Faculty profile

Mingyao Liu

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ProfessorDepartment of SurgeryUniversity of Toronto

Mingyao Liu

Professor

Department of Surgery

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
70 publications in the last five years, latest in 2026.
Senior (last) author on 25 recent papers, a sign of leading a research group.
Principal investigator on 3 research grants (3 CIHR), most recently in 2016.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

238

Publications

313

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Education

Master's Degree, Pathophysiology
Doctor of Medicine (MD)

Profiles and links

University Profile Search on Google Scholar iDORCID

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Acute Lung Injury Alpha-1-Antitrypsin Delta-V1-1 Drug Therapy Ex Vivo Lung Perfusion Large Animal Model Lung Allograft Rejection Lung Transplantation

Latest papers

GSK'872 mitigates ischemia-reperfusion injury in rat lung transplants by regulating PANoptosis and inflammation in cell type specific manner.
Cell communication and signaling : CCS · 2026
Cell type-specific inflammatory response of ischemia-reperfusion injury in lung transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026 · senior author
Itaconate supplementation leads to improvement in donor lung function after extended hypothermic preservation.
The Journal of thoracic and cardiovascular surgery · 2026

All 238 publications

Latest funding

Whole organ gene editing for immunomodulation in lung transplantation
CIHR · 2025 · Co-investigator
$1,071,000
Aiming at a new target in endotoxin-associated lung damage: The Ig domain 3 of ICAM-1
CIHR · 2023 · Co-investigator
$982,260
New nanotechnology for non-invasive deep lung-activatable antimicrobial photodynamic therapy of hospital-associated pneumonia
CIHR · 2023 · Co-investigator
$837,676

All 14 grants and awards

From the 150 most recent of 238 publications.

GSK'872 mitigates ischemia-reperfusion injury in rat lung transplants by regulating PANoptosis and inflammation in cell type specific manner.

Li J, Ma X, Huang J, Yu Y, Lou Z, Liang F, Hu X, Fang Q, Wang Y, Liu M, Lu Y, Wu M

Cell communication and signaling : CCS2026

DOI: 10.1186/s12964-026-03037-1 PMID: 42401940

Cell type-specific inflammatory response of ischemia-reperfusion injury in lung transplantation.

Li J, Zhao Y, Keshavjee S, Liu M

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026Senior author

DOI: 10.1016/j.ajt.2026.02.007 PMID: 41921751

Itaconate supplementation leads to improvement in donor lung function after extended hypothermic preservation.

Siebiger G, Wang A, Yune J, Montagne J, Garza G, Lima T, Yamanashi K, Oliveira P, Gao FY, Zhang Y, Bellissimo CA, Aujla T, Beroncal E, Ali A, Goligher EC, Andreazza AC, Liu M, Keshavjee S, Cypel M

The Journal of thoracic and cardiovascular surgery2026

DOI: 10.1016/j.jtcvs.2026.03.570 PMID: 41864278

Economic evaluation of ex-vivo lung perfusion for lung transplantation: A cost-utility analysis from a large Canadian center.

Peel JK, Naimark DMJ, Pullenayegum EM, Singer LG, Aversa M, Liu M, Del Sorbo L, Cypel M, Barrett K, Keshavjee S, Sander B

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2026

DOI: 10.1016/j.healun.2026.01.032 PMID: 41663040

More is not better: The role of the leukocyte filter in ex vivo lung perfusion.

Hough O, Mariscal A, Yamamoto H, Mangat H, Gokhale H, Chen M, Shan H, Juvet S, Pal P, Cypel M, Liu M, Keshavjee S

The Journal of thoracic and cardiovascular surgery2026

DOI: 10.1016/j.jtcvs.2025.12.026 PMID: 41520723

Characterizing the myeloid and lymphoid immune response in a porcine model of pulmonary ischemia-reperfusion injury through flow cytometry.

Duong A, Mariscal A, Caldarone L, Xu C, Huang L, Ramendra R, Keshavjee S, Liu M, Juvet S, Martinu T

PloS one2026

DOI: 10.1371/journal.pone.0344691 PMID: 42166474

MetaboSense: An Integrated Quantum Dot-Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In-Line Monitoring of Lung Metabolism During Ex Vivo Perfusion.

Srikant S, Keshavarz Motamed P, Borrillo T, Ronen L, Siebiger G, Garza G, Abouali H, Fattah MFA, Jaber I, Ban D, Cypel M, Liu M, Keshavjee S, Sage AT, Poudineh M

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026

DOI: 10.1002/advs.77123 PMID: 42593849

Metabolomic atlas of ischemia-reperfusion injury in human lung transplants: Mitochondrial stress and primary graft dysfunction.

Liang L, Zhao Y, Wang A, Zhu B, Hsin MK, Cypel M, Keshavjee S, Liu M

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2026Senior author

DOI: 10.1016/j.ajt.2026.04.007 PMID: 42173490

Digital twins of ex vivo human lungs enable accurate and personalized evaluation of therapeutic efficacy.

Zhou X, Wang B, Wei Y, Hacker S, Kim S, Borrillo T, McCaig A, Ahmed H, Ren Y, Hough O, Orsini L, Chao BT, McInnis M, Cypel M, Liu M, Yeung JC, Del Sorbo L, Keshavjee S, Sage AT

Nature biotechnology2026

DOI: 10.1038/s41587-026-03121-4 PMID: 42082790

Safety risks of intratracheal lipid nanoparticle gene delivery to the lung and potential mitigation strategies.

