Faculty profile

Samuel Aparicio

ResearcherMolecular OncologyUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.

Samuel Aparicio

Researcher

Molecular Oncology

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
27 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (12 CIHR), most recently in 2023.
Supervised 3 trainees who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

110

Publications

173

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Cancer Therapeutics Crc Clonal Evolution Genomic Instability Single Cell Analysis Breast Cancer Clonal Genomes

Latest papers

The UVA-induced single-base mutational signature of CX-5461 in human cells.
Nucleic acids research · 2026 · senior author
Evolution of oncogene amplification across 86,000 cancer cell genomes.
bioRxiv : the preprint server for biology · 2026
Single-cell spatial atlas of the aging human breast.
Nature aging · 2026

All 110 publications

Latest funding

Decoding the impact of single cell mutational processes in triple negative breast cancer and high grade serous ovarian cancer
CIHR · 2023 · Nominated PI
$1,040,400
Computational approaches for exploring the spatial dynamics of the cellular ecosystem
CIHR · 2023 · Supervisor
$105,000
Mechanisms and targeting of repair deficient cancers with G-quadruplex small molecule ligands
CIHR · 2023 · Nominated PI
$1,048,050

All 29 grants and awards

110 publications.

The UVA-induced single-base mutational signature of CX-5461 in human cells.

Zaikova E, Yap D, Sarvar A, Hafezi A, Tan J, Cerda V, Li K, Lai D, Gelmon K, Hilton J, Seymour L, Stirling P, Cescon DW, Aparicio S

Nucleic acids research2026Senior author

DOI: 10.1093/nar/gkag836 PMID: 42639791

Evolution of oncogene amplification across 86,000 cancer cell genomes.

Lee JJ, Salehi S, Myers MA, Williams MJ, Yao MA, Al-Rawi DH, Lee J, Sun EG, Thol K, Choi S, Havasov E, Steinberg AP, Wu M, Rusk N, Timmons C, Phua CZJ, Martis S, Mohibullah N, Manoj P, Redin E, Quintanal-Villalonga Á, Razavi P, Aparicio S, Rekhtman N, Tabar V, Awad MM, Yu HA, Yu KKH, Ventura A, McPherson A, Rudin CM, Shah SP

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.02.12.705658 PMID: 41727087

Single-cell spatial atlas of the aging human breast.

Gupta P, Lee E, Masqué Soler N, Schrader E, Wang XQ, Mayer S, Flores C, Beatty S, Roth A, Aparicio S, Ali HR

Nature aging2026

DOI: 10.1038/s43587-026-01104-3 PMID: 41917190

Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER.

Lucas O, Ward S, Zaidi R, Bunkum A, Frankell AM, Moore DA, Hill MS, Liu WK, Marinelli D, Lim EL, Hessey S, Naceur-Lombardelli C, Rowan A, Purewal-Mann SK, Zhai H, Dietzen M, Ding B, Royle G, Aparicio S, TRACERx Consortium, PEACE Consortium, McGranahan N, Jamal-Hanjani M, Kanu N, Swanton C, Zaccaria S

Nature genetics2025

DOI: 10.1038/s41588-024-01989-z PMID: 39614124

Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones.

Nguyen LV, Eyal-Lubling Y, Guerrero-Romero D, Kronheim S, Chin SF, Manzano Garcia R, Sammut SJ, Lerda G, Lui AJW, Bardwell HA, Greenwood W, Shin HJ, Masina R, Kania K, Bruna A, Esmaeilishirazifard E, Kolyvas EA, Aparicio S, Rueda OM, Caldas C

Cell reports2025

DOI: 10.1016/j.celrep.2025.115699 PMID: 40359107

Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells.

Samarasekera G, Go NE, Choutka C, Xu J, Takemon Y, Chan J, Chan M, Perera S, Aparicio S, Morin GB, Marra MA, Chittaranjan S, Gorski SM

PLoS biology2025

DOI: 10.1371/journal.pbio.3003034 PMID: 39982959

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer.

