Jeffrey Dickhout, McMaster University

Research

Research areas, by share of publications

Endoplasmic Reticulum Stress and DiseaseBiochemistry, Genetics and Molecular Biology
Chronic Kidney Disease and DiabetesMedicine
Biomedical Research and PathophysiologyMedicine
Renin-Angiotensin System StudiesMedicine

Research areas are derived from OpenAlex topics of their publications.

Latest papers

Follistatin improves vascular function by inhibiting oxidative stress and inducing browning of perivascular adipose tissue in essential hypertension
2026 · senior author
Follistatin Alleviates Vascular Dysfunction by Reducing Oxidative Stress and Promoting Browning in Perivascular Adipose Tissue.
Hypertension · 2026 · senior author
AI is a viable alternative to high throughput screening: a 318-target study
Scientific Reports · 2024

All 103 publications

Latest funding

Influence of high dietary sodium chloride on blood vessel dysfunction in the genesis of chronic kidney disease and stroke.
CIHR · 2016 · Nominated PI
$370,782
Inhibition of endoplasmic reticulum (ER) stress in the prevention of kidney disease
CIHR · 2014 · Nominated PI
$75,000
Role of the unfolded protein response in hypertension induced end organ damage.
CIHR · 2013 · Nominated PI
$323,142

All 5 grants and awards

Researchers with similar interests

Richard C Austin

Medicine

Endoplasmic Reticulum Stress and Disease

Joseph Macri

Pathology & Molecular Medicine

Endoplasmic Reticulum Stress and Disease

Muhammad Imran Khan

Anesthesia

Endoplasmic Reticulum Stress and Disease

Asghar Naqvi

Pathology & Molecular Medicine

Endoplasmic Reticulum Stress and Disease

Michael Walsh

Medicine

Chronic Kidney Disease and Diabetes

Catherine Clase

Medicine

Chronic Kidney Disease and Diabetes

103 publications.

01

Follistatin improves vascular function by inhibiting oxidative stress and inducing browning of perivascular adipose tissue in essential hypertension

Kuganathan A, Lu V, MacDonald M, Farkona S, Campbell T, Akimoto M, Gao B, Manion K, Konvalinka A, Dickhout J

20261 citationsSenior author

DOI: 10.64898/2025.12.31.697255

02

Follistatin Alleviates Vascular Dysfunction by Reducing Oxidative Stress and Promoting Browning in Perivascular Adipose Tissue.

Kuganathan A, Lu C, MacDonald M, Farkona S, Campbell T, Akimoto M, Gao B, Manion K, Konvalinka A, Dickhout J

Hypertension2026Senior author

DOI: 10.1161/hypertensionaha.126.26722

03

AI is a viable alternative to high throughput screening: a 318-target study

Wallach I, Bernard D, Nguyen K, Ho G, Morrison A, Stecula A, Rosnik A, O’Sullivan AM, Davtyan A, Samudio B

Scientific Reports2024147 citations

DOI: 10.1038/s41598-024-54655-z

04

Renal Medulla in Hypertension

Cowley AW, Roman RJ, Mattson DL, Franchini KG, O’Connor PM, Makino A, Taylor NE, Evans LC, Mori T, Dickhout JG

Hypertension20249 citationsSenior author

DOI: 10.1161/hypertensionaha.124.21711

05

Follistatin lowers blood pressure and improves vascular structure and function in essential and secondary hypertension

Kuganathan A, Leal M, Mehta N, Lu V, Gao B, MacDonald M, Dickhout J, Krepinsky JC

Hypertension Research20248 citations

DOI: 10.1038/s41440-024-01872-8

06

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Wallach I, Bernard D, Nguyen K, Ho G, Morrison A, Stecula A, Rosnik A, O’Sullivan AM, Davtyan A, Samudio B

Scientific Reports20245 citations

DOI: 10.1038/s41598-024-70321-w

07

Abstract P448: Follistatin Improves Vascular Function by Regulating Perivascular Adipose Tissue in Essential Hypertension

Kuganathan A, Lu V, Gao B, MacDonald M, Dickhout J, Krepinsky J

Hypertension2024

DOI: 10.1161/hyp.81.suppl_1.p448

08

Abstract P104: EXAMINING THE EFFECTS OF FOLLISTATIN ON CONTRACTION OF VESSELS FROM NORMOTENSIVE AND HYPERTENSIVE RATS

Sadat Afjeh N, Kuganathan A, Leal M, Lu V, Dickhout J, Krepinsky J

Hypertension2023

DOI: 10.1161/hyp.80.suppl_1.p104

09

Abstract P3001: Regulation Of Perivascular Adipose Tissue By Follistatin In Hypertension

Kuganathan A, Leal M, Lu V, MacDonald M, Gao B, Dickhout J, Krepinsky J

Circulation Research2023

DOI: 10.1161/res.133.suppl_1.p3001

10

Inhibitory Antibodies against PCSK9 Reduce Surface CD36 and Mitigate Diet-Induced Renal Lipotoxicity

Byun JH, Lebeau PF, Platko K, Carlisle RE, Faiyaz M, Chen J, MacDonald ME, Makda Y, Yousof T, Lynn EG

Kidney360202239 citations

DOI: 10.34067/kid.0007022021

Influence of high dietary sodium chloride on blood vessel dysfunction in the genesis of chronic kidney disease and stroke.

