Faculty profile

Linda Hiraki

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Associate ProfessorEpidemiology DivisionUniversity of Toronto

Linda Hiraki

Associate Professor

Epidemiology Division

Dalla Lana School of Public Health

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
9 publications in the last five years, latest in 2025.
Principal investigator on 6 research grants (6 CIHR), most recently in 2026.
Supervised 1 trainee who won CIHR awards, most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Lupus Nephritis Systemic Lupus Erythematosus Child/Adolescent Health Disease Activity Kidney Pathology Outcomes Treatment Response Crc

Latest papers

Examining Self-Reported Executive Function and Its Relationship to Patient-Reported Outcomes and Disease-Related Factors in Youth With Childhood-Onset Lupus: A Cross-Sectional Study.
ACR open rheumatology · 2025
Frontoparietal functional connectivity is related to active disease and processing speed in adolescents with childhood-onset lupus.
Annals of the rheumatic diseases · 2025
Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus.
Lupus science & medicine · 2025

All 12 publications

Latest funding

Liquid Biopsy for Pediatric Lupus Nephritis: Urine Proteomics to Guide Therapy and Reduce Biopsy Burden
CIHR · 2026 · Nominated PI
$1,105,424
Understanding the immunophenotype and genetics of treatment response in children and adolescents with lupus nephritis.
CIHR · 2024 · Nominated PI
$501,076
Canada Research Chair - Tier 2
CIHR · 2024 · Nominated PI
$500,000

All 12 grants and awards

12 publications.

Examining Self-Reported Executive Function and Its Relationship to Patient-Reported Outcomes and Disease-Related Factors in Youth With Childhood-Onset Lupus: A Cross-Sectional Study.

El Tal T, Jaffan J, Ledochowski J, Mossad SI, Ng L, Jeyanathan A, Davis AL, Hiraki L, Levy DM, Touma Z, Cunningham NR, Danguecan A, Knight A

ACR open rheumatology2025

DOI: 10.1002/acr2.70102 PMID: 41310958

Frontoparietal functional connectivity is related to active disease and processing speed in adolescents with childhood-onset lupus.

Cabrera DV, Mwizerwa O, Zapparoli B, Jeyanathan A, Ng L, Tal TE, Ertl-Wagner B, Yeh A, Branson H, Davis A, Hiraki L, Levy D, Danguecan A, Knight A

Annals of the rheumatic diseases2025

DOI: 10.1016/j.ard.2025.06.2129 PMID: 40675898

Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus.

Lewandowski L, Hiraki L, Scott C, Barrera-Vargas A, Romo Tena J, Gómez-Martín D, Ombrello MJ, Aksentijevich I, Deng Z, Musolf AM, Paul S, Lu S, Gadina M, Hupalo D, Dalgard CL, Hasni S, Silverman ED, Kaplan MJ

Lupus science & medicine2025

DOI: 10.1136/lupus-2024-001475 PMID: 40499977

Improving routine mental health screening for depression and anxiety in a paediatric lupus clinic: a quality improvement initiative for enhanced mental healthcare.

El Tal T, Chen A, Wong S, Jeyanathan A, Longmore A, Convery H, Finkelstein D, Hiraki L, Kulkarni C, Lerman N, Leslie K, Levy DM, Lorber S, Mwizerwa O, Ng L, Rawal V, Smith E, Toulany A, Knight AM

Lupus science & medicine2024

DOI: 10.1136/lupus-2024-001282 PMID: 39438087

Longitudinal program evaluation of an inter-institutional mentorship network for pediatric rheumatology using a quality improvement framework.

Hayward K, Grom A, Muscal E, Nigrovic PA, Rouster-Stevens KA, Ardalan K, Hiraki L, Moorthy LN, A. C. R./CARRA Mentoring Interest Group

Pediatric rheumatology online journal2024

DOI: 10.1186/s12969-024-00993-1 PMID: 38982530

Evaluation of depressive and anxiety symptoms in childhood-onset systemic lupus erythematosus: Frequency, course, and associated risk factors.