McPherson A, Vázquez-García I, Myers MA, Al-Rawi DH, Zatzman M, Weiner AC, Freeman S, Mohibullah N, Satas G, Williams MJ, Ceglia N, Norkūnaitė D, Zhang AW, Li J, Lim JLP, Wu M, Choi S, Havasov E, Grewal D, Shi H, Kim M, Schwarz RF, Kaufmann T, Dinh KN, Uhlitz F, Tran J, Wu Y, Patel R, Ramakrishnan S, Kim D, Clarke J, Green H, Ali E, DiBona M, Varice N, Kundra R, Broach V, Gardner GJ, Roche KL, Sonoda Y, Zivanovic O, Kim SH, Grisham RN, Liu YL, Viale A, Rusk N, Lakhman Y, Ellenson LH, Tavaré S, Aparicio S, Chi DS, Aghajanian C, Abu-Rustum NR, Friedman CF, Zamarin D, Weigelt B, Bakhoum SF, Shah SP

Nature2025

DOI: 10.1038/s41586-025-09240-3 PMID: 40670783

The Somatic Mosaicism across Human Tissues Network.

Coorens THH, Oh JW, Choi YA, Lim NS, Zhao B, Voshall A, Abyzov A, Antonacci-Fulton L, Aparicio S, Ardlie KG, Bell TJ, Bennett JT, Bernstein BE, Blanchard TG, Boyle AP, Buenrostro JD, Burns KH, Chen F, Chen R, Choudhury S, Doddapaneni HV, Eichler EE, Evrony GD, Faith MA, Fazzio TG, Fulton RS, Garber M, Gehlenborg N, Germer S, Getz G, Gibbs RA, Hernandez RG, Jin F, Korbel JO, Landau DA, Lawson HA, Lennon NJ, Li H, Li Y, Loh PR, Marth G, McConnell MJ, Mills RE, Montgomery SB, Natarajan P, Park PJ, Satija R, Sedlazeck FJ, Shao DD, Shen H, Stergachis AB, Underhill HR, Urban AE, VonDran MW, Walsh CA, Wang T, Wu TP, Zong C, Lee EA, Vaccarino FM, Somatic Mosaicism across Human Tissues Network

Nature2025

DOI: 10.1038/s41586-025-09096-7 PMID: 40604182

Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers.

Kabeer F, Tran H, Andronescu M, Singh G, Lee H, Salehi S, Wang B, Biele J, Brimhall J, Gee D, Cerda V, O'Flanagan C, Algara T, Kono T, Beatty S, Zaikova E, Lai D, Lee E, Moore R, Mungall AJ, IMAXT Consortium, Williams MJ, Roth A, Campbell KR, Shah SP, Aparicio S

Genome biology2024

DOI: 10.1186/s13059-024-03318-3 PMID: 39026273

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.

Williams MJ, Oliphant MUJ, Au V, Liu C, Baril C, O'Flanagan C, Lai D, Beatty S, Van Vliet M, Yiu JC, O'Connor L, Goh WL, Pollaci A, Weiner AC, Grewal D, McPherson A, Norton K, Moore M, Prabhakar V, Agarwal S, Garber JE, Dillon DA, Shah SP, Brugge JS, Aparicio S

Nature genetics2024Senior author

DOI: 10.1038/s41588-024-01988-0 PMID: 39567747

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Samuel Aparicio

Research

Latest papers

Latest funding

The UVA-induced single-base mutational signature of CX-5461 in human cells.

Evolution of oncogene amplification across 86,000 cancer cell genomes.

Single-cell spatial atlas of the aging human breast.

Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER.

Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones.

Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells.

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer.

The Somatic Mosaicism across Human Tissues Network.

Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers.

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.

Frequent collaborators

Martin Hirst

Ali Bashashati

David Huntsman

Adi Steif

Sohrab Shah

Jiarui Ding

Steven Jones

Christian Steidl

Peter Watson

Anne-Marie Mes-Masson

Leigh Murphy

Inanc Birol

John Hilton

Marco Marra

Lesley Seymour

Jason Wong

Carl Hansen

Aly Karsan

Connie Eaves

James Piret

Peter Stirling

Helen McNeill

Morag Park

Kasmintan Schrader

ATILLA Omeroglu

Kevin Petrecca

Kuo-Shyan Lin

Yuzhuo Wang

Wan Lam

Timothy Whelan