Faculty profile

Heyu Ni

ResearcherLaboratory Medicine & PathobiologyUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Heyu Ni

Researcher

Laboratory Medicine & Pathobiology

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
41 publications in the last five years, latest in 2026.
Senior (last) author on 13 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (7 CIHR), most recently in 2026.
Supervised 1 trainee who won CIHR awards, most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

123

Publications

355

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Thrombosis And Hemostasis Adhesion Molecules, Integrins, P-Selectin Animal Models Atherogenic Related Inflammation And Atherosclerosis Atherothrombosis And Deep Vein Thrombosis Immunology, Cell Biology, Pathology Intravital Microscopy Thrombosis Model Molecular And Cellular Techniques

Latest papers

Cathelicidin LL-37-ApoB-100 interaction promotes LDL clearance and attenuates cholesterol accumulation in the liver.
Science China. Life sciences · 2026
Age-associated inflammation is accompanied by JAK1-STAT1 signaling activation, megakaryocyte apoptosis, and enhanced thrombopoiesis in naturally aged mice.
Experimental gerontology · 2026
Inhibition of human FcγRIII prevents platelet destruction in a dual-humanized murine model of FNAIT.
Blood advances · 2026

All 123 publications

Latest funding

Apolipoprotein A-IV and platelet function: Novel links with thrombosis, inflammation, atherosclerosis and stroke
CIHR · 2026 · Nominated PI
$1,109,250
Targeted Nanoparticle Therapy to Rescue Preeclamptic Placenta
CIHR · 2025 · Co-investigator
$1,013,626
Novel mechanisms of thrombopoietin generation: the essential role of Kupffer cells
CIHR · 2021 · Supervisor
$105,000

All 9 grants and awards

123 publications.

Cathelicidin LL-37-ApoB-100 interaction promotes LDL clearance and attenuates cholesterol accumulation in the liver.

Fang Y, Zhang Z, Cao Q, Wang G, Duan Z, Meng P, Zhou S, Fei S, Tadese DA, Mwangi J, Lu Q, Ni H, Lai R

Science China. Life sciences2026

DOI: 10.1007/s11427-025-3006-2 PMID: 40971038

Age-associated inflammation is accompanied by JAK1-STAT1 signaling activation, megakaryocyte apoptosis, and enhanced thrombopoiesis in naturally aged mice.

Xu Y, Xie S, He F, Song F, Mao YH, Wang R, Ni H, Yang Y

Experimental gerontology2026

DOI: 10.1016/j.exger.2026.113279 PMID: 42586387

Inhibition of human FcγRIII prevents platelet destruction in a dual-humanized murine model of FNAIT.

Tawhidi Z, Sachs UJ, Gil Gonzalez L, Khoury CJ, Tundidor Y, Wu XG, Cruz-Leal Y, Gupta A, Shehata N, Lieberman L, Ni H, Lazarus AH

Blood advances2026

DOI: 10.1182/bloodadvances.2025019475 PMID: 42269082

The hepatic FGFR-ERK-HRG axis regulates heparin-induced thrombocytopenia with thrombosis.

Zhou S, Wang T, Neves MAD, Liu M, Liu K, Yang W, Yan J, Ling Q, Chen H, Awais M, Feng Y, Lu Y, Liu W, Xie J, Xu M, Wu D, Wang L, Yu W, Lv Z, Slavkovic S, Weitz JI, Zhang J, Ni H, Shen C

Blood2026

DOI: 10.1182/blood.2026033378 PMID: 42574324

All-Trans Retinoic Acid for Immune Thrombocytopenia - Sustained Response?

Peng M, Ni H

NEJM evidence2026Senior author

DOI: 10.1056/evide2600196 PMID: 42517707

CD47 promotes mitogen-activated protein kinase and epithelial-to-mesenchymal transition molecular programs to drive prometastatic phenotypes in non-small cell lung cancer.

Lau APY, Zhai LG, Hoshi R, Rousseau Z, Zakhary A, Wu YF, Saleeb RM, Ni H, Thu KL

Molecular oncology2026

DOI: 10.1002/1878-0261.70237 PMID: 42007973

FVIII-containing platelets modulate immune responses and attenuate inhibitor development in hemophilia A mice.

Chen Y, Xue F, Kumar S, Schroeder JA, Jing W, Ni H, Shi Q

Haematologica2026

DOI: 10.3324/haematol.2025.289331 PMID: 41676910

From haemostasis to immunity: The expanding frontiers of platelet biology.

Wu XG, Tomei N, Ni H

British journal of haematology2026Senior author

DOI: 10.1111/bjh.70710 PMID: 42502172

PRKCA and ABCB1 dual-enriched exosomes are key drivers of drug resistance in chronic myeloid leukemia.

Li F, Lin JF, Tian P, Chen H, Yang Q, Guo Q, Wang J, He Y, Chen J, Hu X, Li C, Mai W, Duan M, Peng M, Rousseau Z, Chen C, Ni H, Zhang Q

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy2026

DOI: 10.1016/j.drup.2026.101421 PMID: 42235483

Platelet CLEC-2 activation leads to GPIb⍺ shedding: Implications for doxorubicin chemotherapy and thrombosis.

Rousseau Z, Ma W, Long T, Slavkovic S, Qiu X, Lao X, Wu XG, Joshi K, Zhu YA, Zhu G, Thu KL, Ni H

The Journal of biological chemistry2026Senior author

DOI: 10.1016/j.jbc.2026.113074 PMID: 42055323

Apolipoprotein A-IV and platelet function: Novel links with thrombosis, inflammation, atherosclerosis and stroke

Nominated PICIHR2026Project Grant

Principal investigators: Ni, Heyu

Keywords: Adhesion Molecules, Integrins, P-Selectin; Animal Models; Atherogenic Related Inflammation And Atherosclerosis; Atherothrombosis And Deep Vein Thrombosis; Immunology, Cell Biology, Pathology; Intravital Microscopy Thrombosis Model; Molecular And Cellular Techniques; Platelets And Platelet Receptors; Stroke; Thrombosis And Hemostasis

$1,109,250

Targeted Nanoparticle Therapy to Rescue Preeclamptic Placenta

Co-investigatorCIHR2025Project Grant

Principal investigators: Labouta, Hagar I

Keywords: Drug Delivery; Nanomedicine; Organ-On-A-Chip; Women'S Health

$1,013,626

Novel mechanisms of thrombopoietin generation: the essential role of Kupffer cells

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Karakas, Danielle

Keywords: Blood; Hematology; Hepatocytes; Immunology; Kupffer Cells; Liver; Molecular Biology; Platelets; Thrombopoietin

$105,000

Apolipoprotein A-IV and platelet function: Novel links with thrombosis, inflammation, and atherosclerosis

Nominated PICIHR2018Project Grant

Principal investigators: Ni, Heyu

Keywords: Apolipoprotein A-Iv; Atherosclerosis; Blood Coagulation And Deep Vein Thrombosis; Cardiovascular Diseases; Inflammation; Integrins And Integrin Ligands; Intravital Microscopy; Platelet Biology; Thrombosis And Hemostasis; Thrombosis Models

$612,841

Thrombosis and Thrombocytopenia: Novel mechanisms and treatments

Nominated PICIHR2017Foundation Grant

Principal investigators: Ni, Heyu

Keywords: Anti-Platelet Therapies; Antibody Fc - Independent Phagocytosis; Atherosclerosis And Vascular Biology; Autoimmune Thrombocytopenia; Fetal And Neonatal Alloimmune Thrombocytopenia; Hematopoietic Stem Cell Migrantion And Differentiation; Placental Pathology And Fetal Liver/Bond Marrow Development; Platelet Biology And Biochemistry; Platelet-Cancer Cell Interaction; Thrombosis And Hemostasis

$2,406,044

Pathogenesis and treatment of immune thrombocytopenia: Are there fundamental differences between anti-GPIba- and anti-GPIIbIIIa-mediated thrombocytopenia?

