Faculty profile
Colin McKerlie
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Read how they describe their research on their University of Toronto profile.
Latest papers
Searching for New Genes That Cause Usher Syndrome.
American journal of ophthalmology · 2026
Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes
Investigative Ophthalmology & Visual Science · 2025
Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes.
BMC genomics · 2025 · senior author
Latest funding
- $2,100,092
Integrated Nanotechnology and Biomedical Sciences Laboratory
CIHR · 2017 · Co-investigator
- $4,135,120
MRI of the mouse: linking structure, function, and disease
CFI · 2017 · Co-investigator
- $150,000
Sex differences in NETosis: effects on infection and inflammation in children
CIHR · 2015 · Co-investigator
23 publications.
Searching for New Genes That Cause Usher Syndrome.
Moshiri A, Kasiri N, Shea M, Ali L, Yang B, Shao A, Clary D, Flenniken AM, Eskandarian M, Amarie OV, Becker L, Sangermano R, Place EM, Bujakowska KM, Huckfeldt RM, Berberovic Z, Bour R, Riet F, Brown SD, D'Souza A, Fuchs H, Gailus-Durner V, Guimond A, Hérault Y, Angelis MH, Lux A, Mittelhaeuser C, Nutter LMJ, Palkova M, Lindovsky J, Petit-Demouliere B, Prochazka J, Bradaschia V, Kelsey L, McKerlie C, Raishbrook MJ, Sedlacek R, INTERNATIONAL MOUSE PHENOTYPING CONSORTIUM, Lanoue L, Lloyd KCK, Roux MJ, Bermingham-McDonogh O
Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes
Abraham Hang, Andy Shao, Michael Shea, Michel Joseph Roux, Denise M. Imai-Leonard, David J. Adams, Takanori Amano, Oana Veronica Amarie, Zorana Berberovic, Raphaël Bour, Lynette R. Bower, Brian C. Leonard, Steve D. M. Brown, Soo Young Cho, Sharon Clementson-Mobbs, Abigail J. D’Souza, Mary E. Dickinson, Mohammad Eskandarian, Ann Marie Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Jason D. Heaney, Yann Hérault, Martin Hrabě de Angelis, Chih‐Wei Hsu, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, et al. (60 authors)
Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes.
Vo P, Imai-Leonard DM, Yang B, Briere A, Shao A, Casanova MI, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Braun R, Brown S, Burrill S, Cho SY, Clementson-Mobbs S, D'Souza A, Dickinson M, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Heaney J, Hérault Y, Angelis MH, Hsu CW, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Meziane H, Murray S, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Ryan J, Salazar J, Seavey Z, Seavitt JR, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Udensi U, Wells S, White J, Willett A, Wotton J, Wurst W, Yoshiki A, International Mouse Phenotyping Consortium, Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C, Moshiri A
Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies.
Briere A, Vo P, Yang B, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Brown SDM, Burrill S, Cho SY, Clementson-Mobbs S, D'souza A, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Hérault Y, Hrabe de Angelis M, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Meziane H, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Salazar J, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Wells S, Wurst W, Yoshiki A, Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C, Moshiri A, International Mouse Phenotyping Consortium
Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations
Sateesh Maddirevula, Mohammad Ali Shagrani, Ae‐Ri Ji, Christopher R. Horne, Samuel N. Young, Lucy J. Mather, Mashael F. Alqahtani, Colin McKerlie, Geoffrey A. Wood, Paul K Potter, Firdous Abdulwahab, Tarfa Al‐Sheddi, Wendy L. van der Woerd, Koen L.I. van Gassen, Dalal Albogami, Kishwer Kumar, Ali Syed Muhammad Akhtar, Hiba Mohammed Amin Binomar, Hadeel M. AlManea, Eissa Faqeih, Sabine A. Fuchs, John W. Scott, James M. Murphy, Fowzan Sami Alkuraya
Co-expression of prepulse inhibition and Schizophrenia genes in the mouse and human brain.
Garrett L, Trümbach D, Lee D, Mandillo S, Samaco R, Flenniken AM, Stewart M, IMPC consortium, White JK, McKerlie C, Nutter LMJ, Vukobradovic I, Veeraragavan S, Yuva L, Heaney JD, Dickinson ME, Meziane H, Hérault Y, Wells S, Lloyd KCK, Bower L, Lanoue L, Clary D, Zimprich A, Gailus-Durner V, Fuchs H, Brown SDM, Chesler EJ, Wurst W, Hrabě de Angelis M, Hölter SM
Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice.
Oestereicher MA, Wotton JM, Ayabe S, Bou About G, Cheng TK, Choi JH, Clary D, Dew EM, Elfertak L, Guimond A, Haseli Mashhadi H, Heaney JD, Kelsey L, Keskivali-Bond P, Lopez Gomez F, Marschall S, McFarland M, Meziane H, Munoz Fuentes V, Nam KH, Nichtová Z, Pimm D, Bower L, Prochazka J, Rozman J, Santos L, Stewart M, Tanaka N, Ward CS, Willett AME, Wilson R, Braun RE, Dickinson ME, Flenniken AM, Herault Y, Lloyd KCK, Mallon AM, McKerlie C, Murray SA, Nutter LMJ, Sedlacek R, Seong JK, Sorg T, Tamura M, Wells S, Schneltzer E, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, White JK, Spielmann N
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development.
Chee JM, Lanoue L, Clary D, Higgins K, Bower L, Flenniken A, Guo R, Adams DJ, Bosch F, Braun RE, Brown SDM, Chin HG, Dickinson ME, Hsu CW, Dobbie M, Gao X, Galande S, Grobler A, Heaney JD, Herault Y, de Angelis MH, Mammano F, Nutter LMJ, Parkinson H, Qin C, Shiroishi T, Sedlacek R, Seong JK, Xu Y, International Mouse Phenotyping Consortium, Brooks B, McKerlie C, Lloyd KCK, Westerberg H, Moshiri A
Bridging mouse and human anatomies; a knowledge-based approach to comparative anatomy for disease model phenotyping.
Ruberte J, Schofield PN, Sundberg JP, Rodriguez-Baeza A, Carretero A, McKerlie C
(NZW × BXSB) F1 male mice: An unusual, severe and fatal mouse model of lupus erythematosus
Ruqayyah J. Almizraq, Kayluz Frias Boligan, Melika Loriamini, Colin McKerlie, Donald R. Branch
Integrated Nanotechnology and Biomedical Sciences Laboratory
Principal investigators: Chan, Warren C
Keywords: Cancer; Nanotechnology
MRI of the mouse: linking structure, function, and disease
Principal investigators: Sled, John G
Keywords: magnetic resonance imaging, mouse models of disease, gene function, brain morphometry, mental health, autism spectrum disorder, fetal development, cancer Ultra-high field magnetic resonance imaging scanner
Sex differences in NETosis: effects on infection and inflammation in children
Principal investigators: Palaniyar, Nades
Keywords: Imaging (Confocal; Live Cell); Male And Female Mice; Males And Female Children; Neutrophil Extracellular Traps (Nets); Pseudomonas And Lps; Pulmonary Bacterial Infection; Pulmonary Inflammation; Reactive Oxygen Species (Ros) Generation; Sex Hormones (Estrogen; Sex-Linked Genes; Testosterone)
Next generation genome editing and functional evaluation of pre-clinical models of human disease
Principal investigators: Justice, Monica
Keywords: Mouse Models, Human Disease, Direct Genome Editing, Functional Genomics, Phenotyping, Drug Discovery, Biomedicine, Pre-clinical Development, Clinical Diagnosis Molecular Genetics, Genotyping, Clinical Phenotyping, Mouse facility
Toronto Centre for Phenogenomics
Principal investigators: McKerlie, Colin
Keywords: Mouse Models of Human Disease, Functional Genomics, Disease Phenotyping, Drug Discovery, Pre-clinical Development Genome Engineering, Imaging, Clinical Phenotyping, Pathology, Biorepository
