This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
BRCA1 deficiency induces NFκB-dependent type-I interferon signaling in fallopian tube epithelial cells.
Neoplasia (New York, N.Y.) · 2026
ISGylation enhances dsRNA-induced interferon response and NFκB signaling in fallopian tube epithelial cells.
The Journal of biological chemistry · 2024
A phase I study of romidepsin, gemcitabine, dexamethasone and cisplatin combination therapy in the treatment of peripheral T-cell and diffuse large B-cell lymphoma; the Canadian cancer trials group LY.15 study†.
Leukemia & lymphoma · 2019
Latest funding
Understanding the role of type 1 interferon in resistance to cancer immunotherapy
CIHR · 2017 · Nominated PI
- $459,000
Targeting Interferon-beta in leukemia immunotherapy
CIHR · 2016 · Nominated PI
- $377,124
Improving Glucocorticoid Therapy in Leukemia
CIHR · 2013 · Nominated PI
18 publications.
BRCA1 deficiency induces NFκB-dependent type-I interferon signaling in fallopian tube epithelial cells.
Madaan V, Kollara A, Spaner D, Brown TJ
ISGylation enhances dsRNA-induced interferon response and NFκB signaling in fallopian tube epithelial cells.
Madaan V, Kollara A, Spaner D, Brown TJ
A phase I study of romidepsin, gemcitabine, dexamethasone and cisplatin combination therapy in the treatment of peripheral T-cell and diffuse large B-cell lymphoma; the Canadian cancer trials group LY.15 study†.
Reiman T, Savage KJ, Crump M, Cheung MC, MacDonald D, Buckstein R, Couban S, Piliotis E, Imrie K, Spaner D, Shivakumar S, Kuruvilla J, Villa D, Shepherd LE, Skamene T, Winch C, Chen BE, Hay AE
A phase 2 study of lenalidomide and dexamethasone in previously untreated patients with chronic lymphocytic leukemia (CLL).
Chen CI, Paul H, Snitzler S, Kakar S, Le LW, Wei EN, Lau A, Johnston JB, Gibson SB, Queau M, Spaner D, Croucher D, Sherry B, Trudel S
Autologous stem cell transplant and combination immunotherapy of rituximab and interferon-α induces prolonged clinical and molecular remissions in patients with follicular lymphoma.
Smyth L, Buckstein R, Pennell N, Weerasinghe R, Cheung MC, Imrie K, Spaner D, Piliotis E, Chodirker L, Reis M, Ghorab Z, Zhang L, Boudreau V, Miliken A, Berinstein N
Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemia.
Song J, Yuan C, Yang J, Liu T, Yao Y, Xiao X, Gajendran B, Xu D, Li YJ, Wang C, Liu W, Wen M, Spaner D, Filmus J, Zacksenhaus E, Zhang Y, Hao X, Ben-David Y
Peroxisome Proliferator-Activated Receptor-δ Supports the Metabolic Requirements of Cell Growth in TCRβ-Selected Thymocytes and Peripheral CD4+ T Cells.
Zhao FL, Ahn JJ, Chen ELY, Yi TJ, Stickle NH, Spaner D, Zúñiga-Pflücker JC, Dunn SE
An autologous tumor vaccine for CLL.
Zhu F, Khatri I, Spaner D, Gorczynski RM
Response.
Mozessohn L, Earle CC, Spaner D, Cheng SY, Kumar M, Buckstein R
The Association of Dyslipidemia With Chronic Lymphocytic Leukemia: A Population-Based Study.
