Faculty profile

Earl Silverman

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ProfessorDepartment of PaediatricsUniversity of Toronto

Earl Silverman

Professor

Department of Paediatrics

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
2 publications in the last five years, latest in 2024.
Supervisor on 1 trainee award (1 CIHR), most recently in 2011.

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Academic metrics

Publications

1,496

Citations

Collaborators

Grants

Publications by year

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Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry
Rheumatology · 2024
Evaluation of Progression From Preclinical to Systemic Autoimmune Rheumatic Disease: Novel Use of the European Alliance of Associations for Rheumatology/American College of Rheumatology Systemic Lupus Erythematosus Classification Criteria as an Outcome Measure.
ACR open rheumatology · 2024
Effects of Transplacental Dexamethasone Therapy on Fetal Immune-Mediated Complete Heart Block.
Fetal diagnosis and therapy · 2021

All 25 publications

Latest funding

Identifying genetic determinants of lupus nephritis and kidney function in children and adults with systemic lupus erythematosus (SLE).
CIHR · 2018 · Co-investigator
$520,200
Genetics of longitudinal, quantitative renal measures in systemic lupus erythematosus
CIHR · 2016 · Co-investigator
$100,000
Improving design and analysis of longitudinal studies of prognosis in uncommon diseases
CIHR · 2011 · Supervisor
$105,000

All 7 grants and awards

25 publications.

A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry

Nguyen K, Barsalou J, Basodan D, Batthish M, Benseler SM, Berard RA, Blanchette N, Boire G, Bolaria R, Bruns A

Rheumatology202421 citationsOpen Access

DOI: 10.1093/rheumatology/kead560

Evaluation of Progression From Preclinical to Systemic Autoimmune Rheumatic Disease: Novel Use of the European Alliance of Associations for Rheumatology/American College of Rheumatology Systemic Lupus Erythematosus Classification Criteria as an Outcome Measure.

Johnson SR, Alahmari H, Bonilla D, Ahmad Z, Bookman A, Hiraki LT, Silverman E, Touma Z, Movahedi M, Wither JE

ACR open rheumatology20247 citationsOpen Access

DOI: 10.1002/acr2.11723 PMID: 39348240

Effects of Transplacental Dexamethasone Therapy on Fetal Immune-Mediated Complete Heart Block.

Saito M, Silverman E, Golding F, Guerra V, Hiraki L, Thakur V, Jaeggi E

Fetal diagnosis and therapy202120 citationsOpen Access

DOI: 10.1159/000513202 PMID: 33592603

Cutaneous sequelae in neonatal lupus: A retrospective cohort study.

Levy R, Briggs L, Silverman E, Pope E, Lara-Corrales I

Journal of the American Academy of Dermatology2020

DOI: 10.1016/j.jaad.2019.09.083 PMID: 31626881

Fatigue severity in anti-nuclear antibody-positive individuals does not correlate with pro-inflammatory cytokine levels or predict imminent progression to symptomatic disease.

Hafiz W, Nori R, Bregasi A, Noamani B, Bonilla D, Lisnevskaia L, Silverman E, Bookman AAM, Johnson SR, Landolt-Marticorena C, Wither J

Arthritis research & therapy201921 citationsOpen Access

DOI: 10.1186/s13075-019-2013-9 PMID: 31685018

Evaluation of Dry Eye Disease in Children With Systemic Lupus Erythematosus and Healthy Controls.

Ong Tone S, Elbaz U, Silverman E, Levy D, Williams S, Mireskandari K, Ali A

Cornea201920 citations

DOI: 10.1097/ico.0000000000001902 PMID: 30933962

Persistent Disease Activity Remains a Burden for Patients with Systemic Lupus Erythematosus.

