Faculty profile

Prashen Chelikani

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ProfessorOral BiologyUniversity of Manitoba

Prashen Chelikani

Professor

Oral Biology

Dr. Gerald Niznick College of Dentistry

University of Manitoba

Winnipeg, Manitoba, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
29 publications in the last five years, latest in 2026.
Senior (last) author on 16 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (4 CIHR, 3 NSERC), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Education

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Signals and details

Research

Read how they describe their research on their University of Manitoba profile.

Early Childhood Caries Oral Fungi Bitter Taste Receptors Chronic Medical Condition Covid-19 Genetic Variant Older Adults Serology

Latest papers

Microbial Metabolite-Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026 · senior author
The Association Between Exclusive Breastfeeding, Bottle-Feeding, and Oral Rothia on Early Childhood Caries.
Pediatric dentistry · 2026
Severe Hypoxia Reduces Adenylyl Cyclase 6 Expression and Function in Bronchial Epithelial Cells.
FASEB bioAdvances · 2026 · senior author

All 79 publications

Latest funding

Regulation of Pulmonary Arterial Relaxation by Nitrosylation in Hypoxic Pulmonary Hypertension
CIHR · 2025 · Co-investigator
$994,500
Oral mycobiome and caries risk in young Indigenous children in Manitoba
CIHR · 2023 · Nominated PI
$1,319,625
Bitter taste receptors and COVID-19
CIHR · 2022 · Principal investigator
$70,000

All 10 grants and awards

79 publications.

Microbial Metabolite-Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions.

Gupte T, Singh N, Bhatia V, Arora K, Amiri S, Fernyhough P, Naren AP, Dakshinamurti S, Chelikani P

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2026Senior author

DOI: 10.1096/fj.202501312r PMID: 42216476

The Association Between Exclusive Breastfeeding, Bottle-Feeding, and Oral Rothia on Early Childhood Caries.

Szeto A, Khan MW, de Jesus VC, Balshaw R, Menon A, Mittermuller BA, Baltus TH, Chelikani P, Schroth RJ

Pediatric dentistry2026

PMID: 42271613

Severe Hypoxia Reduces Adenylyl Cyclase 6 Expression and Function in Bronchial Epithelial Cells.

Cunnington RH, Singh N, Shafizadeh M, Hanrahan JW, Dakshinamurti S, Chelikani P

FASEB bioAdvances2026Senior author

DOI: 10.1096/fba.2025-00309 PMID: 42004995

Beef-Derived Peptides Mediated Desensitization of Bitter Taste Receptor T2R14 Through GPCR Kinase 2.

Singh N, Drube J, Hoffmann C, Aluko RE, Chelikani P

Nutrients2026Senior author

DOI: 10.3390/nu18060901 PMID: 41901075

Effect of the G-Protein-Coupled Receptor T2R14 on Proliferation and Cell Population Growth in Oral Cancer Cells.

Chen Y, Kella M, Austin K, Bhullar RP, Chelikani P

Cells2026Senior author

DOI: 10.3390/cells15030279 PMID: 41677642

Effects of silver diamine fluoride on oral bacteriome and mycobiome: a randomized clinical trial.

Manerkar M, de Jesus VC, Mittermuller BA, Lee VHK, Singh S, Bertone M, Chelikani P, Schroth RJ

BMC oral health2025

DOI: 10.1186/s12903-025-06986-0 PMID: 41120980

Genetic Variations in Bitter Taste Receptors and COVID-19 in the Canadian Longitudinal Study on Aging.

Shafizadeh M, Khan MW, Drögemöller B, Stavropoulou C, St John P, Bhullar RP, Chelikani P, Hitchon CA

Biomedicines2025

DOI: 10.3390/biomedicines13102473 PMID: 41153757

Integrative analysis of taste genetics and the dental plaque microbiome in early childhood caries.

Khan MW, Cruz de Jesus V, Mittermuller BA, Schroth RJ, Hu P, Chelikani P

Cell reports2025Senior author

DOI: 10.1016/j.celrep.2025.116245 PMID: 40934079

Role of Yin Yang 1 (YY1) on microenvironment, signaling pathways, and epigenetics in lung cancer.

Kumari S, Ponamgi SPD, Chelikani P, Srilatha M, Nagaraju GP, Peela S

Biochimica et biophysica acta. Reviews on cancer2025

DOI: 10.1016/j.bbcan.2025.189359 PMID: 40451394

Identifying training needs of healthcare providers to implement caries risk assessment.

Olatosi OO, Schroth RJ, DeMaré D, Manigque M, Mittermuller BA, Edwards J, Yerex K, Wong PD, Lavoie J, Sanguins J, Chelikani P, Nicolae A, Lamoureux J, Campbell R, Bertone M, Amin M

Frontiers in oral health2025

DOI: 10.3389/froh.2025.1641307 PMID: 40951537

Regulation of Pulmonary Arterial Relaxation by Nitrosylation in Hypoxic Pulmonary Hypertension

Co-investigatorCIHR2025Project Grant

Principal investigators: Dakshinamurti, Shyamala

Keywords: Adenylyl Cyclase; Camp; Enzyme Activity; G Protein; Gpcr; Hypoxia; Neonatal Pulmonary Hypertension; Post-Translational Modification; Reactive Oxygen Species; S-Nitrosylation

