Fraser Rubens, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Acute Coronary Syndromes Antiplatelet Therapy Coronary Artery Bypass Surgery Platelet Function Ticagrelor

Latest papers

Preoperative Iron-Deficiency Anemia and Survival After Cardiac Surgery: A Retrospective Cohort Study.
Journal of cardiothoracic and vascular anesthesia · 2026
Intra-institutional use of positive deviancy in surgical infections in isolated coronary bypass.
Infection control and hospital epidemiology · 2026 · first author
Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation.
Theranostics · 2026

All 37 publications

Latest funding

Reassessment of Anti-Platelet therapy using InDividualized Strategies -Ticagrelor in Patients with Acute Coronary Syndromes Treated by Coronary Artery Bypass Graft Surgery - A Pharmacodynamic and Clinical Study to Decrease Bleeding Risks and Ischemic Complications - The RAPID-TITRATE CABG study
CIHR · 2015 · Principal investigator
$512,179
Transfusion Requirement in Cardiac Surgery III (TRICS III)
CIHR · 2013 · Co-investigator
$3,323,110
Transfusion Requirements in Cardaic Surgery II (TRICSII)
CIHR · 2010 · Co-investigator
$293,728

All 4 grants and awards

37 publications.

01

Preoperative Iron-Deficiency Anemia and Survival After Cardiac Surgery: A Retrospective Cohort Study.

Alkadri J, Chen M, Karkouti K, Grudzinski A, Ouzounian M, Rubens F, Raphael J, Callum J, Lin Y, McCluskey SA, McIsaac DI, Bartoszko J

Journal of cardiothoracic and vascular anesthesia2026

DOI: 10.1053/j.jvca.2026.04.018 PMID: 42091376

02

Intra-institutional use of positive deviancy in surgical infections in isolated coronary bypass.

Rubens F, Qiu Y, Dean M, Lajeunesse J, Taljaard M, Neilipovitz K, Charlebois A, Hogan C, Al-Atassi T, Boodhwani M, Guo M, Issa H, Lam BK, Masters R, Ruel M, Toeg H, Voisine P

Infection control and hospital epidemiology2026First author

DOI: 10.1017/ice.2026.10481 PMID: 42219965

03

Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation.

Ahmed N, Ye B, Liang W, Lam BK, Rubens F, Khan S, Courtman D, Stewart DJ, Davis DR

Theranostics2026

DOI: 10.7150/thno.127433 PMID: 42094594

04

Infective Endocarditis in Patients with Mitral Annular Calcification: Clinical and Echocardiographic Presentation, Management, and Outcomes.

Suc G, Lau L, Seo S, Auclair F, Corrales-Medina V, Chan V, Burwash IG, Gauda R, Rubens F, Chan KL, Messika-Zeitoun D

CJC open2026

DOI: 10.1016/j.cjco.2025.10.020 PMID: 41766701

05

Early vs Delayed Bypass Surgery in Patients With Acute Coronary Syndrome Receiving Ticagrelor: The RAPID CABG Randomized Open-Label Noninferiority Trial.

So DYF, Wells GA, Lordkipanidzé M, Chong AY, Ruel M, Perrault LP, Le May MR, Sun L, Tran D, Labinaz M, Glover C, Russo J, Welman M, Chan V, Chen L, Bernick J, Rubens F, Tanguay JF, RAPID CABG Investigators

JAMA surgery2025

DOI: 10.1001/jamasurg.2024.7066 PMID: 39969871

06

Commentary: We mustn't be blinded by the elegance of a complex approach and not consider the simplest solutions.

Neder Issa HM, Maharajh G, Rubens F

JTCVS techniques2025Senior author

DOI: 10.1016/j.xjtc.2024.11.002 PMID: 39991313

07

Secondary Conduits in Coronary Artery Bypass Grafting Surgery

Browne A, Lee SF, Rubens F, Pan X, Noiseux N, Gaudino M, Dimagli A, Lamy A

Annals of Thoracic Surgery20246 citations

DOI: 10.1016/j.athoracsur.2024.07.044

08

Combining Aortic Size With Arterial Hemodynamics Enhances Assessment of Future Thoracic Aortic Aneurysm Expansion.

Zhu T, Mian O, Boodhwani M, Beauchesne L, Dennie C, Chan K, Wells GA, Rubens F, Coutinho T

The Canadian journal of cardiology2023

DOI: 10.1016/j.cjca.2022.09.010 PMID: 36374804

09

Commentary: Can in vitro valve testing reliably predict clinical outcomes?

Issa HMN, Rubens F

JTCVS open2022Senior author

DOI: 10.1016/j.xjon.2022.02.004 PMID: 36003476

10

Platelet Quiescence in Patients With Acute Coronary Syndrome Undergoing Coronary Artery Bypass Graft Surgery.

