Supervised 1 trainee who won CIHR awards, most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Sensory Neuron Neuropathy Mitochondrial Function Muscarinic Receptor Peripheral Neuropathy Animal Models Confocal Imaging Mitochondria

Latest papers

Corrigendum to "Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents" [Mol. Cell. Neurosci. Volume 90, July 2018, Pages 49-59].
Molecular and cellular neurosciences · 2026 · senior author
Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.
ACS chemical neuroscience · 2026
Microbial Metabolite-Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026

All 67 publications

Latest funding

Novel actions of antagonists at muscarinic acetylcholine type 1 receptors
CIHR · 2026 · Nominated PI
$1,059,526
Muscarinic receptor signalling pathways regulating axonal regeneration and sprouting in adult neurons
NSERC · 2019 · Principal investigator
$32,000
Muscarinic receptor antagonism as a novel mechanism for sensory nerve repair
CIHR · 2018 · Nominated PI
$1,090,125

All 14 grants and awards

67 publications.

Corrigendum to "Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents" [Mol. Cell. Neurosci. Volume 90, July 2018, Pages 49-59].

Chowdhury SR, Djordjevic J, Thomson E, Smith DR, Albensi BC, Fernyhough P

Molecular and cellular neurosciences2026Senior author

DOI: 10.1016/j.mcn.2026.104099 PMID: 42321091

Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.

Berida TI, Dodd CJ, Wilkinson JC, Smith DR, Chang S, Presley CC, Peng L, Sant S, Krishnan S, Zagol-Ikapitte I, Watson KJ, Thompson Gray A, Rodriguez AL, Cho HP, Jones CK, Boutaud O, Niswender CM, Engers DW, Fernyhough P, Lindsley CW, Childress ES

ACS chemical neuroscience2026

DOI: 10.1021/acschemneuro.6c00367 PMID: 42411178

Microbial Metabolite-Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions.

Gupte T, Singh N, Bhatia V, Arora K, Amiri S, Fernyhough P, Naren AP, Dakshinamurti S, Chelikani P

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

DOI: 10.1096/fj.202501312r PMID: 42216476

Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis.

Amiri S, Aghanoori MR, Smith DR, Waise TMZ, Lao Y, Inoue A, Zahedi RP, Dunn HA, Fernyhough P

Science signaling2026Senior author

DOI: 10.1126/scisignal.ady7187 PMID: 41915732

Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy

Sivadasan A, Fernyhough P, Calcutt NA, Frizzi KE, Gardner K, Hansen A, Breiner A, Zochodne DW, McInnes N, Punthakee Z

EBioMedicine20265 citations

DOI: 10.1016/j.ebiom.2025.106055

Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy.

Chauhan S, Calcutt NA, Fernyhough P

International journal of molecular sciences2025Senior author

DOI: 10.3390/ijms26157393 PMID: 40806522

Estradiol Prevents Amyloid Beta-Induced Mitochondrial Dysfunction and Neurotoxicity in Alzheimer's Disease via AMPK-Dependent Suppression of NF-κB Signaling.

Mishra P, Esfahani EK, Fernyhough P, Albensi BC

International journal of molecular sciences2025

DOI: 10.3390/ijms26136203 PMID: 40649980

Estradiol activates the CaMKKβ/AMPK pathway to enhance neurite outgrowth in cultured adult sensory neurons.

Mishra P, Albensi BC, Fernyhough P

Molecular and cellular neurosciences2025Senior author

DOI: 10.1016/j.mcn.2025.104008 PMID: 40164320

Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons.

Chauhan S, Smith DR, Shariati-Ievari S, Srivastava A, Dhingra S, Aliani M, Fernyhough P

Molecular metabolism2025Senior author

DOI: 10.1016/j.molmet.2024.102083 PMID: 39694091

A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin.

Casselini CM, Parson HK, Frizzi KE, Marquez A, Smith DR, Guernsey L, Nemmani R, Tayarani A, Jolivalt CG, Weaver J, Fernyhough P, Vinik AI, Calcutt NA

Acta neuropathologica2024

DOI: 10.1007/s00401-024-02710-4 PMID: 38526612

Novel actions of antagonists at muscarinic acetylcholine type 1 receptors

Nominated PICIHR2026Project Grant

Principal investigators: Fernyhough, Paul

Keywords: Mitochondrial Function; Muscarinic Receptor; Neuropathy; Sensory Neuron

$1,059,526

Muscarinic receptor signalling pathways regulating axonal regeneration and sprouting in adult neurons

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Fernyhough, Paul

$32,000

Muscarinic receptor antagonism as a novel mechanism for sensory nerve repair

Nominated PICIHR2018Project Grant

Principal investigators: Fernyhough, Paul

Keywords: Calcium Signaling; Diabetic Neuropathy; In Vivo Imaging; Mitochondrial Function; Mouse Models; Muscarinic Receptor; Peripheral Nervous System; Peripheral Neuropathy; Sensory Neuron

$1,090,125

The Developmental Origins of Pediatric Obesity and Obesity-Related Complications.

Co-investigatorCIHR2015Environments, Genes and Chronic Disease - LOI

Principal investigators: Dolinsky, Vernon W; Davie, James R; Hivert, Marie-France; Kobor, Michael S; Shen, Garry X; Wicklow, Brandy A

Keywords: Cardiovascular Disease; Chronic Kidney Disease; Diabetes; Epigenetics; Fetal Programming; Obesity; Pregnancy

Protective mechanisms of endocannabinoids in cardiac hypertrophy

Co-investigatorCIHR2013Operating Grant

Principal investigators: Anderson, Hope D

Keywords: 2-Photon Laser Scanning Microscopy; Cardiac Hypertrophy; Cardiac Myocytes; Endocannabinoids; Mitochondrial Bioenergetics; Pressure-Overload Model Of Hypertrophy

$611,905

Dysregulation of neuronal mitochondrial function in diabetic sensory neuropathy.

Nominated PICIHR2013Operating Grant

Principal investigators: Fernyhough, Paul

Keywords: Ampk; Animal Models; Confocal Imaging; Diabetes; Metabolism; Mitochondria; Nerve Regeneration; Neuropathy; Transgenic Mice; Viral Transduction

$943,639

Muscarinic receptor antagonism as a novel mechanism for sensory nerve repair.

Nominated PICIHR2012Operating Grant - PA: Regional Partnership Program : Manitoba

Principal investigators: Fernyhough, Paul

Keywords: Animal Models; Chemotherapy-Induced Neuropathy; Confocal Imaging; In Vivo Electrophysiology; Mitochondria; Muscarinic Receptors; Nerve Regeneration; Pain Sensitivity; Peripheral Neuropathy; Sensory Neuron

$111,078

Rabies virus-induced injury to neuronal processes: role of oxidative stress

Co-investigatorCIHR2011Operating Grant - PA: Regional Partnership Program : Manitoba

Principal investigators: Jackson, Alan Clayton

Keywords: Neuropathology; Neurophysiology; Neurovirology; Viral Pathogenesis

$100,000

Glucose metabolism and mitochondrial function in adult neurons

Principal investigatorNSERC2011Discovery Grants Program - Individual

Principal investigators: Fernyhough, Paul

$30,000

Targeting impaired PGC-1alpha expression for therapy of diabetic sensory neuropathy.

SupervisorCIHR2010CIHR Fellowship

Principal investigators: Lefort, Natalie

Keywords: Confocal Microscopy; Diabetes Complications; Dorsal Root Ganglion; Mitochondria Mass And Function; Neurodegeneration; Seahorse Biosciences Xf24 Analyzer; Streptozotocin-Treated Rodents; Transgenic Animals (Inducible)

$135,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Sensory Neuron Dear Professor Fernyhough, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Corrigendum to "Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents" [Mol. Cell. Neurosci. Volume 90, July 2018, Pages 49-59]." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Novel actions of antagonists at muscarinic acetylcholine type 1 receptors" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Paul Fernyhough

Research

Latest papers

Latest funding

Corrigendum to "Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents" [Mol. Cell. Neurosci. Volume 90, July 2018, Pages 49-59].

Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.

Microbial Metabolite-Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions.

Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis.

Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy

Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy.

Estradiol Prevents Amyloid Beta-Induced Mitochondrial Dysfunction and Neurotoxicity in Alzheimer's Disease via AMPK-Dependent Suppression of NF-κB Signaling.

Estradiol activates the CaMKKβ/AMPK pathway to enhance neurite outgrowth in cultured adult sensory neurons.

Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons.

A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin.

Novel actions of antagonists at muscarinic acetylcholine type 1 receptors

Muscarinic receptor signalling pathways regulating axonal regeneration and sprouting in adult neurons

Muscarinic receptor antagonism as a novel mechanism for sensory nerve repair

The Developmental Origins of Pediatric Obesity and Obesity-Related Complications.

Protective mechanisms of endocannabinoids in cardiac hypertrophy

Dysregulation of neuronal mitochondrial function in diabetic sensory neuropathy.

Muscarinic receptor antagonism as a novel mechanism for sensory nerve repair.

Rabies virus-induced injury to neuronal processes: role of oxidative stress

Glucose metabolism and mitochondrial function in adult neurons

Targeting impaired PGC-1alpha expression for therapy of diabetic sensory neuropathy.

Frequent collaborators

Michel Aliani

Sanjiv Dhingra

Miyoung Suh

Paul Fernyhough

Prashen Chelikani

Christine Doucette

Jonathan McGavock

Versha Banerji

Shyamala Dakshinamurti

Aaron Marshall

Natalia McInnes

Zubin Punthakee

Paul Fernyhough

Research

Latest papers

Latest funding

Corrigendum to "Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents" [Mol. Cell. Neurosci. Volume 90, July 2018, Pages 49-59].

Discovery of VU6077564: A Selective M1 Antagonist That Promotes Neurite Outgrowth in Adult Sensory Neurons.

Microbial Metabolite-Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions.

Antimuscarinic drugs exert &#x3b2;-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis.

Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy

Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy.

Estradiol Prevents Amyloid Beta-Induced Mitochondrial Dysfunction and Neurotoxicity in Alzheimer's Disease via AMPK-Dependent Suppression of NF-&#x3ba;B Signaling.

Estradiol activates the CaMKK&#x3b2;/AMPK pathway to enhance neurite outgrowth in cultured adult sensory neurons.

Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons.

A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin.

Muscarinic receptor signalling pathways regulating axonal regeneration and sprouting in adult neurons

Glucose metabolism and mitochondrial function in adult neurons

Frequent collaborators

Michel Aliani

Sanjiv Dhingra

Miyoung Suh

Paul Fernyhough

Prashen Chelikani

Christine Doucette

Jonathan McGavock

Versha Banerji

Shyamala Dakshinamurti

Aaron Marshall

Natalia McInnes

Zubin Punthakee

Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor to promote DRG neuritogenesis.

Estradiol Prevents Amyloid Beta-Induced Mitochondrial Dysfunction and Neurotoxicity in Alzheimer's Disease via AMPK-Dependent Suppression of NF-κB Signaling.

Estradiol activates the CaMKKβ/AMPK pathway to enhance neurite outgrowth in cultured adult sensory neurons.