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Marjorie Brand

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Full ProfessorDepartment of MedicineUniversity of Ottawa

Marjorie Brand

Full Professor

Department of Medicine

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
9 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 11 research grants (11 CIHR), most recently in 2021.
Supervised 1 trainee who won CIHR awards, most recently in 2015.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Read how they describe their research on their University of Ottawa profile.

Leukemia Epigenetics T-Cell Acute Lymphoblastic Leukemia Transcription Factors Epigenetic Proteomics Xenograft Arrested Cell Differentiation

Latest papers

Distinct DNA hydroxymethylation landscape and mitochondrial DNA rearrangement signatures induced by single- and multi-fraction alpha particle radiation in lung fibroblasts.
Environmental epigenetics · 2026
SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles.
Communications biology · 2026
Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis.
bioRxiv : the preprint server for biology · 2025 · senior author

All 46 publications

Latest funding

Glyoxalase-1 loaded nanoparticles for reducing methylglyoxal and promoting vascular repair and cardiac function after myocardial infarction
CIHR · 2022 · Co-investigator
$879,750
Mechanistic insights into non-malignant hematopoietic diseases
CIHR · 2021 · Nominated PI
$952,425
Understanding the mechanism of TLX1-induced T-cell acute lymphoblastic leukemia
CIHR · 2020 · Nominated PI
$937,125

All 13 grants and awards

46 publications.

Distinct DNA hydroxymethylation landscape and mitochondrial DNA rearrangement signatures induced by single- and multi-fraction alpha particle radiation in lung fibroblasts.

Vera-Chang MN, Danforth JM, Stuart M, Brand M, Goodarzi AA, Richardson RB

Environmental epigenetics2026

DOI: 10.1093/eep/dvag020 PMID: 42494923

SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles.

Saleh F, Balakrishnan A, Adnani L, Ahmad ST, Chinchalongporn V, El-Sehemy A, Olender T, Chen MJ, Kshirsagar A, Kennedy A, Kulathunga N, Prokopchuk O, Vasan L, Touahri Y, Islam R, Sujanthan S, Zinyk D, Comanita LC, Kan B, Fleming T, Michael IP, Morshead CM, Leong HS, Okawa S, Brand M, Wallace VA, Chan JA, Schuurmans C

Communications biology2026

DOI: 10.1038/s42003-026-10556-7 PMID: 42365201

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis.

Palii CG, Tur S, Yan S, Longabaugh WJR, Solano R, Dilworth FJ, Ranish JA, Brand M

bioRxiv : the preprint server for biology2025Senior author

DOI: 10.1101/2025.09.11.675740 PMID: 41000825

Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina.

Touahri Y, Hanna J, Tachibana N, Okawa S, Liu H, David LA, Olender T, Vasan L, Pak A, Mehta DN, Chinchalongporn V, Balakrishnan A, Cantrup R, Dixit R, Mattar P, Saleh F, Ilnytskyy Y, Murshed M, Mains PE, Kovalchuk I, Lefebvre JL, Leong HS, Cayouette M, Wang C, Del Sol A, Brand M, Reese BE, Schuurmans C

Cell reports2024

DOI: 10.1016/j.celrep.2024.114005 PMID: 38551961

Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts.

Vera-Chang MN, Danforth JM, Stuart M, Goodarzi AA, Brand M, Richardson RB

Clinical epigenetics2023

DOI: 10.1186/s13148-023-01564-z PMID: 37891670

Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI.

Rondeaux J, Groussard D, Renet S, Tardif V, Dumesnil A, Chu A, Di Maria L, Lemarcis T, Valet M, Henry JP, Badji Z, Vézier C, Béziau-Gasnier D, Neele AE, de Winther MPJ, Guerrot D, Brand M, Richard V, Durand E, Brakenhielm E, Fraineau S

Nature communications2023

DOI: 10.1038/s41467-023-40186-0 PMID: 37491334

Unveiling the complexity of transcription factor networks in hematopoietic stem cells: implications for cell therapy and hematological malignancies.

Benyoucef A, Haigh JJ, Brand M

Frontiers in oncology2023Senior author

DOI: 10.3389/fonc.2023.1151343 PMID: 37441426

The winding road toward transcriptional repression.

Zhang Q, Brand M

Molecular cell2023Senior author

DOI: 10.1016/j.molcel.2023.02.005 PMID: 36868186

JMJD3 activated hyaluronan synthesis drives muscle regeneration in an inflammatory environment.

Nakka K, Hachmer S, Mokhtari Z, Kovac R, Bandukwala H, Bernard C, Li Y, Xie G, Liu C, Fallahi M, Megeney LA, Gondin J, Chazaud B, Brand M, Zha X, Ge K, Dilworth FJ

Science (New York, N.Y.)2022

DOI: 10.1126/science.abm9735 PMID: 35926054

Chromatin and transcription factor profiling in rare stem cell populations using CUT&Tag.

Li Y, Nakka K, Olender T, Gingras-Gelinas P, Wong MM, Robinson DCL, Bandukwala H, Palii CG, Neyret O, Brand M, Blais A, Dilworth FJ

STAR protocols2021

DOI: 10.1016/j.xpro.2021.100751 PMID: 34467227

Glyoxalase-1 loaded nanoparticles for reducing methylglyoxal and promoting vascular repair and cardiac function after myocardial infarction

Co-investigatorCIHR2022Project Grant

Principal investigators: Suuronen, Erik

Keywords: Cardiovascular Disease; Endothelial Cells; Glyoxalase-1; Methylglyoxal; Myocardial Infarction; Nanoparticles

$879,750

Mechanistic insights into non-malignant hematopoietic diseases

Nominated PICIHR2021Project Grant

Principal investigators: Brand, Marjorie C

Keywords: Arrested Cell Differentiation; Cell Biology; Diamond-Blackfan Anemia; Erythropoiesis; Gene Regulatory Network; Mass Cytometry (Cytof); Quantitative Mass Spectrometry; Quantitative Proteomics; Ribosomopathy; Transcriptomics

$952,425

Understanding the mechanism of TLX1-induced T-cell acute lymphoblastic leukemia

Nominated PICIHR2020Project Grant

Principal investigators: Brand, Marjorie C

Keywords: Chip-Seq (Cut And Tag); Chromatin Remodeling; Epigenetic; Genome Topology; Hi-C; Leukemia; Leukemia Patient-Derived Xenograft Model; Ng-Capture C; T-Cell Acute Lymphoblastic Leukemia; Transcription Factors

$937,125

Optimizing cell-based therapies to promote neurovascular regeneration and behavioural recovery after ischemic stroke

Principal investigatorCIHR2019Project Grant

Principal investigators: Wang, Jing; Brand, Marjorie C

Keywords: Cell Transplantation; Enriched Rehabilitation; Focal Ischemic Stroke; Human Endothelial Progenitors; Human Ipsc-Derived Neural Stem Cell; Preconditioning; Regeneration; Stroke Motor Recovery

$780,300

Targeting the epigenetic state of refractory and relapsing acute myeloid leukemia

Principal investigatorCIHR2018Operating Grant: Epigenetics Clinical Translation

Principal investigators: Stanford, William L; Brand, Marjorie C; Couture, Jean-François; Dilworth, Jeffrey J; Ito, Caryn

Keywords: Acute Myeloid Leukemia (Aml); Drug Development; Epigenetics; Polycomb Repressive Complex 2; Trithorax

$1,500,000

Epigenetic changes affecting muscle stem cell function in the aging population

Principal investigatorCIHR2018Team Grant: CEEHRC Phase II

Principal investigators: Dilworth, Jeffrey J; Beaule, Paul E; Bourque, Guillaume; Brand, Marjorie C; Carsen, Sasha; Lapner, Peter; Liew, Allan

Keywords: Aging; Cytof; Epigenetics; Gene Expression; Histone Methylation; Muscle Regeneration; Stem Cells

$1,497,750

Novel approach to destabilize protein interactions in T-ALL

Nominated PICIHR2017Operating Grant: Impact Grant : CEEHRC Phase II

Principal investigators: Brand, Marjorie C; Couture, Jean-François

Keywords: Chip-Seq; Genomics; Leukemia; Mutagenesis; Protein Interactions; Protein Structure / Function; Xenograft

$588,081

Deciphering the molecular mechanism of acquired resistance in leukemia

Nominated PICIHR2017Project Grant

Principal investigators: Brand, Marjorie C

Keywords: Biochemistry; Epigenetic; Genomics (Rna-Seq, Chip-Seq); Leukemia; Ogt; Patient-Derived Xenograft Models; Proteomics

$925,650

Role of oncogenic transcription factors in T-cell acute lymphoblastic leukemia

Nominated PICIHR2015Operating Grant

Principal investigators: Brand, Marjorie C

Keywords: Chromatin Immunoprecipitation And Sequencing; Epigenetics; Gene Expression Profiling; Knock Down; Oncogenes; Proteomics; Rna Sequencing; T-Cell Acute Lymphoblastic Leukemia; Transcription Factors; Xenograft

$823,790

Developing a new therapeutic strategy to treat the MEF2C-positive early T-cell progenitors acute lymphoblastic leukemia

SupervisorCIHR2015CIHR Fellowship

Principal investigators: Benyoucef, Aissa

Keywords: Biochemistry; Cell Biology; Drugs; Epigenetics And Genetics; Human Cell Lines; Human Primary Leukemic Cells; Imaging And Cytometry; Lentivirus And Retrovirus; Mice Model; Molecular Biology; Nsg Immunodeficient Mice; Proteomics

$78,750

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Marjorie Brand

Research

Latest papers

Latest funding

Distinct DNA hydroxymethylation landscape and mitochondrial DNA rearrangement signatures induced by single- and multi-fraction alpha particle radiation in lung fibroblasts.

SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles.

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis.

Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina.

Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts.

Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI.

Unveiling the complexity of transcription factor networks in hematopoietic stem cells: implications for cell therapy and hematological malignancies.

The winding road toward transcriptional repression.

JMJD3 activated hyaluronan synthesis drives muscle regeneration in an inflammatory environment.

Chromatin and transcription factor profiling in rare stem cell populations using CUT&Tag.

Glyoxalase-1 loaded nanoparticles for reducing methylglyoxal and promoting vascular repair and cardiac function after myocardial infarction

Mechanistic insights into non-malignant hematopoietic diseases

Understanding the mechanism of TLX1-induced T-cell acute lymphoblastic leukemia

Optimizing cell-based therapies to promote neurovascular regeneration and behavioural recovery after ischemic stroke

Targeting the epigenetic state of refractory and relapsing acute myeloid leukemia

Epigenetic changes affecting muscle stem cell function in the aging population

Novel approach to destabilize protein interactions in T-ALL

Deciphering the molecular mechanism of acquired resistance in leukemia

Role of oncogenic transcription factors in T-cell acute lymphoblastic leukemia

Developing a new therapeutic strategy to treat the MEF2C-positive early T-cell progenitors acute lymphoblastic leukemia

Frequent collaborators

Carol Schuurmans

Carol Schuurmans

Alexandre Blais

Harold Atkins

Mitchell Sabloff

Michel Cayouette

Kevin Burns

Chao Wang

David Allan

Deborah Kurrasch

Caryn Ito

Jean-François Couture

Monzur Murshed

Xiaohui Zha