Mozessohn L, Earle C, Spaner D, Cheng SY, Kumar M, Buckstein R
Understanding the role of type 1 interferon in resistance to cancer immunotherapy
Principal investigators: Spaner, David E; Schreiber, Gideon
Keywords: Cancer Immunotherapy; Checkpoint Inhibitors; Endocytosis; Gene Expression; Immunosuppression; Janus Kinases; Leukemia; Lipids; Transgenic Mice; Type 1 Interferon
Targeting Interferon-beta in leukemia immunotherapy
Principal investigators: Spaner, David E
Keywords: Chronic Lymphocytic Leukemia; Cytokines; Immunosuppression; Immunotherapy; Interferon; Janus Kinases; Kinase Inhibitors; Microenvironment; Regulatory B Cells; Xenograft Models
Improving Glucocorticoid Therapy in Leukemia
Principal investigators: Spaner, David E
Keywords: Cell Death; Fatty Acid Oxidation; Glucocorticoids; Glycolysis; Leukemia; Mouse Models; Nuclear Receptors; Ppar; Proteomics; Signal Transduction
Cancer Immunotherapy Program
Principal investigators: Bramson, Jonathan L; Dekaban, Gregory A; Foley, Ronan; Galipeau, Jacques; Levings, Megan K; Medin, Jeffrey A; Nelson, Brad H; Perreault, Claude; Spaner, David E; Thibault, Pierre; Wan, Yonghong
Keywords: Cancer; Experimental Therapeutics; Genomics/Proteomics; Imaging; Immunotherapy; Virology
Metabolic Regulation of Toll-like Receptor Agonist Therapy in Leukemia
Principal investigators: Spaner, David E
Keywords: Apoptosis; Cancer; Cytokines; Flow Cytometry; Glucose; Mitochondria
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Tony Reiman and Tony Reiman: 23 shared papers
- Lisa Chodirker and Lee Mozessohn: 9 shared papers
- David Spaner and Kevin Imrie: 4 shared papers
- Kevin Imrie and John Kuruvilla: 3 shared papers
- David Spaner and Suzanne Trudel: 2 shared papers
- David Spaner and Lee Mozessohn: 2 shared papers
- Eldad Zacksenhaus and Jorge Filmus: 2 shared papers
- Tony Reiman and John Kuruvilla: 2 shared papers
- John Kuruvilla and Lee Mozessohn: 2 shared papers
- John Kuruvilla and Tony Reiman: 2 shared papers
- David Spaner and Thierry Mallevaey: 1 shared paper
- David Spaner and Eldad Zacksenhaus: 1 shared paper
- David Spaner and Jorge Filmus: 1 shared paper
- David Spaner and Tony Reiman: 1 shared paper
- David Spaner and Tianru Jin: 1 shared paper
- David Spaner and Sudeep Shivakumar: 1 shared paper
- David Spaner and Lisa Chodirker: 1 shared paper
- David Spaner and John Kuruvilla: 1 shared paper
- David Spaner and Tony Reiman: 1 shared paper
- David Spaner and Arun Seth: 1 shared paper
- Kevin Imrie and Tony Reiman: 1 shared paper
- Kevin Imrie and Sudeep Shivakumar: 1 shared paper
- Kevin Imrie and Lisa Chodirker: 1 shared paper
- Kevin Imrie and Arun Seth: 1 shared paper
- Tony Reiman and Sudeep Shivakumar: 1 shared paper
- Cancer and Cell Biology
- Critical Care Medicine
- Department of Laboratory Medicine and Pathobiology
- Cellular and Molecular Biology
- Medicine
- Immunology
- Oncology
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Kevin Imrie
Critical Care Medicine
4 shared papers, latest 2019
Suzanne Trudel
Faculty
2 shared papers, latest 2019
Lee Mozessohn
Faculty
2 shared papers, latest 2017
Jorge Filmus
Faculty
1 shared papers, latest 2018
Tony Reiman
Oncology
1 shared papers, latest 2019
Tianru Jin
Faculty
1 shared papers, latest 2015
Thierry Mallevaey
Immunology
1 shared papers, latest 2015
Sudeep Shivakumar
Medicine
1 shared papers, latest 2019
Lisa Chodirker
Faculty
1 shared papers, latest 2019
John Kuruvilla
Faculty
1 shared papers, latest 2019
Arun Seth
Department of Laboratory Medicine and Pathobiology
1 shared papers, latest 2006
Tony Reiman
Faculty
1 shared papers, latest 2019
Eldad Zacksenhaus
Cellular and Molecular Biology
1 shared papers, latest 2018
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