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Research
Latest papers
GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders.
Science advances · 2023
Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis.
Diabetes · 2017
ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.
PLoS genetics · 2013
Latest funding
- $100,000
The role of General Transcription Factor 2I in disorders of 7q11.23 copy number variation
CIHR · 2022 · Nominated PI
- $1,400,000
CRC Tier 1
CIHR · 2016 · Nominated PI
- $814,660
Genetic analysis of Williams-Beuren syndrome: linking genes with behaviour and cognition
CIHR · 2013 · Nominated PI
5 publications.
GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders.
López-Tobón A, Shyti R, Villa CE, Cheroni C, Fuentes-Bravo P, Trattaro S, Caporale N, Troglio F, Tenderini E, Mihailovich M, Skaros A, Gibson WT, Cuomo A, Bonaldi T, Mercurio C, Varasi M, Osborne L, Testa G
Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis.
Zhu D, Xie L, Kang Y, Dolai S, Bondo Hansen J, Qin T, Xie H, Liang T, Rubin DC, Osborne L, Gaisano HY
ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.
Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL
The Sweet Pee model for Sglt2 mutation.
Ly JP, Onay T, Sison K, Sivaskandarajah G, Sabbisetti V, Li L, Bonventre JV, Flenniken A, Paragas N, Barasch JM, Adamson SL, Osborne L, Rossant J, Schnermann J, Quaggin SE
Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia.
Wood GA, Flenniken A, Osborne L, Fleming C, Vukobradovic I, Morikawa L, Xu Q, Porter R, Adamson SL, Rossant J, McKerlie C
The role of General Transcription Factor 2I in disorders of 7q11.23 copy number variation
Principal investigators: Osborne, Lucy R
Keywords: 7q11.23 Copy Number Variation; Mouse Models; Neurodevelopmental Disorder; Williams Syndrome
CRC Tier 1
Principal investigators: Osborne, Lucy R
Keywords: Crc
Genetic analysis of Williams-Beuren syndrome: linking genes with behaviour and cognition
Principal investigators: Osborne, Lucy R
Keywords: Gene Regulation; Mouse Models; Neurons; Transcription Factor; Transcriptome; Williams Syndrome
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Lucy Osborne and Janet Rossant: 3 shared papers
- Peter Backx and Lucy Osborne: 1 shared paper
- Peter Backx and Janet Rossant: 1 shared paper
- Department of Medicine
- Department of Physiology
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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