Martin Holcik, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Latest papers

Eukaryotic Initiation Factor 3F (eIF3F) Regulates the IRES-Mediated Translation of Bcl-xL via Its Interaction with Programmed Cell Death 4 (PDCD4) Protein.
International journal of molecular sciences · 2026
SIFD-associated TRNT1 deficiency unveils importance of TSPO during macrophage antibacterial and antiviral responses.
Frontiers in immunology · 2025 · senior author
Cost-Effective Method for Using Cross-Species Spike-In RNA for Normalization and Quantification in Polysome Profiling Experiments.
Genes · 2025 · senior author

All 63 publications

Latest funding

Does maternal physical activity affect placenta biology? A multi-tiered approach
CIHR · 2015 · Co-investigator
$833,864
Localization of RNA binding proteins in the control of cell survival
NSERC · 2015 · Principal investigator
$170,000
Post-transcriptional Regulation of Utrophin in Skeletal Muscle: Implications for New Therapeutic Strategies for Duchenne Muscular Dystrophy
CIHR · 2012 · Co-investigator
$813,750

All 9 grants and awards

63 publications.

01

Eukaryotic Initiation Factor 3F (eIF3F) Regulates the IRES-Mediated Translation of Bcl-xL via Its Interaction with Programmed Cell Death 4 (PDCD4) Protein.

Hegde V, Sharma DK, Patel H, Narasimha PL, Luddu J, Mubaya R, Holcik M, Thakor N

International journal of molecular sciences2026

DOI: 10.3390/ijms27093955 PMID: 42123540

02

SIFD-associated TRNT1 deficiency unveils importance of TSPO during macrophage antibacterial and antiviral responses.

Ahmed D, Slade A, Fatica T, Baird S, Bhattarai K, Atallah T, Cassol E, Holcik M

Frontiers in immunology2025Senior author

DOI: 10.3389/fimmu.2025.1497766 PMID: 41019077

03

Cost-Effective Method for Using Cross-Species Spike-In RNA for Normalization and Quantification in Polysome Profiling Experiments.

Bhattarai K, Slade A, Holcik M

Genes2025Senior author

DOI: 10.3390/genes16111354 PMID: 41300805

04

Patient and family experiences of lysosomal storage diseases in Canada: A qualitative interview study.

Awada N, Holcik M

JIMD reports2024Senior author

DOI: 10.1002/jmd2.12403 PMID: 38444574

05

Oxidative stress-induced YAP1 expression is regulated by NCE102, CDA2, and BCS1.

Takallou S, Hajikarimlou M, Al-Gafari M, Wang J, Jagadeesan SK, Kazmirchuk TDD, Arnoczki C, Moteshareie H, Said KB, Azad T, Holcik M, Samanfar B, Smith M, Golshani A

The FEBS journal2024

DOI: 10.1111/febs.17243 PMID: 39102301

06

Hydrogen peroxide sensitivity connects the activity of COX5A and NPR3 to the regulation of YAP1 expression.

Takallou S, Hajikarimlou M, Al-Gafari M, Wang J, Jagadeesan SK, Kazmirchuk TDD, Moteshareie H, Indrayanti AM, Azad T, Holcik M, Samanfar B, Smith M, Golshani A

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

DOI: 10.1096/fj.202300978rr PMID: 38416461

07

TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins.

Fatica T, Naas T, Liwak U, Slaa H, Souaid M, Frangione B, Kattini R, Gaudreau-Lapierre A, Trinkle-Mulcahy L, Chakraborty P, Holcik M

Genes2023Senior author

DOI: 10.3390/genes14051043 PMID: 37239403

08

A Correlation between 3'-UTR of OXA1 Gene and Yeast Mitochondrial Translation.

Hajikarimlou M, Hooshyar M, Sunba N, Nazemof N, Moutaoufik MT, Phanse S, Said KB, Babu M, Holcik M, Samanfar B, Smith M, Golshani A

Journal of fungi (Basel, Switzerland)2023

DOI: 10.3390/jof9040445 PMID: 37108900

09

Mitochondrial disease registries worldwide: A scoping review.

Abdul-Fatah A, Esmaeilisaraji L, Juan CM, Holcik M

PloS one2022Senior author

DOI: 10.1371/journal.pone.0276883 PMID: 36301904

10

AMPK-related protein kinase ARK5 regulates subcellular localization of RNA-binding protein hnRNP A1 during hypertonic stress.

Bhattarai K, Richard T, Fatica T, Frangione B, Willmore WG, Holcik M

The Journal of biological chemistry2022Senior author

DOI: 10.1016/j.jbc.2022.102364 PMID: 35963429

Does maternal physical activity affect placenta biology? A multi-tiered approach

Co-investigatorCIHR2015Operating Grant

Principal investigators: Adamo, Kristi B

Keywords: Exosome; Fetal Health; Gene Expression; Metabolome; Nutrient Transport; Physical Activity; Placenta; Pregnancy

$833,864

Localization of RNA binding proteins in the control of cell survival

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Holcik, Martin

$170,000

Post-transcriptional Regulation of Utrophin in Skeletal Muscle: Implications for New Therapeutic Strategies for Duchenne Muscular Dystrophy

Co-investigatorCIHR2012Operating Grant

Principal investigators: Jasmin, Bernard J

Keywords: Duchenne Muscular Dystrophy; Dystrophin; Mrna Stability; Post-Transcriptional Regulation; Skeletal Muscle; Therapy; Translation; Utrophin

$813,750

The role of RNA instability determinants in the regulation of cIAP1 expression

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Holcik, Martin

$165,000

The impact of exercise training programs and exercise mimetics on progression of neuromuscular diseases, and on aging and atrophied skeletal muscle

Co-investigatorCIHR2009Team Grant: Physical Activity, Mobility and Health (LOI)

Principal investigators: Jasmin, Bernard J; Côté, Jocelyn; Kothary, Rashmi K

Keywords: Exercise; Microrna; Molecular Mechanisms; Neuromuscular Disease; Rna Metabolism; Skeletal Muscle

$10,000

Translation regulation of the inhibitor of apoptosis, cIAP1, during cellular stress.

