Ryan Alkins, Queen's University

Research

Adeno-Associated Virus Creatine Creatine Transporter Focused Ultrasound

Latest papers

Disparities in Care in Adult Glioblastoma: A Comprehensive Narrative Review.
World neurosurgery · 2026 · senior author
A Primary CNS Sarcoma of the Spinal Cord with DICER1 Mutation: Expanding the Spectrum of DICER1-Driven CNS Sarcomas.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2025 · senior author
Prognostic and predictive determinants in high-grade gliomas: integrating tumor-intrinsic biology with patient and system-level factors.
Frontiers in neurology · 2025 · senior author

All 17 publications

Latest funding

Optimizing dosage and CTA-Enabling Pre-clinical Gene Therapy Studies for Creatine Transporter Deficiency
CIHR · 2023 · Principal investigator
Ultrasound and microbubble enhanced cellular immunotherapy of brain tumours
SSHRC · 2022 · Principal investigator
$125,000
Ultrasound and microbubble enhanced cellular immunotherapy of brain tumours
SSHRC · 2022 · Principal investigator
$125,000

All 3 grants and awards

17 publications.

01

Disparities in Care in Adult Glioblastoma: A Comprehensive Narrative Review.

Davalan W, Alkins R

World neurosurgery2026Senior author

DOI: 10.1016/j.wneu.2026.124992 PMID: 41997291

02

A Primary CNS Sarcoma of the Spinal Cord with DICER1 Mutation: Expanding the Spectrum of DICER1-Driven CNS Sarcomas.

Pasarikovski CR, Davalan W, Rossiter JP, Alkins R

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2025Senior author

DOI: 10.1017/cjn.2025.10489 PMID: 41382284

03

Prognostic and predictive determinants in high-grade gliomas: integrating tumor-intrinsic biology with patient and system-level factors.

Davalan W, Alkins R

Frontiers in neurology2025Senior author

DOI: 10.3389/fneur.2025.1664458 PMID: 41346390

04

End-of-life care in glioblastoma: A population-based study.

Ellenbogen Y, Taslimi S, Shellenberger J, Brogly SB, Zadeh G, Alkins R

Neuro-oncology2025Senior author

DOI: 10.1093/neuonc/noaf043 PMID: 39969219

05

Development of Patient-Specific 3-Dimensional Graphical Entry-Point Maps for External Ventricular Drain Insertion.

Beaulieu K, Alkins R, Ellis RE

World neurosurgery2025

DOI: 10.1016/j.wneu.2025.124046 PMID: 40345382

06

Shear Stress and Microbubble-Mediated Modulation of Endothelial Cell Immunobiology.

Memari E, Singh D, Alkins R, Helfield B

Small science2025

DOI: 10.1002/smsc.202400489 PMID: 40657183

07

A Population-Based Cohort Study of Glioblastoma (World Health Organization Grade 4 Gliomas) in Ontario: Continued Improvement in Care over 25 Years.

Taslimi S, Brogly S, Hanna TP, Shellenberger J, Whitehead M, Alkins R

World neurosurgery2025Senior author

DOI: 10.1016/j.wneu.2025.123821 PMID: 39987972

08

Developmental Venous Anomaly Thrombosis Presenting with Intracerebral Hemorrhage.

Alkins R, Davalan W, Hughes A, Tampieri D

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2025First author

DOI: 10.1017/cjn.2025.46 PMID: 40078157

09

Prophylaxis for venous thromboembolism in traumatic brain injury: protocol for a randomised controlled trial

Pirouzmand F, Mathieu F, Mansouri A, Kavikondala K, Alkins R, Boyd JG, Christie S, Couillard P, Cusimano MD, Engels PT

BMJ Open2025

DOI: 10.1136/bmjopen-2025-114158

10

Focused ultrasound-assisted delivery of immunomodulating agents in brain cancer.

Memari E, Khan D, Alkins R, Helfield B

Journal of controlled release : official journal of the Controlled Release Society2024

DOI: 10.1016/j.jconrel.2024.01.034 PMID: 38266715

Optimizing dosage and CTA-Enabling Pre-clinical Gene Therapy Studies for Creatine Transporter Deficiency

Principal investigatorCIHR2023Op. Grant :Bringing Rare Disease Gene Therapies to Clinical Trial Readiness- LOI

Principal investigators: Walia, Jagdeep S; Trutoiu, Laura; Alkins, Ryan D

Keywords: Adeno-Associated Virus; Creatine; Creatine Transporter; Focused Ultrasound

Ultrasound and microbubble enhanced cellular immunotherapy of brain tumours

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Alkins, Ryan

Keywords: Therapeutic ultrasound ultrasound contrast agents ultrasound biophysics experimental cancer therapy glioblastoma brain tumours

$125,000

Ultrasound and microbubble enhanced cellular immunotherapy of brain tumours

Principal investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Alkins, Ryan

Keywords: Therapeutic ultrasound; ultrasound contrast agents; ultrasound biophysics; experimental cancer therapy; glioblastoma; brain tumours

$125,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Adeno-Associated Virus Dear Professor Alkins, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Disparities in Care in Adult Glioblastoma: A Comprehensive Narrative Review." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Optimizing dosage and CTA-Enabling Pre-clinical Gene Therapy Studies for Creatine Transporter Deficiency" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Ryan Alkins

Research

Latest papers

Latest funding

Disparities in Care in Adult Glioblastoma: A Comprehensive Narrative Review.

A Primary CNS Sarcoma of the Spinal Cord with DICER1 Mutation: Expanding the Spectrum of DICER1-Driven CNS Sarcomas.

Prognostic and predictive determinants in high-grade gliomas: integrating tumor-intrinsic biology with patient and system-level factors.

End-of-life care in glioblastoma: A population-based study.

Development of Patient-Specific 3-Dimensional Graphical Entry-Point Maps for External Ventricular Drain Insertion.

Shear Stress and Microbubble-Mediated Modulation of Endothelial Cell Immunobiology.

A Population-Based Cohort Study of Glioblastoma (World Health Organization Grade 4 Gliomas) in Ontario: Continued Improvement in Care over 25 Years.

Developmental Venous Anomaly Thrombosis Presenting with Intracerebral Hemorrhage.

Prophylaxis for venous thromboembolism in traumatic brain injury: protocol for a randomised controlled trial

Focused ultrasound-assisted delivery of immunomodulating agents in brain cancer.

Optimizing dosage and CTA-Enabling Pre-clinical Gene Therapy Studies for Creatine Transporter Deficiency

Ultrasound and microbubble enhanced cellular immunotherapy of brain tumours

Ultrasound and microbubble enhanced cellular immunotherapy of brain tumours

Frequent collaborators

Brandon Helfield

Susan Brogly

Teresa Purzner

James Purzner

Eve Tsai

Francois Mathieu

Paul Engels

Gelareh Zadeh

Robert Fowler

François Lauzier

Donald Griesdale

Kullervo Hynynen

Shane English

FARHAD Pirouzmand

Sean Christie

Rajiv Midha

Chinthaka Heyn

Maureen Trudeau

Mypinder Sekhon

Nir Lipsman

Pejman Jabehdar Maralani

Arjun Sahgal

Pejman Jabehdar Maralani

Sunjay Sharma

Ying Meng