Sarathy K, Wells GA, Singh K, Couture E, Chong AY, Rubens F, Lordkipanidzé M, Tanguay JF, So D

Journal of the American Heart Association2021

DOI: 10.1161/jaha.120.016602 PMID: 33599134

Reassessment of Anti-Platelet therapy using InDividualized Strategies -Ticagrelor in Patients with Acute Coronary Syndromes Treated by Coronary Artery Bypass Graft Surgery - A Pharmacodynamic and Clinical Study to Decrease Bleeding Risks and Ischemic Complications - The RAPID-TITRATE CABG study

Principal investigatorCIHR2015Operating Grant

Principal investigators: So, Derek Y; Rubens, Fraser D; Tanguay, Jean-François

Keywords: Acute Coronary Syndromes; Antiplatelet Therapy; Coronary Artery Bypass Surgery; Platelet Function; Ticagrelor

$512,179

Transfusion Requirement in Cardiac Surgery III (TRICS III)

Co-investigatorCIHR2013Operating Grant

Principal investigators: Mazer, David; Fergusson, Dean A; Shehata, Nadine; Thorpe, Kevin E; Whitlock, Richard

Keywords: Cardiac Surgery; Randomized Controlled Trial; Red Cell Transfusion; Red Cell Transfusion Thresholds

$3,323,110

Transfusion Requirements in Cardaic Surgery II (TRICSII)

Co-investigatorCIHR2010Operating Grant

Principal investigators: Shehata, Nadine; Mazer, David

Keywords: Cardiac Surgery; Randomized Controlled Trial; Red Cell Transfusion

$293,728

Plasma utilization following cardiac study

Co-investigatorCIHR2009Operating Grant

Principal investigators: Tinmouth, Alan T

Keywords: Cardiac Surgery; Coagulation Testing; Coagulopathy; Cohort Study; Frozen Plasma Transfusions; Postoperative Bleeding

$186,751

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Medicine
Surgery
Cardiac Surgery
Anesthesiology
Clinical Epidemiology
Family Medicine
Pathology and Laboratory Medicine
Other

1 shared papers, latest 2024

Emilie Belley-Cote

Medicine

1 shared papers, latest 2018

Summer Syed

Anesthesia

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Acute Coronary Syndromes Dear Professor Rubens, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Preoperative Iron-Deficiency Anemia and Survival After Cardiac Surgery: A Retrospective Cohort Study." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Fraser Rubens

Research

Latest papers

Latest funding

Preoperative Iron-Deficiency Anemia and Survival After Cardiac Surgery: A Retrospective Cohort Study.

Intra-institutional use of positive deviancy in surgical infections in isolated coronary bypass.

Human atrial extracellular vesicles suppress NLRP3 inflammasome activation and profibrotic signaling in a patient-specific iPSC model of postoperative atrial fibrillation.

Infective Endocarditis in Patients with Mitral Annular Calcification: Clinical and Echocardiographic Presentation, Management, and Outcomes.

Early vs Delayed Bypass Surgery in Patients With Acute Coronary Syndrome Receiving Ticagrelor: The RAPID CABG Randomized Open-Label Noninferiority Trial.

Commentary: We mustn't be blinded by the elegance of a complex approach and not consider the simplest solutions.

Secondary Conduits in Coronary Artery Bypass Grafting Surgery

Combining Aortic Size With Arterial Hemodynamics Enhances Assessment of Future Thoracic Aortic Aneurysm Expansion.

Commentary: Can in&#xa0;vitro valve testing reliably predict clinical outcomes?

Platelet Quiescence in Patients With Acute Coronary Syndrome Undergoing Coronary Artery Bypass Graft Surgery.

Reassessment of Anti-Platelet therapy using InDividualized Strategies -Ticagrelor in Patients with Acute Coronary Syndromes Treated by Coronary Artery Bypass Graft Surgery - A Pharmacodynamic and Clinical Study to Decrease Bleeding Risks and Ischemic Complications - The RAPID-TITRATE CABG study

Transfusion Requirement in Cardiac Surgery III (TRICS III)

Transfusion Requirements in Cardaic Surgery II (TRICSII)

Plasma utilization following cardiac study

Frequent collaborators

Marc Ruel

Munir Boodhwani

Derek So

Richard Whitlock

Marino Labinaz

Paul Hendry

Wenbin Liang

Sean Bagshaw

Steven Hawken

Stephen Fremes

Bobby Yanagawa

Louise Sun

Carl van Walraven

Sharon Chih

François Lellouche

Jeannie Callum

Justyna Bartoszko

Benjamin Hibbert

Vicente Corrales-Medina

David Messika-Zeitoun

Antonio Giulivi

David Glineur

Diem Tran

Ellamae Stadnick

Kevin Chien

Nikita Malhotra

Dean Fergusson

Monica Taljaard

Louis Perrault

Nadine Shehata

Keyvan Karkouti

Alan Tinmouth

Ian Stiell

Shun Fu Lee

David Courtman

Andre Lamy

Emilie Belley-Cote

Summer Syed

Commentary: Can in vitro valve testing reliably predict clinical outcomes?