Neufeld KM, Moaf P, Quilter M, Danguecan AN, Couture J, Dominguez D, Hendrikx O, Ng L, Schachter R, Korczak DD, Levy DM, Hiraki L, Knight AM

Lupus2024

DOI: 10.1177/09612033241254170 PMID: 38774953

Persistently active interferon-γ pathway and expansion of T-bet+ B cells in a subset of patients with childhood-onset systemic lupus erythematosus.

Moneta GM, Bracaglia C, Caiello I, Farroni C, Pires Marafon D, Carlomagno R, Hiraki L, Vivarelli M, Gianviti A, Carbogno S, Ferlin W, de Min C, Silverman E, Carsetti R, De Benedetti F, Marasco E

European journal of immunology2023

DOI: 10.1002/eji.202250319 PMID: 37204055

A multi-site pilot randomized clinical trial of the Treatment and Education Approach for Childhood-onset Lupus (TEACH) program: study design and COVID-19 adaptations.

Cunningham NR, Miller A, Ely SL, Reid MR, Danguecan A, Mossad SI, Pereira LF, Abulaban K, Kessler E, Rosenwasser N, Nanda K, Rubinstein T, Reeves M, Kohut SA, Stinson J, Tal TE, Levy DM, Hiraki L, Smitherman EA, Knight AM

Pediatric rheumatology online journal2023

DOI: 10.1186/s12969-023-00835-6 PMID: 37353795

Serological abnormalities that predict progression to systemic autoimmune rheumatic diseases in antinuclear antibody-positive individuals.

Muñoz-Grajales C, Prokopec SD, Johnson SR, Touma Z, Ahmad Z, Bonilla D, Hiraki L, Bookman A, Boutros PC, Chruscinski A, Wither J

Rheumatology (Oxford, England)2022

DOI: 10.1093/rheumatology/keab501 PMID: 34175923

Evaluation of self-report screening measures in the detection of depressive and anxiety disorders among children and adolescents with systemic lupus erythematosus.

Quilter M, Hiraki L, Knight AM, Couture J, Levy D, Silverman ED, Danguecan AN, Ng L, Dominguez D, Cost KT, Neufeld KM, Schachter R, Korczak DJ

Lupus2021

DOI: 10.1177/09612033211018504 PMID: 34078154

Liquid Biopsy for Pediatric Lupus Nephritis: Urine Proteomics to Guide Therapy and Reduce Biopsy Burden

Nominated PICIHR2026Project Grant

Principal investigators: Hiraki, Linda T

Keywords: Child/Adolescent Health; Disease Activity; Kidney Pathology; Lupus Nephritis; Outcomes; Prediction; Proteinuria; Systemic Lupus Erythematosus; Treatment Response; Urine Biomarker

$1,105,424

Understanding the immunophenotype and genetics of treatment response in children and adolescents with lupus nephritis.

Nominated PICIHR2024Project Grant

Principal investigators: Hiraki, Linda T

Keywords: Child/Adolescent Health; Disease Activity; Genetics; Kidney Pathology; Lupus Nephritis; Outcomes; Predictors; Single Cell Studies; Systemic Lupus Erythematosus; Treatment Response

$501,076

Canada Research Chair - Tier 2

Nominated PICIHR2024Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Hiraki, Linda T

Keywords: Crc

$500,000

Longitudinal Analysis of Immune Gene Expression and Cell Profiles in Childhood-Onset Lupus

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Reid, Reagan A

Keywords: Biostatistics; Child And Youth Health; Gene Expression; Genetic Epidemiology; Genetics; Longitudinal Analysis; Lupus; Outcomes; Predictors; Single Cell Studies

$120,000

Insight into Nephrotic Syndrome: Investigating Genes, Health, and Therapeutics

Co-investigatorCIHR2023Project Grant

Principal investigators: Parekh, Rulan S

Keywords: Children; Cohort Study; Genetics; Kidney Disease; Longitudinal; Nephrotic Syndrome; Prospective

