Mona Nemer, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Transgenic Mice Animal Models Cardiomyocytes Congenital Heart Disease Endocardium Heart Development Transcription Factors Molecular And Cell Biology

Latest papers

A Nucleoside Analogue Bearing a C2'-Stereogenic All-Carbon Quaternary Center for the Treatment of Heart Failure.
Journal of medicinal chemistry · 2025
A Nucleoside Analogue Featuring a C3'-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of KRAS-Mutated Pancreatic Cancer Cells.
ACS medicinal chemistry letters · 2025
Sialyl Lewisx Glycomimetics as E- and P-Selectin Antagonists Targeting Hyperinflammation.
ACS medicinal chemistry letters · 2025

All 39 publications

Latest funding

Metabolomics Advanced Training and International Exchange (CREATE-MATRIX)
NSERC · 2018 · Co-investigator
$1,650,000
Genetic modifiers of congenital heart disease
CIHR · 2016 · Nominated PI
$1,184,975
Molecular and Genetic basis of heart development and disease
CIHR · 2015 · Nominated PI
$2,990,404

All 10 grants and awards

39 publications.

01

A Nucleoside Analogue Bearing a C2'-Stereogenic All-Carbon Quaternary Center for the Treatment of Heart Failure.

Almazloum A, Maharsy W, Dostie S, Becerril-Jiménez F, Eymard C, Komati H, Leblanc L, Manchoju A, Mochirian P, Zelli R, Prevost M, Nemer M, Guindon Y

Journal of medicinal chemistry2025

DOI: 10.1021/acs.jmedchem.5c01999 PMID: 41364793

02

A Nucleoside Analogue Featuring a C3'-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of KRAS-Mutated Pancreatic Cancer Cells.

Tantawi H, Mochirian P, Truong M, Beauregard J, Collins L, Kanaan G, Komati H, Leblanc L, Maharsy W, Manchoju A, Simard R, Tambutet G, Teran C, Dostie S, Prévost M, Nemer M, Guindon Y

ACS medicinal chemistry letters2025

DOI: 10.1021/acsmedchemlett.5c00378 PMID: 40959263

03

Sialyl Lewisx Glycomimetics as E- and P-Selectin Antagonists Targeting Hyperinflammation.

Joyal M, Simard RD, Maharsy W, Prévost M, Nemer M, Guindon Y

ACS medicinal chemistry letters2025

DOI: 10.1021/acsmedchemlett.4c00452 PMID: 39811128

04

The case for a global therapeutics development coalition: Building a therapeutics pipeline for pandemic and endemic diseases.

Machingaidze S, Pérez Casas C, Mburu S, Draghia-Akli R, Mowbray C, Rosen J, Burrone E, Nemer M, Dzau V

PLOS global public health2024

DOI: 10.1371/journal.pgph.0003654 PMID: 39213286

05

Synthesis of 4'-Thionucleoside Analogues Bearing a C2' Stereogenic All-Carbon Quaternary Center.

Eymard C, Manchoju A, Almazloum A, Dostie S, Prévost M, Nemer M, Guindon Y

Molecules (Basel, Switzerland)2024

DOI: 10.3390/molecules29071647 PMID: 38611926

06

Sialyl LewisX glycomimetics bearing an extended anionic chain targeting E- and P- selectin binding sites.

Belouin A, Simard RD, Joyal M, Maharsy W, Lau A, Prévost M, Nemer M, Guindon Y

Bioorganic & medicinal chemistry2024

DOI: 10.1016/j.bmc.2023.117553 PMID: 38128297

07

Synthesis of Sialyl LewisX Mimetics with E- and P-Selectin Binding Properties and Immunosuppressive Activity.

Simard RD, Joyal M, Beaugrand T, Gauthier J, Hardine E, Desriac A, Buffet CH, Prévost M, Nemer M, Guindon Y

The Journal of organic chemistry2023

DOI: 10.1021/acs.joc.3c00956 PMID: 37449872

08

KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.

Bernhardt C, Sock E, Fröb F, Hillgärtner S, Nemer M, Wegner M

Nucleic acids research2022

DOI: 10.1093/nar/gkac953 PMID: 36318265

09

Atrial Electrical Remodeling in Mice With Cardiac-Specific Overexpression of Angiotensin II Type 1 Receptor.

Demers J, Ton AT, Huynh F, Thibault S, Ducharme A, Paradis P, Nemer M, Fiset C

Journal of the American Heart Association2022

DOI: 10.1161/jaha.121.023974 PMID: 35435021

10

Clr-f expression regulates kidney immune and metabolic homeostasis.

