Faculty profile

Ekaterina Rogaeva

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ProfessorTanz Centre for Research in Neurodegenerative DiseasesUniversity of Toronto

Ekaterina Rogaeva

Professor

Tanz Centre for Research in Neurodegenerative Diseases

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
58 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 2 research grants (2 CIHR), most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

182

Publications

1,522

Citations

h-index

137

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Education

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Alzheimer Disease Dementia Diagnosis Prevention Quality Of Life Sex Treatment

Latest papers

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.
Nature genetics · 2026
A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.
Nature genetics · 2026
Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset.
NPJ Parkinson's disease · 2026

All 182 publications

Latest funding

Resilience to age-related dementia by the microglial ABI-WAVE2 signaling axis
CIHR · 2023 · Co-investigator
$749,990
Leveraging Advances in Human Electrophysiology in Identifying Mild Cognitive Impairment Subtypes
CIHR · 2022 · Co-investigator
$378,676
Genetic Frontotemporal Dementia Initiative (GENFI) in Canada: Combined Investigation of Clinical, MRI, Genomic, and Epigenomic Biomarkers
CIHR · 2020 · Co-investigator
$1,128,375

All 11 grants and awards

From the 150 most recent of 182 publications.

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.

Hop PJ, Kooyman M, Kenna BJ, Zwamborn RAJ, van Eijk KR, Wang Y, van Dijk CH, Bekema E, van Rheenen W, Beele P, van Vugt JJFA, Project MinE ALS sequencing Consortium, NYGC ALS Consortium, FALS sequencing Consortium, GTAC Consortium, Khleifat AA, Iacoangeli A, Cooper-Knock J, Smith BN, Topp S, van der Kooi AJ, Fominykh V, Drory V, Lerner Y, Shovman Y, Rowe DB, Williams KL, McLaughlin RL, Hurt J, Huang Y, Chen CY, Tsai E, Runz H, Aronica E, Groen EJN, van Es MA, Pasterkamp RJ, Farhan SMK, Garton FC, McRae AF, McCombe PA, Henderson RD, Fan D, Šlachtová L, Høyer H, Nishimura AL, Cauchi RJ, Brylev L, Rogelj B, Koritnik B, Zidar J, Salas T, Mora Pardina JS, Gotkine M, Povedano M, Corcia P, Vourc'h P, Couratier P, Weber M, Kiernan MC, Pamphlett R, Blair IP, de Carvalho M, Başak NA, Ingre C, Andersen PM, Zinman L, Rogaeva E, MacKenzie IR, Dupre N, Rouleau GA, Traynor BJ, Ticozzi N, Chiò A, Silani V, Hardiman O, Phatnani H, Harms MB, Dalgard CL, Glass JD, Landers JE, Van Damme P, Morrison KE, Shaw PJ, Shaw CE, Al-Chalabi A, van den Berg LH, Kenna KP, Veldink JH

Nature genetics2026

DOI: 10.1038/s41588-026-02535-9 PMID: 41917433

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

De Coster W, Van den Broeck M, Baker M, Ghayal NB, Wynants S, Batzler A, Pottier C, Alidadiani S, Küçükali F, Jenkins GD, Policarpo R, van Blitterswijk M, DeJesus-Hernandez M, Soto-Beasley AI, Faura J, Coopman E, Hutten S, Mol MO, Wallon D, Sieben A, Finger EC, Murray ME, Forrest SL, Tartaglia MC, Troakes C, van Rooij JGJ, Nguyen AT, Reichard RR, Woodman NL, Nana AL, Weintraub S, Gefen T, De Vil B, Bodi I, Lopez OL, Boluda S, Belliard S, Lebert F, Marguet F, Mao Q, Mesulam MM, Boxer AL, Vandenbulcke M, Suh E, Schaeverbeke J, Lambert JC, Scholz SW, Dalgard CL, Traynor BJ, Gibbs RJ, Schellenberg GD, Dormann D, Joris G, De Pooter T, De Rijk P, D'Hert S, Van Dongen J, van der Zee J, Strazisar M, Gearing M, Kukar T, Flanagan M, Engelborghs S, Ghetti B, Newell KL, King A, Roeber S, Rosen HJ, Spina S, Cras P, Ertekin-Taner N, Wszolek ZK, Uitti RJ, Cheshire WP, Singer W, Herms J, Josephs KA, Whitwell JL, Petersen RC, Pasquier F, Nicolas G, Castellani R, Glass J, Miller BL, Kovacs GG, Rissman RA, Hiniker A, Deramecourt V, Ang LC, Lee-Way J, Van Deerlin VM, Dugger BN, Thal DR, Grinberg LT, Cruchaga C, Arzberger T, Munoz DG, Keith J, Zinman L, Rogaeva E, Lee EB, Haggarty SJ, Ansorge O, Husain M, Halliday GM, Al-Sarraj S, Ross OA, Sleegers K, Vandenberghe R, Boeve BF, Graff-Radford NR, Kofler J, White CL, Lashley T, Neumann M, Biernacka JM, Seeley WW, Seelaar H, van Swieten JC, Rohrer JD, Dickson DW, Mackenzie IRA, Rademakers R

Nature genetics2026

DOI: 10.1038/s41588-026-02537-7 PMID: 41820575

Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset.