Nagoya A, Nakajima K, Yune J, Wang A, Guan Z, Xu Y, Dong S, Strilchuk A, Li B, Juvet S, Cypel M, Liu M, Keshavjee S

The Journal of thoracic and cardiovascular surgery2026

DOI: 10.1016/j.jtcvs.2025.10.021 PMID: 41138809

Whole organ gene editing for immunomodulation in lung transplantation

Co-investigatorCIHR2025Project Grant

Principal investigators: Keshavjee, Shaf; Juvet, Stephen C; Li, Bowen

Keywords: Acute Lung Injury; Chronic Rejection; Crispr; Ex Vivo Lung Perfusion; Gene Therapy; Interleukin (Il)-10; Lipid Nanoparticles; Lung Transplantation; Pre-Clinical Human Model; Whole Organ Gene Editing

$1,071,000

Aiming at a new target in endotoxin-associated lung damage: The Ig domain 3 of ICAM-1

Co-investigatorCIHR2023Project Grant

Principal investigators: Zhang, Haibo

Keywords: Microbiology& Infection Diseases

$982,260

New nanotechnology for non-invasive deep lung-activatable antimicrobial photodynamic therapy of hospital-associated pneumonia

Co-investigatorCIHR2023Project Grant

Principal investigators: Zheng, Gang

Keywords: Bacterial Pneumonia; Lung Surfactant; Nanoemulsion; Near-Infrared Light Delivery; Photosensitizers; Targeted Respiratory Delivery

$837,676

Aiming at a novel target in endotoxin-associated lung damage: The Ig domain 3 of ICAM-1

Co-investigatorCIHR2022Project Grant

Principal investigators: Zhang, Haibo

Keywords: Microbiology& Infection Diseases

$100,000

Advanced Artificial Intelligence for Human Ex Vivo Lung Perfusion using Digital Twins

Co-investigatorCIHR2022Project Grant

Principal investigators: Sage, Andrew T; Keshavjee, Shaf; WANG, BO

Keywords: Artificial Intelligence; Biomarkers; Computer Modeling; Digital Twins; Ex Vivo Lung Perfusion; Interventional Diagnostics; Lung Transplantation

$726,750

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Keshavjee, Shaf

$8,000,000

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Keshavjee, Shaf

Keywords: Immunology Immunotolerance Organ transplantation Ex vivo organ perfusion Gene modification Cell therapy Translational research Organ repair Medical ethics Biomedical engineering Patient-centred approach Precision medicine

$8,000,000

Development and Translation of Novel Donor Lung Gene Regulation Strategies for Lung Transplantation

Co-investigatorCIHR2020Project Grant

Principal investigators: Keshavjee, Shaf

Keywords: Acute Lung Injury; Chronic Rejection; Crispr; Ex Vivo Lung Perfusion; Gene Regulation; Immunology; Interleukin (Il)-10; Lung Transplantation; Mesenchymal Stem Cells; Primary Graft Dysfunction

$956,250

Prevention of primary graft dysfunction after lung transplantation; a bench to bedside approach

Nominated PICIHR2016Project Grant

Principal investigators: Liu, Mingyao

Keywords: Acute Lung Injury; Alpha-1-Antitrypsin; Delta-V1-1; Drug Therapy; Ex Vivo Lung Perfusion; Large Animal Model; Lung Allograft Rejection; Lung Transplantation; Nanotechnology; Primary Graft Dysfunction

$787,435

Mechanisms and Therapies of ARDS

Co-investigatorCIHR2014Foundation Grant

Principal investigators: Zhang, Haibo; Slutsky, Arthur S

Keywords: Bone-Marrow-Derived Mesenchymal Stromal Cells (Msc); Cytokines; Endotoxin; Icam-1; Lung Injury; Lung Mechanics; Mechanical Ventilation; Mechanotransduction; Neutrophil Peptides; Sepsis

$2,588,884

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 26, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Mingyao Liu

Research

Latest papers

Latest funding

GSK'872 mitigates ischemia-reperfusion injury in rat lung transplants by regulating PANoptosis and inflammation in cell type specific manner.

Cell type-specific inflammatory response of ischemia-reperfusion injury in lung transplantation.

Itaconate supplementation leads to improvement in donor lung function after extended hypothermic preservation.

Economic evaluation of ex-vivo lung perfusion for lung transplantation: A cost-utility analysis from a large Canadian center.

More is not better: The role of the leukocyte filter in ex vivo lung perfusion.

Characterizing the myeloid and lymphoid immune response in a porcine model of pulmonary ischemia-reperfusion injury through flow cytometry.

MetaboSense: An Integrated Quantum Dot-Mediated Aptamer Assay and Modular Microfluidic Platform for Continuous In-Line Monitoring of Lung Metabolism During Ex Vivo Perfusion.

Metabolomic atlas of ischemia-reperfusion injury in human lung transplants: Mitochondrial stress and primary graft dysfunction.

Digital twins of ex vivo human lungs enable accurate and personalized evaluation of therapeutic efficacy.

Safety risks of intratracheal lipid nanoparticle gene delivery to the lung and potential mitigation strategies.

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Frequent collaborators

Shaf Keshavjee

Marcelo Cypel

Tereza Martinu

Stephen Juvet

Jonathan Yeung

Haibo Zhang

Aizhou Wang

David Hwang

Lorenzo Del Sorbo

Jim Hu

Bo Wang

Andrew Sage

Tianru Jin

Eddy Fan

Beate Sander

Thomas Waddell

Sonya MacParland

Andras Kapus

Laurent Brochard

Atul Humar

Melanie Tsang

Wei-Yang Lu

Beverley Orser

John Granton

Patricia Chia-Ying Liaw

Mark David Inman

Hong Han

Stefanos Voglis

Martin Post

David Wishart

Jeffrey Medin

Anthony Gramolini

Lori West

Burton Yang

Lauralyn McIntyre

Joseph Beyene

Claudia Dos Santos

Alison Fox-Robichaud

Jeremy Hirota

Paul O'Byrne