Zemin Yao, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Apociii Er Stress Hepatosteatosis Lumenal Lipid Droplets Proteomics Systems Biology Triacylglycerol Vldl Overproduction

Latest papers

Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?
World journal of gastroenterology · 2020
Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.
Arteriosclerosis, thrombosis, and vascular biology · 2020
Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice.
Scientific reports · 2019

All 42 publications

Latest funding

New lipid and protein factors regulating hepatic TAG homeostasis
CIHR · 2012 · Nominated PI
$617,400
Functional analysis of a new candidate gene for familial combined hyperlipidemia
CIHR · 2008 · Nominated PI
$100,000
CIHR Training Grant in Neurodegenerative Lipidomics: A Targeted Systems Biology Approach to Integrative Research Training
CIHR · 2008 · Co-investigator
$1,790,000

All 4 grants and awards

42 publications.

01

Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?

Cao Y, Shu XB, Yao Z, Ji G, Zhang L

World journal of gastroenterology2020

DOI: 10.3748/wjg.v26.i38.5812 PMID: 33132636

02

Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.

Qin Y, Ting F, Kim MJ, Strelnikov J, Harmon J, Gao F, Dose A, Teng BB, Alipour MA, Yao Z, Crooke R, Krauss RM, Medina MW

Arteriosclerosis, thrombosis, and vascular biology2020

DOI: 10.1161/atvbaha.120.314033 PMID: 32188273

03

Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice.

Li M, Dang Y, Li Q, Zhou W, Zuo J, Yao Z, Zhang L, Ji G

Scientific reports2019

DOI: 10.1038/s41598-019-44576-7 PMID: 31142783

04

Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy.

Zhang L, Yao Z, Ji G

Frontiers in pharmacology2018

DOI: 10.3389/fphar.2018.01459 PMID: 30618753

05

Co-inhibition of mTORC1, HDAC and ESR1α retards the growth of triple-negative breast cancer and suppresses cancer stem cells.

Sulaiman A, McGarry S, Lam KM, El-Sahli S, Chambers J, Kaczmarek S, Li L, Addison C, Dimitroulakos J, Arnaout A, Nessim C, Yao Z, Ji G, Song H, Liu S, Xie Y, Gadde S, Li X, Wang L

Cell death & disease2018

DOI: 10.1038/s41419-018-0811-7 PMID: 30050079

06

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Kim K, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, Pajvani UB

Cell metabolism2018

DOI: 10.1016/j.cmet.2018.02.010 PMID: 29576536

07

Dual inhibition of Wnt and Yes-associated protein signaling retards the growth of triple-negative breast cancer in both mesenchymal and epithelial states.

Sulaiman A, McGarry S, Li L, Jia D, Ooi S, Addison C, Dimitroulakos J, Arnaout A, Nessim C, Yao Z, Ji G, Song H, Gadde S, Li X, Wang L

Molecular oncology2018

DOI: 10.1002/1878-0261.12167 PMID: 29316250

08

Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/β-catenin signaling in colorectal cancer cells.

Pan J, Xu Y, Song H, Zhou X, Yao Z, Ji G

BMC complementary and alternative medicine2017

DOI: 10.1186/s12906-017-2006-7 PMID: 29183322

09

Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes.

Hiyoshi T, Fujiwara M, Yao Z

Journal of biomedical research2017Senior author

DOI: 10.7555/jbr.31.20160164 PMID: 29089472

10

The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.

Sundaram M, Curtis KR, Amir Alipour M, LeBlond ND, Margison KD, Yaworski RA, Parks RJ, McIntyre AD, Hegele RA, Fullerton MD, Yao Z

Journal of lipid research2017Senior author

DOI: 10.1194/jlr.m077313 PMID: 28887372

New lipid and protein factors regulating hepatic TAG homeostasis

Nominated PICIHR2012Operating Grant

Principal investigators: Yao, Zemin

Keywords: Apociii; Er Stress; Hepatosteatosis; Lumenal Lipid Droplets; Proteomics; Systems Biology; Triacylglycerol; Vldl Overproduction

$617,400

Functional analysis of a new candidate gene for familial combined hyperlipidemia

Nominated PICIHR2008Operating Grant - PA: Inst of Nutrition, Metabolism and Diabetes -Bridge Funding

Principal investigators: Yao, Zemin

Keywords: Apob; Apociii; Familial Combined Hyperlipdemia; Ipla2; Lipin; Recombinant Dna

$100,000

CIHR Training Grant in Neurodegenerative Lipidomics: A Targeted Systems Biology Approach to Integrative Research Training

Co-investigatorCIHR2008Training Grant

Principal investigators: Bennett, Steffany A; Figeys, Daniel

Keywords: Alzheimer And Parkinson'S Disease; Cell Biology; Lipidomics; Mass Spectrometry; Neurodegenerative Disease; Systems Biology

$1,790,000

Autophagic compartment for post-ER, pre-secretory degradation of lipid/lipoprotein

Co-investigatorNSERC2004Collaborative Research and Development Grants

Principal investigators: Jamieson, James

$125,474

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry, Microbiology and Immunology
Clinical Epidemiology
Cancer Therapeutics
Department of Medicine
Department of Laboratory Medicine and Pathobiology
Medicine
Cellular and Molecular Medicine
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Daniel Figeys

Biochemistry, Microbiology and Immunology

7 shared papers, latest 2015

Lisheng Wang

Biochemistry, Microbiology and Immunology

5 shared papers, latest 2018

Suresh Gadde

Biochemistry, Microbiology and Immunology

3 shared papers, latest 2018

Angel Arnaout

Clinical Epidemiology

2 shared papers, latest 2018

Christina Addison

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2018

Jim Dimitroulakos

Cancer Therapeutics

2 shared papers, latest 2018

Wandong Zhang

Cellular and Molecular Medicine

1 shared papers, latest 2014

Alexandre Blais

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2010

Khosrow Adeli

Department of Laboratory Medicine and Pathobiology

1 shared papers, latest 2017

David Allan

Department of Medicine

1 shared papers, latest 2017

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Apociii Dear Professor Yao, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?" (2020), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Zemin Yao

Research

Latest papers

Latest funding

Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?

Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.

Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice.

Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy.

Co-inhibition of mTORC1, HDAC and ESR1α retards the growth of triple-negative breast cancer and suppresses cancer stem cells.

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Dual inhibition of Wnt and Yes-associated protein signaling retards the growth of triple-negative breast cancer in both mesenchymal and epithelial states.

Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/β-catenin signaling in colorectal cancer cells.

Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes.

The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.

New lipid and protein factors regulating hepatic TAG homeostasis

Functional analysis of a new candidate gene for familial combined hyperlipidemia

CIHR Training Grant in Neurodegenerative Lipidomics: A Targeted Systems Biology Approach to Integrative Research Training

Autophagic compartment for post-ER, pre-secretory degradation of lipid/lipoprotein

Frequent collaborators

Daniel Figeys

Lisheng Wang

Suresh Gadde

Angel Arnaout

Christina Addison

Jim Dimitroulakos

Jing Zhang

Wandong Zhang

Ruth McPherson

Alexandre Blais

Khosrow Adeli

Jennifer Taher

David Allan

Zemin Yao

Research

Latest papers

Latest funding

Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?

Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation.

Berberine alleviates hyperglycemia by targeting hepatic glucokinase in diabetic db/db mice.

Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy.

Co-inhibition of mTORC1, HDAC and ESR1&#x3b1; retards the growth of triple-negative breast cancer and suppresses cancer stem cells.

&#x3b3;-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Dual inhibition of Wnt and Yes-associated protein signaling retards the growth of triple-negative breast cancer in both mesenchymal and epithelial states.

Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/&#x3b2;-catenin signaling in colorectal cancer cells.

Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes.

The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.

New lipid and protein factors regulating hepatic TAG homeostasis

Functional analysis of a new candidate gene for familial combined hyperlipidemia

CIHR Training Grant in Neurodegenerative Lipidomics: A Targeted Systems Biology Approach to Integrative Research Training

Autophagic compartment for post-ER, pre-secretory degradation of lipid/lipoprotein

Frequent collaborators

Daniel Figeys

Lisheng Wang

Suresh Gadde

Angel Arnaout

Christina Addison

Jim Dimitroulakos

Jing Zhang

Wandong Zhang

Ruth McPherson

Alexandre Blais

Khosrow Adeli

Jennifer Taher

David Allan

Co-inhibition of mTORC1, HDAC and ESR1α retards the growth of triple-negative breast cancer and suppresses cancer stem cells.

γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/β-catenin signaling in colorectal cancer cells.