Jamie Near, University of Toronto

Research

Alzheimer'S Disease Brain Metabolism Aging Cerebral Organoids Epigenetics Gene Regulatory Networks Magnetic Resonance Imaging Neurochemistry

Latest papers

Early treatment with naproxen alters hippocampal metabolites in the TgF344-AD rat model of Alzheimer's disease.
Neurochemistry international · 2026 · senior author
SelExNet: A Self-Supervised Physics-Informed Framework for Multi-Channel Joint RF and Gradient Waveform Optimization in 2D Spatially Selective Excitation.
Magnetic resonance in medicine · 2026
Metabolic Assessment in Human Pluripotent Stem Cell-Derived Cerebral Organoids Using HR-MAS NMR Spectroscopy.
NMR in biomedicine · 2026 · senior author

All 34 publications

Latest funding

Mitochondrial Genetics in Relation to Brain Metabolism and Energy Phenotypes in Bipolar Disorder Across the Lifespan
CIHR · 2026 · Co-investigator
$934,491
Mapping patterns of brain metabolic alterations in neurodegenerative diseases using ultra-high-field MRSI
CIHR · 2025 · Nominated PI
$883,575
Prize 202203PJT - NMR spectroscopy in brain organoids: identifying neurochemical and gene regulatory network signatures of the healthy and Alzheimer's Disease brain
CIHR · 2022 · Nominated PI
$50,000

All 4 grants and awards

34 publications.

01

Early treatment with naproxen alters hippocampal metabolites in the TgF344-AD rat model of Alzheimer's disease.

Fowler CF, Osipyan E, Devenyi GA, Madularu D, Breitner J, Near J

Neurochemistry international2026Senior author

DOI: 10.1016/j.neuint.2026.106226 PMID: 42476460

02

SelExNet: A Self-Supervised Physics-Informed Framework for Multi-Channel Joint RF and Gradient Waveform Optimization in 2D Spatially Selective Excitation.

Xiao Y, Rock J, Wu Z, Near J, Chiew M, Graham SJ

Magnetic resonance in medicine2026

DOI: 10.1002/mrm.70431 PMID: 42136067

03

Metabolic Assessment in Human Pluripotent Stem Cell-Derived Cerebral Organoids Using HR-MAS NMR Spectroscopy.

Bolanos MAC, Chinchalongporn V, Biswas RG, Bailey C, Wu M, Soong R, Saleh F, Simpson A, Schuurmans C, Near J

NMR in biomedicine2026Senior author

DOI: 10.1002/nbm.70343 PMID: 42360098

04

The Impact and Reliability of Tissue Segmentation on In Vivo Magnetic Resonance Spectroscopy Metabolite Quantification.

Archibald J, Igwe KC, Kaiser A, Landheer K, Lee J, Kramer JLK, Gudmundson AT, Zöllner HJ, Oeltzschner G, Fleischer CC, Zölch N, Near J, Mikkelsen M

Magnetic resonance in medicine2026

DOI: 10.1002/mrm.70380 PMID: 41964041

05

Correction: MRS4Brain: a software for preclinical proton and deuterium-based MR spectroscopic imaging data.

Alves B, Phan TT, Briand G, Siviglia A, Nossa G, Mosso J, Mougel E, Near J, Dinh TNA, Zenteno O, Lanz B, Lê TP, Cudalbu C

Magma (New York, N.Y.)2026

DOI: 10.1007/s10334-026-01377-0 PMID: 42397459

06

Group Differences of Multiregion Glutamate Concentration in Clinical High Risk and Schizophrenia.

Man SK, Blasco MB, Alemi R, Raminfard S, Rusjan PM, Near J, Sarpal DK, Mizrahi R

The European journal of neuroscience2026

DOI: 10.1111/ejn.70626 PMID: 42432829

07

Prenatal maternal stress is associated with alterations in the structural integrity of the hypothalamic-pituitary-gonadal axis 20 years later: Project Ice Storm.

Jones SL, Anastassiadis C, Dupuis M, Elgbeili G, Marcoux FP, Gazetas J, Devenyi GA, Near J, Laplante DP, Pruessner JC, King S

Human reproduction (Oxford, England)2026

DOI: 10.1093/humrep/deag067 PMID: 42166041

08

MRS4Brain: a software for preclinical proton and deuterium-based MR spectroscopic imaging data.

Alves B, Phan TT, Briand G, Siviglia A, Nossa G, Mosso J, Mougel E, Near J, Dinh TNA, Zenteno O, Lanz B, Lê TP, Cudalbu C

Magma (New York, N.Y.)2026

DOI: 10.1007/s10334-026-01351-w PMID: 41949812

09

Elevated brain glutamine levels in adults with autism spectrum disorder: A 7T MRS study.

Kubota M, Yoshihara Y, Uwatoko T, Shoji R, Near J, Dehghani M, Aoki YY, Urayama SI, Okada T, Murai T

Molecular psychiatry2026

DOI: 10.1038/s41380-025-03440-z PMID: 41455837

10

Methodological comparison of fetal brain 1H-MRS data analysis techniques and gestational age analysis using LCModel in the fetal sheep brain.

Minns JA, Darby JRT, Williams GK, Tu JT, Sun Z, Guo J, Miller SP, Macgowan CK, Seed M, Near J, Morrison JL

Experimental physiology2026

DOI: 10.1113/ep093728 PMID: 41770610

Mitochondrial Genetics in Relation to Brain Metabolism and Energy Phenotypes in Bipolar Disorder Across the Lifespan

Co-investigatorCIHR2026Project Grant

Principal investigators: Goldstein, Benjamin I

Keywords: Activity; Bipolar Disorder; Energy; Genetics; Lifespan; Mitochondria; Neuroimaging; Sex Differences

$934,491

Mapping patterns of brain metabolic alterations in neurodegenerative diseases using ultra-high-field MRSI

Nominated PICIHR2025Project Grant

Principal investigators: Near, Jamie

Keywords: Alzheimer'S Disease; Amyotrophic Lateral Sclerosis; Apoe; Brain Metabolism; Cell Membrane Metabolism,; Choline; Magnetic Resonance Spectroscopic Imaging; Magnetic Resonance Spectroscopy,; Neurodegeneration; Ultra-High-Field Mri

$883,575

Prize 202203PJT - NMR spectroscopy in brain organoids: identifying neurochemical and gene regulatory network signatures of the healthy and Alzheimer's Disease brain

Nominated PICIHR2022PRIZE - Project Grant - PA: Mid Career Investigator Prize in Research in Aging

Principal investigators: Near, Jamie

Keywords: Aging; Alzheimer'S Disease; Brain Metabolism; Cerebral Organoids; Epigenetics; Gene Regulatory Networks; Magnetic Resonance Imaging; Neurochemistry; Nuclear Magnetic Resonance Spectroscopy

$50,000

NMR spectroscopy in brain organoids: identifying neurochemical and gene regulatory network signatures of the healthy and Alzheimer's Disease brain

Nominated PICIHR2022Project Grant

Principal investigators: Near, Jamie; Schuurmans, Carol J

Keywords: Aging; Alzheimer'S Disease; Brain Metabolism; Cerebral Organoids; Epigenetics; Gene Regulatory Networks; Magnetic Resonance Imaging; Neurochemistry; Nuclear Magnetic Resonance Spectroscopy

$940,950

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Psychiatry
Psychology
Department of Laboratory Medicine and Pathobiology
Department of Surgery
Neurosciences and Mental Health
Department of Medical Biophysics
Pharmacologie - Physiologie
Other

1 shared papers, latest 2025

Suzanne King

Psychiatry

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Alzheimer'S Disease Dear Professor Near, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Early treatment with naproxen alters hippocampal metabolites in the TgF344-AD rat model of Alzheimer's disease." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Mapping patterns of brain metabolic alterations in neurodegenerative diseases using ultra-high-field MRSI" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]