David Williams, University of Toronto

Research

Calnexin Calreticulin Cis-Trans Proline Isomerization Disulfide Bond Endoplasmic Reticulum Er Associated Degradation Genome-Wide Shrna Screen Human Disease

Latest papers

Effect of Endovascular Thrombectomy for Acute Ischemic Stroke on Cognitive Outcomes
Neurology · 2024
Early Trajectory of Stroke Severity Predicts Long-Term Functional Outcomes in Ischemic Stroke Subjects: Results From the ESCAPE Trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times).
Stroke · 2017
Analysis of Workflow and Time to Treatment on Thrombectomy Outcome in the Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) Randomized, Controlled Trial.
Circulation · 2016

All 5 publications

Latest funding

Protein folding and quality control within the endoplasmic reticulum
CIHR · 2012 · Nominated PI
$739,741
Knowledge translation of surgical innovations: Exploring development, implementation and evaluation of robotic and simulation training programs
CIHR · 2009 · Principal investigator
$60,000
CIHR Training Program in Protein Folding and Interaction Dynamics: Principles and Diseases
CIHR · 2008 · Co-investigator
$1,950,000

All 4 grants and awards

5 publications.

01

Effect of Endovascular Thrombectomy for Acute Ischemic Stroke on Cognitive Outcomes

Joundi RA, Smith EE, Mandzia J, Ganesh A, Menon BK, Rempel JL, Thornton J, Roy D, Jovin TG, Dowlatshahi D

Neurology202416 citations

DOI: 10.1212/wnl.0000000000209270

02

Early Trajectory of Stroke Severity Predicts Long-Term Functional Outcomes in Ischemic Stroke Subjects: Results From the ESCAPE Trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times).

Sajobi TT, Menon BK, Wang M, Lawal O, Shuaib A, Williams D, Poppe AY, Jovin TG, Casaubon LK, Devlin T, Dowlatshahi D, Fanale C, Lowerison MW, Demchuk AM, Goyal M, Hill MD, ESCAPE Trial Investigators

Stroke2017

DOI: 10.1161/strokeaha.116.014456 PMID: 27924049

03

Analysis of Workflow and Time to Treatment on Thrombectomy Outcome in the Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) Randomized, Controlled Trial.

Menon BK, Sajobi TT, Zhang Y, Rempel JL, Shuaib A, Thornton J, Williams D, Roy D, Poppe AY, Jovin TG, Sapkota B, Baxter BW, Krings T, Silver FL, Frei DF, Fanale C, Tampieri D, Teitelbaum J, Lum C, Dowlatshahi D, Eesa M, Lowerison MW, Kamal NR, Demchuk AM, Hill MD, Goyal M

Circulation2016

DOI: 10.1161/circulationaha.115.019983 PMID: 27076599

04

Unfolding the complexities of ER chaperones in health and disease: report on the 11th international calreticulin workshop.

Gold L, Williams D, Groenendyk J, Michalak M, Eggleton P

Cell stress & chaperones2015

DOI: 10.1007/s12192-015-0638-4 PMID: 26395641

05

Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones.

Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G

PLoS pathogens2009

DOI: 10.1371/journal.ppat.1000608 PMID: 19798432

Protein folding and quality control within the endoplasmic reticulum

Nominated PICIHR2012Operating Grant

Principal investigators: Williams, David B

Keywords: Calnexin; Calreticulin; Cis-Trans Proline Isomerization; Disulfide Bond; Endoplasmic Reticulum; Er Associated Degradation; Genome-Wide Shrna Screen; Human Disease; Molecular Chaperone; Peptidyl Prolyl Isomerases; Prion Protein; Protein Aggregation; Protein Disulfide Isomerases; Protein Folding; Protein Trafficking; Quality Control; Rna Interference; Site-Directed Mutagenesis; Structure-Function Analysis

$739,741

Knowledge translation of surgical innovations: Exploring development, implementation and evaluation of robotic and simulation training programs

Principal investigatorCIHR2009Operating Grant - Priority Announcement: Knowledge Translation

Principal investigators: Gagliardi, Anna R; Williams, David

Keywords: Interviews; Network Development; Patient Safety; Surgical Robotics; Surgical Simulation; Systematic Review

$60,000

CIHR Training Program in Protein Folding and Interaction Dynamics: Principles and Diseases

Co-investigatorCIHR2008Training Grant

Principal investigators: Houry, Walid A; Forman-Kay, Julie D

Keywords: Absorbance; Alzheimer; Analytical Ultracentrifugation; Bacterial Infection; Bioinformatics; Cancer; Chaperones; Circular Dichroism; Computational Biology; Disease; Fluorescence; Folding; Microscopes; Misfolding; Nmr; Parkinson; Prions; Protein-Protein Interactions; Proteins; Proteomics; Training; X-Ray

$1,950,000

Mechanisms of MHC Class I intracellular export and degradation

SupervisorCIHR2008Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Chapman, Daniel C

Keywords: Cargo Receptors; Endoplasmic Reticulum; Golgi Apparatus; Immunoisolation; Immunology; Intracellular Transport; Major Histocompatibility Complex Class I; Radiolabeling

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Clinical Neurosciences
Clinical Public Health Division
Department of Medicine
Neurosciences
Neurology and Neurosciences
Tanz Centre for Research in Neurodegenerative Diseases
Biochemistry
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Dar Dowlatshahi

Department of Medicine

3 shared papers, latest 2024

Marek Michalak

Biochemistry

1 shared papers, latest 2015

Mayank Goyal

Clinical Neurosciences

1 shared papers, latest 2024

Gerold Schmitt-Ulms

Tanz Centre for Research in Neurodegenerative Diseases

1 shared papers, latest 2009

Jennifer Mandzia

Faculty

1 shared papers, latest 2024

Andrew Demchuk

Clinical Neurosciences

1 shared papers, latest 2024

Aravind Ganesh

Clinical Neurosciences

1 shared papers, latest 2024

Alexandre Poppe

Neurosciences

1 shared papers, latest 2024

Andrew Demchuk

Neurology and Neurosciences

1 shared papers, latest 2024

Aravind Ganesh

Faculty

1 shared papers, latest 2024

Philip Barber

Clinical Neurosciences

1 shared papers, latest 2024

Raed Joundi

Medicine

1 shared papers, latest 2024

Write to this professor

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Applying for

Paper to mention

Subject: Prospective PhD student: Calnexin Dear Professor Williams, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Effect of Endovascular Thrombectomy for Acute Ischemic Stroke on Cognitive Outcomes" (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]