Faculty profile
Katherine Siminovitch
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Research
Latest papers
Correction: Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.
Frontiers in immunology · 2026 · senior author
Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.
Frontiers in immunology · 2026 · senior author
A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice.
BMC developmental biology · 2019
Latest funding
- $749,990
Resilience to age-related dementia by the microglial ABI-WAVE2 signaling axis
CIHR · 2023 · Nominated PI
- $1,032,750
Characterizing roles of the WAVE2 actin-regulatory protein in immune homeostasis and autoimmunity
CIHR · 2022 · Nominated PI
- $31,625,000
Phase Two of the Canadian Consortium on Neurodegeneration in Aging
CIHR · 2019 · Principal investigator
23 publications.
Correction: Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.
Liu M, Duan D, Li C, Hu X, Huang J, Tang Y, Palayew S, Zhang L, Pagnoux C, Guidos C, Zhang J, Siminovitch K
Comprehensive immune profiling identifies alterations in adaptive and innate immune responses in granulomatosis with polyangiitis patients in remission.
Liu M, Duan D, Li C, Hu X, Huang J, Tang Y, Palayew S, Zhang L, Pagnoux C, Guidos C, Zhang J, Siminovitch K
A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice.
Varshney S, Wei HX, Batista F, Nauman M, Sundaram S, Siminovitch K, Tanwar A, Stanley P
Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.
Li Y, Xiao X, Bossé Y, Gorlova O, Gorlov I, Han Y, Byun J, Leighl N, Johansen JS, Barnett M, Chen C, Goodman G, Cox A, Taylor F, Woll P, Wichmann HE, Manz J, Muley T, Risch A, Rosenberger A, Han J, Siminovitch K, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Houlston R, Artigas MS, Grankvist K, Johansson M, Shepherd FA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Liu G, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Bertazzi PA, Pesatori AC, Christiani DC, Caporaso N, Johansson M, McKay JD, Brennan P, Hung RJ, Amos CI
TIE: A Method to Electroporate Long DNA Templates into Preimplantation Embryos for CRISPR-Cas9 Gene Editing.
Bagheri H, Friedman H, Shao H, Chong Y, Lo CA, Emran F, Kays I, Yang XJ, Cooper E, Chen BE, Siminovitch K, Peterson A
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.
Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH, (The CARDIOGENICS consortium), Tohma S, Alfredsson L, Okada Y, Xie G, Constantin A, Balsa A, Kawasaki A, Nicaise P, Amos C, Rodriguez-Rodriguez L, Chiocchia G, Boileau C, Zhang J, Vittecoq O, Barnetche T, Gonzalez Gay MA, Furukawa H, Cantagrel A, Le Loët X, Sumida T, Hurtado-Nedelec M, Richez C, Chollet-Martin S, Schaeverbeke T, Combe B, Khoryati L, Coustet B, El-Benna J, Siminovitch K, Plenge R, Padyukov L, Martin J, Tsuchiya N, Dieudé P
The Arabidopsis SWI2/SNF2 chromatin Remodeler BRAHMA regulates polycomb function during vegetative development and directly activates the flowering repressor gene SVP.
Li C, Chen C, Gao L, Yang S, Nguyen V, Shi X, Siminovitch K, Kohalmi SE, Huang S, Wu K, Chen X, Cui Y
The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.
Kottyan LC, Zoller EE, Bene J, Lu X, Kelly JA, Rupert AM, Lessard CJ, Vaughn SE, Marion M, Weirauch MT, Namjou B, Adler A, Rasmussen A, Glenn S, Montgomery CG, Hirschfield GM, Xie G, Coltescu C, Amos C, Li H, Ice JA, Nath SK, Mariette X, Bowman S, UK Primary Sjögren's Syndrome Registry, Rischmueller M, Lester S, Brun JG, Gøransson LG, Harboe E, Omdal R, Cunninghame-Graham DS, Vyse T, Miceli-Richard C, Brennan MT, Lessard JA, Wahren-Herlenius M, Kvarnström M, Illei GG, Witte T, Jonsson R, Eriksson P, Nordmark G, Ng WF, UK Primary Sjögren's Syndrome Registry, Anaya JM, Rhodus NL, Segal BM, Merrill JT, James JA, Guthridge JM, Scofield RH, Alarcon-Riquelme M, Bae SC, Boackle SA, Criswell LA, Gilkeson G, Kamen DL, Jacob CO, Kimberly R, Brown E, Edberg J, Alarcón GS, Reveille JD, Vilá LM, Petri M, Ramsey-Goldman R, Freedman BI, Niewold T, Stevens AM, Tsao BP, Ying J, Mayes MD, Gorlova OY, Wakeland W, Radstake T, Martin E, Martin J, Siminovitch K, Moser Sivils KL, Gaffney PM, Langefeld CD, Harley JB, Kaufman KM
Significance of left ventricular apical-basal muscle bundle identified by cardiovascular magnetic resonance imaging in patients with hypertrophic cardiomyopathy.
