Faculty profile

Lois Shepherd

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Professor EmeritusPathologyQueen's University

Signals and details

Research

Read how they describe their research on their Queen's University profile.

Latest papers

Transfer Learning and Machine Learning for Training Five-Year Survival Prognostic Models in Early Breast Cancer: Development and Validation Study
Journal of Medical Internet Research · 2026
Primary refractory disease in large B-cell lymphoma: definition and outcomes from a secondary analysis of the LY.12 clinical trial.
Blood advances · 2026
Strengthening Biomarker Research in Canadian Cancer Clinical Trials: A Pathology-Focused White Paper.
Current oncology (Toronto, Ont.) · 2026

All 30 publications

Latest funding

A Phase III Non-Inferiority Randomized Controlled Trial (RCT) of Fixed-Duration Daratumumab Versus Continuous Daratumumab Among Transplant Ineligible Older Adults with Newly-Diagnosed Multiple Myeloma
CIHR · 2023 · Co-investigator
$3,056,172
The TACtful Trial: A first-in-human multi-centre trial of BCMA specific T-cell antigen coupler infusion, generated from cryopreserved G-CSF-mobilized peripheral blood, in patients with relapsed and refractory multiple myeloma.
CIHR · 2023 · Co-investigator
$3,056,176
Digital pathology in support of cancer clinical trials
CFI · 2017 · Co-investigator
$197,065

All 6 grants and awards

30 publications.

Transfer Learning and Machine Learning for Training Five-Year Survival Prognostic Models in Early Breast Cancer: Development and Validation Study

Pilgram L, Yang K, Beltran-Bless A-A, Pond GR, Vandermeer L, Hilton J, Savard M-F, LeBlanc A, Shepherd L, Chen B

Journal of Medical Internet Research20261 citationsOpen Access

DOI: 10.2196/88665

Primary refractory disease in large B-cell lymphoma: definition and outcomes from a secondary analysis of the LY.12 clinical trial.

Gong IY, Kuruvilla J, Prica A, Olney H, Fraser G, Buckstein R, Skrabek P, Keating MM, Hay A, Shepherd L, Chen BE, Crump M

Blood advances20261 citationsOpen Access

DOI: 10.1182/bloodadvances.2025018491 PMID: 41587423

Strengthening Biomarker Research in Canadian Cancer Clinical Trials: A Pathology-Focused White Paper.

Schaeffer DF, Chan J, Morin J, Guiot MC, Yousef GM, Streutker CJ, Sekhon H, Fitzpatrick M, Virk S, Wyatt A, Spatz A, Shepherd L, Loree JM, Kinloch M, CCTG Pathology Working Group

Current oncology (Toronto, Ont.)2026Open Access

DOI: 10.3390/curroncol33060347 PMID: 42346247

Desert Immune Phenotype in Endometrial Carcinoma: A Distinct Subgroup With Poor Prognosis and Targetable Mutations.

Kaya M, Lin LH, Oosting J, Powell ME, Davidson EJ, Leary A, Mileshkin LR, Shepherd L, de Bruyn M, Jobsen J, Kroep JR, Creutzberg CL, Horeweg N, Léon-Castillo A, Parra-Herran C, Smit VTHBM, Nucci MR, Bosse T

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2026

DOI: 10.1016/j.modpat.2026.101000 PMID: 41967711

Sexual Health and Quality of Life in Patients With Low-Risk Early-Stage Cervical Cancer: Results From GCIG/CCTG CX.5/SHAPE Trial Comparing Simple Versus Radical Hysterectomy.

Ferguson SE, Brotto LA, Kwon J, Samouelian V, Ferron G, Maulard A, Kroon C, Driel WV, Tidy J, Williamson K, Mahner S, Kommoss S, Goffin F, Tamussino K, Eyjolfsdottir B, Kim JW, Gleeson N, Tu D, Shepherd L, Plante M

Journal of clinical oncology : official journal of the American Society of Clinical Oncology202530 citationsOpen Access

DOI: 10.1200/jco.24.00440 PMID: 39353164

Prosigna Risk of Recurrence score and intrinsic subtypes are associated with adjuvant anthracycline chemotherapy benefit in high-risk breast cancer

Maj‐Britt Jensen, Torsten O. Nielsen, John M.S. Bartlett, Anne‐Vibeke Lænkholm, Lois E. Shepherd, Bent Ejlertsen

npj Breast Cancer20255 citationsOpen Access

DOI: 10.1038/s41523-025-00738-7 PMID: 40064871

Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer.

