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Research
Latest papers
Measurements of urinary biomarkers at 2 years following a lupus nephritis flare are associated with subsequent renal outcomes.
Lupus science & medicine · 2026 · senior author
Type I interferons enhance B cell activation and promote differentiation of double negative 2 cells in SLE.
Lupus science & medicine · 2026 · senior author
Type I Interferon status and clinical manifestations in a large cohort of patients with systemic lupus erythematosus.
Joint bone spine · 2026
Latest funding
- $15,430
Characterizing the variability that underlies mechanisms of alloimmune and autoimmune kidney injury through glycoproteomics
CIHR · 2024 · Principal investigator
- $501,076
Understanding the immunophenotype and genetics of treatment response in children and adolescents with lupus nephritis.
CIHR · 2024 · Co-investigator
- $910,350
Characterization of the T cell populations that regulate autoimmunity in asymptomatic anti-nuclear positive individuals and how they become altered in early untreated systemic autoimmune rheumatic disease
CIHR · 2023 · Nominated PI
47 publications.
Measurements of urinary biomarkers at 2 years following a lupus nephritis flare are associated with subsequent renal outcomes.
Baker R, Whittall Garcia LP, Li Q, Kim M, Bonilla D, Gladman DD, Urowitz M, Touma Z, Wither J
Type I interferons enhance B cell activation and promote differentiation of double negative 2 cells in SLE.
Faheem Z, Boukhaled GM, Nassar C, Manion K, Kim M, Bonilla D, Gladman DD, Whittall Garcia L, Touma Z, Brooks DG, Wither J
Type I Interferon status and clinical manifestations in a large cohort of patients with systemic lupus erythematosus.
Smith JD, Garcia LW, Bonilla D, Li Q, Keeling S, Avina-Zubieta JA, Wijesuriya H, Richards I, Jacobs A, Reidy J, Terbrueggen R, Wither J, Gladman DD, Touma Z
Characterizing arthritis subtypes in lupus: prevalence, clinical features and role of type I interferon signatures.
Mehta P, Kharouf F, Carrizo-Abarza V, Wither J, Patel M, Li Q, Gladman DD, Whittall Garcia LP, Touma Z
Elevated serum brain injury markers are associated with disease activity, pro-inflammatory cytokine levels and cognitive dysfunction in adolescents with childhood-onset SLE.
Mwizerwa O, Ledochowski J, Ramanathan G, Tal TE, Mossad SI, Zapparoli B, Ng L, Jeyanathan A, Davis A, Hiraki LT, Levy DM, Wither J, Touma Z, Danguecan A, Yeh A, Knight AM
Sex differences in biomarkers and biologic mechanisms in psoriatic diseases and spondyloarthritis.
Dang S, Wither J, Jurisica I, Chandran V, Eder L
Single-cell RNA sequencing of circulating immune cells supports inhibition of TNFAIP3 and NFKBIA translation as psoriatic arthritis biomarkers.
Garrido AN, Machhar R, Cruz-Correa OF, Ganatra D, Crome SQ, Wither J, Jurisica I, Gladman DD
Lupus nephritis: Biomarkers.
Dobrowolski C, Lao SM, Kharouf F, Croci PP, Wither J, Gladman DD, Garcia LW, Jauhal A, Touma Z
Lupus nephritis II: Treatment and monitoring.
Dobrowolski C, Lao SM, Kharouf F, Croci PP, Wither J, Gladman DD, Garcia LW, Jauhal A, Touma Z
Intraindividual cognitive function course over time in patients with systemic lupus erythematosus.
Tayer-Shifman OE, Su J, Bingham K, Kakvan M, Tartaglia MC, Ruttan L, Marzouk S, Wither J, Choi MY, Bonilla D, Appenzeller S, Beaton D, Katz P, Green R, Gladman DD, Touma Z
Characterizing the variability that underlies mechanisms of alloimmune and autoimmune kidney injury through glycoproteomics
Principal investigators: Konvalinka, Ana; Das, Jishnu; Mahal, Lara K; Sarkar, Aniruddh; Wither, Joan E
Keywords: Antibody; Causal Inference; Complement; Computational Biology; Glycomics; Kidney Transplant; Lupus Nephritis; Proteomics; Rejection; Systemic Lupus Erythematosus
Understanding the immunophenotype and genetics of treatment response in children and adolescents with lupus nephritis.