$994,500

Oral mycobiome and caries risk in young Indigenous children in Manitoba

Nominated PICIHR2023Project Grant

Principal investigators: Chelikani, Prashen V; Campbell, Rhonda; Chartrand, Frances; Decaire, Elizabeth; Kloss, Olena; Schroth, Robert J; Yerex, Katherine

Keywords: Early Childhood Caries; Oral Fungi

$1,319,625

Bitter taste receptors and COVID-19

Principal investigatorCIHR2022Catalyst Grant: Analysis of CLSA Data

Principal investigators: Hitchon, Carol A; Chelikani, Prashen V

Keywords: Bitter Taste Receptors; Chronic Medical Condition; Covid-19; Genetic Variant; Older Adults; Serology

$70,000

Oral microbiome and caries risk in young First Nations and Metis children in Manitoba

Principal investigatorCIHR2021Project Grant

Principal investigators: Schroth, Robert J; Campbell, Rhonda; Chelikani, Prashen V; Sanguins, Julianne; Yerex, Katherine

Keywords: Early Childhood Caries; First Nations Children; Infants And Preschoolers; Metis Children; Oral Microbiome

$1,422,900

Effect of Hypoxia and Nitric Oxide Therapy on Adenylyl Cyclase Activity in Persistent Pulmonary Hypertension of the Newborn

Co-investigatorCIHR2020Project Grant

Principal investigators: Dakshinamurti, Shyamala

Keywords: Adenylyl Cyclase; Camp; Enzyme Activity; Gpcr; Hypoxia; Molecular Modeling; Neonatal Pulmonary Hypertension; Nitric Oxide; Post-Translational Protein Modification; S-Nitrosylation

$784,125

Food chemosensation: Characterization of novel bitter taste blockers and structure-function analysis

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Chelikani, Prashen

$300,000

Role of taste signaling and host-microbial interactions on caries risk in young children

Nominated PICIHR2018Project Grant

Principal investigators: Chelikani, Prashen V; Schroth, Robert J

Keywords: Cariogenic Bacteria; Oral Health; Taste Receptors

$885,870

Molecular, biochemical and physiological studies on bitter taste receptors

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Chelikani, Prashen

$282,000

Functional regulation of pulmonary arterial thromboxane receptor by post-translational modification, in hypoxic persistent pulmonary hypertension of the newborn

Co-investigatorCIHR2010Operating Grant - PA: Regional Partnership Program : Manitoba

Principal investigators: Dakshinamurti, Shyamala

Keywords: Hypoxia; Molecular Modelling; Persistent Pulmonary Hypertension Of The Newborn; Pulmonary Arterial Hypertension; Regulation Of Receptor-G-Protein Coupling; Serine Phosphorylation; Site-Directed Mutagenesis; Thromboxane Receptor Sensitization

$100,000

Molecular mechanisms of signal transduction by bitter taste receptors

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Chelikani, Prashen

$193,250

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on July 30, 2025 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Prashen Chelikani

Research

Latest papers

Latest funding

Microbial Metabolite-Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions.

The Association Between Exclusive Breastfeeding, Bottle-Feeding, and Oral Rothia on Early Childhood Caries.

Severe Hypoxia Reduces Adenylyl Cyclase 6 Expression and Function in Bronchial Epithelial Cells.

Beef-Derived Peptides Mediated Desensitization of Bitter Taste Receptor T2R14 Through GPCR Kinase 2.

Effect of the G-Protein-Coupled Receptor T2R14 on Proliferation and Cell Population Growth in Oral Cancer Cells.

Effects of silver diamine fluoride on oral bacteriome and mycobiome: a randomized clinical trial.

Genetic Variations in Bitter Taste Receptors and COVID-19 in the Canadian Longitudinal Study on Aging.

Integrative analysis of taste genetics and the dental plaque microbiome in early childhood caries.

Role of Yin Yang 1 (YY1) on microenvironment, signaling pathways, and epigenetics in lung cancer.

Identifying training needs of healthcare providers to implement caries risk assessment.

Regulation of Pulmonary Arterial Relaxation by Nitrosylation in Hypoxic Pulmonary Hypertension

Oral mycobiome and caries risk in young Indigenous children in Manitoba

Bitter taste receptors and COVID-19

Oral microbiome and caries risk in young First Nations and Metis children in Manitoba

Effect of Hypoxia and Nitric Oxide Therapy on Adenylyl Cyclase Activity in Persistent Pulmonary Hypertension of the Newborn

Food chemosensation: Characterization of novel bitter taste blockers and structure-function analysis

Role of taste signaling and host-microbial interactions on caries risk in young children

Molecular, biochemical and physiological studies on bitter taste receptors

Functional regulation of pulmonary arterial thromboxane receptor by post-translational modification, in hypoxic persistent pulmonary hypertension of the newborn

Molecular mechanisms of signal transduction by bitter taste receptors

Frequent collaborators

Shyamala Dakshinamurti

Kangmin Duan

Pingzhao Hu

Mary Bertone

Anil Menon

Katherine Yerex

Jeanette Edwards

Julianne Sanguins

Thomas Klonisch

Rhonda Campbell

Sabine Hombach-Klonisch

Maryam Amin

Chrysi Stavropoulou

Devi Atukorallaya

Yvonne Myal

Philip St.John

Andrew Halayko

Marshall Pitz

Paul Fernyhough