Peter Backx, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Human physiology

Latest papers

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α.
The Journal of clinical investigation · 2020
Cardiac-specific inducible overexpression of human plasma membrane Ca2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury.
Clinical science (London, England : 1979) · 2018
Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models
Cardiovascular Research (CVR) · 2018

All 9 publications

Latest funding

Canada Research Chair - Tier 1
CIHR · 2022 · Nominated PI
$1,400,000
Platform technology for maturation of human stem cell derived cardiomyocytes and cardiotoxicity screening
CIHR · 2015 · Co-investigator
$149,788
Next generation arrhythmia modeling: the role of pluripotent stem cells and the future of personalized medicine
CIHR · 2015 · Nominated PI
$668,536

All 8 grants and awards

9 publications.

01

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α.

Siraj MA, Mundil D, Beca S, Momen A, Shikatani EA, Afroze T, Sun X, Liu Y, Ghaffari S, Lee W, Wheeler MB, Keller G, Backx P, Husain M

The Journal of clinical investigation2020

DOI: 10.1172/jci99934 PMID: 31985487

02

Cardiac-specific inducible overexpression of human plasma membrane Ca2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury.

Sadi AM, Afroze T, Siraj MA, Momen A, White-Dzuro C, Zarrin-Khat D, Handa S, Ban K, Kabir MG, Trivieri MG, Gros R, Backx P, Husain M

Clinical science (London, England : 1979)2018

DOI: 10.1042/cs20171337 PMID: 29487197

03

Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models

Barichello S, Roberts JD, Backx P, Boyle PM, Laksman Z

Cardiovascular Research (CVR)201814 citations

DOI: 10.1093/cvr/cvy090

04

Mechanisms of Long-Duration Ventricular Fibrillation in Human Hearts and Experimental Validation in Canine Purkinje Fibers.

Jackson N, Massé S, Zamiri N, Azam MA, Lai PFH, Kusha M, Asta J, Quadros K, King B, Backx P, Ideker RE, Nanthakumar K

JACC. Clinical electrophysiology2015

DOI: 10.1016/j.jacep.2015.04.003 PMID: 29759364

05

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

Xie L, Liang T, Kang Y, Lin X, Sobbi R, Xie H, Chao C, Backx P, Feng ZP, Shyng SL, Gaisano HY

Journal of molecular and cellular cardiology2014

DOI: 10.1016/j.yjmcc.2014.07.012 PMID: 25073062

06

Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts.

Sivagangabalan G, Nazzari H, Bignolais O, Maguy A, Naud P, Farid T, Massé S, Gaborit N, Varro A, Nair K, Backx P, Vigmond E, Nattel S, Demolombe S, Nanthakumar K

PloS one2014

DOI: 10.1371/journal.pone.0082179 PMID: 24427266

07

Dantrolene Improves Survival After Ventricular Fibrillation by Mitigating Impaired Calcium Handling in Animal Models

Zamiri N, Massé S, Ramadeen A, Kusha M, Hu X, Azam MA, Liu J, Lai PFH, Vigmond EJ, Boyle PM

Circulation201462 citations

DOI: 10.1161/circulationaha.113.005443

08

ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.

Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL

PLoS genetics2013

DOI: 10.1371/journal.pgen.1003612 PMID: 23874215

09

Evidence for calreticulin attenuation of cardiac hypertrophy induced by pressure overload and soluble agonists.

Papp S, Dziak E, Kabir G, Backx P, Clement S, Opas M

The American journal of pathology2010

DOI: 10.2353/ajpath.2010.090392 PMID: 20110410

Canada Research Chair - Tier 1

Nominated PICIHR2022Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Backx, Peter H

Keywords: Crc

$1,400,000

Platform technology for maturation of human stem cell derived cardiomyocytes and cardiotoxicity screening

Co-investigatorCIHR2015Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Radisic, Milica; Nanthakumar, Kumaraswamy

Keywords: Cardiotoxicity; Contraction; Drug; Heart; Mapping; Microfabrication; Myocardium; Pluripotent Stem Cells; Tissue; Tissue Engineering

$149,788

Next generation arrhythmia modeling: the role of pluripotent stem cells and the future of personalized medicine

Nominated PICIHR2015Operating Grant

Principal investigators: Backx, Peter H

Keywords: Arrhythmias; Atrial; Electrophysiology; Human Stem Cells; Induced Pluripotent Stem Cells; Ion Channels; Optical Mapping; Patch-Clamp; Pharmacological Agents; Ventricular

$668,536

Cardiac Consequences of Excessive Exercise

Co-investigatorCIHR2013Operating Grant

Principal investigators: Goodman, Jack

Keywords: Arrhythmia; Athlete; Cardiac Magnetic Resonance; Cardiac Remodeling; Cardiovascular; Echocardiography; Electrocardiogram; Endurance; Exercise; Inflammation

$199,196

Iroquois transcription factors in heart development and function

Co-investigatorCIHR2013Operating Grant

Principal investigators: Hui, Chi-Chung

Keywords: Arrhythmias; Cardiac Conduction System; Cardiac Transcription Factors; Congenital Heart Diseases; Connexin 40; Electrophysiology; Genetic Mouse Models; Iroquois Homeobox Genes; Tbx3; Voltage-Gated Ion Channels

$724,330

Modulation of excitation-contraction coupling by interaction between sodium-calcium exchangers and transient outward potassium currents

Nominated PICIHR2012Operating Grant

Principal investigators: Backx, Peter H

Keywords: Action Potential; Arrhythmias; Calcium; Contraction; Electrophysiology; Heart Disease; Ion Channels; Sodium

$549,655

Role of oxidative stress and TNF-alpha in exercise-induced atrial fibrillation

Nominated PICIHR2011Operating Grant

Principal investigators: Backx, Peter H

Keywords: Arrhythmias; Atrial Fibrillation; Heart Disease; Inflammation; Ion Channels

$762,213

Iroquois transcription factors in cardiac development and function

Co-investigatorCIHR2008Operating Grant

Principal investigators: Hui, Chi-Chung

Keywords: Cardiac Physiology; Cardiomyopathies; Heart Development; Homeobox Gene; Mutant Mouse Analysis; Transcription Factor

$716,470

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Department of Physiology
Biology
Medicine/Cardiology
Medical Biophysics
Laboratory Medicine & Pathobiology
Cardiology
Other

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Human physiology Dear Professor Backx, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α." (2020), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Canada Research Chair - Tier 1" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Peter Backx

Research

Latest papers

Latest funding

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-&#x3b1;.

Cardiac-specific inducible overexpression of human plasma membrane Ca2+ ATPase 4b is cardioprotective and improves survival in mice following ischemic injury.

Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models

Mechanisms of Long-Duration Ventricular&#xa0;Fibrillation in Human Hearts&#xa0;and Experimental Validation in&#xa0;Canine Purkinje&#xa0;Fibers.

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts.

Dantrolene Improves Survival After Ventricular Fibrillation by Mitigating Impaired Calcium Handling in Animal Models

ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.

Evidence for calreticulin attenuation of cardiac hypertrophy induced by pressure overload and soluble agonists.

Frequent collaborators

Peter Backx

Kumaraswamy Nanthakumar

Mansoor Husain

Lucy Osborne

Janet Rossant

Stanley Nattel

Zhong-Ping Feng

Paul Dorian

Warren Lee

Zachary Laksman

Michal Opas

Jason Roberts

Andrew Ramadeen

Gordon Keller

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α.

Mechanisms of Long-Duration Ventricular Fibrillation in Human Hearts and Experimental Validation in Canine Purkinje Fibers.