Nominated PICIHR2016Project Grant

Principal investigators: Dickhout, Jeffrey G

Keywords: Er Stress/Upr Activation; Kidney Disease; Salt Sensitive Hypertension; Stroke

$370,782

Inhibition of endoplasmic reticulum (ER) stress in the prevention of kidney disease

Nominated PICIHR2014KRESCENT / CIHR New Investigators

Principal investigators: Dickhout, Jeffrey G

Keywords: Acute Kidney Injury; Apoptosis; Chop/Gadd153; Chronic Inflammation; Chronic Kidney Disease; Endoplasmic Reticulum Stress; Hypertension; Proteinuria; Renal Fibrosis

$75,000

Role of the unfolded protein response in hypertension induced end organ damage.

Nominated PICIHR2013Operating Grant

Principal investigators: Dickhout, Jeffrey G

Keywords: Blood Vessel Function; Chronic Heart Disease; Er Stress/Upr Activation; Fibrosis; Hypertension; Kidney Disease; Lung Disease; Myofibroblast; Stroke; Whole Animal Physiology

$323,142

Endoplasmic reticulum (ER) stress and the unfolded protein response as modulators of inflammation in chronic disease.

Co-investigatorCIHR2012Team Grant: Health Challenges in Chronic Inflammation Initiative (LOI)

Principal investigators: Austin, Richard C

Keywords: Atherothrombosis; Chronic Inflammation; Chronic Kidney Disease; Endoplasmic Reticulum Stress; Fibrosis; Hypertension; Interstitial Lung Disease; Macrophages; T-Cells; Unfolded Protein Response

$20,000

Role of endoplasmic reticulum (ER) stress in the development of kidney disease.

Nominated PICIHR2011Operating Grant-PA: Sodium and Health

Principal investigators: Dickhout, Jeffrey G

Keywords: Atherothrombosis; Cellular Pysiology; Confocal Microscopy/Electron Microscopy; Er Stress/Upr Activation; Hypertension; Kidney Disease; Programmed Cell Death; Quantitative Protein Expression Analysis; Tdag51; Whole Animal Physiology

$227,019

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Courses taught

2

Introduction to Pharmacology
PHARMAC 3A06B · last taught 2026
Undergraduate
Introduction to Pharmacology
PHARMAC 3A06A · last taught 2017
Undergraduate

Frequent collaborators

Richard C Austin

Medicine

41 shared papers, latest 2024

Kjetil Ask

Medicine

16 shared papers, latest 2019

Joan Krepinsky

Medicine

15 shared papers, latest 2026

Robert M K W Lee

Anesthesia

9 shared papers, latest 2017

Martin Rainer Kolb

Medicine

5 shared papers, latest 2019

Alistair John Ingram

Medicine

5 shared papers, latest 2014

Geoff Werstuck

Medicine

3 shared papers, latest 2008

Mark David Inman

Medicine

3 shared papers, latest 2016

Damu Tang

Medicine

3 shared papers, latest 2013

Carl Richards

Medicine

2 shared papers, latest 2019

Jeffrey Weitz

Medicine

2 shared papers, latest 2015

Bernardo Trigatti

Biochemistry & Biomedical Sciences

2 shared papers, latest 2013

Adam Mazzetti

Medicine

1 shared papers, latest 2012

Peter Margetts

Medicine

1 shared papers, latest 2012

John Capone

Biochemistry & Biomedical Sciences

1 shared papers, latest 2013

Anthony Chan

Pediatrics

1 shared papers, latest 2003

Darren Bridgewater

Pathology & Molecular Medicine

1 shared papers, latest 2016

Helen Neighbour

Medicine

1 shared papers, latest 2015

Jean-claude Cutz

Pathology & Molecular Medicine

1 shared papers, latest 2011

Suleiman Igdoura

Biology

1 shared papers, latest 2022

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Subject: Prospective PhD student: Endoplasmic Reticulum Stress and Disease Dear Professor Dickhout, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Follistatin improves vascular function by inhibiting oxidative stress and inducing browning of perivascular adipose tissue in essential hypertension" (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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