Faculty profile

Gordon Keller

ResearcherMedical BiophysicsUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Gordon Keller

Researcher

Medical Biophysics

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
9 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (12 CIHR), most recently in 2017.
Supervised 5 trainees who won CIHR awards, most recently in 2018.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

1,779

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Differentiation Mesoderm Signaling Pathways Hematopoietic Stem Cells Regenerative Medicine Human Pluripotent Stem Cells Transplantation Pluripotent Stem Cells

Latest papers

Modeling human B cell development with pluripotent stem cells.
bioRxiv : the preprint server for biology · 2026 · senior author
Computationally identified peptides immobilized to hydrogel delivery vehicles enable affinity-controlled release of proteins.
Acta biomaterialia · 2026
Retinoic acid regulates the development of human definitive hematopoiesis in a non-cell-autonomous manner.
Development (Cambridge, England) · 2026 · senior author

All 62 publications

Latest funding

Enabling novel cardiac therapies with pluripotent stem cells
SSHRC · 2022 · Co-investigator
$7,908,900
Generation of Human Pluripotent Stem Cell-Derived Left Ventricular Cardiomyocytes for the Treatment of Hypoplastic Left Heart Syndrome
CIHR · 2018 · Supervisor
$275,000
Translating human development to new therapies with pluripotent stem cells
CIHR · 2017 · Nominated PI
$4,550,634

All 23 grants and awards

62 publications.

Modeling human B cell development with pluripotent stem cells.

Sun X, Kwan JJ, Kothari K, Nazzari AF, Kosters A, Fields CA, Thai BQ, Bhattacharya D, Atkins M, Tung KC, Zhao X, Manchev VT, Kennedy M, Ghosn E, Keller G

bioRxiv : the preprint server for biology2026Senior author

DOI: 10.64898/2026.05.04.722674 PMID: 42146710

Computationally identified peptides immobilized to hydrogel delivery vehicles enable affinity-controlled release of proteins.

Yao Y, Hong C, Teal CJ, Bahsoun NE, Lu SP, Fernandes I, Keller G, Shoichet M

Acta biomaterialia2026

DOI: 10.1016/j.actbio.2025.12.034 PMID: 41412290

Retinoic acid regulates the development of human definitive hematopoiesis in a non-cell-autonomous manner.

Fernandez NA, Durland LJ, Garcia A, Atkins MH, Kennedy M, Sturgeon CM, Keller G

Development (Cambridge, England)2026Senior author

DOI: 10.1242/dev.205213 PMID: 41948969

Heart-on-a-Chip Model of Epicardial-Myocardial Interaction in Ischemia Reperfusion Injury.

Bannerman D, Pascual-Gil S, Wu Q, Fernandes I, Zhao Y, Wagner KT, Okhovatian S, Landau S, Rafatian N, Bodenstein DF, Wang Y, Nash TR, Vunjak-Novakovic G, Keller G, Epelman S, Radisic M

Advanced healthcare materials2024

DOI: 10.1002/adhm.202302642 PMID: 38683053

Noninvasive Quantification of Contractile Dynamics in Cardiac Cells, Spheroids, and Organs-on-a-Chip Using High-Frequency Ultrasound.

Strohm EM, Callaghan NI, Ding Y, Latifi N, Rafatian N, Funakoshi S, Fernandes I, Reitz CJ, Di Paola M, Gramolini AO, Radisic M, Keller G, Kolios MC, Simmons CA

ACS nano2024

DOI: 10.1021/acsnano.3c06325 PMID: 38147684

Aberrant early hematopoietic progenitor formation marks the onset of hematopoietic defects in Shwachman-Diamond syndrome.

Lagos-Monzon A, Ng S, Luca AM, Li H, Sabanayagam M, Benicio M, Moshiri H, Armstrong R, Tailor C, Kennedy M, Grunebaum E, Keller G, Dror Y

European journal of haematology2024

DOI: 10.1111/ejh.14260 PMID: 38967591

Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells.

Fernandes I, Funakoshi S, Hamidzada H, Epelman S, Keller G

Nature communications2023Senior author

DOI: 10.1038/s41467-023-43312-0 PMID: 38081833

Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation.

Wauchop M, Rafatian N, Zhao Y, Chen W, Gagliardi M, Massé S, Cox BJ, Lai P, Liang T, Landau S, Protze S, Gao XD, Wang EY, Tung KC, Laksman Z, Lu RXZ, Keller G, Nanthakumar K, Radisic M, Backx PH

Biomaterials2023

DOI: 10.1016/j.biomaterials.2023.122255 PMID: 37651922

In Vitro Matured Human Pluripotent Stem Cell-Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts.

Dhahri W, Sadikov Valdman T, Wilkinson D, Pereira E, Ceylan E, Andharia N, Qiang B, Masoudpour H, Wulkan F, Quesnel E, Jiang W, Funakoshi S, Mazine A, Gomez-Garcia MJ, Latifi N, Jiang Y, Huszti E, Simmons CA, Keller G, Laflamme MA

Circulation2022

DOI: 10.1161/circulationaha.121.053563 PMID: 35089805

A 3-D human model of complex cardiac arrhythmias.

Williams K, Liang T, Massé S, Khan S, Hatkar R, Keller G, Nanthakumar K, Nunes SS

Acta biomaterialia2021

DOI: 10.1016/j.actbio.2021.03.004 PMID: 33713861

Enabling novel cardiac therapies with pluripotent stem cells

Co-investigatorSSHRC2022New Frontiers in Research Fund - Transformation

Principal investigators: Laflamme, Michael

Keywords: Cardiac regeneration; Pluripotent stem cells; Cell manufacturing; Heart failure; Synthetic biology; Tissue engineering; Biomedical imaging; 3D bioprinting; Mathematical modeling; Health technology assessment; Bioethics

$7,908,900

Generation of Human Pluripotent Stem Cell-Derived Left Ventricular Cardiomyocytes for the Treatment of Hypoplastic Left Heart Syndrome

SupervisorCIHR2018CIHR Fellowship

Principal investigators: Mazine, Amine

Keywords: Cardiac Regeneration; Cardiac Surgery; Cell Signaling; Cell Therapy; Congenital Heart Disease; Developmental Biology; Preclinical Models Of Cardiac Disease; Regenerative Medicine; Stem Cell Differentiation; Stem Cells

$275,000

Translating human development to new therapies with pluripotent stem cells

Nominated PICIHR2017Foundation Grant

Principal investigators: Keller, Gordon M

Keywords: Cardiovascular Cells; Developmental Biology; Differentiation; Embryonic Stem Cells; Hematopoietic Cells; Hematopoietic Stem Cells; Hepatic Cells; Induced Pluripotent Stem Cells; Regenerative Medicine; Signaling Pathways

$4,550,634

Derivation of hematopoietic stem cells from human pluripotent stem cells

Nominated PICIHR2017Project Grant

Principal investigators: Keller, Gordon M

Keywords: Cell Therapy; Differentiation; Embryonic; Hematological Diseases; Hematopoietic Stem Cell; Mesoderm; Pluripotent Stem Cell; Progenitor; Signaling Pathways; Transplantation

$1,032,750

Generation of mature ventricular cardiomyocytes from human pluripotent stem cells

Nominated PICIHR2017Project Grant

Principal investigators: Keller, Gordon M

Keywords: Atrial; Cardiovascular; Differentiation; Human Pluripotent Stem Cells; Maturation; Mesoderm; Rna-Seq; Specification; Transplantation; Ventricular

$100,000

Modeling human cardiac pacemaker development and function with pluripotent stem cells

Nominated PICIHR2016Project Grant

Principal investigators: Keller, Gordon M

Keywords: Atrioventricular Node Pacemaker; Biological Pacemaker; Cardiomyoctes; Directed Differentiation; Human Pluripotent Stem Cells; Signaling Pathways; Sinoatrial Node Pacemaker

$879,175

Modeling human embryonic hematopoietic development with pluripotent stem cells

SupervisorCIHR2016Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Atkins, Michael H

Keywords: Blood; Cell Signaling; Crispr-Cas9 Genome Editing; Hematopoiesis; Human Development; Human Pluripotent Stem Cells; Tissue-Resident Macrophage

$105,000

Next generation arrhythmia modeling: the role of pluripotent stem cells and the future of personalized medicine

Co-investigatorCIHR2015Operating Grant

Principal investigators: Backx, Peter H

Keywords: Arrhythmias; Atrial; Electrophysiology; Human Stem Cells; Induced Pluripotent Stem Cells; Ion Channels; Optical Mapping; Patch-Clamp; Pharmacological Agents; Ventricular

$668,536

Generating Functional Liver Sinusoidal Endothelial Cells from Human Pluripotent Stem Cells

SupervisorCIHR2014CIHR Fellowship

Principal investigators: Gage, Blair K

Keywords: Cell Differentiation; Cellualar Therapy; Development; Growth Factor; Hepatocyte Maturation; Human Pluripotent Stem Cells; Liver Disease; Liver Sinusoidal Endothelial Cells; Regenerative Medicine; Transplantation

$135,000

CANADA RESEARCH CHAIRHOLDER - Tier 1 / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA - Niveau 1

Nominated PICIHR2013Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Keller, Gordon M

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Gordon Keller

Research

Latest papers

Latest funding

Modeling human B cell development with pluripotent stem cells.

Computationally identified peptides immobilized to hydrogel delivery vehicles enable affinity-controlled release of proteins.

Retinoic acid regulates the development of human definitive hematopoiesis in a non-cell-autonomous manner.

Heart-on-a-Chip Model of Epicardial-Myocardial Interaction in Ischemia Reperfusion Injury.

Noninvasive Quantification of Contractile Dynamics in Cardiac Cells, Spheroids, and Organs-on-a-Chip Using High-Frequency Ultrasound.

Aberrant early hematopoietic progenitor formation marks the onset of hematopoietic defects in Shwachman-Diamond syndrome.

Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cells.

Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation.

In Vitro Matured Human Pluripotent Stem Cell-Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts.

A 3-D human model of complex cardiac arrhythmias.

Enabling novel cardiac therapies with pluripotent stem cells

Frequent collaborators

Milica Radisic

Ren-Ke Li

Shinichiro Ogawa

Kumaraswamy Nanthakumar

Stephanie Protze

Zachary Laksman

Mansoor Husain

Boyang Zhang

Boyang Zhang

James Ellis

Yu Sun

Slava Epelman

Anand Ghanekar

Andrew Emili

Ming-Sound Tsao

Nazia Selzner

Edgar Jaeggi

Patrick Blit

Janet Rossant

Robert Hamilton

Jason Moffat

Hong Han

Molly Shoichet

Uri Tabori

Thomas Kislinger

Ralph Dacosta

Jun Liu