Nina Jones, University of Guelph

Research

Cancer Metastasis Signal Transduction Actin Cytoskeleton Podocyte Biochemistry Cell Biology Genetics

Latest papers

Deletion of Adaptor Protein ShcD Impairs Olfactory Bulb Morphology and Function.
Molecular and cellular biology · 2026 · senior author
ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling.
Molecular oncology · 2025 · senior author
Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease.
iScience · 2025 · senior author

All 37 publications

Latest funding

Conference on Signalling in Normal and Cancer Cells 2025
CIHR · 2024 · Nominated PI
$10,000
Exploring molecular and cellular mechanisms of podocyte adhesion in kidney health and disease
CIHR · 2023 · Nominated PI
$879,750
Canada Research Chair - Tier 1
CIHR · 2023 · Nominated PI
$1,400,000

All 35 grants and awards

37 publications.

01

Deletion of Adaptor Protein ShcD Impairs Olfactory Bulb Morphology and Function.

Robeson HN, New LA, Alural B, Clausen C, Ervin KSJ, Yang H, Cooper CJ, Choleris E, Lalonde J, Jones N

Molecular and cellular biology2026Senior author

DOI: 10.1080/10985549.2025.2567559 PMID: 41392689

02

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling.

Lau HR, Smith HS, Alural B, Martin CE, New LA, Tilak M, Banerjee SL, Robeson HN, Bisson N, Gingras AC, Lalonde J, Jones N

Molecular oncology2025Senior author

DOI: 10.1002/1878-0261.70022 PMID: 40152177

03

Reduced nephrin tyrosine phosphorylation impairs podocyte force transmission and accelerates detachment in disease.

Williamson CR, Martin CE, Kumar JD, Lu P, New LA, Wang AY, Kronenberg NM, Gather MC, Reynolds PA, Jones N

iScience2025Senior author

DOI: 10.1016/j.isci.2025.112673 PMID: 40510123

04

Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyte.

Williamson CR, Pantic UV, Wang AY, Jones N

The Biochemical journal2025Senior author

DOI: 10.1042/bcj20230234 PMID: 40457651

05

TccP4: a novel effector identified in the Escherichia albertii strain 1551-2 required for attaching and effacing lesion formation on infected Nck-null cells.

Fernandes IdA, Ooka T, de Lira DRP, Martins FH, Orsi H, Jones N, Elias WP, Hayashi T, Gomes TAT, Hernandes RT

Microbiology spectrum2025

DOI: 10.1128/spectrum.02055-24 PMID: 39878470

06

Adapting to change: resolving the dynamic and dual roles of NCK1 and NCK2.

Teyssier V, Williamson CR, Shata E, Rosen SP, Jones N, Bisson N

The Biochemical journal2024

DOI: 10.1042/bcj20230232 PMID: 39392452

07

Reduced Nephrin Tyrosine Phosphorylation Enhances Insulin Secretion and Increases Glucose Tolerance With Age.

Williamson CR, Jones N

Endocrinology2024Senior author

DOI: 10.1210/endocr/bqae078 PMID: 38954536

08

Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation.

Hewitt T, Alural B, Tilak M, Wang J, Becke N, Chartley E, Perreault M, Haggarty SJ, Sheridan SD, Perlis RH, Jones N, Mellios N, Lalonde J

Molecular psychiatry2023

DOI: 10.1038/s41380-023-02152-6 PMID: 37402854

09

Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development.

Golding AP, Ferrier B, New LA, Lu P, Martin CE, Shata E, Jones RA, Moorehead RA, Jones N

Journal of mammary gland biology and neoplasia2023Senior author

DOI: 10.1007/s10911-023-09541-1 PMID: 37479911

10

Sex Differences in Glomerular Protein Expression and Effects of Soy-Based Diet on Podocyte Signaling.

