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Gerold Schmitt-Ulms

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ProfessorTanz Centre for Research in Neurodegenerative DiseasesUniversity of Toronto

Gerold Schmitt-Ulms

Professor

Tanz Centre for Research in Neurodegenerative Diseases

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
17 publications in the last five years, latest in 2026.
Senior (last) author on 10 recent papers, a sign of leading a research group.
Principal investigator on 3 research grants (3 CIHR), most recently in 2022.
Supervised 3 trainees who won CIHR awards, most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Education

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Medical infection agents (including prions)Protein and gene networks Proteomics

Latest papers

The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein.
PLoS pathogens · 2026
A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.
PLoS pathogens · 2026 · senior author
A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.
bioRxiv : the preprint server for biology · 2026 · senior author

All 76 publications

Latest funding

Targeting sodium potassium pumps for the treatment of prion diseases
CIHR · 2022 · Nominated PI
$516,375
Identification of a cardiac glycoside exhibiting favorable brain bioavailability and potency for reducing levels of the cellular prion protein
CIHR · 2022 · Supervisor
$105,000
Novel animal and cellular paradigms for studying prion formation
CIHR · 2019 · Co-investigator
$852,975

All 12 grants and awards

76 publications.

The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein.

Amano G, Arshad H, Patel Z, Schmitt-Ulms G, Watts JC

PLoS pathogens2026

DOI: 10.1371/journal.ppat.1014536 PMID: 42611925

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

Zerbes T, Verkuyl C, Zhang C, Grunnesjoe S, Eid S, Arshad H, Zhao W, Nasser Z, O'Shea T, Bel A, Lamoureux L, Frost KL, Myskiw J, Li LY, Stuart E, Wille H, Booth S, Watts JC, Schmitt-Ulms G

PLoS pathogens2026Senior author

DOI: 10.1371/journal.ppat.1014124 PMID: 42550881

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

Zerbes T, Verkuyl C, Zhang C, Grunnesjoe S, Eid S, Arshad H, Zhao W, Nasser Z, O'Shea T, Belotserkovsky A, Lamoureux L, Frost KL, Myskiw J, Li L, Stuart E, Wille H, Booth S, Watts JC, Schmitt-Ulms G

bioRxiv : the preprint server for biology2026Senior author

DOI: 10.64898/2026.03.27.714700 PMID: 41929092

The delivery challenge of adeno-associated virus vector-based gene therapies for neurological diseases.

Pak A, Wear D, Tahmasian N, Min JY, Premraj D, Gibbs R, Spencer K, Fang S, Zerbes T, Krishnan M, Nasser Z, Schmitt-Ulms G

Frontiers in neuroscience2026Senior author

DOI: 10.3389/fnins.2026.1768545 PMID: 41835941

Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology.

Verkuyl C, Belotserkovsky A, Zerbes T, Williams D, Krishnan MR, Zhu S, Grunnesjӧ S, Eid S, Zhang C, Zhao W, Xu L, Lin E, O'Shea T, Draper B, Jungman A, Most P, Schmitt-Ulms G

PloS one2025Senior author

DOI: 10.1371/journal.pone.0336578 PMID: 41202069

Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs.

Perry N, Eid S, Schmitt-Ulms G, Nagorny P

Chemistry (Weinheim an der Bergstrasse, Germany)2025

DOI: 10.1002/chem.202501552 PMID: 40532177

Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice.

Zhao W, Eid S, Sackmann C, Williams D, Wang X, Ouyang Y, Zerbes T, Schmitt-Ulms G

Acta neuropathologica2025Senior author

DOI: 10.1007/s00401-025-02906-2 PMID: 40549026

The brain interactome of a permissive prion replication substrate.

Arshad H, Eid S, Mehra S, Williams D, Kaczmarczyk L, Stuart E, Jackson WS, Schmitt-Ulms G, Watts JC

Neurobiology of disease2025

DOI: 10.1016/j.nbd.2025.106802 PMID: 39800229

A unified model for the origins of spongiform degeneration and other neuropathological features in prion diseases.

Schmitt-Ulms G, Wang X, Watts J, Booth S, Wille H, Zhao W

ArXiv2025First author

DOI: 10.1101/2024.12.18.629254 PMID: 39876936

Update on a brain-penetrant cardiac glycoside that can lower cellular prion protein levels in human and guinea pig paradigms.

Eid S, Zhao W, Williams D, Nasser Z, Griffin J, Nagorny P, Schmitt-Ulms G

PloS one2024Senior author

DOI: 10.1371/journal.pone.0308821 PMID: 39316592

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Gerold Schmitt-Ulms

Research

Latest papers

Latest funding

The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein.

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model.

The delivery challenge of adeno-associated virus vector-based gene therapies for neurological diseases.

Toward an all-in-one recombinant adeno-associated virus vector for functionally ablating the prion gene using CRISPR-Cas technology.

Development of CPA-Catalyzed &#x3b2;-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs.

Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice.

The brain interactome of a permissive prion replication substrate.

A unified model for the origins of spongiform degeneration and other neuropathological features in prion diseases.

Update on a brain-penetrant cardiac glycoside that can lower cellular prion protein levels in human and guinea pig paradigms.

Frequent collaborators

Peter ST GEORGE-HYSLOP

Ekaterina Rogaeva

Holger Wille

Thomas Kislinger

Stephanie Booth

Joel Watts

David Westaway

Simon Sharpe

Lili-Naz Hazrati

Paul Fraser

Angus Lau

Vivian Ng

Suneil Kalia

Mei Zhen

Anurag Tandon

David Williams

Frank Sicheri

Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs.