Faculty profile

Felix Ratjen

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Felix Ratjen

Researcher

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
106 publications in the last five years, latest in 2026.
Senior (last) author on 29 recent papers, a sign of leading a research group.
Principal investigator on 3 research grants (3 CIHR), most recently in 2016.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

317

Publications

1,429

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Cftr Modulator Therapy Cystic Fibrosis Hyperpolarized 129xe Lung Clearance Index Magnetic Resonance Imaging Multiple Breath Washout Paediatric Pulmonary Function Test

Latest papers

Safety and efficacy of elexacaftor/tezacaftor/ivacaftor in children ≥2 years with cystic fibrosis: 96-week interim results from a phase 3 open-label extension study.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
AI-driven CT quantification of mucus plugs to evaluate the effect of inhaled hypertonic saline in children aged 3-6 years with cystic fibrosis: a randomised controlled trial.
The European respiratory journal · 2026
PangyPlot: multi-scale interactive visualization of pangenome variation graphs.
Bioinformatics (Oxford, England) · 2026

All 317 publications

Latest funding

Investigating complex genetic and epigenetic variations across the genome using long-read sequencing
CIHR · 2025 · Co-investigator
$50,000
Magnetic Resonance Imaging Toolbox for Assessment of Lung Structure and Function in the Early Years of Life
CIHR · 2020 · Co-investigator
$627,635
Determining The Architecture Of Genetic Disease: Statistical Methods and Applications
CIHR · 2018 · Co-investigator
$2,154,594

All 11 grants and awards

From the 150 most recent of 317 publications.

Safety and efficacy of elexacaftor/tezacaftor/ivacaftor in children ≥2 years with cystic fibrosis: 96-week interim results from a phase 3 open-label extension study.

Goralski JL, Daines C, Pittman JE, Rayment JH, Robinson P, Thursfield R, Stehling F, Ratjen F, Ahluwalia N, Shi P, Lu M, Weinstock TG, Mall MA, VX20-445-112 Study Group

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2026

DOI: 10.1016/j.jcf.2026.05.014 PMID: 42315414

AI-driven CT quantification of mucus plugs to evaluate the effect of inhaled hypertonic saline in children aged 3-6 years with cystic fibrosis: a randomised controlled trial.

Chen Y, Latisenko R, Davis SD, Rosenfeld M, Ratjen F, Hinckley Stukovsky KD, Stick S, Tiddens HAWM, on behalf the SHIP-CT study group

The European respiratory journal2026

DOI: 10.1183/13993003.01917-2025 PMID: 42492957

PangyPlot: multi-scale interactive visualization of pangenome variation graphs.

Mastromatteo S, Chirmade S, Roshandel D, Thiruvahindrapuram B, Wang Z, Patel RV, Sung WWL, Hajianpour A, Wang C, Lin F, Keenan K, Avolio J, Eckford PDW, Ratjen F, Canadian Cystic Fibrosis Gene Modifier Consortium, Strug LJ

Bioinformatics (Oxford, England)2026

DOI: 10.1093/bioinformatics/btag619 PMID: 42613741

Post-infectious bronchiolitis obliterans in children: pathogenesis, treatment strategies, and future directions.

Ben-Meir E, Teper A, Strug L, Ratjen F, Kerem E

Current opinion in pediatrics2026

DOI: 10.1097/mop.0000000000001585 PMID: 42234623

Reducing multiple-breath washout test burden in cystic fibrosis: agreement between the first acceptable trial and mean lung clearance index.

Escobar NS, Ben-Meir E, Jensen R, Sagel S, Hamblett N, Shaw M, Ratjen F

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2026Senior author

DOI: 10.1016/j.jcf.2026.09.002 PMID: 42728177

Automated Ultrashort Echo Time (UTE) MRI Low Signal Volume Analysis in Stable Pediatric Cystic Fibrosis and After Elexacaftor/Tezacaftor/Ivacaftor Therapy.

Zanette B, Bierbrier J, Munidasa S, Genkin D, Kirby M, Ratjen F, Santyr G

Journal of magnetic resonance imaging : JMRI2026

DOI: 10.1002/jmri.70333 PMID: 42080522

Assessing the impact of elexacaftor/tezacaftor/ivacaftor on work productivity and activity impairment in people living with cystic fibrosis in Canada.

Kim GG, Wong T, Rayment J, Bilodeau L, Tullis E, Lands LC, Leung WM, Lam GY, Ratjen F, Quon BS, Can-IMPACT-CF Study Group

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2026

DOI: 10.1016/j.jcf.2026.09.005 PMID: 42736062

Treatment with elexacaftor/tezacaftor/ivacaftor does not alter SpiroNose-derived electronic breath profiles in children with cystic fibrosis.

Seidl E, Zikic A, Micic S, de Vries R, Avolio J, Moeller A, Ratjen F, Grasemann H

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2026

DOI: 10.1016/j.jcf.2026.03.014 PMID: 41881763

Real-world impact of elexacaftor/tezacaftor/ivacaftor on health-related quality of life in adults with cystic fibrosis: A 12-month multicenter cohort study.

Kharraz R, Tullis E, Sykes J, Ma X, Sandhu A, Gryz Z, Shulman Y, Tam J, Love A, Ratjen F, Rayment JH, Quon BS, Stephenson AL

Respiratory medicine2026

DOI: 10.1016/j.rmed.2026.108827 PMID: 42019640

Comparison of Single-Breath and Multi-Breath Xe-MRI in the Longitudinal Assessment of Treatment in Children With Cystic Fibrosis.

Alam FS, Munidasa S, Zanette B, Li D, Braganza S, Ratjen F, Santyr G

Journal of magnetic resonance imaging : JMRI2026

DOI: 10.1002/jmri.70242 PMID: 41609189

Investigating complex genetic and epigenetic variations across the genome using long-read sequencing

Co-investigatorCIHR2025Project Grant - Priority Announcement: Cystic fibrosis across the lifespan

Principal investigators: Strug, Lisa J

Keywords: Cystic Fibrosis; Dna Methylation; Genetic Association; Long-Read Sequencing; Phase; Statistical Genetics; Structural Variation

$50,000

Magnetic Resonance Imaging Toolbox for Assessment of Lung Structure and Function in the Early Years of Life

Co-investigatorCIHR2020Project Grant

Principal investigators: Santyr, Giles E

Keywords: Asthma; Cystic Fibrosis; Free Breathing; Hardware; Lung Function; Lung Structure; Mri; Preschoolers; Software; Treatment

$627,635

Determining The Architecture Of Genetic Disease: Statistical Methods and Applications

Co-investigatorCIHR2018Foundation Grant

Principal investigators: Strug, Lisa J

Keywords: Cystic Fibrosis; Epilepsy; Genetic Epidemiology; Genome Sequencing; Rna Sequencing; Statistical Genetics

$2,154,594

Structural and Functional MRI Assessment of Treatment Response in Early Cystic Fibrosis Lung Disease

Principal investigatorCIHR2016Project Grant

Principal investigators: Santyr, Giles E; Ratjen, Felix

Keywords: Cftr Modulator Therapy; Cystic Fibrosis; Hyperpolarized 129xe; Lung Clearance Index; Magnetic Resonance Imaging; Multiple Breath Washout; Paediatric; Pulmonary Function Test

$619,650

Lung function in preschool children: Utility in diagnosis of asthma

Co-investigatorCIHR2013Operating Grant

Principal investigators: Subbarao, Padmaja

Keywords: Asthma; Cohort Studies; Diagnosis; Health Assessment; Lung Function; Physiology; Predictors; Preschool Children; Wheezing

$447,196

Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA trial)

Co-investigatorCIHR2012Operating Grant

Principal investigators: Cohen, Eyal

Keywords: Child; Dornase Alpha; Empyema; Infant; Length Of Stay; Pleural; Preschool; Randomized Controlled Trial; Tissue Plasminogen Activator

$315,121

The Canadian Respiratory Research Network; Exploring the Origin and Progression of Airway Disease

Co-investigatorCIHR2012ICRH Emerging Network Grants - LOI

Principal investigators: Aaron, Shawn D; Martin, James G

Keywords: Asthma; Biomedical Research; Clinical Research; Copd; Health Services Research; Knowledge Translation; Obstructive Lung Disease; Population Health Research; Research Training

$30,000

Ensuring effective newborn screening: The case of cystic fibrosis

Co-investigatorCIHR2010Operating Grant

Principal investigators: Miller, Fiona A; Guttmann, Astrid

Keywords: Administrative Health Data; Child Health Policy; Mixed Methods Research; Population Screening; Qualitative Research; Survey Research

$636,506

CIHR Team Grant in Exercise in Chronically Ill Children

Co-investigatorCIHR2009Team Grant: Physical Activity, Mobility and Health (LOI)

Principal investigators: Feldman, Brian M; Noseworthy, Michael D; Tein, Ingrid; Wells, Greg D

Keywords: Chronic Disease; Exercise Intolerance; Mechanisms; Pediatrics; Psychosocial Constructs

$10,000

CIHR Emerging Team in Cystic Fibrosis Therapy

Nominated PICIHR2009Emerging Team Grant: From Genes to Proteins, Cells, Tissues and Patients

Principal investigators: Ratjen, Felix; Bear, Christine E; Durie, Peter R; Ellis, James R; Rotin, Daniela

Keywords: Clinical Assays Of Lung Disease; Cystic Fibrosis; Differentiated Respiratory Epithelium; Induced Pluripotent Cells; Molecular Recognition; Small Molecules

$2,401,449

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Something wrong or missing on this profile? Suggest a correction

Felix Ratjen

Research

Latest papers

Latest funding

Safety and efficacy of elexacaftor/tezacaftor/ivacaftor in children &#x2265;2 years with cystic fibrosis: 96-week interim results from a phase 3 open-label extension study.

AI-driven CT quantification of mucus plugs to evaluate the effect of inhaled hypertonic saline in children aged 3-6 years with cystic fibrosis: a randomised controlled trial.

PangyPlot: multi-scale interactive visualization of pangenome variation graphs.

Post-infectious bronchiolitis obliterans in children: pathogenesis, treatment strategies, and future directions.

Reducing multiple-breath washout test burden in cystic fibrosis: agreement between the first acceptable trial and mean lung clearance index.

Automated Ultrashort Echo Time (UTE) MRI Low Signal Volume Analysis in Stable Pediatric Cystic Fibrosis and After Elexacaftor/Tezacaftor/Ivacaftor Therapy.

Assessing the impact of elexacaftor/tezacaftor/ivacaftor on work productivity and activity impairment in people living with cystic fibrosis in Canada.

Treatment with elexacaftor/tezacaftor/ivacaftor does not alter SpiroNose-derived electronic breath profiles in children with cystic fibrosis.

Real-world impact of elexacaftor/tezacaftor/ivacaftor on health-related quality of life in adults with cystic fibrosis: A 12-month multicenter cohort study.

Comparison of Single-Breath and Multi-Breath Xe-MRI in the Longitudinal Assessment of Treatment in Children With Cystic Fibrosis.

Frequent collaborators

Giles Santyr

Tanja Gonska

Padmaja Subbarao

Reshma Amin

Brandon Zanette

Sanja Stanojevic

Candice Bjornson

Greg Wells

Zihang Lu

Wendy Lou

Michael Parkins

Lei Sun

Annie Dupuis

Neil Sweezey

Pranesh Chakraborty

Astrid Guttmann

Malcolm Sears

Christine Bear

Jaques Belik

Janet Rossant

Paul Pencharz

Muhammad Mamdani

Miranda Kirby

Mary Brindle

Teresa To

Michael Livingston

Yvonne Bombard

Sanjay Mahant

Martin Post

Michael Noseworthy

Lisa Strug

Liane Heale

Lucia Giglia

Piush Mandhane

Jonathan Rayment

Brian Kalish

Julian Tam

Theo Moraes

Sara Thompson

Fiona Moola

Safety and efficacy of elexacaftor/tezacaftor/ivacaftor in children ≥2 years with cystic fibrosis: 96-week interim results from a phase 3 open-label extension study.