Faculty profile

Kullervo Hynynen

ResearcherMedical BiophysicsUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Kullervo Hynynen

Researcher

Medical Biophysics

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
53 publications in the last five years, latest in 2026.
Senior (last) author on 19 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2026.
Supervisor on 3 trainee awards (3 CIHR), most recently in 2015.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

229

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Ultrasound 7t Magnetic Resonance Imaging Blood-Brain Barrier Cerebral Blood Flow Focused Ultrasound High-Grade Gliomas Microvasculature Passive Cavitation Imaging

Latest papers

Multi-target focused ultrasound neuromodulation of a subcallosal cingulate mediated depression network: A case study using personalized functional mapping.
Brain stimulation · 2026
How can we best utilize magnetic resonance for microbubble-mediated drug delivery to the brain.
Expert opinion on drug delivery · 2026 · senior author
The modulation of the blood-brain barrier by focused ultrasound stimulates oligodendrogenesis.
Acta neuropathologica communications · 2026

All 229 publications

Latest funding

Network-Guided Focused Ultrasound Neuromodulation for Treatment-Resistant Depression
CIHR · 2026 · Co-investigator
$550,800
Cavitation enhanced chemoimmunotherapy in a triple negative breast cancer setting
CIHR · 2026 · Co-investigator
$761,176
A personalized approach to focused ultrasound-induced blood-brain barrier opening using 7T MRI in patients with high-grade gliomas
CIHR · 2026 · Principal investigator
$382,500

All 35 grants and awards

From the 150 most recent of 229 publications.

Multi-target focused ultrasound neuromodulation of a subcallosal cingulate mediated depression network: A case study using personalized functional mapping.

Davidson B, Jones RM, McMahon D, Xhima K, Bocca LF, Huang Y, Blanco S, Pople CB, Giacobbe P, Nestor SM, Rabin JS, Hamani C, Uludag K, Goubran M, Hynynen K, Lipsman N

Brain stimulation2026

DOI: 10.1016/j.brs.2026.103198 PMID: 42692166

How can we best utilize magnetic resonance for microbubble-mediated drug delivery to the brain.

Huang Y, Hynynen K

Expert opinion on drug delivery2026Senior author

DOI: 10.1080/17425247.2026.2711975 PMID: 42536357

The modulation of the blood-brain barrier by focused ultrasound stimulates oligodendrogenesis.

Noseworthy K, Silburt J, Apa A, Rubio-Atonal LF, Wu SK, Schuurmans C, Hynynen K, Aubert I

Acta neuropathologica communications2026

DOI: 10.1186/s40478-026-02364-1 PMID: 42436585

Parametric optimization of transcranial focused ultrasound neuromodulation of the periaqueductal grey for blood pressure reduction.

Lea-Banks H, Chauhan N, Kim O, Rabelo T, Wu SK, Hamani C, Hynynen K

Brain stimulation2026Senior author

DOI: 10.1016/j.brs.2026.103146 PMID: 42331055

Anti-focus driving signals to mitigate bone heating during focused ultrasound ablation of uterine fibroids with phased arrays.

Sadeghi-Goughari M, Jones RM, Hynynen K

Physics in medicine and biology2026Senior author

DOI: 10.1088/1361-6560/ae7248 PMID: 42173149

Focused ultrasound in pediatric neuro-oncology: Current applications and future directions.

Lin C, Llinas M, Lipsman N, Krumholtz S, Mithani K, Hynynen K, Rutka J

Neuro-oncology advances2026

DOI: 10.1093/noajnl/vdaf019 PMID: 42281805

Focused Ultrasound Treatment of Vitreous Hemorrhage in an In Vivo Rabbit Model.

Yau GL, Ning B, Hu C, Hynynen K

Ophthalmology science2026Senior author

DOI: 10.1016/j.xops.2026.101188 PMID: 42111620

Histotripsy of Blood Clots within Hollow Cylindrical Transducers for Aspiration Thrombectomy Applications.

