Jean-Marc Renaud, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Adenylate Cyclase Channelopathy Clc-1 Cl Channel Hyperkalemic Periodic Paralysis Katp Channel Phosphodiesterase Pka Pkc

Latest papers

Glucose and glycogen affects Ca2+ transient during fatigue to a greater extent in the least than in the most fatigue resistant mouse FDB fibers.
Physiological reports · 2024 · senior author
Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice.
Skeletal muscle · 2024
A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration-historical developments.
European journal of applied physiology · 2024

All 42 publications

Latest funding

Mechanisms of fatigue pre-conditionning (FPC)
NSERC · 2020 · Principal investigator
$168,000
Novel therapy for Hyperkalemic Periodic Paralysis (HyperKPP)
CIHR · 2016 · Nominated PI
$673,200
Regulation of KATP and Cl channel activity by AMPK, ATP and adenosine receptors: impact on membrane excitability during muscle activity and fatigue
NSERC · 2015 · Principal investigator
$200,000

All 12 grants and awards

42 publications.

01

Glucose and glycogen affects Ca2+ transient during fatigue to a greater extent in the least than in the most fatigue resistant mouse FDB fibers.

Hesse E, Ammar T, Renaud JM

Physiological reports2024Senior author

DOI: 10.14814/phy2.70065 PMID: 39411805

02

Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice.

Freeman E, Langlois S, Leyba MF, Ammar T, Léger Z, McMillan HJ, Renaud JM, Jasmin BJ, Cowan KN

Skeletal muscle2024

DOI: 10.1186/s13395-024-00340-8 PMID: 38671506

03

A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration-historical developments.

McKenna MJ, Renaud JM, Ørtenblad N, Overgaard K

European journal of applied physiology2024

DOI: 10.1007/s00421-023-05335-9 PMID: 38206444

04

Exercise and fatigue: integrating the role of K+, Na+ and Cl- in the regulation of sarcolemmal excitability of skeletal muscle.

Renaud JM, Ørtenblad N, McKenna MJ, Overgaard K

European journal of applied physiology2023First author

DOI: 10.1007/s00421-023-05270-9 PMID: 37584745

05

The potassium-glycogen interaction on force and excitability in mouse skeletal muscle: implications for fatigue.

Cairns SP, Renaud JM

The Journal of physiology2023Senior author

DOI: 10.1113/jp285129 PMID: 37934587

06

Angiotensin 1-7 increases fiber cross-sectional area and force in juvenile mouse skeletal muscle.

Albadrani H, Ammar T, Rajgara R, Bader M, Wiper-Bergeron N, Renaud JM

American journal of physiology. Cell physiology2022Senior author

DOI: 10.1152/ajpcell.00271.2021 PMID: 36280388

07

The peak force-resting membrane potential relationships of mouse fast- and slow-twitch muscle.

Cairns SP, Leader JP, Higgins A, Renaud JM

American journal of physiology. Cell physiology2022Senior author

DOI: 10.1152/ajpcell.00401.2021 PMID: 35385328

08

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression.

Addicks GC, Zhang H, Ryu D, Vasam G, Green AE, Marshall PL, Patel S, Kang BE, Kim D, Katsyuba E, Williams EG, Renaud JM, Auwerx J, Menzies KJ

The Journal of cell biology2022

DOI: 10.1083/jcb.202104022 PMID: 35024765

09

Angiotensin 1-7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle.

Albadrani H, Ammar T, Bader M, Renaud JM

The Journal of general physiology2021Senior author

DOI: 10.1085/jgp.201912556 PMID: 34739541

10

Studying t-tubular functionality in mechanically skinned fibres to understand the mechanism of muscle fatigue.

Renaud JM

The Journal of physiology2020First author

DOI: 10.1113/jp280698 PMID: 32936938

Mechanisms of fatigue pre-conditionning (FPC)

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Renaud, Jean-Marc

$168,000

Novel therapy for Hyperkalemic Periodic Paralysis (HyperKPP)

Nominated PICIHR2016Project Grant

Principal investigators: Renaud, Jean-Marc E

Keywords: Adenylate Cyclase; Channelopathy; Clc-1 Cl Channel; Hyperkalemic Periodic Paralysis; Katp Channel; Phosphodiesterase; Pka; Pkc; Skeletal Muscle; Sodium Potassium Atpase Pump

$673,200

Regulation of KATP and Cl channel activity by AMPK, ATP and adenosine receptors: impact on membrane excitability during muscle activity and fatigue

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Renaud, JeanMarc

$200,000

Contribution of intracellular sodium to paralytic attack in HyperKPP muscle

SupervisorCIHR2013Undergraduate: Mobility, musculoskeletal health and arthritis - ICS

Principal investigators: Nishi, Cameron

Keywords: Action Potential; Electrophysiology; Hyperkalemic Periodic Paralysis; Intracellular Sodium; Membrane Potential; Muscle Contraction; Sodium Channel

$4,950

Mechanism by which calcium alleviates symptoms of hyperkalemic periodic paralysis.

