John Coles, University of Toronto

Research

Biologic Therapeutics Drug Discovery Protein Therapeutics Heart Failure Biologic Drug Delivery Fibrosis Human Tissue Disease Modeling Organoids

Latest papers

Extracardiac conduit restriction is associated with increased liver fibrosis in adolescent Fontan patients.
The Journal of thoracic and cardiovascular surgery · 2026
Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic review.
EBioMedicine · 2025
Longitudinal Evaluation of Congenital Cardiovascular Surgical Performance and Skills Retention Using Silicone-Molded Heart Models.
World journal for pediatric & congenital heart surgery · 2024

All 18 publications

Latest funding

Regenerative Therapies for Ischemic Heart Disease
CIHR · 2022 · Principal investigator
$883,576
Novel Biologic Therapies and Delayed Release Scaffolds for Tissue Fibrosis
CIHR · 2020 · Principal investigator
$1,021,275
Neonatal Stem Cell Secretomes as a Novel Regenerative Therapy for Heart Failure
NSERC · 2019 · Co-investigator
$318,560

All 7 grants and awards

18 publications.

01

Extracardiac conduit restriction is associated with increased liver fibrosis in adolescent Fontan patients.

Ponzoni M, Saleh J, Chaturvedi RR, Dipchand AI, Valverde I, Seed M, Yoo SJ, Coles J, Honjo O, Lam CZ

The Journal of thoracic and cardiovascular surgery2026

DOI: 10.1016/j.jtcvs.2025.09.044 PMID: 41047073

02

Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic review.

Elbatarny M, Lu YT, Hu M, Coles J, Mital S, Ross-White A, Honjo O, Barron DJ, Gramolini AO

EBioMedicine2025

DOI: 10.1016/j.ebiom.2025.105839 PMID: 40651188

03

Longitudinal Evaluation of Congenital Cardiovascular Surgical Performance and Skills Retention Using Silicone-Molded Heart Models.

Ponzoni M, Alamri R, Peel B, Haller C, Coles J, Vanderlaan RD, Honjo O, Barron DJ, Yoo SJ

World journal for pediatric & congenital heart surgery2024

DOI: 10.1177/21501351241237785 PMID: 38646823

04

3D Modeling and Printing in Congenital Heart Surgery: Entering the Stage of Maturation.

Yoo SJ, Hussein N, Peel B, Coles J, van Arsdell GS, Honjo O, Haller C, Lam CZ, Seed M, Barron D

Frontiers in pediatrics2021

DOI: 10.3389/fped.2021.621672 PMID: 33614554

05

Survival to Stage II with Ventricular Dysfunction: Secondary Analysis of the Single Ventricle Reconstruction Trial.

Jean-St-Michel E, Meza JM, Maguire J, Coles J, McCrindle BW

Pediatric cardiology2018

DOI: 10.1007/s00246-018-1845-4 PMID: 29520465

06

Sutureless Versus Conventional Pulmonary Vein Repair: A Magnetic Resonance Pilot Study.

Tremblay C, Yoo SJ, Mertens L, Seed M, Jacques F, Slorach C, Vanderlaan R, Greenway S, Caldarone C, Coles J, Grosse-Wortmann L

The Annals of thoracic surgery2018

DOI: 10.1016/j.athoracsur.2017.11.015 PMID: 29482852

07

Fontan Failure and Death in Contemporary Fontan Circulation: Analysis From the Last Two Decades.

Kotani Y, Chetan D, Zhu J, Saedi A, Zhao L, Mertens L, Redington AN, Coles J, Caldarone CA, Van Arsdell GS, Honjo O

The Annals of thoracic surgery2018

DOI: 10.1016/j.athoracsur.2017.10.047 PMID: 29397930

08

Human Stem Cell-Derived Cardiac Model of Chronic Drug Exposure.

Nunes SS, Feric N, Pahnke A, Miklas JW, Li M, Coles J, Gagliardi M, Keller G, Radisic M

ACS biomaterials science & engineering2017

DOI: 10.1021/acsbiomaterials.5b00496 PMID: 33440549

09

More than meets the eye.

Haller C, Coles J

The Journal of thoracic and cardiovascular surgery2017Senior author

DOI: 10.1016/j.jtcvs.2016.10.009 PMID: 27964973

10

Younger is Better.

Haller C, Coles J

Seminars in thoracic and cardiovascular surgery2015Senior author

DOI: 10.1053/j.semtcvs.2015.08.011 PMID: 26708378

Regenerative Therapies for Ischemic Heart Disease

Principal investigatorCIHR2022Project Grant

Principal investigators: Maynes, Jason T; Cheng, Hai-Ling M; Coles, John G

Keywords: Biologic Drug Delivery; Biologic Therapeutics; Drug Discovery; Protein Therapeutics

$883,576

Novel Biologic Therapies and Delayed Release Scaffolds for Tissue Fibrosis

Principal investigatorCIHR2020Project Grant

Principal investigators: Maynes, Jason T; Coles, John G; Santerre, Paul; Sun, Yu

Keywords: Biologic Therapeutics; Drug Discovery; Fibrosis; Human Tissue Disease Modeling; Organoids; Protein Therapeutics

$1,021,275

Neonatal Stem Cell Secretomes as a Novel Regenerative Therapy for Heart Failure

Co-investigatorNSERC2019Collaborative Health Research Projects

Principal investigators: Maynes, Jason

$318,560

Neonatal Stem Cell Secretomes as a Novel Regenerative Therapy for Heart Failure

Principal investigatorCIHR2018Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Maynes, Jason T; Deans, Robert; Coles, John G; Santerre, Paul

Keywords: Heart Failure; Regenerative Medicine; Secretome

$318,560

Integrin Linked Kinase as a Novel Therapeutic Target for Heart Failure

Nominated PICIHR2017Project Grant

Principal investigators: Coles, John G; Bouvier, Michel; Maynes, Jason T

Keywords: Drug Development; Heart Failure; Integrin Linked Kinase; Mechanical Stress

$512,550

Pulmonary Vein Stenosis: Focus on Upstream Vasculopathology

Co-investigatorCIHR2013Operating Grant

Principal investigators: Caldarone, Christopher A

Keywords: Congenital Heart Surgery; Pulmonary Hypertension; Pulmonary Vein Stenosis

$211,509

Regenerative Approaches to Re-sequencing and Resynchronizing the Heart (R3 Heart)

Principal investigatorCIHR2009Emerging Team Grant: Regenerative Medicine and Nanomedicine - LOI

Principal investigators: Hamilton, Robert M; Ackerley, Cameron A; Coles, John G; Keller, Gordon M; Nanthakumar, Kumaraswamy; Radisic, Milica

Keywords: Cardiac Conduction; Cell Sorting; Embryonic Stem Cells; Induced Progenitor Stem Cells; Rabbit Model; Tissue Culture

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pediatrics
Institute of Biomaterials and Biomedical Engineering
Cardiovascular Surgery
Medical Biophysics
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Christopher Caldarone

Institute of Biomaterials and Biomedical Engineering

2 shared papers, latest 2018

Gordon Keller

Medical Biophysics

1 shared papers, latest 2017

Milica Radisic

Institute of Biomaterials and Biomedical Engineering

1 shared papers, latest 2017

Jonathon Maguire

Pediatrics

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Biologic Therapeutics Dear Professor Coles, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Extracardiac conduit restriction is associated with increased liver fibrosis in adolescent Fontan patients." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Regenerative Therapies for Ischemic Heart Disease" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

John Coles

Research

Latest papers

Latest funding

Extracardiac conduit restriction is associated with increased liver fibrosis in adolescent Fontan patients.

Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic review.

Longitudinal Evaluation of Congenital Cardiovascular Surgical Performance and Skills Retention Using Silicone-Molded Heart Models.

3D Modeling and Printing in Congenital Heart Surgery: Entering the Stage of Maturation.

Survival to Stage II with Ventricular Dysfunction: Secondary Analysis of the Single Ventricle Reconstruction Trial.

Sutureless Versus Conventional Pulmonary Vein Repair: A Magnetic Resonance Pilot Study.

Fontan Failure and Death in Contemporary Fontan Circulation: Analysis From the Last Two Decades.

Human Stem Cell-Derived Cardiac Model of Chronic Drug Exposure.

More than meets the eye.

Younger is Better.

Regenerative Therapies for Ischemic Heart Disease

Novel Biologic Therapies and Delayed Release Scaffolds for Tissue Fibrosis

Neonatal Stem Cell Secretomes as a Novel Regenerative Therapy for Heart Failure

Neonatal Stem Cell Secretomes as a Novel Regenerative Therapy for Heart Failure

Integrin Linked Kinase as a Novel Therapeutic Target for Heart Failure

Pulmonary Vein Stenosis: Focus on Upstream Vasculopathology

Regenerative Approaches to Re-sequencing and Resynchronizing the Heart (R3 Heart)

Frequent collaborators

Luc Mertens

Christopher Caldarone

Emilie Jean-St-Michel

David Barron

Cedric Manlhiot

Gordon Keller

Seema Mital

Milica Radisic

Jonathon Maguire