Gruner C, Chan RH, Crean A, Rakowski H, Rowin EJ, Care M, Deva D, Williams L, Appelbaum E, Gibson CM, Lesser JR, Haas TS, Udelson JE, Manning WJ, Siminovitch K, Ralph-Edwards AC, Rastegar H, Maron BJ, Maron MS
Resilience to age-related dementia by the microglial ABI-WAVE2 signaling axis
Principal investigators: Siminovitch, Katherine A
Keywords: Aging
Characterizing roles of the WAVE2 actin-regulatory protein in immune homeostasis and autoimmunity
Principal investigators: Siminovitch, Katherine A
Keywords: Autoimmune Disease; Cytoskeletal Regulators; Immune Cell Differentiation; Immune Cell Homeostasis; Immune Cell Signaling; Immune Deficiency; Mouse Models Of Disease
Phase Two of the Canadian Consortium on Neurodegeneration in Aging
Principal investigators: Chertkow, Howard M; Anderson, Nicole D; Andrew, Melissa K; Bartha, Robert; Bellec, Pierre; Belleville, Sylvie N; Bergman, Howard; Bherer, Louis; Black, Sandra E; Borrie, Michael J; Camicioli, J. Richard M; Carrier, Julie; Cashman, Neil R; Collins, Donald L; Cuello, A. Claudio G; Dixon, Roger A; Ducharme, Simon; Duchesne, Simon; Einstein, Gillian; Eintracht, Shaun; Evans, Alan C; Fahnestock, Margaret; Feldman, Howard; Ferland, Guylaine; Fisk, John D; Gan-Or, Ziv; Giguère, Anik; Herrmann, Nathan; Hsiung, Ging-Yuek R; Lanctôt, Krista L; Lim, Andrew S; Mackenzie, Ian R; Masellis, Mario; Maxwell, Colleen J; McGilton, Katherine S; Mclaurin, Joanne; Montero Odasso, Manuel M; Morgan, Debra G; Naglie, Gary; Nygaard, Haakon B; O'Connell, Megan E; Phillips, Natalie A; Poirier, Judes; Rapoport, Mark J; Robillard, Julie; Rockwood, Kenneth; Rogaeva, Ekaterina; Rosa-Neto, Pedro; Rylett, Jane R; Seitz, Dallas P; Siminovitch, Katherine A; Smith, Eric E; ST GEORGE-HYSLOP, Peter H; Vedel, Isabelle; Walker, Jennifer; Wittich, Walter
Keywords: Alzheimer Disease; Dementia; Diagnosis; Prevention; Quality Of Life; Sex; Treatment
Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies
Principal investigators: ST GEORGE-HYSLOP, Peter H
Keywords: Alzheimer Disease; Biomarkers; Frontotemporal Lobar Degeneration; Functional Genetics Of Risk Genes; Intrinsically Disordered Phase Separating Proteins; Neurological Disorders; Therapeutic Targets
Standardization of Immuno-analytic Platforms for Autoimmunity Research (SIPAR)
Principal investigators: Guidos, Cynthia J
Keywords: Autoimmune Disease; Bioinformatics; Flow Cytometry; Gene Expression Profiling; Immune Phenotyping; Mass Cytometry; Rna Sequencing
Characterizing molecular determinants of autoimmune disease
Principal investigators: Siminovitch, Katherine A
Keywords: Autoimmune Disease; Cytoskeletal Regulators; Epigenetics; Flow Cytometry; Genotyping; Immune Cell Signaling; Mouse Models Of Disease; Primary Biliary Cirrhosis; Rheumatoid Arthritis; Risk Alleles
CanDu COER - A Canadian-Dutch COnsortium for Ending Rheumatoid arthritis
Principal investigators: Siminovitch, Katherine A; Huizinga, Tom
Keywords: Biomarkers; Genomics; Immune-Mediated Inflammatory Musculoskeletal Disease; Immunobiology; Personalized Healthcare; Proteomics; Rheumatoid Arthritis
Regulation of immunity by TNFR family members: from mechanisms of viral control to biomarkers of therapeutic outcome
Principal investigators: Watts, Tania H
Keywords: Biomarkers; Cancer; Conditional Knockout Mice; Hiv; Influenza; Lymphocytic Choriomeningitis Virus; Multiparameter Flow Cytometry; Rheumatoid Arthritis; Single Nucleotide Polymorphisms; Tnfr Superfamily
Characterization of genetic/molecular pathways underpinning rheumatoid arthritis
Principal investigators: Siminovitch, Katherine A
Keywords: Genetic Association Analysis; Inflammation; Lymphocyte Activation; Rheumatoid Arthritis