Zein HS, Abou-Samra E, Scur M, Gutsol A, Hall CW, Dasgupta B, Gharibeh L, Abujamel T, Medina-Luna D, Gamage GS, Pelino TJ, Nemer M, Rahim MMA, Steinle A, Parsons BD, Makrigiannis AP

Scientific reports2022

DOI: 10.1038/s41598-022-08547-9 PMID: 35318366

Metabolomics Advanced Training and International Exchange (CREATE-MATRIX)

Co-investigatorNSERC2018Collaborative Research and Training Experience

Principal investigators: Harper, MaryEllen

$1,650,000

Genetic modifiers of congenital heart disease

Nominated PICIHR2016Project Grant

Principal investigators: Nemer, Mona

Keywords: Animal Models; Biscuspic Aortic Valve; Cardiomyocytes; Congenital Heart Disease; Endocardium; Heart Development; Transcription Factors; Transcription Regulators; Transgenic Mice

$1,184,975

Molecular and Genetic basis of heart development and disease

Nominated PICIHR2015Foundation Grant

Principal investigators: Nemer, Mona

Keywords: Animal Models; Bicuspid Aortic Valve; Cardiomyocytes; Congenital Heart Disease; Endocardium; Heart Development; Molecular And Cell Biology; Transcription Factors; Transcription Regulation; Transgenic Mice

$2,990,404

Role of GATA transcription factors in the heart

Nominated PICIHR2015Operating Grant

Principal investigators: Nemer, Mona

Keywords: Congenital Heart Disease/Heart Failure; Molecular And Cell Biology; Protein Characterization; Transcription Factors/Heart Development; Transcription Regulation; Transcription/Signal Transduction; Transgenic Mice

$100,000

Identification of GATA4 regulatory mechanisms associated with heart development and disease

SupervisorCIHR2012Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Whitcomb, Elizabeth J

Keywords: Cardiac Development; Gene Regulation; Molecular Biology; Mutagenesis; Post-Translational Modifications; Protein-Protein Interactions; Proteomics

$105,000

molecular identification of Tbx5 transcription complexes

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Dali, Rola

Keywords: Biochemistry; Congenital Heart Disease; Holt Oram Syndrom; Mass Spectroscopy; Molecular Biology; Proteomics; Tbx5; Transcription Factors

$17,500

Molecular dissection of valve and outflow tract development

Nominated PICIHR2010Operating Grant

Principal investigators: Nemer, Mona

Keywords: Animal Experimentation; Cell And Molecular Bioloby; Cell Culture; Congenital Heart Disease; Dna Cloning; Transcription Factors; Transcription Regulation In The Heart; Transgenic Mice

$758,295

Role of GATA transcription factors in the heart

Nominated PICIHR2009Operating Grant

Principal investigators: Nemer, Mona

Keywords: Molecular And Cell Biology; Protein Characterization; Transcription / Signal Transduction; Transcription Factors / Heart Development; Transcriptional Regulation; Transgenic Mice / Congenital Heart Disease / Heart Failure

$878,729

EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health

Principal investigatorCIHR2008Neurosciences and Mental Health

Principal investigators: Northoff, Georg F; Nemer, Mona

$550,000

Contribution to the France-Canada Research Fund

Principal investigatorNSERC2007Presidential Fund

Principal investigators: Nemer, Mona

$179,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry, Microbiology and Immunology
Surgery
Pathology and Laboratory Medicine
Interdisciplinary Health Sciences
Cardiac Surgery
Department of Medicine
Medicine
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Patrick Mathieu

Surgery

2 shared papers, latest 2018

Mary-Ellen Harper

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2018

Wenbin Liang

Cellular and Molecular Medicine

1 shared papers, latest 2021

Keir Menzies

Interdisciplinary Health Sciences

1 shared papers, latest 2018

Munir Boodhwani

Cardiac Surgery

1 shared papers, latest 2018

John Veinot

Pathology and Laboratory Medicine

1 shared papers, latest 2018

Robert deKemp

Department of Medicine

1 shared papers, latest 2014

Ruth McPherson

Medicine

1 shared papers, latest 2015

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Transgenic Mice Dear Professor Nemer, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A Nucleoside Analogue Bearing a C2'-Stereogenic All-Carbon Quaternary Center for the Treatment of Heart Failure." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]