SupervisorCIHR2012Undergraduate: Mobility, musculoskeletal health and arthritis - ICS

Principal investigators: Nishi, Cameron

Keywords: Electrophysiology; Hyperkalemic Periodic Paralysis; Muscle Contraction; Sodium Channel

$4,950

Development of better and more effective treatments for patients suffering of hyperkalemic periodic paralysis (HyperKPP)

Nominated PICIHR2011Operating Grant

Principal investigators: Renaud, Jean-Marc E

Keywords: Channelopathy; Chloride Channel; Membrane Excitability; Potassium Channel; Skeletal Muscle; Sodium Channel

$534,532

Role of potassium and chloride channel during non-fatiguing and fatiguing muscular activity in skeletal muscles

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Renaud, JeanMarc

$198,000

Dual excitation-emission fluorescence/contractility system

Principal investigatorNSERC2008Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Renaud, JeanMarc

$97,791

Prevention of muscle dysfunction by the cell membrane Katp channel in skeletal muscle

Principal investigatorNSERC2004Discovery Grants Program - Individual

Principal investigators: Renaud, JeanMarc

$191,550

The regulation and physiological role of Katp channel in skeletal muscle

Principal investigatorNSERC2000Discovery Grants Program - Individual

Principal investigators: Renaud, JeanMarc

$101,600

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cellular and Molecular Medicine
Kinesiology
Biochemistry, Microbiology and Immunology
Regenerative Medicine
School of Pharmaceutical Sciences
Anesthesia
Orthopedic Surgery
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Rashmi Kothary

Cellular and Molecular Medicine

3 shared papers, latest 2020

Mary-Ellen Harper

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2016

Allan Liew

Regenerative Medicine

1 shared papers, latest 2014

Geoffrey Wilkin

Orthopedic Surgery

1 shared papers, latest 2014

Aymeric Ravel-Chapuis

School of Pharmaceutical Sciences

1 shared papers, latest 2017

Jean Michaud

Pathology and Laboratory Medicine

1 shared papers, latest 2020

Jerry Radziuk

Department of Medicine

1 shared papers, latest 2008

Gianni Parise

Office of the Vice-President, Research

1 shared papers, latest 2012

Nadine Wiper Bergeron

Cellular and Molecular Medicine

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2020

Subject: Prospective PhD student: Adenylate Cyclase Dear Professor Renaud, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Glucose and glycogen affects Ca2+ transient during fatigue to a greater extent in the least than in the most fatigue resistant mouse FDB fibers." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Mechanisms of fatigue pre-conditionning (FPC)" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Jean-Marc Renaud

Research

Latest papers

Latest funding

Glucose and glycogen affects Ca2+ transient during fatigue to a greater extent in the least than in the most fatigue resistant mouse FDB fibers.

Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice.

A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration-historical developments.

Exercise and fatigue: integrating the role of K+, Na+ and Cl- in the regulation of sarcolemmal excitability of skeletal muscle.

The potassium-glycogen interaction on force and excitability in mouse skeletal muscle: implications for fatigue.

Angiotensin 1-7 increases fiber cross-sectional area and force in juvenile mouse skeletal muscle.

The peak force-resting membrane potential relationships of mouse fast- and slow-twitch muscle.

GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression.

Angiotensin 1-7 prevents the excessive force loss resulting from 14- and 28-day denervation in mouse EDL and soleus muscle.

Studying t-tubular functionality in mechanically skinned fibres to understand the mechanism of muscle fatigue.

Mechanisms of fatigue pre-conditionning (FPC)

Novel therapy for Hyperkalemic Periodic Paralysis (HyperKPP)

Regulation of KATP and Cl channel activity by AMPK, ATP and adenosine receptors: impact on membrane excitability during muscle activity and fatigue

Contribution of intracellular sodium to paralytic attack in HyperKPP muscle

Mechanism by which calcium alleviates symptoms of hyperkalemic periodic paralysis.

Development of better and more effective treatments for patients suffering of hyperkalemic periodic paralysis (HyperKPP)

Role of potassium and chloride channel during non-fatiguing and fatiguing muscular activity in skeletal muscles

Dual excitation-emission fluorescence/contractility system

Prevention of muscle dysfunction by the cell membrane Katp channel in skeletal muscle

The regulation and physiological role of Katp channel in skeletal muscle

Frequent collaborators

Vladimir Ljubicic

Rashmi Kothary

Mary-Ellen Harper

Allan Liew

Geoffrey Wilkin

Aymeric Ravel-Chapuis

Jean Michaud

Jerry Radziuk

Martin Holcik

Gianni Parise

Cameron Nishi

Nadine Wiper Bergeron