Nominated PICIHR2014Operating Grant - Priority Announcement: Blood Utilization and Conservation

Principal investigators: Ni, Heyu

Keywords: Immune Thrombocytopenia (Itp): Autoimmune Bleeding Disorder; Intravenous Immunoglobulin G (Ivig); Monoclonal Antibody Epitope Mapping; Platelet Antigens: Gpiibiiia Versus Gpib; Platelet Clearance And Phagocytosis; Platelet Desialylation; Platelet Function; Platelet Generation

Novel mechanisms of platelet aggregation: Roles of fibronectin and other non-classical beta 3 integrin ligands in thrombosis and hemostasis

Nominated PICIHR2011Operating Grant

Principal investigators: Ni, Heyu

Keywords: Confocal Intravital Microscopy Thrombosis Model; Fibronectin; Integrins And Their Ligands; Mass Spectrometry And Proteomics; Platelet Aggregation; Thrombosis And Hemostasis

$638,411

Pathogenesis of fetal and neonatal alloimmune thrombocytopenia and mechanisms of IVIG and anti-FcRn therapies

Nominated PICIHR2011Operating Grant

Principal investigators: Ni, Heyu

Keywords: Angiogenesis And Fetal Bleeding Disorders; Antibodies And Cellular Immune Responses; Fetal And Neonatal Alloimmune Thrombocytopenia; Intravenous Immunoglobulin G (Ivig) And Anti-Fcrn Antibody; Novel Animal Models; Platelet Destruction And Phagocytosis

$557,347

Pathogenesis and treatment of immune thrombocytopenia: Are there fundamental differences between anti-GPIba and anti-GPIIbIIIa mediated thrombocytopenia?

Nominated PICIHR2009Operating Grant

Principal investigators: Ni, Heyu

$726,927

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Heyu Ni

Research

Latest papers

Latest funding

Cathelicidin LL-37-ApoB-100 interaction promotes LDL clearance and attenuates cholesterol accumulation in the liver.

Age-associated inflammation is accompanied by JAK1-STAT1 signaling activation, megakaryocyte apoptosis, and enhanced thrombopoiesis in naturally aged mice.

Inhibition of human Fc&#x3b3;RIII prevents platelet destruction in a dual-humanized murine model of FNAIT.

The hepatic FGFR-ERK-HRG axis regulates heparin-induced thrombocytopenia with thrombosis.

All-Trans Retinoic Acid for Immune Thrombocytopenia - Sustained Response?

CD47 promotes mitogen-activated protein kinase and epithelial-to-mesenchymal transition molecular programs to drive prometastatic phenotypes in non-small cell lung cancer.

FVIII-containing platelets modulate immune responses and attenuate inhibitor development in hemophilia A mice.

From haemostasis to immunity: The expanding frontiers of platelet biology.

PRKCA and ABCB1 dual-enriched exosomes are key drivers of drug resistance in chronic myeloid leukemia.

Platelet CLEC-2 activation leads to GPIb&#x237a; shedding: Implications for doxorubicin chemotherapy and thrombosis.

Frequent collaborators

Yiming Wang

Mohammed Al-Omran

Peter Lawrence Gross

Mohammad Qadura

Haibo Zhang

Ori Rotstein

Michael Thompson

Jeffrey Weitz

Catherine Pauline Ma Hayward

Chun Peng

William Sheffield

Hwee Teoh

Bobby Yanagawa

John Marshall

Xiao-Yan Wen

Lani Lieberman

Charles De Mestral

Khosrow Adeli

Samira Mubareka

Scott Heximer

Oksana Shynlova

Mansoor Husain

Minna Woo

Claudia Dos Santos

Paul Kubes

Andras Kapus

Nadine Shehata

Philip Britz Mckibbin

Kim Connelly

Paul Kim

Colin Kretz

David Lillicrap

Howard Leong-Poi

Inhibition of human FcγRIII prevents platelet destruction in a dual-humanized murine model of FNAIT.

Platelet CLEC-2 activation leads to GPIb⍺ shedding: Implications for doxorubicin chemotherapy and thrombosis.