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Xiaohui Zha

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Associate ProfessorBiochemistry, Microbiology and ImmunologyUniversity of Ottawa

Xiaohui Zha

Associate Professor

Biochemistry, Microbiology and Immunology

Faculty of Medicine

University of Ottawa

Ottawa, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
4 publications in the last five years, latest in 2025.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 5 research grants (3 NSERC, 1 SSHRC, 1 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications by year

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Research

Read how they describe their research on their University of Ottawa profile.

Abca1 Atherosclerosis Cholesterol Cytokine Gene Regulation Inflammation Lipid Raft Macrophage

Latest papers

What to Measure in Aneurysmal Subarachnoid Haemorrhage Research-An International Delphi Survey.
Translational stroke research · 2025
Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating Jmjd3.
eLife · 2024 · senior author
Patient Relevance of the Modified Rankin Scale in Subarachnoid Hemorrhage Research: An International Cross-sectional Survey.
Neurology · 2023

All 19 publications

Latest funding

Establishing An International Core Outcome Set for Subarachnoid Hemorrhage (SAH) - What and How to Measure Outcomes in SAH Research
CIHR · 2024 · Co-investigator
$726,752
MEMS based quantum photo-acoustic sensing for early detection of neuronal degeneration diseases
SSHRC · 2024 · Co-investigator
$125,000
Establishing an International Core Outcome Set in SAH - What and When to Measure in SAH Research
CIHR · 2019 · Co-investigator
$100,000

All 8 grants and awards

19 publications.

What to Measure in Aneurysmal Subarachnoid Haemorrhage Research-An International Delphi Survey.

Andersen CR, Presseau J, Shea B, Marti ML, McCoy M, Fernie G, McIntyre L, Delaney A, Chassé M, Saigle V, Marshall S, Fergusson DA, Graham I, Brehaut J, Turgeon AF, Lauzier F, Tugwell P, Zha X, Talbot P, Muscedere J, Marshall JC, Thavorn K, Griesdale D, Canadian Critical Care Trials Group, English SW

Translational stroke research2025

DOI: 10.1007/s12975-024-01271-8 PMID: 38997598

Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating Jmjd3.

Salloum Z, Dauner K, Li YF, Verma N, Valdivieso-González D, Almendro-Vedia V, Zhang JD, Nakka K, Chen MX, McDonald J, Corley CD, Sorisky A, Song BL, López-Montero I, Luo J, Dilworth JF, Zha X

eLife2024Senior author

DOI: 10.7554/elife.85964 PMID: 38602170

Patient Relevance of the Modified Rankin Scale in Subarachnoid Hemorrhage Research: An International Cross-sectional Survey.

Niznick N, Saigle V, Marti ML, Laframboise J, Zha X, Andersen C, Presseau J, Chassé M, McIntyre L, Fergusson D, Turgeon AF, Lauzier F, Mayer SA, Lahiri S, Ramsay T, English S, APOC Investigators and the Canadian Critical Care Trials Group

Neurology2023

DOI: 10.1212/wnl.0000000000206879 PMID: 36750387

JMJD3 activated hyaluronan synthesis drives muscle regeneration in an inflammatory environment.

Nakka K, Hachmer S, Mokhtari Z, Kovac R, Bandukwala H, Bernard C, Li Y, Xie G, Liu C, Fallahi M, Megeney LA, Gondin J, Chazaud B, Brand M, Zha X, Ge K, Dilworth FJ

Science (New York, N.Y.)2022

DOI: 10.1126/science.abm9735 PMID: 35926054

Dynamic Actin Reorganization and Vav/Cdc42-Dependent Actin Polymerization Promote Macrophage Aggregated LDL (Low-Density Lipoprotein) Uptake and Catabolism.

Singh RK, Haka AS, Bhardwaj P, Zha X, Maxfield FR

Arteriosclerosis, thrombosis, and vascular biology2019

DOI: 10.1161/atvbaha.118.312087 PMID: 30580573

Comment on 'Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol'.

Courtney KC, Fung KY, Maxfield FR, Fairn GD, Zha X

eLife2018Senior author

DOI: 10.7554/elife.38493 PMID: 30422112

mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells.

Eid W, Dauner K, Courtney KC, Gagnon A, Parks RJ, Sorisky A, Zha X

Proceedings of the National Academy of Sciences of the United States of America2017Senior author

DOI: 10.1073/pnas.1705304114 PMID: 28696297

mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery.

Dauner K, Eid W, Raghupathy R, Presley JF, Zha X

The Journal of biological chemistry2017Senior author

DOI: 10.1074/jbc.m116.771451 PMID: 28196862

Disruption in the autophagic process underlies the sensory neuropathy in dystonia musculorum mice.

Ferrier A, De Repentigny Y, Lynch-Godrei A, Gibeault S, Eid W, Kuo D, Zha X, Kothary R

Autophagy2015

DOI: 10.1080/15548627.2015.1052207 PMID: 26043942

Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1.

Dong F, Mo Z, Eid W, Courtney KC, Zha X

PloS one2014Senior author

DOI: 10.1371/journal.pone.0113789 PMID: 25415591

Establishing An International Core Outcome Set for Subarachnoid Hemorrhage (SAH) - What and How to Measure Outcomes in SAH Research

Co-investigatorCIHR2024Project Grant

Principal investigators: English, Shane W; Andersen, Christopher R; Marti, Maria Luisa; Presseau, Justin; Shea, Beverley J

Keywords: Aneurysmal Subarachnoid Hemorrhage; Multidisciplinary Team Members; Patient And Family Partners; Patient-Centred Outcome Measures; Patient-Oriented Research

$726,752

MEMS based quantum photo-acoustic sensing for early detection of neuronal degeneration diseases

Co-investigatorSSHRC2024New Frontiers in Research Fund - Exploration

Principal investigators: Bao, Xiaoyi

$125,000

Establishing an International Core Outcome Set in SAH - What and When to Measure in SAH Research

Co-investigatorCIHR2019Project Grant - Priority Announcement: Patient-Oriented Research

Principal investigators: English, Shane W; Marti, Maria Luisa; Presseau, Justin

Keywords: Aneurysmal Subarachnoid Hemorrhage; Multidisciplinary Stakeholders; Patient And Family Partners; Patient-Centred Outcome Measures

$100,000