$726,752

RareKids-CAN: Pediatric Rare Disease Clinical Trials and Treatment Network

Co-investigatorCIHR2023Team Grant: Pediatric Rare Disease Clinical Network

Principal investigators: Lacaze-Masmonteil, Thierry; Anagnostou, Evdokia; Baribeau, Danielle A; Batthish, Michelle; Bernard, Geneviève; Bernier, Francois P; Butcher, Nancy J; Campbell, Craig Gordon N; Cross, Andrea; Dyack, Sarah; Gantt, Soren M; Gravel, Christopher; Haddad, Elie; Heath, Anna; Kelly, Lauren; King, Alexandra; Klassen, Terry P; Knisley, Lisa; Lai, Meng-Chuan; Lewis, Tamorah R; Marwaha, Ashish K; McBride, Kim; Mitchell, John J; Moore Hepburn, Charlotte; Mooser, Vincent E; Myers, Kenneth A; Offringa, Martin; Oskoui, Maryam; Portales-Casamar, Elodie; Pot, Sara; Potter, Elizabeth K; Richer, Lawrence P; Round, Jeff; Stewart, Breanne; Subbarao, Padmaja; Thebaud, Bernard; Turvey, Stuart E; Ward, Leanne M; Wong-Rieger, Durhane; Wright, Nicola A; Yeh, Ann E.

Keywords: Child Health; Data Science; Drug Development; Paediatric Clinical Research Units; Paediatric Clinical Trials; Patient And Public Involvement; Patient Registries; Precision Medicine; Rare Diseases; Real-World Evidence

$19,999,843

Insight Into Nephrotic Syndrome: Investigating Genes, Health, and Therapeutics

Co-investigatorCIHR2022Project Grant

Principal investigators: Parekh, Rulan S

Keywords: Children; Cohort Study; Genetics; Kidney Disease; Longitudinal; Naphrotic Syndrome; Prospective

$100,000

Canada Research Chairs - Tier 2

Nominated PICIHR2020Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Hiraki, Linda T

Keywords: Crc

$600,000

Identifying genetic determinants of lupus nephritis and kidney function in children and adults with systemic lupus erythematosus (SLE).

Nominated PICIHR2018Project Grant

Principal investigators: Hiraki, Linda T

Keywords: Chronic Kidney Disease; Dialysis/Kidney Transplant; Ethnic Differences; Genetic Epidemiology; Kidney Function; Life Course Health; Lupus Nephritis; Repeated Measures; Risk Factors; Systemic Lupus Erythematosus

$520,200

Undiagnosed systemic inflammatory disease - a Canadian Roadmap for Genomic sequencing

Co-investigatorCIHR2017Planning and Dissemination Grant - Institute Community Support

Principal investigators: Kannu, Peter

Keywords: Genomics; Next Generation Sequencing; Rare Disoders; Rheumatology

$20,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2026

Subject: Prospective PhD student: Lupus Nephritis Dear Professor Hiraki, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Examining Self-Reported Executive Function and Its Relationship to Patient-Reported Outcomes and Disease-Related Factors in Youth With Childhood-Onset Lupus: A Cross-Sectional Study." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Liquid Biopsy for Pediatric Lupus Nephritis: Urine Proteomics to Guide Therapy and Reduce Biopsy Burden" (2026), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Profile data last refreshed on July 30, 2025 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Linda Hiraki

Research

Latest papers

Latest funding

Examining Self-Reported Executive Function and Its Relationship to Patient-Reported Outcomes and Disease-Related Factors in Youth With Childhood-Onset Lupus: A Cross-Sectional Study.

Frontoparietal functional connectivity is related to active disease and processing speed in adolescents with childhood-onset lupus.

Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus.

Improving routine mental health screening for depression and anxiety in a paediatric lupus clinic: a quality improvement initiative for enhanced mental healthcare.