Mahesaniya A, Williamson CR, Keyvani Chahi A, Martin CE, Mitro AE, Lu P, New LA, Watson KL, Moorehead RA, Jones N

Canadian journal of kidney health and disease2022Senior author

DOI: 10.1177/20543581221121636 PMID: 36199279

Conference on Signalling in Normal and Cancer Cells 2025

Nominated PICIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Jones, Nina

Keywords: Cancer; Cell Signaling; Metastasis; Precision Oncology

$10,000

Exploring molecular and cellular mechanisms of podocyte adhesion in kidney health and disease

Nominated PICIHR2023Project Grant

Principal investigators: Jones, Nina

Keywords: Actin Cytoskeleton; Cell Adhesion; Cell Culture; Kidney; Kidney Disease; Knockout Mice; Mass Spectrometry; Podocyte

$879,750

Canada Research Chair - Tier 1

Nominated PICIHR2023Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Jones, Nina

Keywords: Crc

$1,400,000

Signaling mechanisms of the ShcD adaptor protein

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Jones, Nina

Keywords: adaptor proteins; cell biology; eukaryotic signal transduction; male reproductive system; molecular biology; mouse development and genetics; neuroscience; protein-protein interactions; receptor tyrosine kinases; tyrosine phosphorylation

$104,000

Kidney Research Scientist Core Education and Training Program 2.0

Co-investigatorCIHR2021Tr. Gr: Health Research Training Platform - Nutrition, Metabolism and Diabetes

Principal investigators: Alexander, Robert T; Beaucage, Mary B; Burns, Kevin D; Farragher, Janine; Hartwig, Sunny; Ho, Julie; King, Malcolm; Konvalinka, Ana; Levin, Adeera; Madore, François; Pandeya, Sanjay; Schick-Makaroff, Kara L; Stalker, Leanne; Tennankore, Karthik K

Keywords: Training Grant All Pillars

$2,399,987

Control of neuron growth and depressive-like behavior by adaptor protein ShcD.

SupervisorCIHR2021CIHR Fellowship

Principal investigators: Alural, Begum

Keywords: Behavioural Neuroscience; Cerebral Organoids; Depression; Molecular Neuroscience; Neurodevelopment; Neurogenesis; Sex Differences; Stress

$135,000

Investigating the role of ShcD signaling in metastatic breast cancer

Nominated PICIHR2021CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Jones, Nina

Keywords: Metastasis; Oncogenes; Suppressors; Tumour; Tumour Progression And Metastasis

$60,000

Measuring the influence of biomechanical forces on biological processes.

Principal investigatorNSERC2020Research Tools and Instruments

Principal investigators: Jones, Nina

$74,128

Investigating the role of Nck signaling in breast epithelial cell invasion and metastasis

Nominated PICIHR2019Project Grant

Principal investigators: Jones, Nina

Keywords: Adaptor Proteins; Breast Cancer; Cytoskeleton; Discovery Research; Focal Adhesions; Genetically Modified Mice; Metastasis; Model Organism; Signal Transduction; Tyrosine Kinases

$879,750

12th Conference on Signalling in Normal and Cancer Cells

Nominated PICIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Jones, Nina

Keywords: Biochemistry; Cancer; Cell Biology; Genetics; Signal Transduction

$10,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Molecular and Cellular Biology
Medicine/Nephrology
Medicine
Department of Molecular Genetics
Nephrology
Department of Medicine
Internal Medicine
Other

Co-authors at University of Guelph, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Jasmin Lalonde

Molecular and Cellular Biology

6 shared papers, latest 2026

Tomoko Takano

Medicine/Nephrology

5 shared papers, latest 2022

Nicolas Bisson

Faculty

4 shared papers, latest 2025

Anne-Claude Gingras

Department of Molecular Genetics

2 shared papers, latest 2025

Kevin Burns

Department of Medicine

1 shared papers, latest 2022

Melissa Perreault

Molecular and Cellular Biology

1 shared papers, latest 2023

Nancy Verdin

Medicine/Nephrology

1 shared papers, latest 2022

Pedro Geraldes

Medicine

1 shared papers, latest 2015

Sunny Hartwig

Biomedical Sciences

1 shared papers, latest 2022

Susan Samuel

Pediatrics

1 shared papers, latest 2022

Pietro Ravani

Community Health Sciences

1 shared papers, latest 2022

Catherine Clase

Medicine

1 shared papers, latest 2022

Adeera Levin

Nephrology

1 shared papers, latest 2022

James Scholey

Medicine/Nephrology

1 shared papers, latest 2022

Navdeep Tangri

Internal Medicine

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Cancer Dear Professor Jones, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Deletion of Adaptor Protein ShcD Impairs Olfactory Bulb Morphology and Function." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Conference on Signalling in Normal and Cancer Cells 2025" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]