Faculty profile

Bruce Vallance

ResearcherPediatricsUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.

Bruce Vallance

Researcher

Pediatrics

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
3 publications in the last five years, latest in 2025.
Principal investigator on 15 research grants (12 CIHR, 3 NSERC), most recently in 2026.
Supervised 9 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Mucus Organoids Colon Nutrition Intestinal Epithelial Cells Microbes Mice Bacterial Pathogen

Latest papers

Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease.
World journal of gastroenterology · 2025
Early Life Exposure to Parental Crohn’s Disease Is Associated With Offspring’s Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn’s Disease
Gastroenterology · 2025
Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study
Journal of Crohn's and Colitis · 2024

All 6 publications

Latest funding

Mid-Colon Goblet Cells: Primary Source of the Protective Colonic Mucus Barrier
CIHR · 2026 · Nominated PI
$1,078,650
Mid-Colon Goblet Cells: Primary Source of the Protective Colonic Mucus Barrier
CIHR · 2025 · Nominated PI
$100,000
Modeling Microbe-Host Interactions in Patients with Crohn's Disease
CIHR · 2025 · Supervisor
$120,000

All 26 grants and awards

Mid-Colon Goblet Cells: Primary Source of the Protective Colonic Mucus Barrier

Nominated PICIHR2026Project Grant

Principal investigators: Vallance, Bruce A

Keywords: Colon; Microbes; Mucus; Organoids

$1,078,650

Mid-Colon Goblet Cells: Primary Source of the Protective Colonic Mucus Barrier

Nominated PICIHR2025Project Grant - PA: Nutrition, Metabolism and Diabetes

Principal investigators: Vallance, Bruce A

Keywords: Colon; Microbes; Mucus; Organoids

$100,000

Modeling Microbe-Host Interactions in Patients with Crohn's Disease

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Sousa, James A

Keywords: Inflammatory Bowel Disease; Microbiome; Mucus; Organoid

$120,000

Using patient-derived organoids to reveal how Bacteroides vulgatus proteases disrupt the intestinal barrier in inflammatory bowel disease.

SupervisorCIHR2025Canada Postdoctoral Research Award (CPRA) program

Principal investigators: Wood, Hannah M

Keywords: Bacteria; Barrier Dysfunction; Gut Microbiota; Host-Microbe Interactions; Human Intestinal Organoids; Inflammatory Bowel Disease; Intestinal Barrier Integrity; Microbial Proteases; Protease; Proteolytic Activity

$140,000

Colonic mucus-derived sugars fuel the growth and virulence of pathogenic enteric bacteria.

Nominated PICIHR2023Project Grant

Principal investigators: Vallance, Bruce A

Keywords: Colon; Colonoids; Enteric Bacterial Infection; Metabolism; Mice; Monosaccharides; Mucinases; Mucus Glycans; Nutrition

$956,250

Crossing the barrier: Defining mechanisms of IBD pathobiont-based mucus degradation

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Gilliland, Ashley R

Keywords: Gastrointestinal Mucus; Intestinal Bowel Diseases; Knockout Gene Mutants; Liquid Chromatography-Mass Spectrometry; Luminescent Gene Reporters; Microbiome 16s Rrna; Mouse Models; Organoids; Pathobionts; Rna-Seq

$105,000

Colonic Goblet Cells and Mucus: Defining Their Roles in Host Defense and Mucosal Protection

Nominated PICIHR2021Project Grant

Principal investigators: Vallance, Bruce A

Keywords: Bacterial Pathogen; Intestinal Epithelial Cells; Intestine; Microbiome; Mucus

$918,000

Hypoxia Culture Suite

Co-investigatorNSERC2021Research Tools and Instruments

Principal investigators: Beristain, Alexander

$150,000

Role of microbes in the pathogenesis of PIBD: From discovery, through causation, to novel treatments

Nominated PICIHR2019Team Grant: Canadian Microbiome Initiative 2: Research Teams - IHDCYH Pool

Principal investigators: Vallance, Bruce A; Griffiths, Anne Marie; Mack, David R; Muise, Aleixo M; Parkinson, John; Ricciuto, Amanda; Surette, Michael G; Tropini, Carolina; Wine, Eytan

Keywords: Children; Inflammatory Bowel Disease; Microbiome; Mucus; Multi-Omics; Nutrition; Organoids; Pathobionts; Pediatrics; Therapeutic Interventions

$2,000,000

SIGIRR: Preserving Gut Defense by Suppressing Epithelial TLR/IL-1R Signaling

Nominated PICIHR2018Project Grant

Principal investigators: Vallance, Bruce A

Keywords: Bacterial Pathogen; Cell Culture; Commensal Bacteria; Enteric Infections; Ibd; Innate Immunity; Intestinal Epithelial Cells; Mice; Mucus; Organoids

$994,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Bruce Vallance

Research

Latest papers

Latest funding

Serum C-X-C motif chemokine ligand 9, interleukin 8, and interleukin 22 as key biomarkers in pediatric inflammatory bowel disease.

Early Life Exposure to Parental Crohn’s Disease Is Associated With Offspring’s Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn’s Disease

Outcomes Following Acute Severe Colitis at Initial Presentation: A Multi-centre, Prospective, Paediatric Cohort Study

Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition.

A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function.

Requirement of epithelial integrin-linked kinase for facilitation of Citrobacter rodentium-induced colitis.

Hypoxia Culture Suite

Frequent collaborators

Michael Surette

Levinus Dieleman

Gilaad Kaplan

Karen Madsen

Simon Hirota

Kenneth Croitoru

Anthony Otley

David Mack

Alain Bitton

Wei Xu

Gilaad Kaplan

Kristi Baker

Sanjay Murthy

Eytan Wine

Kirk Bergstrom

Amanda Ricciuto

Remo Panaccione

Osvaldo Espin Garcia

Paul Moayyedi

John Kenneth Marshall

Paul Beck

Aleixo Muise

Thomas Walters