Peschken CA, Wang Y, Abrahamowicz M, Pope J, Silverman E, Sayani A, Iczkovitz S, Ross J, Zummer M, Tucker L, Pineau C, Levy D, Hudson M, Hitchon CA, Huber AM, Smith CD, Avina-Zubieta A, Arbillaga H, Chédeville G, Wynant W, Fortin PR, CaNIOS 1000 Faces Investigators

The Journal of rheumatology201919 citationsOpen Access

DOI: 10.3899/jrheum.171454 PMID: 30219771

Establishing Surrogate Kidney End Points for Lupus Nephritis Clinical Trials: Development and Validation of a Novel Approach to Predict Future Kidney Outcomes.

Mackay M, Dall'Era M, Fishbein J, Kalunian K, Lesser M, Sanchez-Guerrero J, Levy DM, Silverman E, Petri M, Arriens C, Lewis EJ, Korbet SM, Conti F, Tesar V, Hruskova Z, Borba EF, Bonfa E, Chan TM, Rathi M, Gupta KL, Jha V, Hasni S, West MR, Solomons N, Houssiau FA, Romero-Diaz J, Mejia-Vilet J, Rovin BH

Arthritis & rheumatology (Hoboken, N.J.)2019

DOI: 10.1002/art.40724 PMID: 30225865

Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test.

Lionel AC, Costain G, Monfared N, Walker S, Reuter MS, Hosseini SM, Thiruvahindrapuram B, Merico D, Jobling R, Nalpathamkalam T, Pellecchia G, Sung WWL, Wang Z, Bikangaga P, Boelman C, Carter MT, Cordeiro D, Cytrynbaum C, Dell SD, Dhir P, Dowling JJ, Heon E, Hewson S, Hiraki L, Inbar-Feigenberg M, Klatt R, Kronick J, Laxer RM, Licht C, MacDonald H, Mercimek-Andrews S, Mendoza-Londono R, Piscione T, Schneider R, Schulze A, Silverman E, Siriwardena K, Snead OC, Sondheimer N, Sutherland J, Vincent A, Wasserman JD, Weksberg R, Shuman C, Carew C, Szego MJ, Hayeems RZ, Basran R, Stavropoulos DJ, Ray PN, Bowdin S, Meyn MS, Cohn RD, Scherer SW, Marshall CR

Genetics in medicine : official journal of the American College of Medical Genetics2018584 citationsOpen Access

DOI: 10.1038/gim.2017.119 PMID: 28771251

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease.

Baglaenko Y, Chang NH, Johnson SR, Hafiz W, Manion K, Ferri D, Noamani B, Bonilla D, Rusta-Sellehy S, Lisnevskaia L, Silverman E, Bookman A, Landolt-Marticorena C, Wither J

Arthritis research & therapy201834 citationsOpen Access

DOI: 10.1186/s13075-018-1752-3 PMID: 30486869

Identifying genetic determinants of lupus nephritis and kidney function in children and adults with systemic lupus erythematosus (SLE).

Co-investigatorCIHR2018Project Grant

Principal investigators: Hiraki, Linda T

Keywords: Chronic Kidney Disease; Dialysis/Kidney Transplant; Ethnic Differences; Genetic Epidemiology; Kidney Function; Life Course Health; Lupus Nephritis; Repeated Measures; Risk Factors; Systemic Lupus Erythematosus

$520,200

Genetics of longitudinal, quantitative renal measures in systemic lupus erythematosus

Co-investigatorCIHR2016Project Grant

Principal investigators: Hiraki, Linda T

Keywords: Chronic Kidney Disease; Dialysis/Transplant; Ethnic Differences; Genetic Epidemiology; Kidney Function; Life Course Health; Lupus Nephritis; Repeated Measures; Risk Factors; Systemic Lupus Erythematosus

$100,000

Improving design and analysis of longitudinal studies of prognosis in uncommon diseases

SupervisorCIHR2011Doctoral Research Award - PA: Patient-Oriented Research - Clinical Epidemiology

Principal investigators: Lim, Siok Hoon Lily

Keywords: Children; Epidemiology; Latent Class Methods; Longitudinal Modeling; Lupus; Outcomes; Prognosis; Rare Disease

