Faculty profile

Aleixo Muise

ResearcherPediatricsUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Aleixo Muise

Researcher

Pediatrics

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
8 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 12 research grants (12 CIHR), most recently in 2025.
Supervisor on 11 trainee awards (11 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Pediatrics Inflammatory Bowel Disease Crc Ulcerative Colitis Apoptosis Lysosome-Mediated Cellular Repair Oraganoids Sex And Gender

Latest papers

TTC7A deficiency: A retrospective international study on treatment and outcomes from the Inborn Errors Working Party of EBMT.
Journal of human immunity · 2026
Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.
Gut · 2026
Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study
Journal of Crohn's and Colitis · 2024

All 22 publications

Latest funding

Microbial and immune drivers of adverse intestinal responses to ultra-processed foods (UPFs) in paediatric Crohn disease.
CIHR · 2026 · Co-investigator
$10,000
Studies of VEOIBD
CIHR · 2025 · Supervisor
$6,000
Canada Research Chair - Tier 1
CIHR · 2025 · Nominated PI
$1,400,000

All 29 grants and awards

22 publications.

TTC7A deficiency: A retrospective international study on treatment and outcomes from the Inborn Errors Working Party of EBMT.

Prunotto G, Parreillet M, Neven B, Moshous D, de Saint Basile G, Lindemans C, Leahy TR, Haddad E, Pichler H, Farela Neves J, Slatter M, Radwan N, Speckmann C, Tzivinikos C, Hoffenberg EJ, Ooi CY, Pinzon-Charry A, Ee LC, Ricci S, Albert MH, O'Donnell J, Worth A, Uhlig HH, Muise A, Lucchini G

Journal of human immunity2026

DOI: 10.70962/jhi.20250271 PMID: 42421851

Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.

Gharahdaghi N, Yeh PJ, Vadakethala K, Coy M, Kabiri L, Naz B, Jayamanne C, Hansson L, Zouboulis V, Rodrigues A, Howarth L, Alqahtani F, Ghate A, Vázquez López F, Green Z, Beattie RM, Gasparetto M, Nedelkopoulou N, Iyengar A, Gopan A, Croft NM, Grimaldi C, Kammermeier J, Jones K, Barendregt DMH, Chen M, Barnardo M, Zhang Q, Fachal L, Anderson CA, Adams A, Johnson H, Gordon H, Tal N, Renji E, Wilson DC, Henderson P, Muhammed R, Lee KY, Kapoor A, Levi R, Zilbauer M, Griffiths AM, Turner D, Hambleton S, Doffinger R, Samsom JN, UK PIBD BioResource, Parkes M, Travis SP, Shouval DS, de Ridder L, Muise A, Snapper SB, Ashton JJ, Ennis S, Uhlig HH

Gut2026

DOI: 10.1136/gutjnl-2026-339329 PMID: 42580871

Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study

Dhaliwal J, Tertigas D, Carman N, Lawrence S, Debruyn JC, Wine E, Church PC, Huynh HQ, Rashid M, El-Matary W

Journal of Crohn's and Colitis202419 citations

DOI: 10.1093/ecco-jcc/jjad143

Gut Immunomodulation with Vedolizumab prior to Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients with Inflammatory Bowel Disease.

Chopra Y, Acevedo K, Muise A, Frost K, Schechter T, Krueger J, Ali M, Chiang KY, Kim VH, Grunebaum E, Wall D

Transplantation and cellular therapy2024

DOI: 10.1016/j.jtct.2024.03.006 PMID: 38458476

Improved long-term outcome of children with congenital diarrhea followed by an intestinal rehabilitation program.

Spector Cohen I, Belza C, Courtney-Martin G, Srbely V, Wales PW, Muise A, Avitzur Y

Journal of pediatric gastroenterology and nutrition2024

DOI: 10.1002/jpn3.12275 PMID: 38828718

Diet management in congenital diarrheas and enteropathies - general concepts and disease-specific approach, a narrative review.

Avitzur Y, Jimenez L, Martincevic I, Acra S, Courtney-Martin G, Gray M, Hope K, Muise A, Prieto Jimenez PM, Taylor N, Thiagarajah JR, Martín MG, PediCODE Consortium

The American journal of clinical nutrition2024

DOI: 10.1016/j.ajcnut.2024.05.004 PMID: 38734141

Beyond IBD: the genetics of other early-onset diarrhoeal disorders.

Stallard L, Siddiqui I, Muise A

Human genetics2023Senior author

DOI: 10.1007/s00439-023-02524-6 PMID: 36788146

Long-Term Outcomes With Adalimumab Therapy in Pediatric Crohn Disease: Associations With Adalimumab Exposure.

Rinawi F, Popalis C, Tersigni C, Frost K, Muise A, Church PC, Walters TD, Ricciuto A, Griffiths AM

Journal of pediatric gastroenterology and nutrition2022

DOI: 10.1097/mpg.0000000000003366 PMID: 35226647

Whipple disease mimicking inflammatory bowel disease.

Tatsuki M, Ishige T, Igarashi Y, Hatori R, Hokama A, Hirato J, Muise A, Takizawa T, Arakawa H

Intestinal research2021

DOI: 10.5217/ir.2019.09177 PMID: 32610889

Multisystem Autoimmune Inflammatory Disease, Including Colitis, Due to Inborn Error of Immunity.

Malik A, Stringer E, Warner N, van Limbergen J, Vandersteen A, Muise A, Derfalvi B

Pediatrics2021

DOI: 10.1542/peds.2021-050614 PMID: 34686572

Microbial and immune drivers of adverse intestinal responses to ultra-processed foods (UPFs) in paediatric Crohn disease.

