Burton Yang, University of Toronto

Research

Circular Rna Non-Coding Rna Senescence Crc Aortic Stenosis Cardiac Fibrosis Circ-Slc8a1 Mitral Stenosis

Latest papers

Osteocytes under Mechanical Loading Regulate PC-3 Cancer Cell-Mineral Interactions during Early-Stage Metastasis to Bone.
Advanced biology · 2025
Integration of Primary Murine Osteocytes for In Vitro Mechanobiology Studies.
Current protocols · 2025
Focal Adhesion Kinase Intersects With the BRD4-MYC Axis and YAP1 to Drive Tumor Cell Growth, Phenotypic Plasticity, Stemness, and Metastatic Potential in Colorectal Cancer.
Cancer medicine · 2025

All 7 publications

Latest funding

Circular RNA-mediated Vibration Inhibition of Breast Cancer Bone Metastasis on Chip
SSHRC · 2022 · Co-investigator
$125,000
Canada Research Chairs - Tier 1
CIHR · 2021 · Nominated PI
$1,400,000
Regulation of ventricular remodeling by a circular RNA circ-Slc8a1
CIHR · 2019 · Nominated PI
$925,650

All 14 grants and awards

7 publications.

01

Osteocytes under Mechanical Loading Regulate PC-3 Cancer Cell-Mineral Interactions during Early-Stage Metastasis to Bone.

Seaman K, Guo B, Du WW, Yang B, Sun Y, You L

Advanced biology2025

DOI: 10.1002/adbi.202500379 PMID: 41222128

02

Integration of Primary Murine Osteocytes for In Vitro Mechanobiology Studies.

Seaman K, Lin CY, Song X, Sassi A, Du WW, Sun Y, Yang B, You L

Current protocols2025

DOI: 10.1002/cpz1.70217 PMID: 41060719

03

Focal Adhesion Kinase Intersects With the BRD4-MYC Axis and YAP1 to Drive Tumor Cell Growth, Phenotypic Plasticity, Stemness, and Metastatic Potential in Colorectal Cancer.

Han R, Shi J, Cheng K, Wang Z, Chen Y, Spellecy O, Faisal ASM, Aryal I, Chen J, Craven R, Thibault O, Baldwin L, Brewer LD, Erfani S, Wang C, Guo Z, Chen E, Yang B, Ueland F, Guo R, Yang X

Cancer medicine2025

DOI: 10.1002/cam4.71227 PMID: 40959971

04

Mechanical Loading of Osteocytes via Oscillatory Fluid Flow Regulates Early-Stage PC-3 Prostate Cancer Metastasis to Bone.

Seaman K, Lin CY, Song X, Sassi A, Du WW, Yang B, Sun Y, You L

Advanced biology2025

DOI: 10.1002/adbi.202400824 PMID: 39969425

05

XB130/Tks5 scaffold protein interaction regulates Src-mediated cell proliferation and survival.

Moodley S, Hui Bai X, Kapus A, Yang B, Liu M

Molecular biology of the cell2015

DOI: 10.1091/mbc.e15-07-0483 PMID: 26446840

06

Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A.

Li Y, Shi Y, McCaw L, Li YJ, Zhu F, Gorczynski R, Duncan GS, Yang B, Ben-David Y, Spaner DE

Blood2015

DOI: 10.1182/blood-2014-12-618678 PMID: 26041742

07

The effect of versican G3 domain on local breast cancer invasiveness and bony metastasis.

Yee AJ, Akens M, Yang BL, Finkelstein J, Zheng PS, Deng Z, Yang B

Breast cancer research : BCR2007Senior author

DOI: 10.1186/bcr1751 PMID: 17662123

Circular RNA-mediated Vibration Inhibition of Breast Cancer Bone Metastasis on Chip

Co-investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: You, Lidan

Keywords: Organ-on-Chip; Microfluidics; Vibration; Bone; circRNA; Exercise; Brest cancer bone metastasis; Osteocyte; Mechanobiology

$125,000

Canada Research Chairs - Tier 1

Nominated PICIHR2021Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Yang, Burton B

Keywords: Crc

$1,400,000

Regulation of ventricular remodeling by a circular RNA circ-Slc8a1

Nominated PICIHR2019Project Grant

Principal investigators: Yang, Burton B

Keywords: Aortic Stenosis; Cardiac Fibrosis; Circ-Slc8a1; Circular Rna; Mitral Stenosis; Non-Coding Rna; Sodium-Calcium Exchanger; Solute Carrier Family 8 Member A1; Tetralogy Of Fallot; Transverse Aortic Constriction

$925,650

The role of circ-Itga9 in cardiac remodeling

Nominated PICIHR2017Project Grant

Principal investigators: Yang, Burton B

Keywords: Cardiovascular System; Cell Adhesion; Circular Rna; Extracellular Matrix; Heart Disease; Integrin; Non-Coding Rna; Rna Splicing; Rna-Protein Interaction; Senescence

$990,675

The role of circ-Dnmt1 in cardiac remodeling and senescence

Nominated PICIHR2016Project Grant

Principal investigators: Yang, Burton B

Keywords: Cardiovascular Biology; Circular Rna; Microrna; Non-Coding Rna; Pseudogene; Senescence; Singaling; Tissue Regeneration; Tissue Remodeling; Tissue Repair

$695,770

The inhibitory effect of a circular RNA circ-CCNB1 on ovarian cancer cell growth

Nominated PICIHR2016Project Grant

Principal investigators: Yang, Burton B

Keywords: Ccnb1; Cdk1; Circ-Ccnb1; Circular Rna; Ovarian Cancer

$100,000

Technology for Analysis of miRNA Signatures (TAmiRS): a Novel Tool for Personalized Cancer Medicine

Co-investigatorNSERC2014Collaborative Health Research Projects

Principal investigators: Krylov, Sergey

$451,599

Development of fatty liver and hypercholesterolemia regulated by miR-17

Nominated PICIHR2012China-Canada Joint Health Research Initiative

Principal investigators: Yang, Burton B; Zhang, Yaou

Keywords: Fatty Liver; Hypercholesterolemia; Mirna; Molecular Signaling; Nutrition

$225,000

Expression and Function of Proteoglycan Versican Regulated by MicroRNAs

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Yang, Burton

$240,000

miR-17-5p in Tissue Development, Regeneration and Angiogenesis

Nominated PICIHR2010Operating Grant

Principal investigators: Yang, Burton B

Keywords: Angiogenesis; Cell Biology; Gene Expression; Microrna; Sirna; Wound Healing

$419,755

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Surgery
Biological Sciences
Centre for Research on Biomolecular Interactions
Toronto General Research Institute
Physics
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Burton Yang

Centre for Research on Biomolecular Interactions

7 shared papers, latest 2025

Lidan You

Faculty

3 shared papers, latest 2025

Yu Sun

Toronto General Research Institute

3 shared papers, latest 2025

Mingyao Liu

Department of Surgery

1 shared papers, latest 2015

Andras Kapus

Department of Surgery

1 shared papers, latest 2015

Margarete Akens

Physics

1 shared papers, latest 2007

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Circular Rna Dear Professor Yang, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Osteocytes under Mechanical Loading Regulate PC-3 Cancer Cell-Mineral Interactions during Early-Stage Metastasis to Bone." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Canada Research Chairs - Tier 1" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]