Faculty profile

Patrick Mathieu

ResearcherSurgeryUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Patrick Mathieu

Researcher

Surgery

Health Sciences

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
42 publications in the last five years, latest in 2026.
Senior (last) author on 11 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (6 CIHR), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

210

Publications

809

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Gene Expression Biomarkers Mitral Valve Prolapse Molecular And Genetic Epidemiology Proteome Pathobiology Animal Model Cell Culture

Latest papers

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.
Nature genetics · 2026
Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.
Circulation · 2026
Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues.
Atherosclerosis · 2026

All 210 publications

Latest funding

The lung molecular and cellular transition to adenocarcinoma
CIHR · 2025 · Co-investigator
$1,189,576
The lung molecular and cellular transition to adenocarcinoma
CIHR · 2024 · Co-investigator
$100,000
Molecular and Genetic Epidemiology to Understand Mitral Valve Prolapse
CIHR · 2023 · Nominated PI
$1,025,100

All 23 grants and awards

From the 150 most recent of 210 publications.

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.

Small AM, Yang TY, Itoh S, Thériault S, Dufresne L, Kurosawa R, Komuro I, Matsuda K, Vy HMT, Farber-Eger EH, Shaffer LL, Boulier KM, Corey KM, Ramaker ME, Laporte F, Schott JJ, Le Scouarnec S, Singh SA, Sonawane AR, Smith HA, Rafaels N, Colorado Center for Personalized Medicine, Ghouse J, Raja AA, Ostrowski SR, Sørensen E, Mikkelsen C, Pedersen OB, Erikstrup C, Ullum H, DBDS Genomic Consortium, Sveinbjornsson G, Gudbjartsson DF, Abner E, Estonian Biobank Research Team, Lee J, Ganna A, Nowak-Göttl U, Finer S, Genes & Health Research Team, Schumacher J, Maj C, Al-Kassou B, Nickenig G, Trenkwalder T, Dreβen M, Krane M, Nöthen MM, Moksnes MR, Brumpton BM, Knight S, Knowlton KU, Nadauld L, Debiec R, Musameh MD, Braund PS, Nelson CP, Czuba T, Melander O, Selvaraj MS, Koyama S, Bhukar R, Ruan Y, Ljungberg J, Damrauer SM, Levin MG, Franke A, Berger K, Ruff CT, Melloni GEM, Kamanu FK, Ito K, Do R, Loos RJF, Schunkert H, Wells QS, Shah SH, Le Tourneau T, Messika-Zeitoun D, Gignoux C, Bundgaard H, Larsson SC, Michaëlsson K, Holm H, Helgadottir A, Esko T, van Heel DA, Mathieu P, Samani NJ, Smith JG, Söderberg S, Rader DJ, Marston NA, Sabatine MS, Pasaniuc B, Cho K, Wilson PWF, O'Donnell CJ, Stefansson K, Bossé Y, Aikawa E, Engert JC, Peloso GM, Natarajan P, Thanassoulis G

Nature genetics2026

DOI: 10.1038/s41588-025-02417-6 PMID: 41419686

Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.

Thériault S, Holdcraft JA, Sharipova D, Faucherre A, Debiec RM, Peloso GM, Al-Kassou B, Aranki S, Ashikhmina Swan E, Ballotta A, Bellino M, Björck HM, Boureau AS, Braund PS, Corriveau F, Dagenais F, Folkersen L, Forte A, Francke MD, Frigiola A, Gorbatov S, Guo D, Habchi KM, Heydarpour M, Isselbacher EM, Jopling C, Laporte F, Le Scouarnec S, Li Z, Lichtner P, Maj C, Manikpurage HD, Nelson CP, Nguyen TB, Norris RA, Ong CS, Pibarot P, Roychowdhury T, Sarubbi B, Simonet F, Sundt T, Surakka I, Tessler I, Willer CJ, Wittmann S, Yang B, Berezovets I, Doppler SA, Dreßen M, Knoll K, Puehler T, Schunkert H, Avierinos JF, Bissell MM, Bolger AP, Bossé Y, Bossone E, Brion M, Citro R, de Vincentiis C, Deeb GM, Della Corte A, Dina C, Durst R, Ensminger S, Eriksson P, Evangelista A, Franco-Cereceda A, Gilon D, Giusti B, Hetherington SL, Huggins GS, Krane M, Le Tourneau T, Limongelli G, Mathieu P, Messika-Zeitoun D, Michelena HI, Milewicz D, Muehlschlegel JD, Murdock DR, Nickenig G, Nistri S, Nöthen MM, Pluchinotta F, Prakash SK, Samani NJ, Schott JJ, Webb TR, Zaffran S, Abdelilah-Seyfried S, Eagle K, Schumacher J, Trenkwalder T, Body SC

Circulation2026

DOI: 10.1161/circulationaha.125.074752 PMID: 41645906

Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues.