Imaging the Mouse
Principal investigators: Sled, John G
Keywords: Imaging of mouse models of human diseases MRI, micro CT, 2 photon microscopy, optical projection tomography (OPT)
NorCOMM2: Functional genomics tools to drive stem cell & regenerative medicine research in Ontario
Principal investigators: McKerlie, Colin
Keywords: Genome
The CMHD: An integrated and regional platform for mouse models of human disease
Principal investigators: Adamson, S. Lee
Keywords: Mouse genetics, Targeted mutagenesis, Human disease models, Phenotyping, Cardiovascular disease, Neurobiology, Hematopoiesis, Bone Disease, Undecalcified Tissue Processing, archiving/distribution of mouse models
Discovering Genes Responsible for Human Disease Using Genome-Wide Mutagenesis
Principal investigators: McKerlie, Colin
Toronto Centre for Comparative Models of Human Disease
Principal investigators: Rossant, Janet
Keywords: mouse models, genetics, physiology, functional genomics, imaging, mouse mutants
From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.
Frequent collaborators
- Katherine Siminovitch and Jinyi Zhang: 13 shared papers
- Rama Khokha and Geoffrey Wood: 12 shared papers
- Donald Branch and Katherine Siminovitch: 6 shared papers
- Keith Jarvi and Colin McKerlie: 2 shared papers
- Geoffrey Wood and Colin McKerlie: 2 shared papers
- Rama Khokha and Colin McKerlie: 1 shared paper
- Donald Branch and Heyu Ni: 1 shared paper
- Donald Branch and Colin McKerlie: 1 shared paper
- Katherine Siminovitch and Heyu Ni: 1 shared paper
- Katherine Siminovitch and Philip Marsden: 1 shared paper
- Katherine Siminovitch and Patrick Shannon: 1 shared paper
- Katherine Siminovitch and Colin McKerlie: 1 shared paper
- Heyu Ni and Philip Marsden: 1 shared paper
- Heyu Ni and Patrick Shannon: 1 shared paper
- Heyu Ni and Colin McKerlie: 1 shared paper
- Heyu Ni and Jinyi Zhang: 1 shared paper
- Philip Marsden and Patrick Shannon: 1 shared paper
- Philip Marsden and Colin McKerlie: 1 shared paper
- Philip Marsden and Jinyi Zhang: 1 shared paper
- Elif Acar and Colin McKerlie: 1 shared paper
- Patrick Shannon and Colin McKerlie: 1 shared paper
- Colin McKerlie and Jinyi Zhang: 1 shared paper
- Department of Laboratory Medicine & Pathobiology
- Department of Medicine
- Department of Pathobiology
- Department of Surgery
- Department of Statistics
- Department of Medical Biophysics
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Keith Jarvi
Department of Surgery
2 shared papers, latest 2018
Geoffrey Wood
Department of Pathobiology
2 shared papers, latest 2024
Jinyi Zhang
Department of Medicine
1 shared papers, latest 2005
Katherine Siminovitch
Department of Medicine
1 shared papers, latest 2005
Heyu Ni
Department of Laboratory Medicine & Pathobiology
1 shared papers, latest 2005
Philip Marsden
Department of Laboratory Medicine & Pathobiology
1 shared papers, latest 2005
Michelle Stewart
Faculty
1 shared papers, latest 2025
Elif Acar
Department of Statistics
1 shared papers, latest 2020
Rama Khokha
Department of Medical Biophysics
1 shared papers, latest 2015
Patrick Shannon
Department of Laboratory Medicine & Pathobiology
1 shared papers, latest 2005
Donald Branch
Department of Laboratory Medicine & Pathobiology
1 shared papers, latest 2022
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Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.