Gong L, Wright AR, Hynynen K, Goertz DE

Ultrasound in medicine & biology2026

DOI: 10.1016/j.ultrasmedbio.2026.02.016 PMID: 41850958

Acute Effects of Cavitation-based Focused Ultrasound on Vitreous Hemorrhage: A Preclinical Study.

Ning B, Hu C, Hynynen K, Yau GL

Ultrasound in medicine & biology2026

DOI: 10.1016/j.ultrasmedbio.2026.07.012 PMID: 42624730

Focused ultrasound expands intra-CSF AAV delivery to deep brain regions in rats and non-human primates.

Kofoed RH, Elmer B, Noseworthy K, Ardinger J, Wu K, Wischhof E, Vecchio LM, Mahendran TA, Dibia CL, Koch H, Chou SC, Sivadas S, Bu J, Wu SK, McMahon D, Mikloska K, White M, Ramachandran S, Hynynen K, Mueller C, Aubert I

Molecular therapy : the journal of the American Society of Gene Therapy2026

DOI: 10.1016/j.ymthe.2026.02.021 PMID: 41691370

Network-Guided Focused Ultrasound Neuromodulation for Treatment-Resistant Depression

Co-investigatorCIHR2026Project Grant

Principal investigators: Davidson, Benjamin; Lipsman, Nir

Keywords: Clinical Neuroscience; Focused Ultrasound; Magnetic Resonance Imaging; Major Depressive Disorder; Mri-Guided Intervention; Neuromodulation; Non-Invasive Brain Stimulation; Treatment-Resistant Depression

$550,800

Cavitation enhanced chemoimmunotherapy in a triple negative breast cancer setting

Co-investigatorCIHR2026Project Grant

Principal investigators: Goertz, David E

Keywords: Breast Cancer; Cavitation; Chemotherapy; Focused Ultrasound; Immunotherapy; Microbubbles; Ultrasound

$761,176

A personalized approach to focused ultrasound-induced blood-brain barrier opening using 7T MRI in patients with high-grade gliomas

Principal investigatorCIHR2026Project Grant

Principal investigators: Meng, Ying; Hynynen, Kullervo H; Uludag, Kamil

Keywords: 7t Magnetic Resonance Imaging; Blood-Brain Barrier; Cerebral Blood Flow; Focused Ultrasound; High-Grade Gliomas; Microvasculature; Passive Cavitation Imaging

$382,500

Immune and Targeted Therapeutic Interception of DIPG with Enhanced Delivery Strategies

Co-investigatorCIHR2025Project Grant

Principal investigators: Rutka, James T

Keywords: Brain Tumour; Focused Ultrasound; Immune Checkpoint Inhibitor; Immunomodulation; Immunotherapy; Molecular Profiling; Molecular Stratification; Paediatric; Pontine Glioma; Small Molecule Therapeutic

$833,850

Focused Ultrasound for Vitreous Hemorrhage: Preclinical Evaluation of Safety, Efficacy, and Mechanism of Action

Co-investigatorCIHR2025Project Grant

Principal investigators: Yau, Gary

Keywords: Commercialization; Focused Ultrasound; Medical Device; Vitreous Hemorrhage

$596,700

Focused ultrasound-mediated regenerative strategies for Alzheimer's disease

Co-investigatorCIHR2024Project Grant

Principal investigators: Aubert, Isabelle

Keywords: Alzheimer Disease; Brain Plasticity; Focused Ultrasound; Gene Therapy; Neurogenesis; Non-Invasive Delivery To The Brain; Oligodendrogenesis; Regeneration

$1,290,555

Development of a novel catheter based ultrasound device and methods for enhancing aspiration mechanical thrombectomies in acute stroke

