Wandong Zhang, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Latest papers

Semi-Covariance Coefficient Analysis of Spike Proteins from SARS-CoV-2 and Its Variants Omicron, BA.5, EG.5, and JN.1 for Viral Infectivity, Virulence and Immune Escape.
Viruses · 2024 · senior author
sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway.
Biology · 2024 · senior author
Blood-Brain Barrier (BBB)-Crossing Strategies for Improved Treatment of CNS Disorders.
Handbook of experimental pharmacology · 2024 · first author

All 30 publications

Latest funding

Rapid Research Response to the 2019 Novel Coronavirus Outbreak: Development of Targeted Diagnostics, Therapeutics and Comparative Pathogenicity Assessment
CIHR · 2020 · Co-investigator
$999,999
Identify and characterize the genetic changes in cholesterol-regulator genes in late-onset Alzheimer's disease
CIHR · 2010 · Nominated PI
$150,000

All 2 grants and awards

30 publications.

01

Semi-Covariance Coefficient Analysis of Spike Proteins from SARS-CoV-2 and Its Variants Omicron, BA.5, EG.5, and JN.1 for Viral Infectivity, Virulence and Immune Escape.

Zhu B, Lin H, Huang JS, Zhang W

Viruses2024Senior author

DOI: 10.3390/v16081192 PMID: 39205166

02

sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway.

Arsenault R, Marshall S, Salois P, Li Q, Zhang W

Biology2024Senior author

DOI: 10.3390/biology13020087 PMID: 38392305

03

Blood-Brain Barrier (BBB)-Crossing Strategies for Improved Treatment of CNS Disorders.

Zhang W

Handbook of experimental pharmacology2024First author

DOI: 10.1007/164_2023_689 PMID: 37528323

04

Differential Expression of ABC Transporter Genes in Brain Vessels vs. Peripheral Tissues and Vessels from Human, Mouse and Rat.

Zhang W, Liu QY, Haqqani AS, Liu Z, Sodja C, Leclerc S, Baumann E, Delaney CE, Brunette E, Stanimirovic DB

Pharmaceutics2023First author

DOI: 10.3390/pharmaceutics15051563 PMID: 37242805

05

RAC1, a Potential Diagnostic and Prognostic Marker for Diffuse Large B Cell Lymphoma.

Wu X, Li Y, Zhang W, Zhang J, Chen B, Ge Z

Cells2022

DOI: 10.3390/cells11244039 PMID: 36552804

06

Differentiation of Human Induced Pluripotent Stem Cells (hiPSC) into Endothelial-Type Cells and Establishment of an In Vitro Blood-Brain Barrier Model.

Li Y, Terstappen GC, Zhang W

Methods in molecular biology (Clifton, N.J.)2022Senior author

DOI: 10.1007/7651_2021_363 PMID: 33689164

07

Meta-Analysis and Structural Dynamics of the Emergence of Genetic Variants of SARS-CoV-2.

Castonguay N, Zhang W, Langlois MA

Frontiers in microbiology2021

DOI: 10.3389/fmicb.2021.676314 PMID: 34267735

08

Strategies for delivering therapeutics across the blood-brain barrier.

Terstappen GC, Meyer AH, Bell RD, Zhang W

Nature reviews. Drug discovery2021Senior author

DOI: 10.1038/s41573-021-00139-y PMID: 33649582

09

Semicovariance Coefficient Analysis of Spike Proteins from SARS-CoV-2 and Other Coronaviruses for Viral Evolution and Characteristics Associated with Fatality.

Huang JS, Huang JM, Zhang W

Entropy (Basel, Switzerland)2021Senior author

DOI: 10.3390/e23050512 PMID: 33922613

10

Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human.

Zhang W, Liu QY, Haqqani AS, Leclerc S, Liu Z, Fauteux F, Baumann E, Delaney CE, Ly D, Star AT, Brunette E, Sodja C, Hewitt M, Sandhu JK, Stanimirovic DB

Fluids and barriers of the CNS2020First author

DOI: 10.1186/s12987-020-00209-0 PMID: 32698806

Rapid Research Response to the 2019 Novel Coronavirus Outbreak: Development of Targeted Diagnostics, Therapeutics and Comparative Pathogenicity Assessment

Co-investigatorCIHR2020Operating Grant: COVID-19 - Diagnostics

Principal investigators: Langlois, Marc-Andre

Keywords: 2019-Ncov; Coronavirus; Covid-19; Diagnostics; Mers; Pathogenicity; Sars; Sars-Cov-2; Vaccine; Viral Evolution

$999,999

Identify and characterize the genetic changes in cholesterol-regulator genes in late-onset Alzheimer's disease

Nominated PICIHR2010China-Canada Joint Health Research Initiative

Principal investigators: Zhang, Wandong; Yang, Ze

Keywords: Abeta Production; App Processing; Cholesterol Metabolism; Genes; Late-Onset Alzheimer'S Disease; Nuclear Receptors; Risk Factors; Secretase Activities; Snp

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cellular and Molecular Medicine
Tanz Centre for Research in Neurodegenerative Diseases
Biochemistry, Microbiology and Immunology
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Zemin Yao

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2014

Ekaterina Rogaeva

Tanz Centre for Research in Neurodegenerative Diseases

1 shared papers, latest 2016

Qiao Li

Cellular and Molecular Medicine

1 shared papers, latest 2024

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Paper to mention

Subject: Prospective PhD student Dear Professor Zhang, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Semi-Covariance Coefficient Analysis of Spike Proteins from SARS-CoV-2 and Its Variants Omicron, BA.5, EG.5, and JN.1 for Viral Infectivity, Virulence and Immune Escape." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Wandong Zhang