Houessou U, Zamani P, Manikpurage HD, Li Z, Gaudreault N, Dahmene M, Dagenais F, Couture C, Clavel MA, Pibarot P, Mathieu P, Bossé Y, Thériault S

Atherosclerosis2026

DOI: 10.1016/j.atherosclerosis.2026.120791 PMID: 42214298

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.

Gobeil É, Bourgault J, Gagnon E, Samson N, Ruel LJ, Côté V, Mitchell PL, Gotti C, Roux-Dalvai F, Droit A, Bossé Y, Mathieu P, Lajeunesse-Trempe F, Vohl MC, Caron A, Tchernof A, Thériault S, Laplante M, Arsenault BJ

The Journal of clinical endocrinology and metabolism2026

DOI: 10.1210/clinem/dgag043 PMID: 41635218

A Transcriptomic Approach to Sex Differences in Calcific Aortic Valve Stenosis in Patients with a Tricuspid Aortic Valve.

Le Nezet E, Tam R, Li Z, Gaudreault N, Mathieu P, Côté N, Guisle I, Thériault S, Bossé Y, Clavel MA

CJC open2025

DOI: 10.1016/j.cjco.2025.02.007 PMID: 40894841

Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets.

Zamani P, Houessou U, Manikpurage HD, Li Z, Dahmene M, Gaudreault N, Dagenais F, Clavel MA, Pibarot P, Arsenault BJ, Mathieu P, Bossé Y, Thériault S

HGG advances2025

DOI: 10.1016/j.xhgg.2025.100448 PMID: 40329539

RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: a drug-target Mendelian randomization study.

Gagnon E, Gill D, Bourgault J, Gobeil É, Mitchell PL, Girard A, Paulin A, Couture C, Bossé Y, Thériault S, Mathieu P, Vohl MC, Tchernof A, Ray KK, Kastelein JJP, Arsenault BJ

Cardiovascular research2025

DOI: 10.1093/cvr/cvaf078 PMID: 40347490

Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions.

Manikpurage HD, Bourgault J, Houessou U, Paulin A, Zamani P, Gagnon E, Li Z, Boudreau DK, Eslami A, Voisine P, Mathieu P, Bossé Y, Arsenault BJ, Thériault S

Communications medicine2025

DOI: 10.1038/s43856-025-00981-w PMID: 40593158

Role of visceral adiposity in the relationship between cardiorespiratory fitness and liver fat in asymptomatic adults.

Chartrand D, Larose E, Poirier P, Mathieu P, Alméras N, Pibarot P, Lamarche B, Rhéaume C, Lemieux I, Després J, Piché M

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2025

DOI: 10.1139/apnm-2024-0478 PMID: 40532238

Transcriptomic Signatures of Calcific Aortic Valve Stenosis Severity in Human Tricuspid and Bicuspid Aortic Valves.

Houessou U, Zamani P, Manikpurage HD, Li Z, Gaudreault N, Dahmene M, Dagenais F, Couture C, Clavel MA, Pibarot P, Mathieu P, Bossé Y, Thériault S

JACC. Basic to translational science2025

DOI: 10.1016/j.jacbts.2025.01.018 PMID: 40562486

The lung molecular and cellular transition to adenocarcinoma

Co-investigatorCIHR2025Project Grant

Principal investigators: Bossé, Yohan

Keywords: Bioinformatics; Causal Genes; Expression Quantitative Trait Loci; Genomics; Genotyping; Lung Cancer; Lung Tissue; Ngs Panel; Single-Cell Analysis; Twas

$1,189,576

The lung molecular and cellular transition to adenocarcinoma

Co-investigatorCIHR2024Project Grant - Priority Announcement: Early Detection/Cancer Prevention

Principal investigators: Bossé, Yohan

Keywords: Bioinformatics; Causal Genes; Expression Quantitative Trait Loci; Genomics; Genotyping; Lung Cancer; Lung Tissue; Ngs Panel; Single-Cell Analysis; Twas

$100,000

Molecular and Genetic Epidemiology to Understand Mitral Valve Prolapse

Nominated PICIHR2023Project Grant

Principal investigators: Mathieu, Patrick

Keywords: Biomarkers; Gene Expression; Mitral Valve Prolapse; Molecular And Genetic Epidemiology; Proteome

$1,025,100

A transcriptome- and proteome-wide association study of non-alcoholic fatty liver disease

Co-investigatorCIHR2021Project Grant

Principal investigators: Arsenault, Benoit

Keywords: Electronic Health Records; Genetic Variation; Liver Histopathology; Mendelian Randomization; Non-Alcoholic Fatty Liver Disease; Proteomics; Single-Nucleotide Polymorphisms; Transcriptomics

$677,026

Elucidating the role of lipoprotein(a) in calcific aortic valve stenosis using novel proteomic and imaging approaches

Co-investigatorCIHR2019Project Grant

Principal investigators: Arsenault, Benoit

Keywords: Aortic Valve Calcification; Calcific Aortic Valve Stenosis; Family Study; Genetics; Inflammation; Lipidomics; Lipoprotein(A); Positron Emission Tomography/Computed Tomography; Proteomics; Transcriptomics

$734,400

Integrative genomics and functional analyses to uncover the molecular mechanisms involved in bicuspid aortic valve disease

Co-investigatorCIHR2018Project Grant

Principal investigators: Thériault, Sébastien

Keywords: Aortic Valve Stenosis; Aortic Valve Tissues; Bicuspid Aortic Valve; Bioinformatics; Epigenomics; Functional Studies; Gene Expression; Genomics; Gwas; Methylation

$608,175

Pharmacological Strategy to Prevent Ischemic Mitral Regurgitation: Preventing the Effects of Serotonin on Heart Valves.

Co-investigatorCIHR2018Project Grant

Principal investigators: Beaudoin, Jonathan

Keywords: Cardiovascular Imaging; Functional Mitral Regurgitation; Large Animal Models; Mitral Valve Disease; Myocardial Infarction

$298,350

Finding the molecular drivers of calcific aortic valve stenosis

Co-investigatorCIHR2018Project Grant

Principal investigators: Bossé, Yohan

Keywords: Aortic Valve Stenosis; Aortic Valve Tissues; Bioinformatics; Candidate Genes; Gene Expression; Genomics; Gwas; Molecular Drivers; Twas; Valve Interstitial Cells

$914,176

Dissecting host-microbiome modifiers of type 2 diabetes risk and complications

Co-investigatorCIHR2018Team Grant: Canadian Microbiome Initiative 2: Research Teams - LOI

Principal investigators: Marette, André; Kramer, Caroline K; Lam, Tony K; Raymond, Frederic; Schertzer, Jonathan D

Keywords: Anti-Diabetic Drugs; Diabetic Complications; Inflammation; Insulin Resistance; Intestine; Metabolism; Microbiome; Nutrition; Obesity; Type 2 Diabetes

$21,753

Functional and clinical characterization of PALMD calcific aortic valve stenosis risk locus

Nominated PICIHR2018Project Grant

Principal investigators: Mathieu, Patrick

Keywords: Pathobiology

$742,050

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Patrick Mathieu

Research

Latest papers

Latest funding

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.

Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.

Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues.

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.

A Transcriptomic Approach to Sex Differences in Calcific Aortic Valve Stenosis in Patients with a Tricuspid Aortic Valve.

Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets.

RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: a drug-target Mendelian randomization study.

Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions.

Role of visceral adiposity in the relationship between cardiorespiratory fitness and liver fat in asymptomatic adults.

Transcriptomic Signatures of Calcific Aortic Valve Stenosis Severity in Human Tricuspid and Bicuspid Aortic Valves.

Frequent collaborators

Marie-Annick Clavel

Pierre Voisine

Philippe Pibarot

Eric Larose

Paul Poirier

Marie Arsenault

Koon Teo

Philippe Joubert

Marie-Claude Vohl

George Thanassoulis

David Messika-Zeitoun

Luigi Bouchard

Benoit Arsenault

Luigi Bouchard

Jonathan Beaudoin

Arnaud Droit

Denis Richard

Francois Dagenais

Denis Boudreau

Mona Nemer

Jacques Couet

Ian Burwash

Gary Sweeney

Patrick Couture

Mathieu Laplante

Mathieu Morissette

Munir Boodhwani

David Gosselin

Alexandre Caron

Jean-Claude Tardif

Marie Kmita

Jean-Claude Tardif

Mark Lathrop

Yohan Bossé