Co-investigatorCIHR2024Project Grant

Principal investigators: Goertz, David E

Keywords: Catheter, Transducer; Cavitation, Histotripsy; Mechanical Thrombectomy; Stroke; Therapeutic Ultrasound

$726,750

Lab2Market: Canada’s National Network for Innovation, Commercialization and Entrepreneurship Skills Training of Students, Researchers and Highly Qualified Persons

Co-investigatorNSERC2023Lab to Market grants

Principal investigators: Larsen, Jeff

Keywords: Research Commercialization; Entrepreneurial Training; Research-based Startups; Innovation Training; Inclusive Innovation

$2,297,316

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Schuurmans, Carol

Keywords: neurodegenerative disease,; Alzheimer's disease; direct neuronal reprogramming; transcription factors; gene regulatory networks ; computer-guided design; nanoparticles; epigenomics ; neurological disorders; self-amplifying RNA; bacteriophage; astrocytes; stroke; epilepsy; focused ultrasound

$8,000,000

Establishment of a drug discovery and delivery platform for diffuse intrinsic pontine glioma (DIPG).

Co-investigatorCIHR2022Project Grant

Principal investigators: Rutka, James T

Keywords: Brain Tumour; Cancer; Drug Discovery; Focused Ultrasound; Molecular Profiling; Molecular Stratification; Paediatric; Pontine Glioma; Small Molecule Therapeutic

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Ultrasound Dear Professor Hynynen, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Multi-target focused ultrasound neuromodulation of a subcallosal cingulate mediated depression network: A case study using personalized functional mapping." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "A personalized approach to focused ultrasound-induced blood-brain barrier opening using 7T MRI in patients with high-grade gliomas" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Kullervo Hynynen

Research

Latest papers

Latest funding

Multi-target focused ultrasound neuromodulation of a subcallosal cingulate mediated depression network: A case study using personalized functional mapping.

How can we best utilize magnetic resonance for microbubble-mediated drug delivery to the brain.

The modulation of the blood-brain barrier by focused ultrasound stimulates oligodendrogenesis.

Parametric optimization of transcranial focused ultrasound neuromodulation of the periaqueductal grey for blood pressure reduction.

Anti-focus driving signals to mitigate bone heating during focused ultrasound ablation of uterine fibroids with phased arrays.

Focused ultrasound in pediatric neuro-oncology: Current applications and future directions.

Focused Ultrasound Treatment of Vitreous Hemorrhage in an In Vivo Rabbit Model.

Histotripsy of Blood Clots within Hollow Cylindrical Transducers for Aspiration Thrombectomy Applications.

Acute Effects of Cavitation-based Focused Ultrasound on Vitreous Hemorrhage: A Preclinical Study.

Focused ultrasound expands intra-CSF AAV delivery to deep brain regions in rats and non-human primates.

Lab2Market: Canada’s National Network for Innovation, Commercialization and Entrepreneurship Skills Training of Students, Researchers and Highly Qualified Persons

A pipeline approach for the rational design of neuronal lineage conversion approaches to treat neurological disorders

Frequent collaborators

Nir Lipsman

Isabelle Aubert

Ying Meng

Clement Hamani

Benjamin Davidson

Maged Goubran

Arjun Sahgal

Chinthaka Heyn

Alexandre Boutet

Alfonso Fasano

Peter Giacobbe

Meaghan O'Reilly

Gregory Czarnota

Bojana Stefanovic

Joanne McLaurin

Gregory Czarnota

Carol Schuurmans

James Rutka

Maureen Trudeau

Julie Ottoy

Robert Kerbel

Jurgen Germann

Anthony Levitt

David Goertz

Mojgan Hodaie

Jackek Michael Kwiecien

Christine Allen

Michael Chan

Cari Whyne

Laura Curiel

Lothar Lilge

Mallar Chakravarty

Robert Chen

Gang Zheng

Mario Masellis

Sandra Black

Cynthia Hawkins

Nathan Herrmann

Jean Gariepy

James Drake