Regulation of articular cartilage homeostasis
Principal investigators: Kandel, Rita A
Keywords: Chondrocyte Biology; Osteoarthritis; Polyphosphate; Signal Transduction
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Geoffrey Liu and Ming-Sound Tsao: 53 shared papers
- David Malkin and Adam Shlien: 49 shared papers
- Geoffrey Liu and Stephen Lam: 45 shared papers
- Ian Mcgilvray and Nazia Selzner: 24 shared papers
- Ming-Sound Tsao and Stephen Lam: 18 shared papers
- Ian Mcgilvray and Steven Gallinger: 11 shared papers
- David Malkin and Steven Gallinger: 5 shared papers
- Ming-Sound Tsao and Steven Gallinger: 5 shared papers
- Geoffrey Liu and Steven Gallinger: 4 shared papers
- Sandra Black and Gustavo Saposnik: 3 shared papers
- Vasundara Venkateswaran and Arun Seth: 3 shared papers
- Nazia Selzner and Steven Gallinger: 3 shared papers
- Katherine Siminovitch and Cynthia Guidos: 2 shared papers
- Adam Shlien and Steven Gallinger: 2 shared papers
- Geoffrey Liu and Katherine Siminovitch: 1 shared paper
- David Malkin and Katherine Siminovitch: 1 shared paper
- David Malkin and Vasundara Venkateswaran: 1 shared paper
- David Malkin and Arun Seth: 1 shared paper
- Alan Peterson and Katherine Siminovitch: 1 shared paper
- Alan Peterson and Xiang-Jiao Yang: 1 shared paper
- Sandra Black and Katherine Siminovitch: 1 shared paper
- Katherine Siminovitch and Vasundara Venkateswaran: 1 shared paper
- Katherine Siminovitch and Ming-Sound Tsao: 1 shared paper
- Katherine Siminovitch and Ian Mcgilvray: 1 shared paper
- Katherine Siminovitch and Nazia Selzner: 1 shared paper
- Katherine Siminovitch and Xiang-Jiao Yang: 1 shared paper
- Katherine Siminovitch and Stephen Lam: 1 shared paper
- Katherine Siminovitch and Adam Shlien: 1 shared paper
- Katherine Siminovitch and Spencer Freeman: 1 shared paper
- Katherine Siminovitch and Steven Gallinger: 1 shared paper
- Katherine Siminovitch and Gustavo Saposnik: 1 shared paper
- Katherine Siminovitch and Arun Seth: 1 shared paper
- Katherine Siminovitch and Clement Ma: 1 shared paper
- Katherine Siminovitch and Yuhai Cui: 1 shared paper
- Ming-Sound Tsao and Clement Ma: 1 shared paper
- Department of Medicine
- Department of Laboratory Medicine & Pathobiology
- Department of Surgery
- Department of Cell & Systems Biology
- Oncology
- Biostatistics Division
- Pediatrics
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Cynthia Guidos
Department of Cell & Systems Biology
2 shared papers, latest 2026
Ian Mcgilvray
Department of Surgery
1 shared papers, latest 2012
Vasundara Venkateswaran
Department of Surgery
1 shared papers, latest 2011
Xiang-Jiao Yang
Medicine
1 shared papers, latest 2018
Spencer Freeman
Cell Biology
1 shared papers, latest 2005
Ming-Sound Tsao
Department of Laboratory Medicine & Pathobiology
1 shared papers, latest 2007
Arun Seth
Department of Laboratory Medicine & Pathobiology
1 shared papers, latest 2011
Steven Gallinger
Department of Medical Biophysics
1 shared papers, latest 2017
Stephen Lam
Faculty
1 shared papers, latest 2019
Gustavo Saposnik
Department of Medicine
1 shared papers, latest 2012
Nazia Selzner
Department of Medicine
1 shared papers, latest 2012
Adam Shlien
Faculty
1 shared papers, latest 2011
Yuhai Cui
Biology
1 shared papers, latest 2015
Clement Ma
Biostatistics Division
1 shared papers, latest 2009
Geoffrey Liu
Epidemiology Division
1 shared papers, latest 2019
David Malkin
Pediatrics
1 shared papers, latest 2011
Alan Peterson
Oncology
1 shared papers, latest 2018
Sandra Black
Department of Medicine
1 shared papers, latest 2012
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