Longitudinal program evaluation of an inter-institutional mentorship network for pediatric rheumatology using a quality improvement framework.

Evaluation of depressive and anxiety symptoms in childhood-onset systemic lupus erythematosus: Frequency, course, and associated risk factors.

Persistently active interferon-γ pathway and expansion of T-bet+ B cells in a subset of patients with childhood-onset systemic lupus erythematosus.

A multi-site pilot randomized clinical trial of the Treatment and Education Approach for Childhood-onset Lupus (TEACH) program: study design and COVID-19 adaptations.

Serological abnormalities that predict progression to systemic autoimmune rheumatic diseases in antinuclear antibody-positive individuals.

Evaluation of self-report screening measures in the detection of depressive and anxiety disorders among children and adolescents with systemic lupus erythematosus.

Liquid Biopsy for Pediatric Lupus Nephritis: Urine Proteomics to Guide Therapy and Reduce Biopsy Burden

Understanding the immunophenotype and genetics of treatment response in children and adolescents with lupus nephritis.

Canada Research Chair - Tier 2

Longitudinal Analysis of Immune Gene Expression and Cell Profiles in Childhood-Onset Lupus

Insight into Nephrotic Syndrome: Investigating Genes, Health, and Therapeutics

RareKids-CAN: Pediatric Rare Disease Clinical Trials and Treatment Network

Insight Into Nephrotic Syndrome: Investigating Genes, Health, and Therapeutics

Canada Research Chairs - Tier 2

Identifying genetic determinants of lupus nephritis and kidney function in children and adults with systemic lupus erythematosus (SLE).

Undiagnosed systemic inflammatory disease - a Canadian Roadmap for Genomic sequencing

Frequent collaborators

Zahi Touma

Andrea Knight

Alene Toulany

Birgit Ertl-Wagner

Gregory Costain

Birgit Ertl-Wagner

Christoph Licht

Karen Leslie

Andrzej Chruscinski

Jennifer Stinson

Rosanna Weksberg

Sarah Bowdin

Edgar Jaeggi

Ann Yeh

Joan Wither

Linda Hiraki

Research

Latest papers

Latest funding

Examining Self-Reported Executive Function and Its Relationship to Patient-Reported Outcomes and Disease-Related Factors in Youth With Childhood-Onset Lupus: A Cross-Sectional Study.

Frontoparietal functional connectivity is related to active disease and processing speed in adolescents with childhood-onset lupus.

Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus.

Improving routine mental health screening for depression and anxiety in a paediatric lupus clinic: a quality improvement initiative for enhanced mental healthcare.

Longitudinal program evaluation of an inter-institutional mentorship network for pediatric rheumatology using a quality improvement framework.

Evaluation of depressive and anxiety symptoms in childhood-onset systemic lupus erythematosus: Frequency, course, and associated risk factors.

Persistently active interferon-&#x3b3; pathway and expansion of T-bet+ B cells in a subset of patients with childhood-onset systemic lupus erythematosus.

A multi-site pilot randomized clinical trial of the Treatment and Education Approach for Childhood-onset Lupus (TEACH) program: study design and COVID-19 adaptations.

Serological abnormalities that predict progression to systemic autoimmune rheumatic diseases in antinuclear antibody-positive individuals.

Evaluation of self-report screening measures in the detection of depressive and anxiety disorders among children and adolescents with systemic lupus erythematosus.

Frequent collaborators

Zahi Touma

Andrea Knight

Alene Toulany

Birgit Ertl-Wagner

Gregory Costain

Birgit Ertl-Wagner

Christoph Licht

Karen Leslie

Andrzej Chruscinski

Jennifer Stinson

Rosanna Weksberg

Sarah Bowdin

Edgar Jaeggi

Ann Yeh

Joan Wither

Persistently active interferon-γ pathway and expansion of T-bet+ B cells in a subset of patients with childhood-onset systemic lupus erythematosus.