$105,000

Congenital Heart Block International Research Network (CIRN)

Co-investigatorCIHR2011Network Catalyst - Infection and Immunity (III)

Principal investigators: Hamilton, Robert M

Keywords: Anti-Ro Antibody; Autoimmunity; Biobank; Congenital; Heart Block; Knowledge Transfer; Network

$311,172

Cancer Risk in Pediatric-Onset Rheumatic Disease

Co-investigatorCIHR2010Operating Grant

Principal investigators: Bernatsky, Sasha R

Keywords: Juvenile Idiopathic Arthritis; Lymphoma; Malignancy; Systemic Lupus Erythematosus

$117,697

Empowering Patients as Active Partners in Their Care: Lupus Interactive Navigator (LIN)

Co-investigatorCIHR2010Partnerships for Health System Improvement (PHSI)

Principal investigators: Fortin, Paul R; Bergeron, Louise; Da Costa, Deborah M

Keywords: Health System Improvement; Interactive Navigator; Knowledge Transfer; Lupus; Patient Centered Care; Patient Empowerment; Psychological Stress; Quality Of Life; Social Support; Systemic Autoimmune Rheumatic Disease

$245,578

Molecular expression and epitopes in congenital heart block

Co-investigatorCIHR2009Operating Grant -PA: Inst of Circulatory and Respiratory Health - Bridge Funding

Principal investigators: Hamilton, Robert M

Keywords: Atrioventricular Node; Cellular Electrophysiology; Gene Expression; Ion Channels; Mouse Model; Protein Array

$100,000

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Earl Silverman

Research

Latest papers

Latest funding

A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry

Evaluation of Progression From Preclinical to Systemic Autoimmune Rheumatic Disease: Novel Use of the European Alliance of Associations for Rheumatology/American College of Rheumatology Systemic Lupus Erythematosus Classification Criteria as an Outcome Measure.

Effects of Transplacental Dexamethasone Therapy on Fetal Immune-Mediated Complete Heart Block.

Cutaneous sequelae in neonatal lupus: A retrospective cohort study.

Fatigue severity in anti-nuclear antibody-positive individuals does not correlate with pro-inflammatory cytokine levels or predict imminent progression to symptomatic disease.

Evaluation of Dry Eye Disease in Children With Systemic Lupus Erythematosus and Healthy Controls.

Persistent Disease Activity Remains a Burden for Patients with Systemic Lupus Erythematosus.

Establishing Surrogate Kidney End Points for Lupus Nephritis Clinical Trials: Development and Validation of a Novel Approach to Predict Future Kidney Outcomes.

Improved diagnostic yield compared with targeted gene sequencing panels suggests a role for whole-genome sequencing as a first-tier genetic test.

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease.

Identifying genetic determinants of lupus nephritis and kidney function in children and adults with systemic lupus erythematosus (SLE).

Genetics of longitudinal, quantitative renal measures in systemic lupus erythematosus

Improving design and analysis of longitudinal studies of prognosis in uncommon diseases

Congenital Heart Block International Research Network (CIRN)

Cancer Risk in Pediatric-Onset Rheumatic Disease

Empowering Patients as Active Partners in Their Care: Lupus Interactive Navigator (LIN)

Molecular expression and epitopes in congenital heart block

Frequent collaborators

Rayfel Schneider

Lynn Spiegel

Brian Feldman

Rae Yeung

Adam Huber

Lori Tucker

Nicole Johnson

Margaret Larche

Elie Haddad

Heinrike Schmeling

Sindhu Johnson

Stuart Turvey

Joan Wither

Gilles Boire

Jaime Guzman

David Cabral

Kimberly Morishita

Alan Rosenberg

Deborah Levy

Arthur Bookman

Paivi Miettunen

Susanne Benseler

Vitor Guerra

Rebecca Levy

Roberto Mendoza-Londono

Elena Pope

Michal Inbar-Feigenberg