Faculty profile
Eldad Zacksenhaus
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Research
Latest papers
TLR7 signature of tumour innervation reveals two distinct pathways of triple-negative breast cancer progression.
British journal of cancer · 2026 · senior author
Yuxingcao formula suppresses acute erythroleukemia through inhibition of AKT1 and FLI1.
Fitoterapia · 2026
The tumor suppressor pRb and its relative p130 are required to maintain murine adult skeletal muscle homeostasis.
Oncogene · 2025 · senior author
Latest funding
- $100,000
Prevention of metastatic triple negative breast cancer (TNBC) by targeting shared- and metastasis-enriched oncogenic pathways
CIHR · 2023 · Nominated PI
- $799,426
Mechanisms of diabetes and aging in constitutively active, phosphorylation-resistant pRb knockin mice
CIHR · 2021 · Nominated PI
- $16,667
Mechanisms of diabetes and aging in constitutively active, phosphorylation-resistant pRb knockin mice
CIHR · 2021 · Nominated PI
87 publications.
TLR7 signature of tumour innervation reveals two distinct pathways of triple-negative breast cancer progression.
Wang DY, Jiang Z, Ben-David Y, Done SJ, Zacksenhaus E
Yuxingcao formula suppresses acute erythroleukemia through inhibition of AKT1 and FLI1.
Yang Z, Hong J, Liu W, Yu K, Hu A, Kuang Y, Zacksenhaus E, Xiao X, Song J, Huang L, Wang C, Li Y, Ben-David Y
The tumor suppressor pRb and its relative p130 are required to maintain murine adult skeletal muscle homeostasis.
Jiang Z, Baechler BL, Li H, Lad H, Ciavarra G, Ben-David Y, Burden SJ, Quadrilatero J, Zacksenhaus E
Vitamin D3 and its active form calcitriol suppress erythroleukemia through upregulation of CHAC1 and downregulation of NOTCH1.
Hong J, Yang Z, Gao J, Yu K, Hu A, Kuang Y, Gajendran B, Zacksenhaus E, Xiao X, Wang C, Liu W, Ben-David Y
FLI1 Induces Plaque Psoriasis and Its Inhibition Attenuates Disease Progression.
Hu M, Yu K, Wang C, Liu W, Hu A, Kuang Y, Gajendran B, Zacksenhaus E, Sartori G, Bertoni F, Xiao X, Ben-David Y
Recent Advances in Pineoblastoma Research: Molecular Classification, Modelling and Targetable Vulnerabilities.
Jiang Z, Allkanjari MS, Chung PED, Tran H, Ghanbari-Azarnier R, Wang DY, Lin DJ, Min JY, Ben-David Y, Zacksenhaus E
The Astragalus Membranaceus Herb Attenuates Leukemia by Inhibiting the FLI1 Oncogene and Enhancing Anti-Tumor Immunity.
Yu K, Tang Y, Wang C, Liu W, Hu M, Hu A, Kuang Y, Zacksenhaus E, Yu XZ, Xiao X, Ben-David Y
UM171 suppresses breast cancer progression by inducing KLF2.
Ran X, Hu A, Kuang Y, Wang C, Liu W, Xiao X, Zacksenhaus E, Yu X, Ben-David Y
An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation.
Wang C, Hu M, Yu K, Liu W, Hu A, Kuang Y, Huang L, Gajendran B, Zacksenhaus E, Xiao X, Ben-David Y
FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression.
Wang J, Wang C, Hu A, Yu K, Kuang Y, Gajendran B, Zacksenhaus E, Sample KM, Xiao X, Liu W, Ben-David Y
Prevention of metastatic triple negative breast cancer (TNBC) by targeting shared- and metastasis-enriched oncogenic pathways
Principal investigators: Zacksenhaus, Eldad
Keywords: Breast Cancer; Metastasis; Prevention; Triple Negative Breast Cancer
Mechanisms of diabetes and aging in constitutively active, phosphorylation-resistant pRb knockin mice
Principal investigators: Zacksenhaus, Eldad
Keywords: Cell Cycle Regulation, Diabetes, Aging
Mechanisms of diabetes and aging in constitutively active, phosphorylation-resistant pRb knockin mice
Principal investigators: Zacksenhaus, Eldad
Keywords: Cell Cycle Regulation, Diabetes, Aging
New mouse models and targeted therapies for aggressive forms of germline and sporadic pineoblastoma
Principal investigators: Zacksenhaus, Eldad
Keywords: Mouse Models; Pineoblastoma; Therapy
Identification and Targeting Oncogenic and Metastatic Driver Genes in Pineoblastoma Induced by Tumour Suppressor Rb/p53- Deficiency
Principal investigators: Ghanbari Azarnier, Ronak
Keywords: Drug Screening; Exome Sequencing; Metastasis; Mouse Models; Pineoblastoma; Sleeping Beauty Mutagenesis
A model for Group C Medulloblastoma induced by deletion of RB1 and p53 tumor suppressors
Principal investigators: Zacksenhaus, Eldad
Keywords: Cancer; Drug Screen; Medulloblastoma; Mouse Models; P53; Rb1; Therapy; Tumor Suppressor
2nd Retinoblastoma Tumor Suppressor Symposium - Toronto 2011
Principal investigators: Bremner, Rod; Zacksenhaus, Eldad
Keywords: Cancer; Cyclin/Cdk; E2f; Rb Pathway; Skp2
Molecular interactions of PTEN with BRCA1, p53 and Rb in breast cancer tumorigenesis
Principal investigators: Wang, Sharon Z
Keywords: Brca1; Breast Cancer; Oncogenic Network; Protein 53; Pten; Retinoblastoma; Rnai; Transgenic Mice; Tumor Initiating Cells (Cancer Stem Cells); Western Blot
Addressing tumor heterogeneity through identification of subgroup-specific "shared maintenance genes" - the right target for each cancer
Principal investigators: Egan, Sean E; Taylor, Michael D; Woodgett, James (Jim) R; Zacksenhaus, Eldad
Keywords: Breast Cancer; Medulloblastoma; Metastasis; Oncogene Addiction; P53; Pi3k; Rb; Shared Maintenance Genes; Shh; Wnt
Inhibition of autophagy by the pRb tumor suppressor
Principal investigators: Zacksenhaus, Eldad
Keywords: Autophagy; Cancer; Myogenesis; Retinoblastoma; Tissue Specific Knockout Mice; Tumor Suppressors
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Andrea Eisen and Andrea Eisen: 162 shared papers
- Ahmed Aman and David Uehling: 11 shared papers
- Annie Huang and Livia Garzia: 6 shared papers
- Livia Garzia and Livia Garzia: 5 shared papers
- Minna Woo and Eldad Zacksenhaus: 4 shared papers
- Eldad Zacksenhaus and Wei Wang: 4 shared papers
- Minna Woo and Xiaohong Wu: 3 shared papers
- Eldad Zacksenhaus and Rod Bremner: 3 shared papers
- Andrea Eisen and Eldad Zacksenhaus: 2 shared papers
- Honglin Luo and Isabella Caniggia: 2 shared papers
- Xiaohong Wu and Eldad Zacksenhaus: 2 shared papers
- Andrea Eisen and Eldad Zacksenhaus: 2 shared papers
- Eldad Zacksenhaus and Vuk Stambolic: 2 shared papers
- Eldad Zacksenhaus and Jorge Filmus: 2 shared papers
- Eldad Zacksenhaus and Livia Garzia: 2 shared papers
- Eldad Zacksenhaus and Livia Garzia: 2 shared papers
- Eldad Zacksenhaus and David Uehling: 2 shared papers
- Annie Huang and Livia Garzia: 2 shared papers
- Benjamin Haibe-Kains and Livia Garzia: 2 shared papers
- Arnim Pause and Ivan Topisirovic: 2 shared papers
- Livia Garzia and Wei Wang: 2 shared papers
- Wei Wang and Livia Garzia: 2 shared papers
- Andre Bedard and Craig McCormick: 1 shared paper
- Andre Bedard and Honglin Luo: 1 shared paper
- Andre Bedard and Eldad Zacksenhaus: 1 shared paper
- Andre Bedard and Isabella Caniggia: 1 shared paper
- Andre Bedard and Dusica Maysinger: 1 shared paper
- Andre Bedard and Arnim Pause: 1 shared paper
- Andre Bedard and Ivan Topisirovic: 1 shared paper
- Craig McCormick and Honglin Luo: 1 shared paper
- Craig McCormick and Eldad Zacksenhaus: 1 shared paper
- Craig McCormick and Isabella Caniggia: 1 shared paper
- Craig McCormick and Dusica Maysinger: 1 shared paper
- Craig McCormick and Arnim Pause: 1 shared paper
- Craig McCormick and Ivan Topisirovic: 1 shared paper
- Honglin Luo and Eldad Zacksenhaus: 1 shared paper
- Honglin Luo and Dusica Maysinger: 1 shared paper
- Minna Woo and Isabella Caniggia: 1 shared paper
- Minna Woo and Vuk Stambolic: 1 shared paper
- Minna Woo and Rod Bremner: 1 shared paper
- David Spaner and Eldad Zacksenhaus: 1 shared paper
- David Spaner and Jorge Filmus: 1 shared paper
- Daniela Rotin and Eldad Zacksenhaus: 1 shared paper
- Daniela Rotin and Vuk Stambolic: 1 shared paper
- Daniela Rotin and Annie Huang: 1 shared paper
- Daniela Rotin and David Uehling: 1 shared paper
- Eldad Zacksenhaus and Isabella Caniggia: 1 shared paper
- Eldad Zacksenhaus and Annie Huang: 1 shared paper
- Eldad Zacksenhaus and Helen Dimaras: 1 shared paper
- Eldad Zacksenhaus and Benjamin Haibe-Kains: 1 shared paper
- Eldad Zacksenhaus and Dusica Maysinger: 1 shared paper
- Eldad Zacksenhaus and Arnim Pause: 1 shared paper
- Eldad Zacksenhaus and Ivan Topisirovic: 1 shared paper
- Eldad Zacksenhaus and Ahmed Aman: 1 shared paper
- Vuk Stambolic and Ahmed Aman: 1 shared paper
- Annie Huang and Benjamin Haibe-Kains: 1 shared paper
- Helen Dimaras and Rod Bremner: 1 shared paper
- Medicine
- Lunenfeld-Tanenbaum Research Institute
- Cellular and Molecular Biology
- Oncology
- Research
- Biology
- Pediatrics
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Wei Wang
Faculty
4 shared papers, latest 2021
Minna Woo
Medicine
4 shared papers, latest 2022
Rod Bremner
Lunenfeld-Tanenbaum Research Institute
3 shared papers, latest 2022
Livia Garzia
Faculty
2 shared papers, latest 2021
Vuk Stambolic
Research
2 shared papers, latest 2020
David Uehling
Faculty
2 shared papers, latest 2014
Livia Garzia
Faculty
2 shared papers, latest 2021
Jorge Filmus
Faculty
2 shared papers, latest 2019
Xiaohong Wu
Medicine
2 shared papers, latest 2014
Andrea Eisen
Faculty
2 shared papers, latest 2017
Andrea Eisen
Oncology
2 shared papers, latest 2017
Marianne Koritzinsky
Faculty
1 shared papers, latest 2023
Steve Jean
Anatomie et biologie cellulaire
1 shared papers, latest 2016
Benjamin Haibe-Kains
Radiation Oncology/Medical Physics
1 shared papers, latest 2020
Jason Moffat
Genetics and Genome Biology
1 shared papers, latest 2014
Dusica Maysinger
Medicine
1 shared papers, latest 2016
Isabella Caniggia
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2016
Joan Wither
Medicine/Nephrology
1 shared papers, latest 2015
Ivan Topisirovic
Lady Davis Institute for Medical Research
1 shared papers, latest 2016
Martin Gleave
Urologic Sciences
1 shared papers, latest 2016
Arnim Pause
Biochemistry
1 shared papers, latest 2016
Ivan Topisirovic
Faculty
1 shared papers, latest 2016
Xi-Long Zheng
Biochemistry and Molecular Biology
1 shared papers, latest 2016
Sharon Nofech-Mozes
Physical Sciences
1 shared papers, latest 2017
Ruth Slack
Cellular and Molecular Medicine
1 shared papers, latest 2016
Robert Rottapel
Medical Biophysics
1 shared papers, latest 2014
Craig McCormick
Microbiology and Immunology
1 shared papers, latest 2016
Honglin Luo
Pathology and Laboratory Medicine
1 shared papers, latest 2016
David Spaner
Cancer and Cell Biology
1 shared papers, latest 2018
Joseph Beyene
Health Research Methods, Evidence, and Impact
1 shared papers, latest 2012
Daniela Rotin
Cell Biology
1 shared papers, latest 2021
Andre Bedard
Biology
1 shared papers, latest 2016
John Lee
Surgery
1 shared papers, latest 2016
Michael Sacher
Biology
1 shared papers, latest 2016
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