Nominated PICIHR2009Operating Grant

Principal investigators: Holcik, Martin

Keywords: Apoptosis; Cancer; Internal Ribosome Entry Site; Rna Binding Proteins; Signal Transduction; Translational Control

$583,550

Dissecting Signaling Pathways Regulating Internal Ribosome Entry Site-mediated Translation

SupervisorCIHR2008Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Jordan, Lindsay E

Keywords: Apoptosis; Bcl-Xl; Cancer; Ires; Pdcd4; Rna Binding Proteins; S6 Kinase 2; Translation; Translational Control; Xiap

$105,000

Mechanisms of Motoneuron Degeneration in Spinal Muscular Atrophy and Identification of Therapeutic Targets

Co-investigatorCIHR2008Emerging Team Grant: From Genes to Proteins, Cells, Tissues and Patients - LOI

Principal investigators: Jasmin, Bernard J; Kothary, Rashmi K

Keywords: Neuromuscular Junction - Mouse Models - Signalling -; Proteomics; Rna Stability - Rna Binding Proteins - Microrna -; Spinal Muscular Atrophy - Motoneurons - Skeletal Muscle -

The role of RNA stability determinants in the regulation of apoptosis

Principal investigatorNSERC2004Discovery Grants Program - Individual

Principal investigators: Holcik, Martin

$145,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Mohan Babu

Chemistry and Biochemistry

5 shared papers, latest 2023

Denis Prud'homme

Human Kinetics

4 shared papers, latest 2021

Jean Michaud

Pathology and Laboratory Medicine

3 shared papers, latest 2016

Margaret Fahnestock

Psychiatry & Behavioural Neurosciences

2 shared papers, latest 2019

Mary-Ellen Harper

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2016

Tyson Graber

Biochemistry, Microbiology & Immunology

2 shared papers, latest 2019

Taha Azad

Microbiology and Infectious Diseases

2 shared papers, latest 2024

Rob Beanlands

Department of Medicine

1 shared papers, latest 2013

Jacek Majewski

Human Genetics

1 shared papers, latest 2016

Ashok Kumar

Pathology and Laboratory Medicine

1 shared papers, latest 2016

Jean-Marc Renaud

Cellular and Molecular Medicine

1 shared papers, latest 2020

Nahum Sonenberg

Biochemistry

1 shared papers, latest 2015

Tommy Alain

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2019

David Grynspan

Nutritional Sciences

1 shared papers, latest 2016

Stephanie Redpath

Mechanical and Aerospace Engineering

1 shared papers, latest 2016

Write to this professor

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Applying for

Paper to mention

Subject: Prospective PhD student Dear Professor Holcik, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Eukaryotic Initiation Factor 3F (eIF3F) Regulates the IRES-Mediated Translation of Bcl-xL via Its Interaction with Programmed Cell Death 4 (PDCD4) Protein." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Martin Holcik

Research

Latest papers

Latest funding

Eukaryotic Initiation Factor 3F (eIF3F) Regulates the IRES-Mediated Translation of Bcl-xL via Its Interaction with Programmed Cell Death 4 (PDCD4) Protein.

SIFD-associated TRNT1 deficiency unveils importance of TSPO during macrophage antibacterial and antiviral responses.

Cost-Effective Method for Using Cross-Species Spike-In RNA for Normalization and Quantification in Polysome Profiling Experiments.

Patient and family experiences of lysosomal storage diseases in Canada: A qualitative interview study.

Oxidative stress-induced YAP1 expression is regulated by NCE102, CDA2, and BCS1.

Hydrogen peroxide sensitivity connects the activity of COX5A and NPR3 to the regulation of YAP1 expression.

TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins.

A Correlation between 3'-UTR of OXA1 Gene and Yeast Mitochondrial Translation.

Mitochondrial disease registries worldwide: A scoping review.

AMPK-related protein kinase ARK5 regulates subcellular localization of RNA-binding protein hnRNP A1 during hypertonic stress.

Does maternal physical activity affect placenta biology? A multi-tiered approach

Localization of RNA binding proteins in the control of cell survival

Post-transcriptional Regulation of Utrophin in Skeletal Muscle: Implications for New Therapeutic Strategies for Duchenne Muscular Dystrophy

The role of RNA instability determinants in the regulation of cIAP1 expression

The impact of exercise training programs and exercise mimetics on progression of neuromuscular diseases, and on aging and atrophied skeletal muscle

Translation regulation of the inhibitor of apoptosis, cIAP1, during cellular stress.

Dissecting Signaling Pathways Regulating Internal Ribosome Entry Site-mediated Translation

Mechanisms of Motoneuron Degeneration in Spinal Muscular Atrophy and Identification of Therapeutic Targets

The role of RNA stability determinants in the regulation of apoptosis

Frequent collaborators

Mohan Babu

Faraz Farooq

Jeremy Walsh

Pranesh Chakraborty

Denis Prud'homme

Jean Michaud

Margaret Fahnestock

Mary-Ellen Harper

Heather Tulloch

Tyson Graber

Taha Azad

Michael Geraghty

Rob Beanlands

Jacek Majewski

Nahum Sonenberg

Ashok Kumar

Jean-Marc Renaud

Nahum Sonenberg

Tommy Alain

David Grynspan

Stephanie Redpath