Co-investigatorCIHR2026Team Grant: Health Effects of Ultra-Processed Foods - In HDCYH -LOI

Principal investigators: Wine, Eytan; Danska, Jayne S; Riggioni, Carmen; Vallance, Bruce A

Keywords: Crohn Disease; Gut Microbes; Host-Microbe Interactions; Immune Response; Inflammatory Bowel Diseases (Ibd); Nutrition; Paediatrics; Ultra Processed Foods

$10,000

Studies of VEOIBD

SupervisorCIHR2025Undergraduate Student Research Awards (USRA)

Principal investigators: Bindoo, Nicholas

Keywords: Gene Function; Genes; Manual Filtering; Pathogenesis; Variants

$6,000

Canada Research Chair - Tier 1

Nominated PICIHR2025Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Muise, Aleixo M

Keywords: Crc

$1,400,000

Functional Genomic Analysis in Paediatric Inflammatory Bowel Disease - Using RNAseq to Identify and Validate Monogenic Variants and Define Novel Immune Mechanisms with Relevance to Precision Medicine

SupervisorCIHR2025Canada Postdoctoral Research Award (CPRA) program

Principal investigators: O'Donnell, Jonathan E

Keywords: Functional Genomics; Immune Dysregulation; Mongenic Disorders; Paediatric Gastroenterology; Pediatric Inflammatory Bowel Disease; Precision Medicine

$140,000

Investigating the role of ITGAV-dependent B cell activation in allergy and autoimmunity

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Yu, Daniel D

Keywords: Allergy; Autoimmunity; Cell Signaling; Inflammatory Bowel Disease; Microscopy; Monogenic Diseases; Signal Transduction

$120,000

Polygenic variant patterns explain new pathway-based molecular models of inflammatory bowel disease pathogenesis

SupervisorCIHR2019Fellowship - Priority Announcement: Gastroenterology

Principal investigators: Mulder, Daniel J

Keywords: Epistasis; Genomics; Inflammatory Bowel Disease; Molecular Pathway Analysis; Next Generation Sequencing; Pedigree Analysis; Personalized Medicine; Phenotype-Genotype Interactions; Polygenic Inheritance; Whole Exome Sequencing

$55,000

Defining the immune dysregulation underlying Pediatric IBD to better diagnose and treat patients.

Nominated PICIHR2019Autoimmune diseases related to digestive system, kidney, pancreas and liver pool

Principal investigators: Muise, Aleixo M; Brumell, John H; Gruenheid, Samantha L; Mortha, Arthur; Vallance, Bruce A

Keywords: Lysosome-Mediated Cellular Repair; Oraganoids; Pediatrics; Sex And Gender; Ulcerative Colitis

$1,514,500

Defining the immuno-dysregulation underlying Pediatric IBD to better diagnose and treat patients.

Nominated PICIHR2018Team Grant: Human Immunology Initiative: Research Teams - LOI

Principal investigators: Muise, Aleixo M; Brumell, John H; Gruenheid, Samantha L; Mortha, Arthur; Vallance, Bruce A

Keywords: Children; Drug Treatment; Enteroids; Immune Dysregulation; Inflammatory Bowel Disease; Mouse Models; Pediatrics

$20,000

Developing Targeted Therapies for Rare and Common Forms of Inflammatory Bowel Disease

Nominated PICIHR2018Foundation Grant

Principal investigators: Muise, Aleixo M

Keywords: Drug Screening; Genetics; Inflammatory Bowel Disease; Monogenic Defects; Pediatrics; Zebrafish

$2,955,578

Canada Research Chair - Tier 1

Nominated PICIHR2018Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Muise, Aleixo M

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Aleixo Muise

Research

Latest papers

Latest funding

TTC7A deficiency: A retrospective international study on treatment and outcomes from the Inborn Errors Working Party of EBMT.

Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.

Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study

Gut Immunomodulation with Vedolizumab prior to Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients with Inflammatory Bowel Disease.

Improved long-term outcome of children with congenital diarrhea followed by an intestinal rehabilitation program.

Diet management in congenital diarrheas and enteropathies - general concepts and disease-specific approach, a narrative review.

Beyond IBD: the genetics of other early-onset diarrhoeal disorders.

Long-Term Outcomes With Adalimumab Therapy in Pediatric Crohn Disease: Associations With Adalimumab Exposure.

Whipple disease mimicking inflammatory bowel disease.

Multisystem Autoimmune Inflammatory Disease, Including Colitis, Due to Inborn Error of Immunity.

Microbial and immune drivers of adverse intestinal responses to ultra-processed foods (UPFs) in paediatric Crohn disease.

Studies of VEOIBD

Canada Research Chair - Tier 1

Functional Genomic Analysis in Paediatric Inflammatory Bowel Disease - Using RNAseq to Identify and Validate Monogenic Variants and Define Novel Immune Mechanisms with Relevance to Precision Medicine

Investigating the role of ITGAV-dependent B cell activation in allergy and autoimmunity

Polygenic variant patterns explain new pathway-based molecular models of inflammatory bowel disease pathogenesis

Defining the immune dysregulation underlying Pediatric IBD to better diagnose and treat patients.

Defining the immuno-dysregulation underlying Pediatric IBD to better diagnose and treat patients.

Developing Targeted Therapies for Rare and Common Forms of Inflammatory Bowel Disease

Canada Research Chair - Tier 1

Frequent collaborators

Amanda Ricciuto

Daniela Rotin

Johan Van Limbergen

Glenda Courtney-Martin

Eytan Wine

Beata Derfalvi

Prévost Jantchou

Bruce Vallance

Michael Surette

Elie Haddad