Vincze K, Szwajda A, Ploner A, Karlsson R, Kang X, Tang B, Qin C, Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschlander AB, Burbulla LF, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, Van de Warrenburg BP, Bloem BR, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Ran C, Belin AC, Puschmann A, Clarke CE, Morrison KE, Tan M, Krainc D, Farrer MJ, Landoulsi Z, Kruger R, Gasser T, Elbaz A, Sharma M, Pedersen NL, Carlsson S, Hägg S, Wirdefeldt K, Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) Consortium, Domenighetti C, Sugier PE, Ashok Kumar Sreelatha A, Schulte C, Portugal B, May P, Bobbili DR, Radivojkov-Blagojevic M, Lichtner P, Singleton AB, Hernandez DG, Edsall C, Mellick GD, Zimprich A, Pirker W, Rogaeva E, Lang AE, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschlander AB, Burbulla LF, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Kolber P, Van de Warrenburg BP, Bloem BR, Toft M, Pihlstrøm L, Correia Guedes L, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Ran C, Belin AC, Puschmann A, Clarke CE, Morrison KE, Tan M, Krainc D, Farrer MJ, Landoulsi Z, Kruger R, Gasser T, Elbaz A, Sharma M, Wirdefeldt K

NPJ Parkinson's disease2026

DOI: 10.1038/s41531-026-01398-5 PMID: 42209523

The study of epigenetic clocks in former professional contact sports athletes with repetitive head impacts.

Tang X, Sumra V, Sato C, Moreno D, Khodadadi M, Sadia N, Wong C, Colella B, Green REA, Ta J, Blennow K, Zetterberg H, Wennberg R, Tator CH, Zhang M, Rogaeva E, Tartaglia MC

Journal of neurology, neurosurgery, and psychiatry2026

DOI: 10.1136/jnnp-2025-338206 PMID: 42114983

Multi-omics analyses identify potential epigenetic loci associated with survival in amyotrophic lateral sclerosis across diverse populations.

Gu Y, Chen Y, Tang X, Guo J, Hu J, Yang W, Li J, Chen X, Fan D, Chen GB, He J, Ren Y, Dong Y, Sato C, Chen Y, Zinman L, Rogaeva E, Zhang M

EBioMedicine2026

DOI: 10.1016/j.ebiom.2025.106071 PMID: 41380476

Genome-wide association study of copy number variations in Parkinson's disease.

Landoulsi Z, Sreelatha AAK, Kuznetsov N, Schulte C, Bobbili DR, Montanucci L, Leu C, Niestroj LM, Hassanin E, Domenighetti C, Sugier PE, Radivojkov-Blagojevic M, Lichtner P, Portugal B, Edsall C, Krüger J, Hernandez DG, Blauwendraat C, Mellick GD, Zimprich A, Pirker W, Tan M, Rogaeva E, Lang A, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Burbulla LF, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Pavelka L, Kolber P, van de Warrenburg BP, Bloem BR, Singleton AB, Vitale D, Toft M, Pihlstrom L, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Clarke CE, Morrison KE, Krainc D, Farrer MJ, Lal D, Global Parkinson Genetics Program (GP2), Elbaz A, Gasser T, Krüger R, Sharma M, May P, Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson’s Disease (COURAGE-PD) consortium

NPJ Parkinson's disease2026

DOI: 10.1038/s41531-025-01245-z PMID: 42009659

Genome-wide association study of copy number variations in Parkinson's disease.