Hoppe R, Winter S, Lo WY, Michailidou K, Bolla MK, Keeman R, Wang Q, Dennis J, Lush M, Kalari KR, Goetz MP, Wang L, Cairns J, Weinshilboum R, Shepherd L, Chen BE, Häberle L, Ruebner M, Beckmann MW, He W, Larson NL, Armasu SM, Schroth W, Chowbay B, Khor CC, Abubakar M, Antoniou AC, Brüning T, Castelao JE, Chang-Claude J, Nbcs Collaborators, Dörk T, Eccles DM, Figueroa JD, Gago-Dominguez M, García-Sáenz JA, Gündert M, Hack CC, Hamann U, Han S, Hooning MJ, Huebner H, Abctb Investigators, John EM, Ko YD, Kristensen VN, Linn S, Margolin S, Mavroudis D, Nevanlinna H, Neven P, Obi N, Park-Simon TW, Pylkäs K, Rashid MU, Romero A, Saloustros E, Sawyer EJ, Tapper WJ, Tomlinson I, Wendt C, Winqvist R, Dunning AM, Simard J, Hall P, Pharoah PDP, Schwab M, Couch FJ, Czene K, Fasching PA, Easton DF, Schmidt MK, Ingle JN, Brauch H

NPJ breast cancer20251 citationsOpen Access

DOI: 10.1038/s41523-025-00733-y PMID: 39971965

Evaluating the Utility and Privacy of Synthetic Breast Cancer Clinical Trial Data Sets

Kababji SE, Mitsakakis N, Fang X, Beltran-Bless A-A, Pond G, Vandermeer L, Radhakrishnan D, Mosquera L, Paterson A, Shepherd L

JCO clinical cancer informatics202330 citationsOpen Access

DOI: 10.1200/cci.23.00116 PMID: W4389061858

Health-related quality of life in early-stage Hodgkin lymphoma: a longitudinal analysis of the ABVD arm in the randomized controlled trial HD.6

Mian H, Ringash J, Meyer R, Hay AE, Shepherd L, Djurfeldt M, Winter JN, Sussman J, Pater J, Chen BE

Supportive Care in Cancer20233 citations

DOI: 10.1007/s00520-023-07717-3

Impact of BMI in Patients With Early Hormone Receptor-Positive Breast Cancer Receiving Endocrine Therapy With or Without Palbociclib in the PALLAS Trial.

Pfeiler G, Hlauschek D, Mayer EL, Deutschmann C, Kacerovsky-Strobl S, Martin M, Meisel JL, Zdenkowski N, Loibl S, Balic M, Park H, Prat A, Isaacs C, Bajetta E, Balko JM, Bellet-Ezquerra M, Bliss J, Burstein H, Cardoso F, Fohler H, Foukakis T, Gelmon KA, Goetz M, Haddad TC, Iwata H, Jassem J, Lee SC, Linderholm B, Los M, Mamounas EP, Miller KD, Morris PG, Munzone E, Gal-Yam EN, Ring A, Shepherd L, Singer C, Thomssen C, Tseng LM, Valagussa P, Winer EP, Wolff AC, Zoppoli G, Machacek-Link J, Schurmans C, Huang X, Gauthier E, Fesl C, Dueck AC, DeMichele A, Gnant M, PALLAS Groups and Investigators

Journal of clinical oncology : official journal of the American Society of Clinical Oncology2023

DOI: 10.1200/jco.23.00126 PMID: 37556775

A Phase III Non-Inferiority Randomized Controlled Trial (RCT) of Fixed-Duration Daratumumab Versus Continuous Daratumumab Among Transplant Ineligible Older Adults with Newly-Diagnosed Multiple Myeloma

Co-investigatorCIHR2023Project Grant

Principal investigators: Hay, Annette; Mian, Hira

Keywords: De-Escalation; Economic Analysis; Multiple Myeloma; Quality Of Life; Randomized Phase Iii Trial

$3,056,172

The TACtful Trial: A first-in-human multi-centre trial of BCMA specific T-cell antigen coupler infusion, generated from cryopreserved G-CSF-mobilized peripheral blood, in patients with relapsed and refractory multiple myeloma.