Principal investigators: Hiraki, Linda T
Keywords: Child/Adolescent Health; Disease Activity; Genetics; Kidney Pathology; Lupus Nephritis; Outcomes; Predictors; Single Cell Studies; Systemic Lupus Erythematosus; Treatment Response
Characterization of the T cell populations that regulate autoimmunity in asymptomatic anti-nuclear positive individuals and how they become altered in early untreated systemic autoimmune rheumatic disease
Principal investigators: Wither, Joan E
Keywords: Anti-Nuclear Antibodies; Immune Profiling; Immune Regulation; Interferon; Single Cell Transcriptomics; Sjogren'S Disease; Systemic Lupus Erythematosus; T Cells
Towards the Discovery of Predictive Biomarkers for Outcomes in Lupus Nephritis
Principal investigators: Whittall-Garcia, Laura
Keywords: Biomarkers; Imaging Mass Cytometry; Lupus Nephritis; Systemic Lupus Erythematosus; Translational Research; Treatment Outcomes
Identification of the immunologic mechanisms leading to flares of disease activity in Systemic Lupus Erythematosus
Principal investigators: Wither, Joan E
Keywords: Autoantibodies; Flare; Flow Cytometry; Immune Profiling; Rnaseq; Systemic Lupus Erythematosus; T Cells
Modeling Cognitive Impairment in Patients with Systemic Lupus Erythematosus: Clinical Phenotyping, Predictive Trajectory, and Associated Risk Factors.
Principal investigators: Touma, Zahi
Keywords: Biomarkers; Clinical Phenotypes; Cognitive Impairment; Machine Learning; Predictives Models; Systemic Lupus Erythematosus
Characterization of the immunologic events that lead to development of Systemic Autoimmune Rheumatic Disease
Principal investigators: Wither, Joan E
Keywords: Autoantibodies; Genomics; Immune Profiling; Pre-Clinical Autoimmunity; Scleroderma; Sjogren'S Disease; Systemic Lupus Erythematosus
Human Immunology Spondyloarthritis Team (HUMISPOT) studying immunopathogenesis, disease heterogeneity and drug discovery in spondyloarthritis
Principal investigators: Haroon, Nigil; Wither, Joan E; Allard-Chamard, Hugues; Chandran, Vinod; Crome, Sarah A; Gladman, Dafna D; Inman, Robert D; Jurisica, Igor; Rahman, Proton
Keywords: Antibody; Immunoassay; Sequencing; Spondyloarthritis; T Cells; T Regulatory Cells
Identification of the immunologic basis for production of pathogenic autoantibodies in Systemic Lupus Erythematosus
Principal investigators: Wither, Joan E
Keywords: Animal Models; Autoimmunity; B Cells; Flow Cytometry; Genetics; Immunology; Lupus; Tolerance; Translational
Development of a test for the early diagnosis and monitoring of lupus nephritis
Principal investigators: Wither, Joan E
Keywords: Biomarkers; Nephritis; Systemic Lupus Erythematosus; Urinary Proteins
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medicine/Nephrology
- Medicine
- Rheumatology
- Biostatistics Division
- Department of Epidemiology and Biostatistics
- Department of Medicine
- Critical Care Medicine
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Zahi Touma
Medicine
24 shared papers, latest 2026
Murray Urowitz
Rheumatology
9 shared papers, latest 2026
Kathleen Bingham
Faculty
7 shared papers, latest 2025
Robin Green
Faculty
7 shared papers, latest 2025
Dorcas Beaton
Faculty
7 shared papers, latest 2025
Dafna Gladman
Medicine
6 shared papers, latest 2023
Heather Reich
Medicine/Nephrology
4 shared papers, latest 2016
Wendy Lou
Biostatistics Division
3 shared papers, latest 2015
Andrea Knight
Faculty
3 shared papers, latest 2023
Igor Jurisica
Rheumatology
3 shared papers, latest 2025
James Scholey
Medicine/Nephrology
3 shared papers, latest 2016
Laura Whittall-Garcia
Rheumatology
2 shared papers, latest 2026
Lihi Eder
Faculty
2 shared papers, latest 2025
Raphael Schneider
Department of Medicine
2 shared papers, latest 2024
Janet Pope
Department of Epidemiology and Biostatistics
2 shared papers, latest 2010
Vinod Chandran
Rheumatology
2 shared papers, latest 2025
May Choi
Medicine
1 shared papers, latest 2024
Ana Konvalinka
Medicine/Nephrology
1 shared papers, latest 2024
Andrzej Chruscinski
Faculty
1 shared papers, latest 2022
Rod Bremner
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2015
Richard Cook
Statistics and Actuarial Science
1 shared papers, latest 2025
Linda Hiraki
Epidemiology Division
1 shared papers, latest 2022
Vincent Piguet
Faculty
1 shared papers, latest 2025
Sasha Bernatsky
Faculty
1 shared papers, latest 2021
Eldad Zacksenhaus
Cellular and Molecular Biology
1 shared papers, latest 2015
Sindhu Johnson
Medicine
1 shared papers, latest 2024
Milica Tanic
Medicine
1 shared papers, latest 2023
Nicole Anderson
Medicine
1 shared papers, latest 2021
Stephanie Keeling
Medicine
1 shared papers, latest 2026
Sasha Bernatsky
Medicine
1 shared papers, latest 2021
Joseph Beyene
Health Research Methods, Evidence, and Impact
1 shared papers, latest 2021
Anna Goldenberg
Critical Care Medicine
1 shared papers, latest 2023
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