Landoulsi Z, Sreelatha AAK, Kuznetsov N, Schulte C, Bobbili DR, Montanucci L, Leu C, Niestroj LM, Hassanin E, Domenighetti C, Sugier PE, Radivojkov-Blagojevic M, Lichtner P, Portugal B, Edsall C, Kru Ger J, Hernandez DG, Blauwendraat C, Mellick GD, Zimprich A, Pirker W, Tan M, Rogaeva E, Lang A, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Burbulla LF, Matsuo H, Nakayama A, Hattori N, Nishioka K, Chung SJ, Kim YJ, Pavelka L, Kolber P, van de Warrenburg BP, Bloem BR, Singleton AB, Vitale D, Toft M, Pihlstrom L, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Clarke CE, Morrison KE, Krainc D, Farrer MJ, Lal D, Global Parkinson Genetics Program (GP2), Elbaz A, Gasser T, Krüger R, Sharma M, May P

medRxiv : the preprint server for health sciences2025

DOI: 10.1101/2024.08.21.24311915 PMID: 39228715

Deep learning analyses of splicing variants identify the link of PCP4 with amyotrophic lateral sclerosis.

Tang X, Chen Y, Ren Y, Yang W, Yu W, Zhou Y, Guo J, Hu J, Chen X, Gu Y, Wang C, Dong Y, Yang H, Sato C, He J, Fan D, You L, Zinman L, Rogaeva E, Chen Y, Zhang M

Brain : a journal of neurology2025

DOI: 10.1093/brain/awaf025 PMID: 39852553

A novel PSEN2 mutation in amnestic early-onset Alzheimer's disease (EOAD): A familial case series.

Leochico CFD, Rogaeva E, Zotovic L, Oliveira ALP, Le T, Singnurkar A, Masellis M, Mitchell SB

Journal of Alzheimer's disease reports2025

DOI: 10.1177/25424823251348676 PMID: 40575115

Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology.

Enomoto M, Martinez-Valbuena I, Forrest SL, Xu X, Munhoz RP, Li J, Rogaeva E, Lang AE, Kovacs GG

Communications biology2025

DOI: 10.1038/s42003-025-08355-7 PMID: 40523906

Resilience to age-related dementia by the microglial ABI-WAVE2 signaling axis

Co-investigatorCIHR2023Operating Grant: Mechanisms in Brain Aging and Dementia

Principal investigators: Siminovitch, Katherine A

Keywords: Aging

$749,990

Leveraging Advances in Human Electrophysiology in Identifying Mild Cognitive Impairment Subtypes

Co-investigatorCIHR2022Project Grant

Principal investigators: Alain, Claude

Keywords: Aging; Auditory Processing; Cognition; Eeg; Mild Cognitive Impairment

$378,676

Genetic Frontotemporal Dementia Initiative (GENFI) in Canada: Combined Investigation of Clinical, MRI, Genomic, and Epigenomic Biomarkers

Co-investigatorCIHR2020Project Grant

Principal investigators: Masellis, Mario; Finger, Elizabeth

Keywords: C9orf72; Dna Methylation; Epigenomics; Frontotemporal Dementia; Genomics; Grn; Mapt; Mri; Quantitative Traits; Single Nucleotide Polymorphisms

$1,128,375

Phase Two of the Canadian Consortium on Neurodegeneration in Aging

Principal investigatorCIHR2019Canadian Consortium on Neurodegeneration in Aging

Principal investigators: Chertkow, Howard M; Anderson, Nicole D; Andrew, Melissa K; Bartha, Robert; Bellec, Pierre; Belleville, Sylvie N; Bergman, Howard; Bherer, Louis; Black, Sandra E; Borrie, Michael J; Camicioli, J. Richard M; Carrier, Julie; Cashman, Neil R; Collins, Donald L; Cuello, A. Claudio G; Dixon, Roger A; Ducharme, Simon; Duchesne, Simon; Einstein, Gillian; Eintracht, Shaun; Evans, Alan C; Fahnestock, Margaret; Feldman, Howard; Ferland, Guylaine; Fisk, John D; Gan-Or, Ziv; Giguère, Anik; Herrmann, Nathan; Hsiung, Ging-Yuek R; Lanctôt, Krista L; Lim, Andrew S; Mackenzie, Ian R; Masellis, Mario; Maxwell, Colleen J; McGilton, Katherine S; Mclaurin, Joanne; Montero Odasso, Manuel M; Morgan, Debra G; Naglie, Gary; Nygaard, Haakon B; O'Connell, Megan E; Phillips, Natalie A; Poirier, Judes; Rapoport, Mark J; Robillard, Julie; Rockwood, Kenneth; Rogaeva, Ekaterina; Rosa-Neto, Pedro; Rylett, Jane R; Seitz, Dallas P; Siminovitch, Katherine A; Smith, Eric E; ST GEORGE-HYSLOP, Peter H; Vedel, Isabelle; Walker, Jennifer; Wittich, Walter

Keywords: Alzheimer Disease; Dementia; Diagnosis; Prevention; Quality Of Life; Sex; Treatment

$31,625,000

Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies

Co-investigatorCIHR2018Foundation Grant

Principal investigators: ST GEORGE-HYSLOP, Peter H

Keywords: Alzheimer Disease; Biomarkers; Frontotemporal Lobar Degeneration; Functional Genetics Of Risk Genes; Intrinsically Disordered Phase Separating Proteins; Neurological Disorders; Therapeutic Targets

$3,062,890

Small Vessel Disease meets protein misfolding: Phenobanking common dementias in clinical care to inform future precision medicine.