Co-investigatorCIHR2023Project Grant

Principal investigators: Hay, Annette; Bramson, Jonathan L; Delisle, Jean-Sébastien; Leblanc, Richard; Quizi, Jennifer L

Keywords: Biomanufacturing; Cancer; Cell Therapy; Clinical Trial; First-In-Human; Immunotherapy; Multiple Myeloma; Relapsed And Refractory; Synthetic Androgen Receptor

$3,056,176

Digital pathology in support of cancer clinical trials

Co-investigatorCFI2017John R. Evans Leaders Fund: John R. Evans Leaders Fund – Funding for research infrastructure

Principal investigators: Dancey, Janet

Keywords: cancer, clinical trials, biomarkers, digital pathology, personalized medicine, oncology scanner, digital pathology, histology, immunofluorescence, image analysis

$197,065

Future NCIC Clinical Trials Group Activities in Oncologic Translational Research Addressing Strategies in Personalized Medicine

Co-investigatorCIHR2011Planning Grants - Priority Announcement: Cancer Research

Principal investigators: Meyer, Ralph M

Keywords: Biomarkers; Cancer; Randomized Controlled Trials; Translational Research

$24,525

Canadian Tumour Repository Network (CTRNet)

Co-investigatorCIHR2010Canadian Tissue Repository Network Grant

Principal investigators: Schacter, Brent A; Mes-Masson, Anne-Marie; Watson, Peter H

Keywords: Biobanking; Biomarkers; Information Management Systems; Quality Assurance; Translational Cancer Research

$2,500,000

The Terry Fox Foundation Training Program in Transdiciplinary Cancer Research at CIHR

Co-investigatorCIHR2008Terry Fox Foundation Training Grant in Cancer Research at CIHR -Full application

Principal investigators: Mulligan, Lois M

Keywords: Cancer; Cancer Control; Drug Development Fellowships; Graduate Students; Post Doctoral Fellows; Post Md-Fellows; Training Program; Transdisciplinary Research

$1,650,000

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Lois Shepherd

Research

Latest papers

Latest funding

Transfer Learning and Machine Learning for Training Five-Year Survival Prognostic Models in Early Breast Cancer: Development and Validation Study

Primary refractory disease in large B-cell lymphoma: definition and outcomes from a secondary analysis of the LY.12 clinical trial.

Strengthening Biomarker Research in Canadian Cancer Clinical Trials: A Pathology-Focused White Paper.

Desert Immune Phenotype in Endometrial Carcinoma: A Distinct Subgroup With Poor Prognosis and Targetable Mutations.

Sexual Health and Quality of Life in Patients With Low-Risk Early-Stage Cervical Cancer: Results From GCIG/CCTG CX.5/SHAPE Trial Comparing Simple Versus Radical Hysterectomy.

Prosigna Risk of Recurrence score and intrinsic subtypes are associated with adjuvant anthracycline chemotherapy benefit in high-risk breast cancer

Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer.

Evaluating the Utility and Privacy of Synthetic Breast Cancer Clinical Trial Data Sets

Health-related quality of life in early-stage Hodgkin lymphoma: a longitudinal analysis of the ABVD arm in the randomized controlled trial HD.6

Impact of BMI in Patients With Early Hormone Receptor-Positive Breast Cancer Receiving Endocrine Therapy With or Without Palbociclib in the PALLAS Trial.

A Phase III Non-Inferiority Randomized Controlled Trial (RCT) of Fixed-Duration Daratumumab Versus Continuous Daratumumab Among Transplant Ineligible Older Adults with Newly-Diagnosed Multiple Myeloma

The TACtful Trial: A first-in-human multi-centre trial of BCMA specific T-cell antigen coupler infusion, generated from cryopreserved G-CSF-mobilized peripheral blood, in patients with relapsed and refractory multiple myeloma.

Digital pathology in support of cancer clinical trials

Future NCIC Clinical Trials Group Activities in Oncologic Translational Research Addressing Strategies in Personalized Medicine

Canadian Tumour Repository Network (CTRNet)

The Terry Fox Foundation Training Program in Transdiciplinary Cancer Research at CIHR

Frequent collaborators

Bingshu Chen

Annette Hay

Wendy Parulekar

Shakeel Virk

Ralph Meyer

Matthew Cheung

Dongsheng Tu

John Kuruvilla

Melanie Spears

Michael Crump

Samuel Aparicio

Tom Kouroukis

Khaled El Emam

Torsten Nielsen

Mark Norman Levine

Gregory Pond

David Scott

Marie-France Savard

Mark Clemons

Donna Reece

Paul Boutros

Jane Bayani

Katerina Pavenski

Rena Buckstein

Vishal Kukreti

Anca Prica

Jolie Ringash

Vivek Rao

Andréanne Leblanc

Harold Olney

Mark Bosch

Mary Kinloch

Harriet Richardson

Jill Dudebout

Marco Marra

Koren Mann