Faculty profile

Seema Mital

ResearcherPediatricsUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Seema Mital

Researcher

Pediatrics

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
45 publications in the last five years, latest in 2026.
Senior (last) author on 13 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (8 CIHR), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

114

Publications

546

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Congenital Heart Disease Fontan Heart Failure Outcomes Precision Medicine Digital Health Technology Electronic Health Records Hypertrophic Cardiomyopathy

Latest papers

Prevalence, risk factors, and outcomes of QT prolongation in primary and RASopathy-associated hypertrophic cardiomyopathy.
Heart rhythm · 2026 · senior author
Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components.
Nature communications · 2026
Abnormal Lipid Signaling Characterizes Diastolic Dysfunction in Pediatric Cardiomyopathy.
JACC. Basic to translational science · 2026 · senior author

All 114 publications

Latest funding

PHUR4Life Precision Health for patients with Univentricular HeaRts across the Lifespan (PHUR4Life)
CIHR · 2023 · Principal investigator
$1,500,000
ImplemeNting a Sudden cardiac dEath Risk assessment Tool in childhood hypertrophic cardiomyopathy (INSERT-HCM)
CIHR · 2022 · Nominated PI
$631,126
A role for novel regulatory variants in childhood cardiomyopathy
CIHR · 2020 · Nominated PI
$940,950

All 11 grants and awards

114 publications.

Prevalence, risk factors, and outcomes of QT prolongation in primary and RASopathy-associated hypertrophic cardiomyopathy.

Österberg AW, Min S, Helle E, Bulic A, Mital S

Heart rhythm2026Senior author

DOI: 10.1016/j.hrthm.2025.05.059 PMID: 40472950

Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components.

Callaghan NI, Durland LJ, Chen W, Kuzmanov U, Miranda MZ, Ding Y, Mirzaei Z, Ireland RG, Reitz C, Gorman RA, Wang EY, Wagner K, Kim MM, Audet J, Santerre JP, Gramolini AO, Billia F, Radisic M, Mital S, Ellis J, Backx PH, Simmons CA

Nature communications2026

DOI: 10.1038/s41467-026-70550-9 PMID: 41916979

Abnormal Lipid Signaling Characterizes Diastolic Dysfunction in Pediatric Cardiomyopathy.

Turinsky AL, Hanafi N, Said A, Kinnear C, Lesurf R, López-Guillén JL, Akilen R, Patel S, Meng G, Wei W, Robillard Frayne I, Daneault C, Mertens L, Ellis J, Ruiz M, Mital S

JACC. Basic to translational science2026Senior author

DOI: 10.1016/j.jacbts.2026.101491 PMID: 41707622

Beyond Wall Thickness: Defining Genotype-Phenotype Relationships in Pediatric Hypertrophic Cardiomyopathy.

Suzuki T, Mital S

JACC. Heart failure2026Senior author

DOI: 10.1016/j.jchf.2026.103357 PMID: 42758063

Mavacamten in symptomatic adolescent patients with obstructive hypertrophic cardiomyopathy: design of the phase 3 SCOUT-HCM trial.

Rossano J, Canter C, Wolf C, Favatella N, Lockman J, Puli S, Javidialsaadi A, Dyme J, Crevar C, Mital S

American heart journal2026Senior author

DOI: 10.1016/j.ahj.2025.107283 PMID: 41038603

DNA methylation analysis of NOTCH1 variants reveals the first episignature for non-syndromic congenital heart defects.

Dombrowsky G, van der Laan L, Silva A, Breckpot J, Audain E, Wilsdon A, Levy MA, Vos N, Mannens M, Wang J, Jain A, Lesurf R, Winlaw D, Bezzina CR, Thomas MA, Caliebe A, Klaassen S, Berger F, Dittrich S, Stiller B, Abdul-Khaliq H, Dähnert I, Bu'Lock F, Loughna S, Brook JD, Mital S, Russell RB, Pickardt T, Bauer U, Kramer HH, Uebing A, Henneman P, Sadikovic B, Postma A, Hitz MP

Genome medicine2026

DOI: 10.1186/s13073-025-01587-6 PMID: 41501857

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism.

Bradley CA, Ko SY, Tian M, Ralph LT, D'Abate L, Lee J, Liu T, Wang J, Tidball P, Mendes M, Fan X, Howe JL, Alexandrova R, Pellecchia G, Casallo G, Paton T, Wybenga-Groot LE, Engchuan W, Thiruvahindrapuram B, Trost B, de Rijke J, Kadia A, Jin F, Salazar NB, Diaz-Mejia JJ, MacDonald JR, Deneault E, Ross PJ, Ellis J, Shum C, Georgiou J, Rennie O, Reuter MS, Hoang N, Sarikaya E, Selvanayagam T, Amini AE, Rutherford A, Rivera-Alfaro N, Marshall CR, Scala M, Runke CK, Kearney HM, Christodoulou J, Francis DI, Chung BHY, Pluciniczak J, Iaboni A, Wigby KM, Nordahl CW, Amaral DG, Hudson ML, Sjaarda CP, Guerin A, Elsabbagh M, Landa R, Mital S, Lesurf R, Jain A, Wilson MD, Ellegood J, Lerch JP, Lee LJ, Frey BJ, Salter MW, Vorstman JAS, Anagnostou E, Frankland PW, Collingridge GL, Scherer SW

Nature2026

DOI: 10.1038/s41586-026-10515-6 PMID: 42129557

Fetal Cardiomyopathy in the Contemporary Era: A Multicenter Fetal Heart Society Research Collaborative Study.

McBrien A, Burande A, Caluseriu O, Conway J, Peyvandi S, Bolin E, Cavallé-Garrido T, Chandra S, Cnota J, Creighton S, Cuneo BF, Despres M, Doan TT, Doucet JS, Freud LR, Grenier M, Hogan W, Kaplinski M, Kavanaugh-McHugh A, Keller S, Kwon EN, Lad M, Leslie M, Majeed A, Mansukhani G, McIntosh AM, McVadon D, Michelfelder E, Miller M, Milligan C, Montes Gil A, Moon-Grady AJ, Mulla N, Patel SR, Pruitt C, Qasim A, Rajagopal HG, Ro S, Schidlow D, Scheider K, Srinivasan R, Sutton J, Taylor C, Trivedi MK, Mital S, Lipshultz SE, Hornberger LK

Circulation. Heart failure2026

DOI: 10.1161/circheartfailure.126.014394 PMID: 42565234

Recessive genetic contribution to congenital heart disease in 5,424 probands.

Dong W, Jin SC, Sierant MC, Lu Z, Li B, Lu Q, Morton SU, Zhang J, López-Giráldez F, Nelson-Williams C, Knight JR, Zhao H, Cao J, Mane S, Gruber PJ, Lek M, Goldmuntz E, Deanfield J, Giardini A, Mital S, Russell M, Gaynor JW, Cnota JF, Wagner M, Srivastava D, Bernstein D, Porter GA, Newburger J, Roberts AE, Yandell M, Yost HJ, Tristani-Firouzi M, Kim R, Seidman J, Chung WK, Gelb BD, Seidman CE, Lifton RP, Brueckner M

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2419992122 PMID: 40030011

Implementation of a Sudden Cardiac Death Risk Prediction Tool in Clinical Practice Through Electronic Health Records (INSERT-HCM Study Design).

Papaz T, Seto E, Anthony SJ, Pol SJ, Hayeems R, Barwick M, Mital S

CJC open2025Senior author

DOI: 10.1016/j.cjco.2024.10.002 PMID: 39872640

PHUR4Life Precision Health for patients with Univentricular HeaRts across the Lifespan (PHUR4Life)

Principal investigatorCIHR2023Team Grant: Congenital Heart Disease (CHD) - Causes and Early Detection

Principal investigators: Mertens, Luc; Abrahamyan, Lusine; Chaix, Marie-A.; Dallaire, Frederic; Friedberg, Mark K; Grewal, Jasmine; Mital, Seema

Keywords: Congenital Heart Disease; Fontan; Heart Failure; Outcomes; Precision Medicine

$1,500,000

ImplemeNting a Sudden cardiac dEath Risk assessment Tool in childhood hypertrophic cardiomyopathy (INSERT-HCM)

Nominated PICIHR2022Project Grant

Principal investigators: Mital, Seema; Barwick, Melanie A

Keywords: Digital Health Technology; Electronic Health Records; Hypertrophic Cardiomyopathy; Implementation; Precision Health; Risk Prediction; Sudden Cardiac Death

$631,126

A role for novel regulatory variants in childhood cardiomyopathy

Nominated PICIHR2020Project Grant

Principal investigators: Mital, Seema; Ellis, James R

Keywords: Cardiomyopathy; Drug Testing; Gene Expression; Genomics; Myocyte Function; Regulatory Variants; Stem Cells

$940,950

PeRsOnalized genomics for CongEnital hEart Disease

Nominated PICIHR2018Team Grant: ERA-Net PerMed

Principal investigators: Mital, Seema

Keywords: Congenital Heart Disease; Personalized; Tetralogy; Transposition; Whole Genome Sequencing

$450,000

Epigenetic regulation of dilated cardiomyopathy by histone demethylation

Co-investigatorCIHR2018Project Grant

Principal investigators: Delgado Olguin, Paul

Keywords: Epigenetic Control Of Gene Expression; Gene Regulation; Heart Disease

$772,650

Optimizing outcomes in survivors of childhood, adolescent and young adult cancer

Co-investigatorCIHR2017Foundation Grant

Principal investigators: Nathan, Paul C

Keywords: Cancer Survivorship; Children, Adolescents And Young Adults; Financial Toxicity; Late Physical Morbidities; Models Of Care; Risk Prediction Models

$2,729,448

Personalized Medicine in the Care of the Child with Heart Disease: Discovery to Application

Nominated PICIHR2012Planning Grants

Principal investigators: Mital, Seema

Keywords: Cardiology; Genetics; Pediatrics; Personalized Medicine

$23,500

iPS cells to model vascular disease in patients with Williams Beuren syndrome

Principal investigatorCIHR2012Operating Grant

Principal investigators: Ellis, James R; Mital, Seema

Keywords: Cell Engineering; Directed Differentiation; Drug Screens; Elastin; Induced Pluripotent Stem Cells; Progenitor Cells; Smooth Muscle Cells; Vascular Disease; Williams Beuren Syndrome

$640,182

Novel approaches to the prediction, diagnosis and treatment of cardiac late effects in survivors of childhood cancer

Principal investigatorCIHR2011Team Grant: Childhood Cancer - Late Effects of Treatment

Principal investigators: Nathan, Paul C; Kantor, Paul F; Liu, Peter P; Mertens, Luc; Mital, Seema

Keywords: Anthracycline Toxicity; Cardiac Biomarkers; Cardiac Dysfunction; Childhood Cancer Survivors; Echocardiography; Genomics; Pilot Intervention Study; Risk Prediction Model

$2,027,749

Clinical Assessment of Thrombosis in Children after Heart surgery: The CATCH study

Co-investigatorCIHR2010Operating Grant

Principal investigators: McCrindle, Brian W

Keywords: Cardiac Sugery; Complications; Congenital Heart Disease; Diagnosis; Pediatrics; Thrombosis

$1,514,330

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Seema Mital

Research

Latest papers

Latest funding

Prevalence, risk factors, and outcomes of QT prolongation in primary and RASopathy-associated hypertrophic cardiomyopathy.

Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components.

Abnormal Lipid Signaling Characterizes Diastolic Dysfunction in Pediatric Cardiomyopathy.

Beyond Wall Thickness: Defining Genotype-Phenotype Relationships in Pediatric Hypertrophic Cardiomyopathy.

Mavacamten in symptomatic adolescent patients with obstructive hypertrophic cardiomyopathy: design of the phase 3 SCOUT-HCM trial.

DNA methylation analysis of NOTCH1 variants reveals the first episignature for non-syndromic congenital heart defects.

An X-linked long non-coding RNA, PTCHD1-AS, and the core features of autism.

Fetal Cardiomyopathy in the Contemporary Era: A Multicenter Fetal Heart Society Research Collaborative Study.

Recessive genetic contribution to congenital heart disease in 5,424 probands.

Implementation of a Sudden Cardiac Death Risk Prediction Tool in Clinical Practice Through Electronic Health Records (INSERT-HCM Study Design).

Frequent collaborators

Cedric Manlhiot

James Ellis

Luc Mertens

Tapas Mondal

David Chitayat

Upton Allen

Lorraine Hamiwka

Filio Billia

Milica Radisic

Tom Blydt-Hansen

Olivier Villemain

Peter Liu

Slava Epelman

Rafik Tadros

Sarah Bowdin

Gregor Andelfinger

Ruth Sapir-Pichhadze

Edgar Jaeggi

Tom Blydt-Hansen

Brett Trost

Eriskay Liston

Rejane Dillenburg

Stacey Marjerrison

Seema Mital

Christopher Overgaard

Charles Boone

Mayada Elsabbagh

Uri Tabori

Padmaja Subbarao

Mark Tarnopolsky

Gordon Keller