Co-investigatorCIHR2017Foundation Grant

Principal investigators: Black, Sandra E

Keywords: Dementia (Alzheimer'S, Frontotemporal, And Lewy Body); Imaging- Genetics; Longitudinal Cohort; Molecular Pet; Mri (Structural/Functional); Neurobehaviour (E.G., Depression, Apathy); Neuropathology; Neuropsychology; Spect; Vascular Cognitive Disorders

$2,081,600

Cohort to illuminate Neurodegeneration, Genetics, Imaging Associations and Leukoaraiosis (CONGENIAL)

Co-investigatorCIHR2015Operating Grant

Principal investigators: Black, Sandra E; Masellis, Mario

Keywords: And Lewy Body); Apathy); Dementia (Alzheimer'S; Depression; Frontotemporal; Imaging-Genetics; Longitudinal Cohort; Mri (Structural/Functional); Neurobehaviour (E.G.; Neuropathology; Neuropsychology; Spect; Vascular Cognitive Disorders

$919,405

Genetic Frontotemporal Dementia Initiative (GENFI) in Canada

Co-investigatorCIHR2014Operating Grant

Principal investigators: Masellis, Mario; Finger, Elizabeth

Keywords: Biomarkers; C9orf72; Cognition; Frontotemporal Dementia; Genomics; Mapt; Mri; Prgn

$932,818

In Vivo Brain Mapping in the Dementias: A Longitudinal Brain-Behaviour Study with a Focus on Cerebrovascular Disease and Heterogeneity

Co-investigatorCIHR2013Operating Grant

Principal investigators: Black, Sandra E; Masellis, Mario

Keywords: Dementia (Alzheimer'S; Frontotemporal; Imaging-Genetics; Lewy Body); Longitudinal Cohort; Mri (Structural/Functional); Neurodegenerative Gait Disorders; Neuropathology; Neuropsychology; Single Photon Emission Computerized Tomography; Vascular Cognitive Disorders

$100,000

Mutational and Functional Analysis of Genes Identified by GWAS Studies of Alzheimer's Disease

Co-investigatorCIHR2011Operating Grant

Principal investigators: ST GEORGE-HYSLOP, Peter H

Keywords: Aging; Genetics; Neurodegeneration; Neuroscience

$1,473,232

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

Something wrong or missing on this profile? Suggest a correction

Ekaterina Rogaeva

Research

Latest papers

Latest funding

Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Genetic variation in antidiabetic drug targets: associations with Parkinson's disease risk and age at onset.

The study of epigenetic clocks in former professional contact sports athletes with repetitive head impacts.

Multi-omics analyses identify potential epigenetic loci associated with survival in amyotrophic lateral sclerosis across diverse populations.

Genome-wide association study of copy number variations in Parkinson's disease.

Genome-wide association study of copy number variations in Parkinson's disease.

Deep learning analyses of splicing variants identify the link of PCP4 with amyotrophic lateral sclerosis.

A novel PSEN2 mutation in amnestic early-onset Alzheimer's disease (EOAD): A familial case series.

Lewy-MSA hybrid fold drives distinct neuronal &#x3b1;-synuclein pathology.

Frequent collaborators

Peter ST GEORGE-HYSLOP

Janice Robertson

Mario Masellis

Elizabeth Finger

Connie Marras

Gerold Schmitt-Ulms

Gustavo Saposnik

Dar Dowlatshahi

Demetrios Sahlas

Michael Borrie

Sanjeev Kumar

Andrew Frank

David Grimes

John Turnbull

Robert Bartha

Anthony Lang

Dallas Seitz

Raphael Schneider

Robert Laforce

Robin Green

David Mikulis

Yana Yunusova

Lili-Naz Hazrati

Alfonso Fasano

Simon Ducharme

Susan Fox

Paul Fraser

Manuel Montero Odasso

Stephen Pasternak

Walter Swardfager

James Raymond Gilbert

Nathan Herrmann

Veronica Hirsch Reinshagen

Sali Farhan

Jason Karamchandani

Jason Karamchandani

Naomi Visanji

Malcolm Binns

Wendy Lou

Howard Chertkow

Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology.